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Network neighborhood for query Sequence : SENP2_MOUSE

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SENP2_MOUSE
SwissProt Accessions	Q91ZX6, Q544T8, Q9D4Z0	Gene names	Senp2, Smt3ip2
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SUMO-1/Smt3-specific isopeptidase 2) (Smt3ip2) (Axam2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SENP2_HUMAN
θ value	0 (rank : 1)	NC score	0.998202 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HC62, Q96SR2, Q9P2L5	Gene names	SENP2, KIAA1331
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZX6, Q544T8, Q9D4Z0	Gene names	Senp2, Smt3ip2
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SUMO-1/Smt3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP1_MOUSE
θ value	6.73165e-80 (rank : 3)	NC score	0.924054 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	P59110	Gene names	Senp1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP1_HUMAN
θ value	1.8332e-77 (rank : 4)	NC score	0.926911 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P0U3, Q86XC8	Gene names	SENP1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP3_HUMAN
θ value	5.0505e-35 (rank : 5)	NC score	0.817770 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4L4, Q96PS4, Q9Y3W9	Gene names	SENP3, SSP3, SUSP3
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3).

SENP3_MOUSE
θ value	5.0505e-35 (rank : 6)	NC score	0.814122 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EP97	Gene names	Senp3, Smt3ip, Smt3ip1
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3) (Smt3-specific isopeptidase 1) (Smt3ip1).

SENP5_HUMAN
θ value	2.77131e-33 (rank : 7)	NC score	0.812624 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q96HI0, Q96SA5	Gene names	SENP5
Domain Architecture
Description	Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5).

SENP6_HUMAN
θ value	3.18553e-13 (rank : 8)	NC score	0.556761 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	9
SwissProt Accessions	Q9GZR1, O94891, Q8TBY4, Q9UJV5	Gene names	SENP6, KIAA0797, SSP1, SUSP1
Domain Architecture
Description	Sentrin-specific protease 6 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP6) (SUMO-1-specific protease 1).

SENP7_HUMAN
θ value	7.34386e-10 (rank : 9)	NC score	0.513076 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	97	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

CHD3_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.007569 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	397	Shared Neighborhood Hits	2
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

LN28B_HUMAN
θ value	3.0926 (rank : 11)	NC score	0.017689 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZN17	Gene names	LIN28B, CSDD2
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

SPTA2_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.007109 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	888	Shared Neighborhood Hits	4
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ILDR1_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.016430 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CBR1, Q6PFB3, Q8CB39, Q91VS0	Gene names	Ildr1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

SETB1_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.011588 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

CCD39_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.002363 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	1026	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

GBRE_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.003875 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P78334, O15345, O15346, Q99520	Gene names	GABRE
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit epsilon precursor (GABA(A) receptor subunit epsilon).

TR11B_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.008506 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	O00300, O60236, Q53FX6, Q9UHP4	Gene names	TNFRSF11B, OCIF, OPG
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

K0690_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.031088 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5B0, Q7TMI5, Q80TU2	Gene names	Kiaa0690
Domain Architecture	No domain graphic available
Description	Protein KIAA0690.

SENP8_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.137138 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q96LD8, Q96QA4	Gene names	SENP8, DEN1, NEDP1, PRSC2
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (Protease, cysteine 2) (NEDD8-specific protease 1) (Deneddylase-1).

SENP8_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.110364 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D2Z4, Q543P0	Gene names	Senp8, Den1, Nedp1
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (NEDD8-specific protease 1) (Deneddylase-1).

Hits sorted by NC score

SENP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZX6, Q544T8, Q9D4Z0	Gene names	Senp2, Smt3ip2
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SUMO-1/Smt3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP2_HUMAN
NC score	0.998202 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HC62, Q96SR2, Q9P2L5	Gene names	SENP2, KIAA1331
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP1_HUMAN
NC score	0.926911 (rank : 3)	θ value	1.8332e-77 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P0U3, Q86XC8	Gene names	SENP1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP1_MOUSE
NC score	0.924054 (rank : 4)	θ value	6.73165e-80 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	P59110	Gene names	Senp1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP3_HUMAN
NC score	0.817770 (rank : 5)	θ value	5.0505e-35 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H4L4, Q96PS4, Q9Y3W9	Gene names	SENP3, SSP3, SUSP3
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3).

SENP3_MOUSE
NC score	0.814122 (rank : 6)	θ value	5.0505e-35 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EP97	Gene names	Senp3, Smt3ip, Smt3ip1
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3) (Smt3-specific isopeptidase 1) (Smt3ip1).

SENP5_HUMAN
NC score	0.812624 (rank : 7)	θ value	2.77131e-33 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q96HI0, Q96SA5	Gene names	SENP5
Domain Architecture
Description	Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5).

SENP6_HUMAN
NC score	0.556761 (rank : 8)	θ value	3.18553e-13 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	9
SwissProt Accessions	Q9GZR1, O94891, Q8TBY4, Q9UJV5	Gene names	SENP6, KIAA0797, SSP1, SUSP1
Domain Architecture
Description	Sentrin-specific protease 6 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP6) (SUMO-1-specific protease 1).

SENP7_HUMAN
NC score	0.513076 (rank : 9)	θ value	7.34386e-10 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	97	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

SENP8_HUMAN
NC score	0.137138 (rank : 10)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q96LD8, Q96QA4	Gene names	SENP8, DEN1, NEDP1, PRSC2
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (Protease, cysteine 2) (NEDD8-specific protease 1) (Deneddylase-1).

SENP8_MOUSE
NC score	0.110364 (rank : 11)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D2Z4, Q543P0	Gene names	Senp8, Den1, Nedp1
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (NEDD8-specific protease 1) (Deneddylase-1).

K0690_MOUSE
NC score	0.031088 (rank : 12)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5B0, Q7TMI5, Q80TU2	Gene names	Kiaa0690
Domain Architecture	No domain graphic available
Description	Protein KIAA0690.

LN28B_HUMAN
NC score	0.017689 (rank : 13)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZN17	Gene names	LIN28B, CSDD2
Domain Architecture	No domain graphic available
Description	Lin-28 homolog B.

ILDR1_MOUSE
NC score	0.016430 (rank : 14)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CBR1, Q6PFB3, Q8CB39, Q91VS0	Gene names	Ildr1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

SETB1_MOUSE
NC score	0.011588 (rank : 15)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

TR11B_HUMAN
NC score	0.008506 (rank : 16)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	O00300, O60236, Q53FX6, Q9UHP4	Gene names	TNFRSF11B, OCIF, OPG
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

CHD3_HUMAN
NC score	0.007569 (rank : 17)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	397	Shared Neighborhood Hits	2
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

SPTA2_HUMAN
NC score	0.007109 (rank : 18)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	888	Shared Neighborhood Hits	4
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

GBRE_HUMAN
NC score	0.003875 (rank : 19)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	P78334, O15345, O15346, Q99520	Gene names	GABRE
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit epsilon precursor (GABA(A) receptor subunit epsilon).

CCD39_MOUSE
NC score	0.002363 (rank : 20)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	1026	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.