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Network neighborhood for query Sequence : MCM3_MOUSE

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MCM3_MOUSE
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MCM3_HUMAN
θ value	0 (rank : 1)	NC score	0.991129 (rank : 2)
Query Neighborhood Hits	95	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

MCM3_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	95
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

MCM2_HUMAN
θ value	5.88354e-84 (rank : 3)	NC score	0.938883 (rank : 5)
Query Neighborhood Hits	95	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P49736, Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7	Gene names	MCM2, BM28, CDCL1, KIAA0030
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM7_HUMAN
θ value	1.71185e-83 (rank : 4)	NC score	0.942788 (rank : 3)
Query Neighborhood Hits	95	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P33993, Q15076, Q96D34, Q96GL1	Gene names	MCM7, CDC47, MCM2
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog) (P1.1-MCM3).

MCM2_MOUSE
θ value	2.23575e-83 (rank : 5)	NC score	0.938702 (rank : 6)
Query Neighborhood Hits	95	Target Neighborhood Hits	33	Shared Neighborhood Hits	17
SwissProt Accessions	P97310, O08971, O89057, Q8C2R0	Gene names	Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM6_MOUSE
θ value	1.44917e-82 (rank : 6)	NC score	0.936989 (rank : 7)
Query Neighborhood Hits	95	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	P97311, Q80YQ7	Gene names	Mcm6, Mcmd6, Mis5
Domain Architecture
Description	DNA replication licensing factor MCM6 (Mis5 homolog).

MCM7_MOUSE
θ value	2.47191e-82 (rank : 7)	NC score	0.941927 (rank : 4)
Query Neighborhood Hits	95	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61881	Gene names	Mcm7, Cdc47, Mcmd7
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog).

MCM4_MOUSE
θ value	7.19216e-82 (rank : 8)	NC score	0.932779 (rank : 11)
Query Neighborhood Hits	95	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	P49717, O89056	Gene names	Mcm4, Cdc21, Mcmd4
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM6_HUMAN
θ value	1.03855e-80 (rank : 9)	NC score	0.936342 (rank : 8)
Query Neighborhood Hits	95	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q14566, Q13504, Q99859	Gene names	MCM6
Domain Architecture
Description	DNA replication licensing factor MCM6 (p105MCM).

MCM5_HUMAN
θ value	4.82422e-78 (rank : 10)	NC score	0.935627 (rank : 9)
Query Neighborhood Hits	95	Target Neighborhood Hits	37	Shared Neighborhood Hits	15
SwissProt Accessions	P33992, O60785, Q14578, Q9BTJ4, Q9BWL8	Gene names	MCM5, CDC46
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM5_MOUSE
θ value	6.96618e-77 (rank : 11)	NC score	0.934811 (rank : 10)
Query Neighborhood Hits	95	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	P49718	Gene names	Mcm5, Cdc46, Mcmd5
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM4_HUMAN
θ value	1.45253e-74 (rank : 12)	NC score	0.930872 (rank : 12)
Query Neighborhood Hits	95	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM8_HUMAN
θ value	1.36585e-56 (rank : 13)	NC score	0.912108 (rank : 13)
Query Neighborhood Hits	95	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCM8_MOUSE
θ value	3.974e-56 (rank : 14)	NC score	0.911917 (rank : 14)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

IWS1_HUMAN
θ value	3.19293e-05 (rank : 15)	NC score	0.064935 (rank : 15)
Query Neighborhood Hits	95	Target Neighborhood Hits	1241	Shared Neighborhood Hits	29
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

RAI14_MOUSE
θ value	0.00298849 (rank : 16)	NC score	0.025335 (rank : 45)
Query Neighborhood Hits	95	Target Neighborhood Hits	1505	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

IWS1_MOUSE
θ value	0.00509761 (rank : 17)	NC score	0.058194 (rank : 16)
Query Neighborhood Hits	95	Target Neighborhood Hits	1258	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

BAZ1B_HUMAN
θ value	0.0431538 (rank : 18)	NC score	0.034840 (rank : 23)
Query Neighborhood Hits	95	Target Neighborhood Hits	701	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

MYH3_HUMAN
θ value	0.0431538 (rank : 19)	NC score	0.025797 (rank : 42)
Query Neighborhood Hits	95	Target Neighborhood Hits	1660	Shared Neighborhood Hits	44
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MY18A_HUMAN
θ value	0.0563607 (rank : 20)	NC score	0.032381 (rank : 26)
Query Neighborhood Hits	95	Target Neighborhood Hits	1929	Shared Neighborhood Hits	45
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	0.163984 (rank : 21)	NC score	0.032734 (rank : 25)
Query Neighborhood Hits	95	Target Neighborhood Hits	1989	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

