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Network neighborhood for query Sequence : APTX_HUMAN

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APTX_HUMAN
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APTX_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_MOUSE
θ value	1.78703e-165 (rank : 2)	NC score	0.992393 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

PNKP_MOUSE
θ value	4.16044e-13 (rank : 3)	NC score	0.517739 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

PNKP_HUMAN
θ value	6.00763e-12 (rank : 4)	NC score	0.503520 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T60, Q9P1V2, Q9UKU8, Q9UNF8	Gene names	PNKP
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

HINT1_HUMAN
θ value	5.44631e-05 (rank : 5)	NC score	0.378913 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P49773, Q9H5W8	Gene names	HINT1, HINT, PKCI1, PRKCNH1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT2_HUMAN
θ value	0.000121331 (rank : 6)	NC score	0.344425 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BX68	Gene names	HINT2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein).

HINT1_MOUSE
θ value	0.000158464 (rank : 7)	NC score	0.370802 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P70349	Gene names	Hint1, Hint, Pkci, Pkci1, Prkcnh1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT2_MOUSE
θ value	0.000270298 (rank : 8)	NC score	0.344963 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D0S9	Gene names	Hint2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3).

DCPS_MOUSE
θ value	0.00665767 (rank : 9)	NC score	0.209625 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DAR7, Q8C5I7	Gene names	Dcps, Dcs1, Hint5
Domain Architecture	No domain graphic available
Description	Scavenger mRNA decapping enzyme DcpS (EC 3.-.-.-) (DCS-1) (Hint- related 7meGMP-directed hydrolase) (Histidine triad protein member 5) (HINT-5).

DCPS_HUMAN
θ value	0.0252991 (rank : 10)	NC score	0.193642 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q96C86, Q8NHL8, Q9Y2S5	Gene names	DCPS, DCS1, HINT5
Domain Architecture	No domain graphic available
Description	Scavenger mRNA decapping enzyme DcpS (EC 3.-.-.-) (DCS-1) (Hint- related 7meGMP-directed hydrolase) (Histidine triad protein member 5) (HINT-5).

CB013_HUMAN
θ value	0.47712 (rank : 11)	NC score	0.098911 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IW19, Q53P47, Q53PB9, Q53QU0	Gene names	C2orf13
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13.

KI67_HUMAN
θ value	0.813845 (rank : 12)	NC score	0.038638 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	581	Shared Neighborhood Hits	2
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

CB013_MOUSE
θ value	3.0926 (rank : 13)	NC score	0.064402 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

HORN_HUMAN
θ value	3.0926 (rank : 14)	NC score	0.018608 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	206	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

ZN512_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.022418 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	444	Shared Neighborhood Hits	3
SwissProt Accessions	Q96ME7, Q96JM0	Gene names	ZNF512, KIAA1805
Domain Architecture	No domain graphic available
Description	Zinc finger protein 512.

ZCHC7_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.028878 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3Z6, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0	Gene names	ZCCHC7
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 7.

CAC1H_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.007503 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	230	Shared Neighborhood Hits	2
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

ZN408_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.002012 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	775	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H9D4	Gene names	ZNF408, PFM14, PRDM17
Domain Architecture	No domain graphic available
Description	Zinc finger protein 408 (PR-domain zinc finger protein 17).

ABCA7_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.007749 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

DGLB_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.012878 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCG7, Q6PIX3, Q8N2N2, Q8N9S1, Q8TED3, Q8WXE6	Gene names
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase beta (EC 3.1.1.-) (DGL-beta) (KCCR13L).

HMCN1_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.001308 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	983	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

MCM3_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.008176 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

TCPW_HUMAN
θ value	8.99809 (rank : 23)	NC score	0.010361 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q92526, Q8TC34	Gene names	CCT6B
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (TCP-1- zeta-like) (CCT-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303).

