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Network neighborhood for query Sequence : ADCY1_HUMAN

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ADCY1_HUMAN
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ADCY1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
θ value	0 (rank : 2)	NC score	0.998040 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	36
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY6_HUMAN
θ value	0 (rank : 3)	NC score	0.983801 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
θ value	0 (rank : 4)	NC score	0.983202 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY8_HUMAN
θ value	1.0077e-184 (rank : 5)	NC score	0.979959 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
θ value	2.24492e-184 (rank : 6)	NC score	0.979784 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY2_MOUSE
θ value	4.85525e-171 (rank : 7)	NC score	0.976907 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY7_MOUSE
θ value	5.19945e-165 (rank : 8)	NC score	0.976827 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY4_HUMAN
θ value	1.15832e-164 (rank : 9)	NC score	0.977705 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY4_MOUSE
θ value	2.85304e-163 (rank : 10)	NC score	0.978174 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY2_HUMAN
θ value	8.30107e-163 (rank : 11)	NC score	0.977116 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY7_HUMAN
θ value	8.20983e-86 (rank : 12)	NC score	0.969829 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY3_HUMAN
θ value	8.79181e-80 (rank : 13)	NC score	0.956498 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_MOUSE
θ value	1.49966e-79 (rank : 14)	NC score	0.957901 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY9_MOUSE
θ value	5.73848e-55 (rank : 15)	NC score	0.908047 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY9_HUMAN
θ value	3.71957e-54 (rank : 16)	NC score	0.907917 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

GCYA3_HUMAN
θ value	2.51237e-26 (rank : 17)	NC score	0.799272 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA2_HUMAN
θ value	3.28125e-26 (rank : 18)	NC score	0.801653 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_MOUSE
θ value	9.54697e-26 (rank : 19)	NC score	0.797354 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GUC2G_MOUSE
θ value	9.54697e-26 (rank : 20)	NC score	0.469628 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	644	Shared Neighborhood Hits	32
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GCYB1_HUMAN
θ value	1.24688e-25 (rank : 21)	NC score	0.793305 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GCYB1_MOUSE
θ value	1.62847e-25 (rank : 22)	NC score	0.793630 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GUC2E_MOUSE
θ value	1.62847e-25 (rank : 23)	NC score	0.502796 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	692	Shared Neighborhood Hits	32
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	1.62847e-25 (rank : 24)	NC score	0.425607 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2C_HUMAN
θ value	1.80048e-24 (rank : 25)	NC score	0.441105 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	624	Shared Neighborhood Hits	31
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	1.80048e-24 (rank : 26)	NC score	0.499619 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

ANPRB_HUMAN
θ value	2.35151e-24 (rank : 27)	NC score	0.446938 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_HUMAN
θ value	4.01107e-24 (rank : 28)	NC score	0.450646 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	612	Shared Neighborhood Hits	31
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	5.23862e-24 (rank : 29)	NC score	0.451590 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	600	Shared Neighborhood Hits	31
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

GCYB2_HUMAN
θ value	8.93572e-24 (rank : 30)	NC score	0.818614 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

ANPRB_MOUSE
θ value	1.16704e-23 (rank : 31)	NC score	0.459543 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	607	Shared Neighborhood Hits	31
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

BCN1_HUMAN
θ value	0.279714 (rank : 32)	NC score	0.035871 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	395	Shared Neighborhood Hits	4
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

BCN1_MOUSE
θ value	0.279714 (rank : 33)	NC score	0.037035 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	367	Shared Neighborhood Hits	4
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

DLGP1_MOUSE
θ value	2.36792 (rank : 34)	NC score	0.014677 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D415, Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0	Gene names	Dlgap1, Kiaa4162
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (SAP90/PSD-95-associated protein 1) (SAPAP1) (PSD-95/SAP90- binding protein 1).

DCAK2_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.001273 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	862	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

HEP2_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.001763 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P05546, Q6IBZ5	Gene names	SERPIND1, HCF2
Domain Architecture
Description	Heparin cofactor 2 precursor (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin 2) (HLS2).

DLGP1_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.009806 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	O14490, O14489, P78335	Gene names	DLGAP1, DAP1, GKAP
Domain Architecture
Description	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (SAP90/PSD-95-associated protein 1) (SAPAP1) (PSD- 95/SAP90-binding protein 1).

GDF9_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.002504 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	O60383	Gene names	GDF9
Domain Architecture
Description	Growth/differentiation factor 9 precursor (GDF-9).