OPTN_MOUSE
θ value	0.21417 (rank : 22)	NC score	0.025051 (rank : 48)
Query Neighborhood Hits	95	Target Neighborhood Hits	1120	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

VPS4A_MOUSE
θ value	0.21417 (rank : 23)	NC score	0.023723 (rank : 50)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

CK5P2_HUMAN
θ value	0.279714 (rank : 24)	NC score	0.025365 (rank : 44)
Query Neighborhood Hits	95	Target Neighborhood Hits	1433	Shared Neighborhood Hits	42
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CC45L_MOUSE
θ value	0.365318 (rank : 25)	NC score	0.052124 (rank : 17)
Query Neighborhood Hits	95	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1X9, O70547, Q9QUK1, Q9R212	Gene names	Cdc45l, Cdc45l2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1).

MYH6_MOUSE
θ value	0.365318 (rank : 26)	NC score	0.025188 (rank : 46)
Query Neighborhood Hits	95	Target Neighborhood Hits	1501	Shared Neighborhood Hits	37
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

STXB4_MOUSE
θ value	0.365318 (rank : 27)	NC score	0.029606 (rank : 29)
Query Neighborhood Hits	95	Target Neighborhood Hits	629	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TXND2_MOUSE
θ value	0.47712 (rank : 28)	NC score	0.027133 (rank : 38)
Query Neighborhood Hits	95	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

GOGA4_MOUSE
θ value	0.62314 (rank : 29)	NC score	0.025740 (rank : 43)
Query Neighborhood Hits	95	Target Neighborhood Hits	1939	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

VPS4A_HUMAN
θ value	0.62314 (rank : 30)	NC score	0.020897 (rank : 60)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

ATRX_MOUSE
θ value	0.813845 (rank : 31)	NC score	0.026836 (rank : 40)
Query Neighborhood Hits	95	Target Neighborhood Hits	682	Shared Neighborhood Hits	36
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

CBP_HUMAN
θ value	0.813845 (rank : 32)	NC score	0.015163 (rank : 73)
Query Neighborhood Hits	95	Target Neighborhood Hits	941	Shared Neighborhood Hits	13
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CND3_HUMAN
θ value	0.813845 (rank : 33)	NC score	0.031567 (rank : 27)
Query Neighborhood Hits	95	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BPX3, Q96SV9, Q9BUR3, Q9BVY1, Q9H914, Q9H9Z6, Q9HBI9	Gene names	NCAPG, CAPG, NYMEL3
Domain Architecture
Description	Condensin complex subunit 3 (Non-SMC condensin I complex subunit G) (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (XCAP-G homolog) (Antigen NY-MEL-3).

K0586_HUMAN
θ value	0.813845 (rank : 34)	NC score	0.036260 (rank : 21)
Query Neighborhood Hits	95	Target Neighborhood Hits	311	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

STK10_MOUSE
θ value	0.813845 (rank : 35)	NC score	0.008361 (rank : 84)
Query Neighborhood Hits	95	Target Neighborhood Hits	2132	Shared Neighborhood Hits	47
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MDN1_HUMAN
θ value	1.06291 (rank : 36)	NC score	0.042078 (rank : 19)
Query Neighborhood Hits	95	Target Neighborhood Hits	662	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

NP1L3_MOUSE
θ value	1.06291 (rank : 37)	NC score	0.027356 (rank : 37)
Query Neighborhood Hits	95	Target Neighborhood Hits	233	Shared Neighborhood Hits	20
SwissProt Accessions	Q794H2, O54802	Gene names	Nap1l3, Mb20
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 3 (Brain-specific protein MB20).

OSBL8_HUMAN
θ value	1.06291 (rank : 38)	NC score	0.016110 (rank : 71)
Query Neighborhood Hits	95	Target Neighborhood Hits	289	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

STXB4_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.029574 (rank : 30)
Query Neighborhood Hits	95	Target Neighborhood Hits	616	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

BPAEA_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.022911 (rank : 55)
Query Neighborhood Hits	95	Target Neighborhood Hits	1369	Shared Neighborhood Hits	39
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CASP_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.025066 (rank : 47)
Query Neighborhood Hits	95	Target Neighborhood Hits	1131	Shared Neighborhood Hits	34
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CN145_HUMAN
θ value	1.81305 (rank : 42)	NC score	0.022228 (rank : 59)
Query Neighborhood Hits	95	Target Neighborhood Hits	1196	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CUTL1_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.023598 (rank : 52)
Query Neighborhood Hits	95	Target Neighborhood Hits	1574	Shared Neighborhood Hits	36
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CUTL1_MOUSE
θ value	1.81305 (rank : 44)	NC score	0.022893 (rank : 56)
Query Neighborhood Hits	95	Target Neighborhood Hits	1620	Shared Neighborhood Hits	34
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

