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Network neighborhood for query Sequence : PAPS1_HUMAN

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PAPS1_HUMAN
SwissProt Accessions	O43252, O43841, O75332, Q96FB1, Q96TF4, Q9P1P9, Q9UE98	Gene names	PAPSS1, ATPSK1, PAPSS
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PAPS1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	O43252, O43841, O75332, Q96FB1, Q96TF4, Q9P1P9, Q9UE98	Gene names	PAPSS1, ATPSK1, PAPSS
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS1_MOUSE
θ value	0 (rank : 2)	NC score	0.999940 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q60967	Gene names	Papss1, Asapk, Atpsk1, Papss
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_HUMAN
θ value	0 (rank : 3)	NC score	0.996570 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	O95340, Q9BZL2, Q9P0G6, Q9UHM1, Q9UKD3, Q9UP30	Gene names	PAPSS2, ATPSK2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_MOUSE
θ value	0 (rank : 4)	NC score	0.996356 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	O88428, Q9Z274	Gene names	Papss2, Atpsk2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

SYS_MOUSE
θ value	1.06291 (rank : 5)	NC score	0.045623 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P26638	Gene names	Sars, Sars1, Sers
Domain Architecture
Description	Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase) (SerRS).

U334_HUMAN
θ value	1.38821 (rank : 6)	NC score	0.095899 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSD7	Gene names	C1orf57
Domain Architecture	No domain graphic available
Description	Probable UPF0334 kinase-like protein C1orf57.

ABCB6_HUMAN
θ value	3.0926 (rank : 7)	NC score	0.011991 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NP58, O75542	Gene names	ABCB6, MTABC3
Domain Architecture
Description	ATP-binding cassette sub-family B member 6, mitochondrial precursor (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (ABC transporter umat).

MCM3_HUMAN
θ value	4.03905 (rank : 8)	NC score	0.028962 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	87	Shared Neighborhood Hits	6
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

MCM3_MOUSE
θ value	4.03905 (rank : 9)	NC score	0.028971 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

RB33B_HUMAN
θ value	4.03905 (rank : 10)	NC score	0.007661 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	278	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H082	Gene names	RAB33B
Domain Architecture
Description	Ras-related protein Rab-33B.

RB33B_MOUSE
θ value	4.03905 (rank : 11)	NC score	0.007720 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	O35963, Q3TWI8	Gene names	Rab33b
Domain Architecture
Description	Ras-related protein Rab-33B.

S6A15_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.008433 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2J7	Gene names	SLC6A15, NTT73
Domain Architecture
Description	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT73 (Orphan transporter v7-3) (Solute carrier family 6 member 15).

ITAM_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.005430 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P11215	Gene names	ITGAM, CD11B, CR3A
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD11b antigen).

Hits sorted by NC score

PAPS1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	O43252, O43841, O75332, Q96FB1, Q96TF4, Q9P1P9, Q9UE98	Gene names	PAPSS1, ATPSK1, PAPSS
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS1_MOUSE
NC score	0.999940 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	Q60967	Gene names	Papss1, Asapk, Atpsk1, Papss
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_HUMAN
NC score	0.996570 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	16	Shared Neighborhood Hits	7
SwissProt Accessions	O95340, Q9BZL2, Q9P0G6, Q9UHM1, Q9UKD3, Q9UP30	Gene names	PAPSS2, ATPSK2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

PAPS2_MOUSE
NC score	0.996356 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	O88428, Q9Z274	Gene names	Papss2, Atpsk2
Domain Architecture
Description	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPS synthetase 2) (PAPSS 2) (Sulfurylase kinase 2) (SK2) (SK 2) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase); Adenylyl-sulfate kinase (EC 2.7.1.25) (Adenylylsulfate 3'-phosphotransferase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)].

U334_HUMAN
NC score	0.095899 (rank : 5)	θ value	1.38821 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BSD7	Gene names	C1orf57
Domain Architecture	No domain graphic available
Description	Probable UPF0334 kinase-like protein C1orf57.

SYS_MOUSE
NC score	0.045623 (rank : 6)	θ value	1.06291 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P26638	Gene names	Sars, Sars1, Sers
Domain Architecture
Description	Seryl-tRNA synthetase (EC 6.1.1.11) (Serine--tRNA ligase) (SerRS).

MCM3_MOUSE
NC score	0.028971 (rank : 7)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P25206, Q61492	Gene names	Mcm3, Mcmd, Mcmd3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3).

MCM3_HUMAN
NC score	0.028962 (rank : 8)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	87	Shared Neighborhood Hits	6
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

ABCB6_HUMAN
NC score	0.011991 (rank : 9)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NP58, O75542	Gene names	ABCB6, MTABC3
Domain Architecture
Description	ATP-binding cassette sub-family B member 6, mitochondrial precursor (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (ABC transporter umat).

S6A15_HUMAN
NC score	0.008433 (rank : 10)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2J7	Gene names	SLC6A15, NTT73
Domain Architecture
Description	Orphan sodium- and chloride-dependent neurotransmitter transporter NTT73 (Orphan transporter v7-3) (Solute carrier family 6 member 15).

RB33B_MOUSE
NC score	0.007720 (rank : 11)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	O35963, Q3TWI8	Gene names	Rab33b
Domain Architecture
Description	Ras-related protein Rab-33B.

RB33B_HUMAN
NC score	0.007661 (rank : 12)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	278	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H082	Gene names	RAB33B
Domain Architecture
Description	Ras-related protein Rab-33B.

ITAM_HUMAN
NC score	0.005430 (rank : 13)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P11215	Gene names	ITGAM, CD11B, CR3A
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD11b antigen).