Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : SENP3_MOUSE

For an explanation of this page, click here

SENP3_MOUSE
SwissProt Accessions	Q9EP97	Gene names	Senp3, Smt3ip, Smt3ip1
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3) (Smt3-specific isopeptidase 1) (Smt3ip1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SENP3_HUMAN
θ value	0 (rank : 1)	NC score	0.995328 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4L4, Q96PS4, Q9Y3W9	Gene names	SENP3, SSP3, SUSP3
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3).

SENP3_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q9EP97	Gene names	Senp3, Smt3ip, Smt3ip1
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3) (Smt3-specific isopeptidase 1) (Smt3ip1).

SENP5_HUMAN
θ value	3.81361e-83 (rank : 3)	NC score	0.926753 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	37	Shared Neighborhood Hits	11
SwissProt Accessions	Q96HI0, Q96SA5	Gene names	SENP5
Domain Architecture
Description	Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5).

SENP1_MOUSE
θ value	1.46607e-42 (rank : 4)	NC score	0.837168 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	P59110	Gene names	Senp1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP1_HUMAN
θ value	4.2656e-42 (rank : 5)	NC score	0.841725 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P0U3, Q86XC8	Gene names	SENP1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP2_HUMAN
θ value	5.0505e-35 (rank : 6)	NC score	0.813431 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HC62, Q96SR2, Q9P2L5	Gene names	SENP2, KIAA1331
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP2_MOUSE
θ value	5.0505e-35 (rank : 7)	NC score	0.814122 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZX6, Q544T8, Q9D4Z0	Gene names	Senp2, Smt3ip2
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SUMO-1/Smt3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP6_HUMAN
θ value	2.61198e-07 (rank : 8)	NC score	0.479389 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	Q9GZR1, O94891, Q8TBY4, Q9UJV5	Gene names	SENP6, KIAA0797, SSP1, SUSP1
Domain Architecture
Description	Sentrin-specific protease 6 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP6) (SUMO-1-specific protease 1).

SENP7_HUMAN
θ value	3.77169e-06 (rank : 9)	NC score	0.446848 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

SENP8_HUMAN
θ value	0.000602161 (rank : 10)	NC score	0.280659 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q96LD8, Q96QA4	Gene names	SENP8, DEN1, NEDP1, PRSC2
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (Protease, cysteine 2) (NEDD8-specific protease 1) (Deneddylase-1).

SENP8_MOUSE
θ value	0.0193708 (rank : 11)	NC score	0.236590 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D2Z4, Q543P0	Gene names	Senp8, Den1, Nedp1
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (NEDD8-specific protease 1) (Deneddylase-1).

JPH2_MOUSE
θ value	0.47712 (rank : 12)	NC score	0.021610 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

KCNH3_HUMAN
θ value	0.813845 (rank : 13)	NC score	0.014601 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

CO4A6_HUMAN
θ value	1.06291 (rank : 14)	NC score	0.025514 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	318	Shared Neighborhood Hits	14
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

CO7A1_HUMAN
θ value	1.06291 (rank : 15)	NC score	0.022012 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	807	Shared Neighborhood Hits	16
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

PP1RA_MOUSE
θ value	1.38821 (rank : 16)	NC score	0.038829 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	175	Shared Neighborhood Hits	7
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

CABIN_HUMAN
θ value	1.81305 (rank : 17)	NC score	0.050292 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	490	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

IL4RA_MOUSE
θ value	1.81305 (rank : 18)	NC score	0.040000 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

ARHGC_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.021923 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	344	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CO1A2_HUMAN
θ value	2.36792 (rank : 20)	NC score	0.025660 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	329	Shared Neighborhood Hits	13
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A1_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.023099 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	425	Shared Neighborhood Hits	14
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

MYH6_HUMAN
θ value	2.36792 (rank : 22)	NC score	0.003562 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	1426	Shared Neighborhood Hits	3
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

CO4A5_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.024255 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	383	Shared Neighborhood Hits	11
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

PP1RA_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.033853 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	180	Shared Neighborhood Hits	6
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

NUAK1_MOUSE
θ value	4.03905 (rank : 25)	NC score	0.000101 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	881	Shared Neighborhood Hits	4
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

SFTPD_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.020470 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	P50404	Gene names	Sftpd, Sftp4
Domain Architecture
Description	Pulmonary surfactant-associated protein D precursor (SP-D) (PSP-D).

TNK1_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.001422 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	815	Shared Neighborhood Hits	4
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

HPS6_MOUSE
θ value	5.27518 (rank : 28)	NC score	0.025826 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLY7, Q8BML5, Q8CIA3	Gene names	Hps6, Ru
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 6 protein homolog (Ruby-eye protein) (Ru).

RKHD1_HUMAN
θ value	5.27518 (rank : 29)	NC score	0.018246 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

SYFM_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.026336 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062	Gene names	FARS2, FARS1
Domain Architecture	No domain graphic available
Description	Phenylalanyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.20) (Phenylalanine--tRNA ligase) (PheRS).