MLL4_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.002091 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	722	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

OAS3_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.004463 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6K5, Q9H3P5	Gene names	OAS3
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 3 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 3) (2-5A synthetase 3) (p100 OAS) (p100OAS).

PRDM5_HUMAN
θ value	8.99809 (rank : 41)	NC score	-0.004348 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	790	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQX1	Gene names	PRDM5, PFM2
Domain Architecture
Description	PR domain zinc finger protein 5 (PR domain-containing protein 5).

TBC17_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.003478 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYH7	Gene names	Tbc1d17
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 17.

ANPRC_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.157751 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.154128 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

Hits sorted by NC score

ADCY1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q08828, Q75MI1	Gene names	ADCY1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY1_MOUSE
NC score	0.998040 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	36
SwissProt Accessions	O88444, Q5SS89	Gene names	Adcy1
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 1 (EC 4.6.1.1) (Adenylate cyclase type I) (ATP pyrophosphate-lyase 1) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY6_HUMAN
NC score	0.983801 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	O43306, Q9NR75	Gene names	ADCY6, KIAA0422
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY6_MOUSE
NC score	0.983202 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	Q01341	Gene names	Adcy6
Domain Architecture
Description	Adenylate cyclase type 6 (EC 4.6.1.1) (Adenylate cyclase type VI) (ATP pyrophosphate-lyase 6) (Ca(2+)-inhibitable adenylyl cyclase).

ADCY8_HUMAN
NC score	0.979959 (rank : 5)	θ value	1.0077e-184 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	P40145	Gene names	ADCY8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY8_MOUSE
NC score	0.979784 (rank : 6)	θ value	2.24492e-184 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	31
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

ADCY4_MOUSE
NC score	0.978174 (rank : 7)	θ value	2.85304e-163 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY4_HUMAN
NC score	0.977705 (rank : 8)	θ value	1.15832e-164 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NFM4, Q96ML7	Gene names	ADCY4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ADCY2_HUMAN
NC score	0.977116 (rank : 9)	θ value	8.30107e-163 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q08462, Q9UPU2	Gene names	ADCY2, KIAA1060
Domain Architecture
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY2_MOUSE
NC score	0.976907 (rank : 10)	θ value	4.85525e-171 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q80TL1, Q8CFU6	Gene names	Adcy2, Kiaa1060
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).

ADCY7_MOUSE
NC score	0.976827 (rank : 11)	θ value	5.19945e-165 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	37	Shared Neighborhood Hits	31
SwissProt Accessions	P51829	Gene names	Adcy7
Domain Architecture
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY7_HUMAN
NC score	0.969829 (rank : 12)	θ value	8.20983e-86 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	44	Shared Neighborhood Hits	31
SwissProt Accessions	P51828	Gene names	ADCY7, KIAA0037
Domain Architecture	No domain graphic available
Description	Adenylate cyclase type 7 (EC 4.6.1.1) (Adenylate cyclase type VII) (ATP pyrophosphate-lyase 7) (Adenylyl cyclase 7).

ADCY3_MOUSE
NC score	0.957901 (rank : 13)	θ value	1.49966e-79 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VHH7	Gene names	Adcy3
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY3_HUMAN
NC score	0.956498 (rank : 14)	θ value	8.79181e-80 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	O60266, Q9UDB1	Gene names	ADCY3, KIAA0511
Domain Architecture
Description	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (Adenylate cyclase, olfactive type) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3).

ADCY9_MOUSE
NC score	0.908047 (rank : 15)	θ value	5.73848e-55 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	31
SwissProt Accessions	P51830, Q61279	Gene names	Adcy9
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10).

ADCY9_HUMAN
NC score	0.907917 (rank : 16)	θ value	3.71957e-54 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	31
SwissProt Accessions	O60503, O60273, Q4ZHT9, Q4ZIR5, Q9BWT4, Q9UGP2	Gene names	ADCY9, KIAA0520
Domain Architecture
Description	Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9).

GCYB2_HUMAN
NC score	0.818614 (rank : 17)	θ value	8.93572e-24 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	61	Shared Neighborhood Hits	31
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GCYA2_HUMAN
NC score	0.801653 (rank : 18)	θ value	3.28125e-26 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P33402	Gene names	GUCY1A2, GUC1A2, GUCSA2
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-2 (EC 4.6.1.2) (GCS-alpha-2).

GCYA3_HUMAN
NC score	0.799272 (rank : 19)	θ value	2.51237e-26 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	Q02108, O43843, Q8TAH3	Gene names	GUCY1A3, GUC1A3, GUCSA3, GUCY1A1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYA3_MOUSE
NC score	0.797354 (rank : 20)	θ value	9.54697e-26 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ERL9, Q9DBQ3	Gene names	Gucy1a3, Gucy1a1
Domain Architecture
Description	Guanylate cyclase soluble subunit alpha-3 (EC 4.6.1.2) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) (GCS-alpha-1).

