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Network neighborhood for query Sequence : CB013_MOUSE

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CB013_MOUSE
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CB013_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

CB013_HUMAN
θ value	8.61018e-152 (rank : 2)	NC score	0.954211 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	55	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IW19, Q53P47, Q53PB9, Q53QU0	Gene names	C2orf13
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13.

APBA1_HUMAN
θ value	0.00298849 (rank : 3)	NC score	0.082264 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

PRGC2_MOUSE
θ value	0.0193708 (rank : 4)	NC score	0.110876 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

ADDB_MOUSE
θ value	0.125558 (rank : 5)	NC score	0.043321 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	574	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

BCAS1_HUMAN
θ value	0.163984 (rank : 6)	NC score	0.074595 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	133	Shared Neighborhood Hits	5
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

ZC11A_MOUSE
θ value	0.279714 (rank : 7)	NC score	0.056355 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

TP53B_MOUSE
θ value	0.47712 (rank : 8)	NC score	0.045578 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	644	Shared Neighborhood Hits	12
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TCOF_MOUSE
θ value	0.62314 (rank : 9)	NC score	0.046948 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	471	Shared Neighborhood Hits	7
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

LEO1_MOUSE
θ value	1.06291 (rank : 10)	NC score	0.033532 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	946	Shared Neighborhood Hits	15
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

NALP5_MOUSE
θ value	1.06291 (rank : 11)	NC score	0.025220 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	560	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NSBP1_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.045499 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	681	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

BPTF_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.030794 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	786	Shared Neighborhood Hits	15
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

TARSH_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.036718 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	768	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

NEK1_MOUSE
θ value	1.81305 (rank : 15)	NC score	0.004229 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	1311	Shared Neighborhood Hits	8
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PRGC2_HUMAN
θ value	1.81305 (rank : 16)	NC score	0.074170 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	272	Shared Neighborhood Hits	6
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

TARA_HUMAN
θ value	1.81305 (rank : 17)	NC score	0.024009 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	1626	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SFRIP_HUMAN
θ value	2.36792 (rank : 18)	NC score	0.056146 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	530	Shared Neighborhood Hits	10
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

APTX_HUMAN
θ value	3.0926 (rank : 19)	NC score	0.064402 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

PNKP_MOUSE
θ value	3.0926 (rank : 20)	NC score	0.076712 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

PROZ_MOUSE
θ value	3.0926 (rank : 21)	NC score	0.011123 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	410	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

SPYA_MOUSE
θ value	3.0926 (rank : 22)	NC score	0.034211 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	O35423	Gene names	Agxt, Agxt1
Domain Architecture
Description	Serine--pyruvate aminotransferase, mitochondrial precursor (EC 2.6.1.51) (SPT) (Alanine--glyoxylate aminotransferase) (EC 2.6.1.44) (AGT).

RHG12_HUMAN
θ value	4.03905 (rank : 23)	NC score	0.013097 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SEC63_MOUSE
θ value	4.03905 (rank : 24)	NC score	0.019613 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	601	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

TAD3L_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.039019 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	189	Shared Neighborhood Hits	5
SwissProt Accessions	O75528, Q9UFS2	Gene names	TADA3L, ADA3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (hADA3).

TAD3L_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.038810 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R0L9, Q8CIH4, Q8K289, Q8R5E3, Q9CTJ0	Gene names	Tada3l, Ada3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (mADA3).

ITIH1_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.014178 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

JHD2A_MOUSE
θ value	5.27518 (rank : 28)	NC score	0.014430 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

NKX61_MOUSE
θ value	5.27518 (rank : 29)	NC score	0.007069 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	439	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MA9, Q9ERQ7	Gene names	Nkx6-1, Nkx6.1, Nkx6a
Domain Architecture
Description	Homeobox protein Nkx-6.1.

CC47_MOUSE
θ value	6.88961 (rank : 30)	NC score	0.021955 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	245	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

AFF1_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.018144 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	506	Shared Neighborhood Hits	15
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

ALMS1_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.014700 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	181	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

APBA2_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.039727 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	220	Shared Neighborhood Hits	3
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

BNIP2_MOUSE
θ value	8.99809 (rank : 34)	NC score	0.011343 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	O54940	Gene names	Bnip2, Nip2l
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

BUB1B_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.014106 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	202	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

EMD_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.020277 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P50402	Gene names	EMD, EDMD, STA
Domain Architecture
Description	Emerin.

HSH2D_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.012986 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IPP1_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.020926 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q13522, Q8TBJ2	Gene names	PPP1R1A, IPP1
Domain Architecture
Description	Protein phosphatase inhibitor 1 (IPP-1) (I-1).

PNKP_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.062139 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q96T60, Q9P1V2, Q9UKU8, Q9UNF8	Gene names	PNKP
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

PPRB_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.014721 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	354	Shared Neighborhood Hits	6
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

SYCP1_MOUSE
θ value	8.99809 (rank : 41)	NC score	0.003096 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	1456	Shared Neighborhood Hits	7
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

WDR22_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.010341 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	328	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

ZN467_HUMAN
θ value	8.99809 (rank : 43)	NC score	-0.000529 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	744	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7K2	Gene names	ZNF467
Domain Architecture	No domain graphic available
Description	Zinc finger protein 467.

Hits sorted by NC score

CB013_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

CB013_HUMAN
NC score	0.954211 (rank : 2)	θ value	8.61018e-152 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	55	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IW19, Q53P47, Q53PB9, Q53QU0	Gene names	C2orf13
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13.