DPOD3_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.043324 (rank : 18)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

LEO1_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.033823 (rank : 24)
Query Neighborhood Hits	95	Target Neighborhood Hits	958	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

RNF34_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.013818 (rank : 78)
Query Neighborhood Hits	95	Target Neighborhood Hits	160	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

SNUT1_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.036975 (rank : 20)
Query Neighborhood Hits	95	Target Neighborhood Hits	129	Shared Neighborhood Hits	11
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

STIP1_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.010850 (rank : 80)
Query Neighborhood Hits	95	Target Neighborhood Hits	147	Shared Neighborhood Hits	3
SwissProt Accessions	P31948	Gene names	STIP1
Domain Architecture
Description	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Transformation-sensitive protein IEF SSP 3521) (NY- REN-11 antigen).

CCD46_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.026935 (rank : 39)
Query Neighborhood Hits	95	Target Neighborhood Hits	1405	Shared Neighborhood Hits	41
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

IF2M_MOUSE
θ value	2.36792 (rank : 51)	NC score	0.019695 (rank : 62)
Query Neighborhood Hits	95	Target Neighborhood Hits	183	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

LATS1_MOUSE
θ value	2.36792 (rank : 52)	NC score	0.000986 (rank : 92)
Query Neighborhood Hits	95	Target Neighborhood Hits	1027	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

LEO1_MOUSE
θ value	3.0926 (rank : 53)	NC score	0.028542 (rank : 36)
Query Neighborhood Hits	95	Target Neighborhood Hits	946	Shared Neighborhood Hits	25
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MRCKB_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.007914 (rank : 86)
Query Neighborhood Hits	95	Target Neighborhood Hits	2180	Shared Neighborhood Hits	43
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PI4KB_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.015203 (rank : 72)
Query Neighborhood Hits	95	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	3.0926 (rank : 56)	NC score	0.015114 (rank : 74)
Query Neighborhood Hits	95	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

RL6_MOUSE
θ value	3.0926 (rank : 57)	NC score	0.022540 (rank : 58)
Query Neighborhood Hits	95	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P47911, Q6P5I2, Q925C3	Gene names	Rpl6
Domain Architecture
Description	60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107).

SH24A_HUMAN
θ value	3.0926 (rank : 58)	NC score	0.026152 (rank : 41)
Query Neighborhood Hits	95	Target Neighborhood Hits	455	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SPTA1_HUMAN
θ value	3.0926 (rank : 59)	NC score	0.018487 (rank : 65)
Query Neighborhood Hits	95	Target Neighborhood Hits	748	Shared Neighborhood Hits	29
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ZIM2_HUMAN
θ value	3.0926 (rank : 60)	NC score	-0.001883 (rank : 95)
Query Neighborhood Hits	95	Target Neighborhood Hits	718	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZV7	Gene names	ZIM2
Domain Architecture
Description	Zinc finger imprinted 2.

CC45L_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.035731 (rank : 22)
Query Neighborhood Hits	95	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	O75419, O60856, Q6UW54, Q9UP68	Gene names	CDC45L, CDC45L2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1) (Cdc45).

EDD1_HUMAN
θ value	4.03905 (rank : 62)	NC score	0.010605 (rank : 81)
Query Neighborhood Hits	95	Target Neighborhood Hits	170	Shared Neighborhood Hits	6
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

MYH4_MOUSE
θ value	4.03905 (rank : 63)	NC score	0.024007 (rank : 49)
Query Neighborhood Hits	95	Target Neighborhood Hits	1476	Shared Neighborhood Hits	42
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH7_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.023535 (rank : 53)
Query Neighborhood Hits	95	Target Neighborhood Hits	1559	Shared Neighborhood Hits	38
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

PAPS1_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.028971 (rank : 34)
Query Neighborhood Hits	95	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O43252, O43841, O75332, Q96FB1, Q96TF4, Q9P1P9, Q9UE98	Gene names	PAPSS1, ATPSK1, PAPSS
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS1_MOUSE
θ value	4.03905 (rank : 66)	NC score	0.028969 (rank : 35)
Query Neighborhood Hits	95	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q60967	Gene names	Papss1, Asapk, Atpsk1, Papss
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_HUMAN
θ value	4.03905 (rank : 67)	NC score	0.029034 (rank : 32)
Query Neighborhood Hits	95	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O95340, Q9BZL2, Q9P0G6, Q9UHM1, Q9UKD3, Q9UP30	Gene names	PAPSS2, ATPSK2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_MOUSE
θ value	4.03905 (rank : 68)	NC score	0.029043 (rank : 31)
Query Neighborhood Hits	95	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	O88428, Q9Z274	Gene names	Papss2, Atpsk2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

