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Network neighborhood for query Sequence : PNKP_HUMAN

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PNKP_HUMAN
SwissProt Accessions	Q96T60, Q9P1V2, Q9UKU8, Q9UNF8	Gene names	PNKP
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PNKP_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q96T60, Q9P1V2, Q9UKU8, Q9UNF8	Gene names	PNKP
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

PNKP_MOUSE
θ value	0 (rank : 2)	NC score	0.993455 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

APTX_HUMAN
θ value	6.00763e-12 (rank : 3)	NC score	0.503520 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_MOUSE
θ value	1.02475e-11 (rank : 4)	NC score	0.500237 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

CB013_HUMAN
θ value	0.279714 (rank : 5)	NC score	0.116334 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IW19, Q53P47, Q53PB9, Q53QU0	Gene names	C2orf13
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13.

HNRPU_HUMAN
θ value	0.365318 (rank : 6)	NC score	0.077847 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q00839, O75507, Q96HY9	Gene names	HNRPU, SAFA, U21.1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120).

DHX34_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.039242 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14147	Gene names	DHX34, DDX34, KIAA0134
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DHX34_MOUSE
θ value	1.81305 (rank : 8)	NC score	0.031828 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

HMGA1_MOUSE
θ value	3.0926 (rank : 9)	NC score	0.060276 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P17095, Q91WV2, Q924L7, Q924L8	Gene names	Hmga1, Hmgi, Hmgiy
Domain Architecture	No domain graphic available
Description	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1).

M4K4_MOUSE
θ value	3.0926 (rank : 10)	NC score	0.005232 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	1560	Shared Neighborhood Hits	5
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

DTX1_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.015871 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q86Y01, O60630, Q9BS04	Gene names	DTX1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (hDTX1).

GIT1_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.010157 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	341	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GLT10_HUMAN
θ value	6.88961 (rank : 13)	NC score	0.005911 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SR1, Q6IN56, Q86VP8, Q8IXJ2, Q8TEJ2, Q96IV2, Q9H8E1, Q9Y4M4	Gene names	GALNT10
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10).

LIRB5_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.007442 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	O75023, Q8N760	Gene names	LILRB5, LIR8
Domain Architecture
Description	Leukocyte immunoglobulin-like receptor subfamily B member 5 precursor (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD85c antigen).

M4K4_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.004056 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	1589	Shared Neighborhood Hits	5
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

AT1A2_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.007234 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	P50993, Q07059, Q86UZ5, Q9UQ25	Gene names	ATP1A2, KIAA0778
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) (Na+/K+ ATPase 2).

AT1A2_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.007231 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PIE5	Gene names	Atp1a2
Domain Architecture	No domain graphic available
Description	Sodium/potassium-transporting ATPase alpha-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) (Na+/K+ ATPase 2) (Alpha(+)).

CB013_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.062139 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

KCY_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.017067 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P30085, Q53GB7, Q5SVZ0, Q96C07, Q9UBQ8, Q9UIA2	Gene names	CMPK, CMK, UCK, UMK, UMPK
Domain Architecture
Description	UMP-CMP kinase (EC 2.7.4.14) (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase).

KCY_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.017034 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBP5	Gene names	Cmpk, Cmk, Uck, Umk, Umpk
Domain Architecture
Description	UMP-CMP kinase (EC 2.7.4.14) (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase).

MINK1_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.003623 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	1477	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

Hits sorted by NC score

PNKP_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q96T60, Q9P1V2, Q9UKU8, Q9UNF8	Gene names	PNKP
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

PNKP_MOUSE
NC score	0.993455 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

APTX_HUMAN
NC score	0.503520 (rank : 3)	θ value	6.00763e-12 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_MOUSE
NC score	0.500237 (rank : 4)	θ value	1.02475e-11 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

CB013_HUMAN
NC score	0.116334 (rank : 5)	θ value	0.279714 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IW19, Q53P47, Q53PB9, Q53QU0	Gene names	C2orf13
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13.

HNRPU_HUMAN
NC score	0.077847 (rank : 6)	θ value	0.365318 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q00839, O75507, Q96HY9	Gene names	HNRPU, SAFA, U21.1
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120).

CB013_MOUSE
NC score	0.062139 (rank : 7)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

HMGA1_MOUSE
NC score	0.060276 (rank : 8)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P17095, Q91WV2, Q924L7, Q924L8	Gene names	Hmga1, Hmgi, Hmgiy
Domain Architecture	No domain graphic available
Description	High mobility group protein HMG-I/HMG-Y (HMG-I(Y)) (High mobility group AT-hook protein 1) (High mobility group protein A1).

DHX34_HUMAN
NC score	0.039242 (rank : 9)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14147	Gene names	DHX34, DDX34, KIAA0134
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DHX34_MOUSE
NC score	0.031828 (rank : 10)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

KCY_HUMAN
NC score	0.017067 (rank : 11)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P30085, Q53GB7, Q5SVZ0, Q96C07, Q9UBQ8, Q9UIA2	Gene names	CMPK, CMK, UCK, UMK, UMPK
Domain Architecture
Description	UMP-CMP kinase (EC 2.7.4.14) (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase).

KCY_MOUSE
NC score	0.017034 (rank : 12)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBP5	Gene names	Cmpk, Cmk, Uck, Umk, Umpk
Domain Architecture
Description	UMP-CMP kinase (EC 2.7.4.14) (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate kinase) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase).

DTX1_HUMAN
NC score	0.015871 (rank : 13)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q86Y01, O60630, Q9BS04	Gene names	DTX1
Domain Architecture
Description	Protein deltex-1 (Deltex-1) (Deltex1) (hDTX1).

GIT1_MOUSE
NC score	0.010157 (rank : 14)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	341	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

LIRB5_HUMAN
NC score	0.007442 (rank : 15)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	O75023, Q8N760	Gene names	LILRB5, LIR8
Domain Architecture
Description	Leukocyte immunoglobulin-like receptor subfamily B member 5 precursor (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD85c antigen).

AT1A2_HUMAN
NC score	0.007234 (rank : 16)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	P50993, Q07059, Q86UZ5, Q9UQ25	Gene names	ATP1A2, KIAA0778
Domain Architecture
Description	Sodium/potassium-transporting ATPase alpha-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) (Na+/K+ ATPase 2).

AT1A2_MOUSE
NC score	0.007231 (rank : 17)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PIE5	Gene names	Atp1a2
Domain Architecture	No domain graphic available
Description	Sodium/potassium-transporting ATPase alpha-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) (Na+/K+ ATPase 2) (Alpha(+)).

GLT10_HUMAN
NC score	0.005911 (rank : 18)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SR1, Q6IN56, Q86VP8, Q8IXJ2, Q8TEJ2, Q96IV2, Q9H8E1, Q9Y4M4	Gene names	GALNT10
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase 10 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 10) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 10) (Polypeptide GalNAc transferase 10) (GalNAc-T10) (pp-GaNTase 10).

M4K4_MOUSE
NC score	0.005232 (rank : 19)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	1560	Shared Neighborhood Hits	5
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_HUMAN
NC score	0.004056 (rank : 20)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	1589	Shared Neighborhood Hits	5
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MINK1_HUMAN
NC score	0.003623 (rank : 21)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	1477	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).