PRGC2_MOUSE
NC score	0.110876 (rank : 3)	θ value	0.0193708 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

APBA1_HUMAN
NC score	0.082264 (rank : 4)	θ value	0.00298849 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	325	Shared Neighborhood Hits	7
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

PNKP_MOUSE
NC score	0.076712 (rank : 5)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

BCAS1_HUMAN
NC score	0.074595 (rank : 6)	θ value	0.163984 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	133	Shared Neighborhood Hits	5
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

PRGC2_HUMAN
NC score	0.074170 (rank : 7)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	272	Shared Neighborhood Hits	6
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

APTX_HUMAN
NC score	0.064402 (rank : 8)	θ value	3.0926 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	24	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

PNKP_HUMAN
NC score	0.062139 (rank : 9)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q96T60, Q9P1V2, Q9UKU8, Q9UNF8	Gene names	PNKP
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

ZC11A_MOUSE
NC score	0.056355 (rank : 10)	θ value	0.279714 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

SFRIP_HUMAN
NC score	0.056146 (rank : 11)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	530	Shared Neighborhood Hits	10
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

TCOF_MOUSE
NC score	0.046948 (rank : 12)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	471	Shared Neighborhood Hits	7
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TP53B_MOUSE
NC score	0.045578 (rank : 13)	θ value	0.47712 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	644	Shared Neighborhood Hits	12
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

NSBP1_MOUSE
NC score	0.045499 (rank : 14)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	681	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

ADDB_MOUSE
NC score	0.043321 (rank : 15)	θ value	0.125558 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	574	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

APBA2_HUMAN
NC score	0.039727 (rank : 16)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	220	Shared Neighborhood Hits	3
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

TAD3L_HUMAN
NC score	0.039019 (rank : 17)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	189	Shared Neighborhood Hits	5
SwissProt Accessions	O75528, Q9UFS2	Gene names	TADA3L, ADA3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (hADA3).

TAD3L_MOUSE
NC score	0.038810 (rank : 18)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R0L9, Q8CIH4, Q8K289, Q8R5E3, Q9CTJ0	Gene names	Tada3l, Ada3
Domain Architecture	No domain graphic available
Description	Transcriptional adapter 3-like (ADA3-like protein) (ADA3 homolog) (mADA3).

TARSH_HUMAN
NC score	0.036718 (rank : 19)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	768	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

SPYA_MOUSE
NC score	0.034211 (rank : 20)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	O35423	Gene names	Agxt, Agxt1
Domain Architecture
Description	Serine--pyruvate aminotransferase, mitochondrial precursor (EC 2.6.1.51) (SPT) (Alanine--glyoxylate aminotransferase) (EC 2.6.1.44) (AGT).

LEO1_MOUSE
NC score	0.033532 (rank : 21)	θ value	1.06291 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	946	Shared Neighborhood Hits	15
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

BPTF_HUMAN
NC score	0.030794 (rank : 22)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	786	Shared Neighborhood Hits	15
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

NALP5_MOUSE
NC score	0.025220 (rank : 23)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	560	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

TARA_HUMAN
NC score	0.024009 (rank : 24)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	1626	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CC47_MOUSE
NC score	0.021955 (rank : 25)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	245	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

IPP1_HUMAN
NC score	0.020926 (rank : 26)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q13522, Q8TBJ2	Gene names	PPP1R1A, IPP1
Domain Architecture
Description	Protein phosphatase inhibitor 1 (IPP-1) (I-1).

EMD_HUMAN
NC score	0.020277 (rank : 27)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P50402	Gene names	EMD, EDMD, STA
Domain Architecture
Description	Emerin.

SEC63_MOUSE
NC score	0.019613 (rank : 28)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	601	Shared Neighborhood Hits	7
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

AFF1_HUMAN
NC score	0.018144 (rank : 29)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	506	Shared Neighborhood Hits	15
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

PPRB_MOUSE
NC score	0.014721 (rank : 30)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	354	Shared Neighborhood Hits	6
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

ALMS1_MOUSE
NC score	0.014700 (rank : 31)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	181	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

JHD2A_MOUSE
NC score	0.014430 (rank : 32)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

ITIH1_MOUSE
NC score	0.014178 (rank : 33)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

BUB1B_MOUSE
NC score	0.014106 (rank : 34)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	202	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

RHG12_HUMAN
NC score	0.013097 (rank : 35)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

HSH2D_HUMAN
NC score	0.012986 (rank : 36)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	159	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

BNIP2_MOUSE
NC score	0.011343 (rank : 37)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	O54940	Gene names	Bnip2, Nip2l
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

PROZ_MOUSE
NC score	0.011123 (rank : 38)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	410	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQW3	Gene names	Proz
Domain Architecture
Description	Vitamin K-dependent protein Z precursor.

WDR22_HUMAN
NC score	0.010341 (rank : 39)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	328	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

NKX61_MOUSE
NC score	0.007069 (rank : 40)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	439	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MA9, Q9ERQ7	Gene names	Nkx6-1, Nkx6.1, Nkx6a
Domain Architecture
Description	Homeobox protein Nkx-6.1.

NEK1_MOUSE
NC score	0.004229 (rank : 41)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	1311	Shared Neighborhood Hits	8
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

SYCP1_MOUSE
NC score	0.003096 (rank : 42)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	1456	Shared Neighborhood Hits	7
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

ZN467_HUMAN
NC score	-0.000529 (rank : 43)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	744	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7K2	Gene names	ZNF467
Domain Architecture	No domain graphic available
Description	Zinc finger protein 467.