CN155_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.017682 (rank : 66)
Query Neighborhood Hits	95	Target Neighborhood Hits	385	Shared Neighborhood Hits	12
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

ITSN1_HUMAN
θ value	5.27518 (rank : 70)	NC score	0.014148 (rank : 76)
Query Neighborhood Hits	95	Target Neighborhood Hits	1757	Shared Neighborhood Hits	39
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MYH2_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.023620 (rank : 51)
Query Neighborhood Hits	95	Target Neighborhood Hits	1491	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

POT14_HUMAN
θ value	5.27518 (rank : 72)	NC score	0.006845 (rank : 88)
Query Neighborhood Hits	95	Target Neighborhood Hits	403	Shared Neighborhood Hits	7
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

SNUT1_MOUSE
θ value	5.27518 (rank : 73)	NC score	0.031101 (rank : 28)
Query Neighborhood Hits	95	Target Neighborhood Hits	159	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z315, Q8K155, Q9R1I9, Q9R270	Gene names	Sart1, Haf
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (mSART-1) (Hypoxia- associated factor).

SPTN2_HUMAN
θ value	5.27518 (rank : 74)	NC score	0.013889 (rank : 77)
Query Neighborhood Hits	95	Target Neighborhood Hits	535	Shared Neighborhood Hits	32
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

TCAL5_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.016422 (rank : 70)
Query Neighborhood Hits	95	Target Neighborhood Hits	806	Shared Neighborhood Hits	23
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

GAK_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.000631 (rank : 93)
Query Neighborhood Hits	95	Target Neighborhood Hits	964	Shared Neighborhood Hits	8
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GP158_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.017038 (rank : 68)
Query Neighborhood Hits	95	Target Neighborhood Hits	221	Shared Neighborhood Hits	11
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

KIF9_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.002449 (rank : 91)
Query Neighborhood Hits	95	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV04, O35070	Gene names	Kif9
Domain Architecture
Description	Kinesin-like protein KIF9.

KU70_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.010419 (rank : 82)
Query Neighborhood Hits	95	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P23475, O88212, Q62027, Q62382, Q62453	Gene names	Xrcc6, G22p1, Ku70
Domain Architecture
Description	ATP-dependent DNA helicase 2 subunit 1 (EC 3.6.1.-) (ATP-dependent DNA helicase II 70 kDa subunit) (Ku autoantigen protein p70 homolog) (Ku70) (CTC box-binding factor 75 kDa subunit) (CTCBF) (CTC75) (DNA- repair protein XRCC6).

NAF1_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.019774 (rank : 61)
Query Neighborhood Hits	95	Target Neighborhood Hits	937	Shared Neighborhood Hits	34
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

TOP2A_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.016689 (rank : 69)
Query Neighborhood Hits	95	Target Neighborhood Hits	135	Shared Neighborhood Hits	19
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

UBP4_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.003551 (rank : 90)
Query Neighborhood Hits	95	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q13107, O43452, O43453	Gene names	USP4, UNP, UNPH
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein homolog).

WDHD1_HUMAN
θ value	6.88961 (rank : 83)	NC score	0.008763 (rank : 83)
Query Neighborhood Hits	95	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

APTX_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.008176 (rank : 85)
Query Neighborhood Hits	95	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

CASP_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.022608 (rank : 57)
Query Neighborhood Hits	95	Target Neighborhood Hits	1152	Shared Neighborhood Hits	34
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD91_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.029001 (rank : 33)
Query Neighborhood Hits	95	Target Neighborhood Hits	868	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CDC37_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.014836 (rank : 75)
Query Neighborhood Hits	95	Target Neighborhood Hits	359	Shared Neighborhood Hits	18
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

DHB4_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.007125 (rank : 87)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

KPCD1_HUMAN
θ value	8.99809 (rank : 89)	NC score	-0.001878 (rank : 94)
Query Neighborhood Hits	95	Target Neighborhood Hits	901	Shared Neighborhood Hits	7
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

LAD1_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.012753 (rank : 79)
Query Neighborhood Hits	95	Target Neighborhood Hits	391	Shared Neighborhood Hits	9
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

MYH1_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.023403 (rank : 54)
Query Neighborhood Hits	95	Target Neighborhood Hits	1478	Shared Neighborhood Hits	42
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

PACN3_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.004509 (rank : 89)
Query Neighborhood Hits	95	Target Neighborhood Hits	385	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

RL6_HUMAN
θ value	8.99809 (rank : 93)	NC score	0.017202 (rank : 67)
Query Neighborhood Hits	95	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q02878, Q2M3Q3, Q8WW97	Gene names	RPL6
Domain Architecture
Description	60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) (Neoplasm-related protein C140).