CO1A1_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.022598 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	475	Shared Neighborhood Hits	14
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO1A1_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.022564 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	457	Shared Neighborhood Hits	14
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO3A1_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.022127 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	466	Shared Neighborhood Hits	12
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

IL4RA_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.030345 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

MK07_MOUSE
θ value	6.88961 (rank : 35)	NC score	-0.000184 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	1054	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MYH6_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.002670 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	1501	Shared Neighborhood Hits	3
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

SFR14_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.022875 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	238	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

ZAR1_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.024780 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ZNF74_HUMAN
θ value	6.88961 (rank : 39)	NC score	-0.001620 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	770	Shared Neighborhood Hits	2
SwissProt Accessions	Q16587, Q6IBV2, Q9UC04, Q9UF05, Q9UF06, Q9UF07	Gene names	ZNF74
Domain Architecture
Description	Zinc finger protein 74 (hZNF7).

ARHGC_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.016431 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	351	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

COBA1_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.019519 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

IWS1_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.008595 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	1258	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KCNB2_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.003066 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	212	Shared Neighborhood Hits	2
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

TNKS1_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.001592 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	477	Shared Neighborhood Hits	3
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

Hits sorted by NC score

SENP3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	44	Target Neighborhood Hits	44	Shared Neighborhood Hits	44
SwissProt Accessions	Q9EP97	Gene names	Senp3, Smt3ip, Smt3ip1
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3) (Smt3-specific isopeptidase 1) (Smt3ip1).

SENP3_HUMAN
NC score	0.995328 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	44	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H4L4, Q96PS4, Q9Y3W9	Gene names	SENP3, SSP3, SUSP3
Domain Architecture
Description	Sentrin-specific protease 3 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP3) (SUMO-1-specific protease 3).

SENP5_HUMAN
NC score	0.926753 (rank : 3)	θ value	3.81361e-83 (rank : 3)
Query Neighborhood Hits	44	Target Neighborhood Hits	37	Shared Neighborhood Hits	11
SwissProt Accessions	Q96HI0, Q96SA5	Gene names	SENP5
Domain Architecture
Description	Sentrin-specific protease 5 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP5).

SENP1_HUMAN
NC score	0.841725 (rank : 4)	θ value	4.2656e-42 (rank : 5)
Query Neighborhood Hits	44	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P0U3, Q86XC8	Gene names	SENP1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP1_MOUSE
NC score	0.837168 (rank : 5)	θ value	1.46607e-42 (rank : 4)
Query Neighborhood Hits	44	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	P59110	Gene names	Senp1
Domain Architecture
Description	Sentrin-specific protease 1 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP1).

SENP2_MOUSE
NC score	0.814122 (rank : 6)	θ value	5.0505e-35 (rank : 7)
Query Neighborhood Hits	44	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZX6, Q544T8, Q9D4Z0	Gene names	Senp2, Smt3ip2
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SUMO-1/Smt3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP2_HUMAN
NC score	0.813431 (rank : 7)	θ value	5.0505e-35 (rank : 6)
Query Neighborhood Hits	44	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HC62, Q96SR2, Q9P2L5	Gene names	SENP2, KIAA1331
Domain Architecture
Description	Sentrin-specific protease 2 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Axam2).

SENP6_HUMAN
NC score	0.479389 (rank : 8)	θ value	2.61198e-07 (rank : 8)
Query Neighborhood Hits	44	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	Q9GZR1, O94891, Q8TBY4, Q9UJV5	Gene names	SENP6, KIAA0797, SSP1, SUSP1
Domain Architecture
Description	Sentrin-specific protease 6 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP6) (SUMO-1-specific protease 1).

SENP7_HUMAN
NC score	0.446848 (rank : 9)	θ value	3.77169e-06 (rank : 9)
Query Neighborhood Hits	44	Target Neighborhood Hits	97	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

SENP8_HUMAN
NC score	0.280659 (rank : 10)	θ value	0.000602161 (rank : 10)
Query Neighborhood Hits	44	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q96LD8, Q96QA4	Gene names	SENP8, DEN1, NEDP1, PRSC2
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (Protease, cysteine 2) (NEDD8-specific protease 1) (Deneddylase-1).

SENP8_MOUSE
NC score	0.236590 (rank : 11)	θ value	0.0193708 (rank : 11)
Query Neighborhood Hits	44	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D2Z4, Q543P0	Gene names	Senp8, Den1, Nedp1
Domain Architecture
Description	Sentrin-specific protease 8 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP8) (NEDD8-specific protease 1) (Deneddylase-1).

CABIN_HUMAN
NC score	0.050292 (rank : 12)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	44	Target Neighborhood Hits	490	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

IL4RA_MOUSE
NC score	0.040000 (rank : 13)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	44	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

PP1RA_MOUSE
NC score	0.038829 (rank : 14)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	44	Target Neighborhood Hits	175	Shared Neighborhood Hits	7
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

PP1RA_HUMAN
NC score	0.033853 (rank : 15)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	44	Target Neighborhood Hits	180	Shared Neighborhood Hits	6
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

IL4RA_HUMAN
NC score	0.030345 (rank : 16)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	44	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	P24394, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188	Gene names	IL4R, 582J2.1, IL4RA
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)].