GCYB1_MOUSE
NC score	0.793630 (rank : 21)	θ value	1.62847e-25 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	31
SwissProt Accessions	O54865	Gene names	Gucy1b3
Domain Architecture	No domain graphic available
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit).

GCYB1_HUMAN
NC score	0.793305 (rank : 22)	θ value	1.24688e-25 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	31
SwissProt Accessions	Q02153, Q86WY5	Gene names	GUCY1B3, GUC1B3, GUCSB3, GUCY1B1
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-1 (EC 4.6.1.2) (GCS-beta-1) (Soluble guanylate cyclase small subunit) (GCS-beta-3).

GUC2E_MOUSE
NC score	0.502796 (rank : 23)	θ value	1.62847e-25 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	692	Shared Neighborhood Hits	32
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2D_HUMAN
NC score	0.499619 (rank : 24)	θ value	1.80048e-24 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
NC score	0.469628 (rank : 25)	θ value	9.54697e-26 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	644	Shared Neighborhood Hits	32
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

ANPRB_MOUSE
NC score	0.459543 (rank : 26)	θ value	1.16704e-23 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	607	Shared Neighborhood Hits	31
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
NC score	0.451590 (rank : 27)	θ value	5.23862e-24 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	600	Shared Neighborhood Hits	31
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.450646 (rank : 28)	θ value	4.01107e-24 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	612	Shared Neighborhood Hits	31
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
NC score	0.446938 (rank : 29)	θ value	2.35151e-24 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	646	Shared Neighborhood Hits	31
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.441105 (rank : 30)	θ value	1.80048e-24 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	624	Shared Neighborhood Hits	31
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2F_HUMAN
NC score	0.425607 (rank : 31)	θ value	1.62847e-25 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	740	Shared Neighborhood Hits	32
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ANPRC_HUMAN
NC score	0.157751 (rank : 32)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P17342	Gene names	NPR3, ANPRC
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor).

ANPRC_MOUSE
NC score	0.154128 (rank : 33)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	8
SwissProt Accessions	P70180, P97804, Q9R025, Q9R027, Q9R028	Gene names	Npr3
Domain Architecture
Description	Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial natriuretic peptide C-type receptor) (EF-2).

BCN1_MOUSE
NC score	0.037035 (rank : 34)	θ value	0.279714 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	367	Shared Neighborhood Hits	4
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

BCN1_HUMAN
NC score	0.035871 (rank : 35)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	395	Shared Neighborhood Hits	4
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

DLGP1_MOUSE
NC score	0.014677 (rank : 36)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D415, Q52KF6, Q5DTK5, Q6P6N4, Q6XBF4, Q8BZL7, Q8BZQ1, Q8C0G0	Gene names	Dlgap1, Kiaa4162
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (SAP90/PSD-95-associated protein 1) (SAPAP1) (PSD-95/SAP90- binding protein 1).

DLGP1_HUMAN
NC score	0.009806 (rank : 37)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	O14490, O14489, P78335	Gene names	DLGAP1, DAP1, GKAP
Domain Architecture
Description	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (SAP90/PSD-95-associated protein 1) (SAPAP1) (PSD- 95/SAP90-binding protein 1).

OAS3_HUMAN
NC score	0.004463 (rank : 38)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y6K5, Q9H3P5	Gene names	OAS3
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 3 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 3) (2-5A synthetase 3) (p100 OAS) (p100OAS).

TBC17_MOUSE
NC score	0.003478 (rank : 39)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYH7	Gene names	Tbc1d17
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 17.

GDF9_HUMAN
NC score	0.002504 (rank : 40)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	O60383	Gene names	GDF9
Domain Architecture
Description	Growth/differentiation factor 9 precursor (GDF-9).

MLL4_HUMAN
NC score	0.002091 (rank : 41)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	722	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

HEP2_HUMAN
NC score	0.001763 (rank : 42)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	P05546, Q6IBZ5	Gene names	SERPIND1, HCF2
Domain Architecture
Description	Heparin cofactor 2 precursor (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin 2) (HLS2).

DCAK2_HUMAN
NC score	0.001273 (rank : 43)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	862	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

PRDM5_HUMAN
NC score	-0.004348 (rank : 44)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	790	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQX1	Gene names	PRDM5, PFM2
Domain Architecture
Description	PR domain zinc finger protein 5 (PR domain-containing protein 5).