ZN516_MOUSE
θ value	8.99809 (rank : 24)	NC score	0.001403 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	1197	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

Hits sorted by NC score

APTX_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_MOUSE
NC score	0.992393 (rank : 2)	θ value	1.78703e-165 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

PNKP_MOUSE
NC score	0.517739 (rank : 3)	θ value	4.16044e-13 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

PNKP_HUMAN
NC score	0.503520 (rank : 4)	θ value	6.00763e-12 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T60, Q9P1V2, Q9UKU8, Q9UNF8	Gene names	PNKP
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

HINT1_HUMAN
NC score	0.378913 (rank : 5)	θ value	5.44631e-05 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P49773, Q9H5W8	Gene names	HINT1, HINT, PKCI1, PRKCNH1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT1_MOUSE
NC score	0.370802 (rank : 6)	θ value	0.000158464 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	P70349	Gene names	Hint1, Hint, Pkci, Pkci1, Prkcnh1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT2_MOUSE
NC score	0.344963 (rank : 7)	θ value	0.000270298 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D0S9	Gene names	Hint2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3).

HINT2_HUMAN
NC score	0.344425 (rank : 8)	θ value	0.000121331 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BX68	Gene names	HINT2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein).

DCPS_MOUSE
NC score	0.209625 (rank : 9)	θ value	0.00665767 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DAR7, Q8C5I7	Gene names	Dcps, Dcs1, Hint5
Domain Architecture	No domain graphic available
Description	Scavenger mRNA decapping enzyme DcpS (EC 3.-.-.-) (DCS-1) (Hint- related 7meGMP-directed hydrolase) (Histidine triad protein member 5) (HINT-5).

DCPS_HUMAN
NC score	0.193642 (rank : 10)	θ value	0.0252991 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q96C86, Q8NHL8, Q9Y2S5	Gene names	DCPS, DCS1, HINT5
Domain Architecture	No domain graphic available
Description	Scavenger mRNA decapping enzyme DcpS (EC 3.-.-.-) (DCS-1) (Hint- related 7meGMP-directed hydrolase) (Histidine triad protein member 5) (HINT-5).

CB013_HUMAN
NC score	0.098911 (rank : 11)	θ value	0.47712 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IW19, Q53P47, Q53PB9, Q53QU0	Gene names	C2orf13
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13.

CB013_MOUSE
NC score	0.064402 (rank : 12)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

KI67_HUMAN
NC score	0.038638 (rank : 13)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	581	Shared Neighborhood Hits	2
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

ZCHC7_HUMAN
NC score	0.028878 (rank : 14)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3Z6, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0	Gene names	ZCCHC7
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 7.

ZN512_HUMAN
NC score	0.022418 (rank : 15)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	444	Shared Neighborhood Hits	3
SwissProt Accessions	Q96ME7, Q96JM0	Gene names	ZNF512, KIAA1805
Domain Architecture	No domain graphic available
Description	Zinc finger protein 512.

HORN_HUMAN
NC score	0.018608 (rank : 16)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	206	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

DGLB_HUMAN
NC score	0.012878 (rank : 17)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCG7, Q6PIX3, Q8N2N2, Q8N9S1, Q8TED3, Q8WXE6	Gene names
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase beta (EC 3.1.1.-) (DGL-beta) (KCCR13L).

TCPW_HUMAN
NC score	0.010361 (rank : 18)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q92526, Q8TC34	Gene names	CCT6B
Domain Architecture
Description	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (TCP-1- zeta-like) (CCT-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303).

MCM3_MOUSE
NC score	0.008176 (rank : 19)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

ABCA7_HUMAN
NC score	0.007749 (rank : 20)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

CAC1H_MOUSE
NC score	0.007503 (rank : 21)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	230	Shared Neighborhood Hits	2
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

ZN408_HUMAN
NC score	0.002012 (rank : 22)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	775	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H9D4	Gene names	ZNF408, PFM14, PRDM17
Domain Architecture	No domain graphic available
Description	Zinc finger protein 408 (PR-domain zinc finger protein 17).

ZN516_MOUSE
NC score	0.001403 (rank : 23)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	1197	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

HMCN1_HUMAN
NC score	0.001308 (rank : 24)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	983	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).