SMC1A_HUMAN
θ value	8.99809 (rank : 94)	NC score	0.019479 (rank : 63)
Query Neighborhood Hits	95	Target Neighborhood Hits	1346	Shared Neighborhood Hits	38
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	8.99809 (rank : 95)	NC score	0.019162 (rank : 64)
Query Neighborhood Hits	95	Target Neighborhood Hits	1384	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

Hits sorted by NC score

MCM3_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	95
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

MCM3_HUMAN
NC score	0.991129 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	95	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

MCM7_HUMAN
NC score	0.942788 (rank : 3)	θ value	1.71185e-83 (rank : 4)
Query Neighborhood Hits	95	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	P33993, Q15076, Q96D34, Q96GL1	Gene names	MCM7, CDC47, MCM2
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog) (P1.1-MCM3).

MCM7_MOUSE
NC score	0.941927 (rank : 4)	θ value	2.47191e-82 (rank : 7)
Query Neighborhood Hits	95	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61881	Gene names	Mcm7, Cdc47, Mcmd7
Domain Architecture
Description	DNA replication licensing factor MCM7 (CDC47 homolog).

MCM2_HUMAN
NC score	0.938883 (rank : 5)	θ value	5.88354e-84 (rank : 3)
Query Neighborhood Hits	95	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P49736, Q14577, Q15023, Q8N2V1, Q969W7, Q96AE1, Q9BRM7	Gene names	MCM2, BM28, CDCL1, KIAA0030
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM2_MOUSE
NC score	0.938702 (rank : 6)	θ value	2.23575e-83 (rank : 5)
Query Neighborhood Hits	95	Target Neighborhood Hits	33	Shared Neighborhood Hits	17
SwissProt Accessions	P97310, O08971, O89057, Q8C2R0	Gene names	Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2
Domain Architecture
Description	DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28).

MCM6_MOUSE
NC score	0.936989 (rank : 7)	θ value	1.44917e-82 (rank : 6)
Query Neighborhood Hits	95	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	P97311, Q80YQ7	Gene names	Mcm6, Mcmd6, Mis5
Domain Architecture
Description	DNA replication licensing factor MCM6 (Mis5 homolog).

MCM6_HUMAN
NC score	0.936342 (rank : 8)	θ value	1.03855e-80 (rank : 9)
Query Neighborhood Hits	95	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q14566, Q13504, Q99859	Gene names	MCM6
Domain Architecture
Description	DNA replication licensing factor MCM6 (p105MCM).

MCM5_HUMAN
NC score	0.935627 (rank : 9)	θ value	4.82422e-78 (rank : 10)
Query Neighborhood Hits	95	Target Neighborhood Hits	37	Shared Neighborhood Hits	15
SwissProt Accessions	P33992, O60785, Q14578, Q9BTJ4, Q9BWL8	Gene names	MCM5, CDC46
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM5_MOUSE
NC score	0.934811 (rank : 10)	θ value	6.96618e-77 (rank : 11)
Query Neighborhood Hits	95	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	P49718	Gene names	Mcm5, Cdc46, Mcmd5
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

MCM4_MOUSE
NC score	0.932779 (rank : 11)	θ value	7.19216e-82 (rank : 8)
Query Neighborhood Hits	95	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	P49717, O89056	Gene names	Mcm4, Cdc21, Mcmd4
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM4_HUMAN
NC score	0.930872 (rank : 12)	θ value	1.45253e-74 (rank : 12)
Query Neighborhood Hits	95	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MCM8_HUMAN
NC score	0.912108 (rank : 13)	θ value	1.36585e-56 (rank : 13)
Query Neighborhood Hits	95	Target Neighborhood Hits	25	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCM8_MOUSE
NC score	0.911917 (rank : 14)	θ value	3.974e-56 (rank : 14)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

IWS1_HUMAN
NC score	0.064935 (rank : 15)	θ value	3.19293e-05 (rank : 15)
Query Neighborhood Hits	95	Target Neighborhood Hits	1241	Shared Neighborhood Hits	29
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
NC score	0.058194 (rank : 16)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	95	Target Neighborhood Hits	1258	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

CC45L_MOUSE
NC score	0.052124 (rank : 17)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	95	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z1X9, O70547, Q9QUK1, Q9R212	Gene names	Cdc45l, Cdc45l2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1).

