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Network neighborhood for query Sequence : HINT1_HUMAN

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HINT1_HUMAN
SwissProt Accessions	P49773, Q9H5W8	Gene names	HINT1, HINT, PKCI1, PRKCNH1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HINT1_HUMAN
θ value	3.13423e-69 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P49773, Q9H5W8	Gene names	HINT1, HINT, PKCI1, PRKCNH1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT1_MOUSE
θ value	4.23606e-66 (rank : 2)	NC score	0.999806 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P70349	Gene names	Hint1, Hint, Pkci, Pkci1, Prkcnh1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT2_MOUSE
θ value	8.04462e-41 (rank : 3)	NC score	0.973547 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D0S9	Gene names	Hint2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3).

HINT2_HUMAN
θ value	2.34062e-40 (rank : 4)	NC score	0.972662 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX68	Gene names	HINT2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein).

APTX_MOUSE
θ value	2.21117e-06 (rank : 5)	NC score	0.390174 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_HUMAN
θ value	5.44631e-05 (rank : 6)	NC score	0.378913 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

ZC3H5_HUMAN
θ value	0.125558 (rank : 7)	NC score	0.111039 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

FHIT_HUMAN
θ value	0.62314 (rank : 8)	NC score	0.167385 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P49789, Q6IU12	Gene names	FHIT
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

ZC3H5_MOUSE
θ value	0.62314 (rank : 9)	NC score	0.099783 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	136	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

FHIT_MOUSE
θ value	1.06291 (rank : 10)	NC score	0.172428 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	O89106, Q6URW5, Q91VL1	Gene names	Fhit
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

PNKP_MOUSE
θ value	θ > 10 (rank : 11)	NC score	0.051832 (rank : 11)
Query Neighborhood Hits	10	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].

Hits sorted by NC score

HINT1_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.13423e-69 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P49773, Q9H5W8	Gene names	HINT1, HINT, PKCI1, PRKCNH1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT1_MOUSE
NC score	0.999806 (rank : 2)	θ value	4.23606e-66 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P70349	Gene names	Hint1, Hint, Pkci, Pkci1, Prkcnh1
Domain Architecture
Description	Histidine triad nucleotide-binding protein 1 (Adenosine 5'- monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C- interacting protein 1) (PKCI-1).

HINT2_MOUSE
NC score	0.973547 (rank : 3)	θ value	8.04462e-41 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D0S9	Gene names	Hint2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3).

HINT2_HUMAN
NC score	0.972662 (rank : 4)	θ value	2.34062e-40 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX68	Gene names	HINT2
Domain Architecture	No domain graphic available
Description	Histidine triad nucleotide-binding protein 2 (EC 3.-.-.-) (HINT-2) (HINT-3) (HIT-17kDa) (PKCI-1-related HIT protein).

APTX_MOUSE
NC score	0.390174 (rank : 5)	θ value	2.21117e-06 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

APTX_HUMAN
NC score	0.378913 (rank : 6)	θ value	5.44631e-05 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z2E3, Q5T781, Q7Z2F3, Q7Z336, Q7Z5R5, Q7Z6V7, Q7Z6V8, Q9NXM5	Gene names	APTX
Domain Architecture
Description	Aprataxin (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

FHIT_MOUSE
NC score	0.172428 (rank : 7)	θ value	1.06291 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	O89106, Q6URW5, Q91VL1	Gene names	Fhit
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

FHIT_HUMAN
NC score	0.167385 (rank : 8)	θ value	0.62314 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P49789, Q6IU12	Gene names	FHIT
Domain Architecture
Description	Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (Diadenosine 5',5'''- P1,P3-triphosphate hydrolase) (Dinucleosidetriphosphatase) (AP3A hydrolase) (AP3AASE) (Fragile histidine triad protein).

ZC3H5_HUMAN
NC score	0.111039 (rank : 9)	θ value	0.125558 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ZC3H5_MOUSE
NC score	0.099783 (rank : 10)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	136	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

PNKP_MOUSE
NC score	0.051832 (rank : 11)	θ value	θ > 10 (rank : 11)
Query Neighborhood Hits	10	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLV6, Q6PFA3	Gene names	Pnkp
Domain Architecture	No domain graphic available
Description	Bifunctional polynucleotide phosphatase/kinase (Polynucleotide kinase- 3'-phosphatase) (DNA 5'-kinase/3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)].