SYFM_HUMAN
NC score	0.026336 (rank : 17)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	44	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	O95363, Q53F66, Q5TCS3, Q6FG29, Q9NPY7, Q9P062	Gene names	FARS2, FARS1
Domain Architecture	No domain graphic available
Description	Phenylalanyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.20) (Phenylalanine--tRNA ligase) (PheRS).

HPS6_MOUSE
NC score	0.025826 (rank : 18)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	44	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BLY7, Q8BML5, Q8CIA3	Gene names	Hps6, Ru
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 6 protein homolog (Ruby-eye protein) (Ru).

CO1A2_HUMAN
NC score	0.025660 (rank : 19)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	44	Target Neighborhood Hits	329	Shared Neighborhood Hits	13
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A6_HUMAN
NC score	0.025514 (rank : 20)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	44	Target Neighborhood Hits	318	Shared Neighborhood Hits	14
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

ZAR1_HUMAN
NC score	0.024780 (rank : 21)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	44	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

CO4A5_HUMAN
NC score	0.024255 (rank : 22)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	44	Target Neighborhood Hits	383	Shared Neighborhood Hits	11
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

CO4A1_HUMAN
NC score	0.023099 (rank : 23)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	44	Target Neighborhood Hits	425	Shared Neighborhood Hits	14
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

SFR14_MOUSE
NC score	0.022875 (rank : 24)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	44	Target Neighborhood Hits	238	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

CO1A1_HUMAN
NC score	0.022598 (rank : 25)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	44	Target Neighborhood Hits	475	Shared Neighborhood Hits	14
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO1A1_MOUSE
NC score	0.022564 (rank : 26)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	44	Target Neighborhood Hits	457	Shared Neighborhood Hits	14
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO3A1_MOUSE
NC score	0.022127 (rank : 27)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	44	Target Neighborhood Hits	466	Shared Neighborhood Hits	12
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO7A1_HUMAN
NC score	0.022012 (rank : 28)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	44	Target Neighborhood Hits	807	Shared Neighborhood Hits	16
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

ARHGC_MOUSE
NC score	0.021923 (rank : 29)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	44	Target Neighborhood Hits	344	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

JPH2_MOUSE
NC score	0.021610 (rank : 30)	θ value	0.47712 (rank : 12)
Query Neighborhood Hits	44	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

SFTPD_MOUSE
NC score	0.020470 (rank : 31)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	44	Target Neighborhood Hits	217	Shared Neighborhood Hits	11
SwissProt Accessions	P50404	Gene names	Sftpd, Sftp4
Domain Architecture
Description	Pulmonary surfactant-associated protein D precursor (SP-D) (PSP-D).

COBA1_HUMAN
NC score	0.019519 (rank : 32)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	44	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

RKHD1_HUMAN
NC score	0.018246 (rank : 33)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	44	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

ARHGC_HUMAN
NC score	0.016431 (rank : 34)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	44	Target Neighborhood Hits	351	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

KCNH3_HUMAN
NC score	0.014601 (rank : 35)	θ value	0.813845 (rank : 13)
Query Neighborhood Hits	44	Target Neighborhood Hits	148	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

IWS1_MOUSE
NC score	0.008595 (rank : 36)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	44	Target Neighborhood Hits	1258	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYH6_HUMAN
NC score	0.003562 (rank : 37)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	44	Target Neighborhood Hits	1426	Shared Neighborhood Hits	3
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

KCNB2_HUMAN
NC score	0.003066 (rank : 38)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	44	Target Neighborhood Hits	212	Shared Neighborhood Hits	2
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

MYH6_MOUSE
NC score	0.002670 (rank : 39)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	44	Target Neighborhood Hits	1501	Shared Neighborhood Hits	3
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

TNKS1_HUMAN
NC score	0.001592 (rank : 40)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	44	Target Neighborhood Hits	477	Shared Neighborhood Hits	3
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

TNK1_HUMAN
NC score	0.001422 (rank : 41)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	44	Target Neighborhood Hits	815	Shared Neighborhood Hits	4
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

NUAK1_MOUSE
NC score	0.000101 (rank : 42)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	44	Target Neighborhood Hits	881	Shared Neighborhood Hits	4
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

MK07_MOUSE
NC score	-0.000184 (rank : 43)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	44	Target Neighborhood Hits	1054	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

ZNF74_HUMAN
NC score	-0.001620 (rank : 44)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	44	Target Neighborhood Hits	770	Shared Neighborhood Hits	2
SwissProt Accessions	Q16587, Q6IBV2, Q9UC04, Q9UF05, Q9UF06, Q9UF07	Gene names	ZNF74
Domain Architecture
Description	Zinc finger protein 74 (hZNF7).