DPOD3_HUMAN
NC score	0.043324 (rank : 18)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	7
SwissProt Accessions	Q15054	Gene names	POLD3, KIAA0039
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

MDN1_HUMAN
NC score	0.042078 (rank : 19)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	95	Target Neighborhood Hits	662	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SNUT1_HUMAN
NC score	0.036975 (rank : 20)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	95	Target Neighborhood Hits	129	Shared Neighborhood Hits	11
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

K0586_HUMAN
NC score	0.036260 (rank : 21)	θ value	0.813845 (rank : 34)
Query Neighborhood Hits	95	Target Neighborhood Hits	311	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

CC45L_HUMAN
NC score	0.035731 (rank : 22)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	95	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	O75419, O60856, Q6UW54, Q9UP68	Gene names	CDC45L, CDC45L2
Domain Architecture
Description	CDC45-related protein (PORC-PI-1) (Cdc45).

BAZ1B_HUMAN
NC score	0.034840 (rank : 23)	θ value	0.0431538 (rank : 18)
Query Neighborhood Hits	95	Target Neighborhood Hits	701	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

LEO1_HUMAN
NC score	0.033823 (rank : 24)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	95	Target Neighborhood Hits	958	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MY18A_MOUSE
NC score	0.032734 (rank : 25)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	95	Target Neighborhood Hits	1989	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_HUMAN
NC score	0.032381 (rank : 26)	θ value	0.0563607 (rank : 20)
Query Neighborhood Hits	95	Target Neighborhood Hits	1929	Shared Neighborhood Hits	45
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CND3_HUMAN
NC score	0.031567 (rank : 27)	θ value	0.813845 (rank : 33)
Query Neighborhood Hits	95	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BPX3, Q96SV9, Q9BUR3, Q9BVY1, Q9H914, Q9H9Z6, Q9HBI9	Gene names	NCAPG, CAPG, NYMEL3
Domain Architecture
Description	Condensin complex subunit 3 (Non-SMC condensin I complex subunit G) (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (XCAP-G homolog) (Antigen NY-MEL-3).

SNUT1_MOUSE
NC score	0.031101 (rank : 28)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	95	Target Neighborhood Hits	159	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z315, Q8K155, Q9R1I9, Q9R270	Gene names	Sart1, Haf
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (Squamous cell carcinoma antigen recognized by T-cells 1) (SART-1) (mSART-1) (Hypoxia- associated factor).

STXB4_MOUSE
NC score	0.029606 (rank : 29)	θ value	0.365318 (rank : 27)
Query Neighborhood Hits	95	Target Neighborhood Hits	629	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.029574 (rank : 30)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	95	Target Neighborhood Hits	616	Shared Neighborhood Hits	26
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PAPS2_MOUSE
NC score	0.029043 (rank : 31)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	95	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	O88428, Q9Z274	Gene names	Papss2, Atpsk2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_HUMAN
NC score	0.029034 (rank : 32)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	95	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O95340, Q9BZL2, Q9P0G6, Q9UHM1, Q9UKD3, Q9UP30	Gene names	PAPSS2, ATPSK2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

CCD91_HUMAN
NC score	0.029001 (rank : 33)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	95	Target Neighborhood Hits	868	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

PAPS1_HUMAN
NC score	0.028971 (rank : 34)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	95	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O43252, O43841, O75332, Q96FB1, Q96TF4, Q9P1P9, Q9UE98	Gene names	PAPSS1, ATPSK1, PAPSS
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS1_MOUSE
NC score	0.028969 (rank : 35)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	95	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q60967	Gene names	Papss1, Asapk, Atpsk1, Papss
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

LEO1_MOUSE
NC score	0.028542 (rank : 36)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	95	Target Neighborhood Hits	946	Shared Neighborhood Hits	25
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

NP1L3_MOUSE
NC score	0.027356 (rank : 37)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	95	Target Neighborhood Hits	233	Shared Neighborhood Hits	20
SwissProt Accessions	Q794H2, O54802	Gene names	Nap1l3, Mb20
Domain Architecture	No domain graphic available
Description	Nucleosome assembly protein 1-like 3 (Brain-specific protein MB20).

