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Network neighborhood for query Sequence : HINT2_HUMAN

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HINT2_HUMAN
SwissProt Accessions	Q9BX68	Gene names	HINT2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HINT2_HUMAN
θ value	1.83746e-69 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BX68	Gene names	HINT2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein).

HINT2_MOUSE
θ value	2.56992e-63 (rank : 2)	NC score	0.998396 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D0S9	Gene names	Hint2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3).

HINT1_HUMAN
θ value	2.34062e-40 (rank : 3)	NC score	0.972662 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P49773, Q9H5W8	Gene names	HINT1, HINT, PKCI1, PRKCNH1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT1_MOUSE
θ value	1.16164e-39 (rank : 4)	NC score	0.972460 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P70349	Gene names	Hint1, Hint, Pkci, Pkci1, Prkcnh1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

APTX_HUMAN
θ value	0.000121331 (rank : 5)	NC score	0.344425 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_MOUSE
θ value	0.00228821 (rank : 6)	NC score	0.346332 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

FHIT_MOUSE
θ value	0.125558 (rank : 7)	NC score	0.200209 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	O89106, Q6URW5, Q91VL1	Gene names	Fhit
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

FHIT_HUMAN
θ value	0.365318 (rank : 8)	NC score	0.191218 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P49789, Q6IU12	Gene names	FHIT
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

RBM28_HUMAN
θ value	6.88961 (rank : 9)	NC score	0.009699 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NW13, Q96CV3	Gene names	RBM28
Domain Architecture	No domain graphic available
Description	RNA-binding protein 28 (RNA-binding motif protein 28).

ANFY1_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.003996 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	480	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

TITIN_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.000382 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	2923	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

Hits sorted by NC score

HINT2_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.83746e-69 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BX68	Gene names	HINT2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein).

HINT2_MOUSE
NC score	0.998396 (rank : 2)	θ value	2.56992e-63 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D0S9	Gene names	Hint2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3).

HINT1_HUMAN
NC score	0.972662 (rank : 3)	θ value	2.34062e-40 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P49773, Q9H5W8	Gene names	HINT1, HINT, PKCI1, PRKCNH1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT1_MOUSE
NC score	0.972460 (rank : 4)	θ value	1.16164e-39 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P70349	Gene names	Hint1, Hint, Pkci, Pkci1, Prkcnh1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

APTX_MOUSE
NC score	0.346332 (rank : 5)	θ value	0.00228821 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_HUMAN
NC score	0.344425 (rank : 6)	θ value	0.000121331 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

FHIT_MOUSE
NC score	0.200209 (rank : 7)	θ value	0.125558 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	O89106, Q6URW5, Q91VL1	Gene names	Fhit
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

FHIT_HUMAN
NC score	0.191218 (rank : 8)	θ value	0.365318 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P49789, Q6IU12	Gene names	FHIT
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

RBM28_HUMAN
NC score	0.009699 (rank : 9)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NW13, Q96CV3	Gene names	RBM28
Domain Architecture	No domain graphic available
Description	RNA-binding protein 28 (RNA-binding motif protein 28).

ANFY1_HUMAN
NC score	0.003996 (rank : 10)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	480	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

TITIN_HUMAN
NC score	0.000382 (rank : 11)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	2923	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).