TXND2_MOUSE
NC score	0.027133 (rank : 38)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	95	Target Neighborhood Hits	828	Shared Neighborhood Hits	26
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

CCD46_MOUSE
NC score	0.026935 (rank : 39)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	95	Target Neighborhood Hits	1405	Shared Neighborhood Hits	41
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

ATRX_MOUSE
NC score	0.026836 (rank : 40)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	95	Target Neighborhood Hits	682	Shared Neighborhood Hits	36
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

SH24A_HUMAN
NC score	0.026152 (rank : 41)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	95	Target Neighborhood Hits	455	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

MYH3_HUMAN
NC score	0.025797 (rank : 42)	θ value	0.0431538 (rank : 19)
Query Neighborhood Hits	95	Target Neighborhood Hits	1660	Shared Neighborhood Hits	44
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

GOGA4_MOUSE
NC score	0.025740 (rank : 43)	θ value	0.62314 (rank : 29)
Query Neighborhood Hits	95	Target Neighborhood Hits	1939	Shared Neighborhood Hits	48
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

CK5P2_HUMAN
NC score	0.025365 (rank : 44)	θ value	0.279714 (rank : 24)
Query Neighborhood Hits	95	Target Neighborhood Hits	1433	Shared Neighborhood Hits	42
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

RAI14_MOUSE
NC score	0.025335 (rank : 45)	θ value	0.00298849 (rank : 16)
Query Neighborhood Hits	95	Target Neighborhood Hits	1505	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

MYH6_MOUSE
NC score	0.025188 (rank : 46)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	95	Target Neighborhood Hits	1501	Shared Neighborhood Hits	37
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

CASP_HUMAN
NC score	0.025066 (rank : 47)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	95	Target Neighborhood Hits	1131	Shared Neighborhood Hits	34
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

OPTN_MOUSE
NC score	0.025051 (rank : 48)	θ value	0.21417 (rank : 22)
Query Neighborhood Hits	95	Target Neighborhood Hits	1120	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

MYH4_MOUSE
NC score	0.024007 (rank : 49)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	95	Target Neighborhood Hits	1476	Shared Neighborhood Hits	42
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

VPS4A_MOUSE
NC score	0.023723 (rank : 50)	θ value	0.21417 (rank : 23)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

MYH2_HUMAN
NC score	0.023620 (rank : 51)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	95	Target Neighborhood Hits	1491	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

CUTL1_HUMAN
NC score	0.023598 (rank : 52)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	95	Target Neighborhood Hits	1574	Shared Neighborhood Hits	36
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

MYH7_HUMAN
NC score	0.023535 (rank : 53)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	95	Target Neighborhood Hits	1559	Shared Neighborhood Hits	38
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH1_HUMAN
NC score	0.023403 (rank : 54)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	95	Target Neighborhood Hits	1478	Shared Neighborhood Hits	42
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

BPAEA_HUMAN
NC score	0.022911 (rank : 55)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	95	Target Neighborhood Hits	1369	Shared Neighborhood Hits	39
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CUTL1_MOUSE
NC score	0.022893 (rank : 56)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	95	Target Neighborhood Hits	1620	Shared Neighborhood Hits	34
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CASP_MOUSE
NC score	0.022608 (rank : 57)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	95	Target Neighborhood Hits	1152	Shared Neighborhood Hits	34
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

RL6_MOUSE
NC score	0.022540 (rank : 58)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	95	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P47911, Q6P5I2, Q925C3	Gene names	Rpl6
Domain Architecture
Description	60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107).

CN145_HUMAN
NC score	0.022228 (rank : 59)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	95	Target Neighborhood Hits	1196	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

VPS4A_HUMAN
NC score	0.020897 (rank : 60)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

NAF1_HUMAN
NC score	0.019774 (rank : 61)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	95	Target Neighborhood Hits	937	Shared Neighborhood Hits	34
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

IF2M_MOUSE
NC score	0.019695 (rank : 62)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	95	Target Neighborhood Hits	183	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YJ5	Gene names	Mtif2
Domain Architecture
Description	Translation initiation factor IF-2, mitochondrial precursor (IF-2Mt) (IF-2(Mt)).

SMC1A_HUMAN
NC score	0.019479 (rank : 63)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	95	Target Neighborhood Hits	1346	Shared Neighborhood Hits	38
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
NC score	0.019162 (rank : 64)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	95	Target Neighborhood Hits	1384	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SPTA1_HUMAN
NC score	0.018487 (rank : 65)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	95	Target Neighborhood Hits	748	Shared Neighborhood Hits	29
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CN155_HUMAN
NC score	0.017682 (rank : 66)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	95	Target Neighborhood Hits	385	Shared Neighborhood Hits	12
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

RL6_HUMAN
NC score	0.017202 (rank : 67)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	95	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q02878, Q2M3Q3, Q8WW97	Gene names	RPL6
Domain Architecture
Description	60S ribosomal protein L6 (TAX-responsive enhancer element-binding protein 107) (TAXREB107) (Neoplasm-related protein C140).

GP158_HUMAN
NC score	0.017038 (rank : 68)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	95	Target Neighborhood Hits	221	Shared Neighborhood Hits	11
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

TOP2A_HUMAN
NC score	0.016689 (rank : 69)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	95	Target Neighborhood Hits	135	Shared Neighborhood Hits	19
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

TCAL5_HUMAN
NC score	0.016422 (rank : 70)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	95	Target Neighborhood Hits	806	Shared Neighborhood Hits	23
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

OSBL8_HUMAN
NC score	0.016110 (rank : 71)	θ value	1.06291 (rank : 38)
Query Neighborhood Hits	95	Target Neighborhood Hits	289	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PI4KB_HUMAN
NC score	0.015203 (rank : 72)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	95	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

CBP_HUMAN
NC score	0.015163 (rank : 73)	θ value	0.813845 (rank : 32)
Query Neighborhood Hits	95	Target Neighborhood Hits	941	Shared Neighborhood Hits	13
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

PI4KB_MOUSE
NC score	0.015114 (rank : 74)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	95	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

CDC37_MOUSE
NC score	0.014836 (rank : 75)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	95	Target Neighborhood Hits	359	Shared Neighborhood Hits	18
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

ITSN1_HUMAN
NC score	0.014148 (rank : 76)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	95	Target Neighborhood Hits	1757	Shared Neighborhood Hits	39
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SPTN2_HUMAN
NC score	0.013889 (rank : 77)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	95	Target Neighborhood Hits	535	Shared Neighborhood Hits	32
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

RNF34_MOUSE
NC score	0.013818 (rank : 78)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	95	Target Neighborhood Hits	160	Shared Neighborhood Hits	5
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

LAD1_MOUSE
NC score	0.012753 (rank : 79)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	95	Target Neighborhood Hits	391	Shared Neighborhood Hits	9
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

STIP1_HUMAN
NC score	0.010850 (rank : 80)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	95	Target Neighborhood Hits	147	Shared Neighborhood Hits	3
SwissProt Accessions	P31948	Gene names	STIP1
Domain Architecture
Description	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Transformation-sensitive protein IEF SSP 3521) (NY- REN-11 antigen).

EDD1_HUMAN
NC score	0.010605 (rank : 81)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	95	Target Neighborhood Hits	170	Shared Neighborhood Hits	6
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

KU70_MOUSE
NC score	0.010419 (rank : 82)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	95	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P23475, O88212, Q62027, Q62382, Q62453	Gene names	Xrcc6, G22p1, Ku70
Domain Architecture
Description	ATP-dependent DNA helicase 2 subunit 1 (EC 3.6.1.-) (ATP-dependent DNA helicase II 70 kDa subunit) (Ku autoantigen protein p70 homolog) (Ku70) (CTC box-binding factor 75 kDa subunit) (CTCBF) (CTC75) (DNA- repair protein XRCC6).

WDHD1_HUMAN
NC score	0.008763 (rank : 83)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	95	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	O75717	Gene names	WDHD1, AND1
Domain Architecture
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

STK10_MOUSE
NC score	0.008361 (rank : 84)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	95	Target Neighborhood Hits	2132	Shared Neighborhood Hits	47
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

APTX_HUMAN
NC score	0.008176 (rank : 85)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	95	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

MRCKB_MOUSE
NC score	0.007914 (rank : 86)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	95	Target Neighborhood Hits	2180	Shared Neighborhood Hits	43
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

DHB4_HUMAN
NC score	0.007125 (rank : 87)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

POT14_HUMAN
NC score	0.006845 (rank : 88)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	95	Target Neighborhood Hits	403	Shared Neighborhood Hits	7
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

PACN3_HUMAN
NC score	0.004509 (rank : 89)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	95	Target Neighborhood Hits	385	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

UBP4_HUMAN
NC score	0.003551 (rank : 90)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	95	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q13107, O43452, O43453	Gene names	USP4, UNP, UNPH
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.1.2.15) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein homolog).

KIF9_MOUSE
NC score	0.002449 (rank : 91)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	95	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV04, O35070	Gene names	Kif9
Domain Architecture
Description	Kinesin-like protein KIF9.

LATS1_MOUSE
NC score	0.000986 (rank : 92)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	95	Target Neighborhood Hits	1027	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

GAK_MOUSE
NC score	0.000631 (rank : 93)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	95	Target Neighborhood Hits	964	Shared Neighborhood Hits	8
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KPCD1_HUMAN
NC score	-0.001878 (rank : 94)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	95	Target Neighborhood Hits	901	Shared Neighborhood Hits	7
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

ZIM2_HUMAN
NC score	-0.001883 (rank : 95)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	95	Target Neighborhood Hits	718	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZV7	Gene names	ZIM2
Domain Architecture
Description	Zinc finger imprinted 2.