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Network neighborhood for query Sequence : GP155_HUMAN

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GP155_HUMAN
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GP155_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

PREX1_HUMAN
θ value	8.11959e-09 (rank : 2)	NC score	0.159394 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RPGF4_MOUSE
θ value	3.41135e-07 (rank : 3)	NC score	0.218179 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
θ value	4.45536e-07 (rank : 4)	NC score	0.216562 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

FYV1_HUMAN
θ value	0.000121331 (rank : 5)	NC score	0.194045 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0.000121331 (rank : 6)	NC score	0.194293 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GP112_HUMAN
θ value	0.000158464 (rank : 7)	NC score	0.140958 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	441	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

GP128_MOUSE
θ value	0.00175202 (rank : 8)	NC score	0.154498 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	141	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BM96, Q80T42	Gene names	Gpr128
Domain Architecture
Description	Probable G-protein coupled receptor 128 precursor.

FZD3_HUMAN
θ value	0.00298849 (rank : 9)	NC score	0.164916 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPG1	Gene names	FZD3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (hFz3).

FZD3_MOUSE
θ value	0.00390308 (rank : 10)	NC score	0.164226 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q61086	Gene names	Fzd3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (mFz3).

GPR64_MOUSE
θ value	0.0252991 (rank : 11)	NC score	0.126865 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	156	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CJ12, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10	Gene names	Gpr64, Me6
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (Me6 receptor).

GP128_HUMAN
θ value	0.0330416 (rank : 12)	NC score	0.131141 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	135	Shared Neighborhood Hits	13
SwissProt Accessions	Q96K78, Q86SQ2	Gene names	GPR128
Domain Architecture
Description	Probable G-protein coupled receptor 128 precursor.

GPR64_HUMAN
θ value	0.0330416 (rank : 13)	NC score	0.124606 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZP9, O00406, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4	Gene names	GPR64, HE6, TM7LN2
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (He6 receptor).

DVL3_HUMAN
θ value	0.0961366 (rank : 14)	NC score	0.056705 (rank : 74)
Query Neighborhood Hits	42	Target Neighborhood Hits	194	Shared Neighborhood Hits	7
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

FZD1_MOUSE
θ value	0.21417 (rank : 15)	NC score	0.138566 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	17
SwissProt Accessions	O70421, O08974	Gene names	Fzd1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (mFz1).

FZD6_HUMAN
θ value	0.21417 (rank : 16)	NC score	0.150029 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	84	Shared Neighborhood Hits	18
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

FZD6_MOUSE
θ value	0.279714 (rank : 17)	NC score	0.147519 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	135	Shared Neighborhood Hits	18
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

SYEP_HUMAN
θ value	0.279714 (rank : 18)	NC score	0.071812 (rank : 55)
Query Neighborhood Hits	42	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

FZD1_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.136616 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	62	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UP38, O94815, Q549T8	Gene names	FZD1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (hFz1) (FzE1).

FZD2_HUMAN
θ value	0.47712 (rank : 20)	NC score	0.135511 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q14332	Gene names	FZD2
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (hFz2) (FzE2).

FZD2_MOUSE
θ value	0.47712 (rank : 21)	NC score	0.135558 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JIP6, Q810M0, Q9JIP5, Q9WUJ2	Gene names	Fzd2, Fzd10
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (mFz2) (mFz10).

FZD4_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.129116 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULV1, Q6S9E4	Gene names	FZD4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (hFz4) (FzE4).

FZD4_MOUSE
θ value	0.62314 (rank : 23)	NC score	0.129235 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	Q61088	Gene names	Fzd4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (mFz4).

OR1C1_HUMAN
θ value	0.62314 (rank : 24)	NC score	0.003366 (rank : 102)
Query Neighborhood Hits	42	Target Neighborhood Hits	842	Shared Neighborhood Hits	2
SwissProt Accessions	Q15619, Q5VVD2, Q6IF97, Q8NGZ1, Q96R83	Gene names	OR1C1
Domain Architecture
Description	Olfactory receptor 1C1 (Olfactory receptor TPCR27) (Olfactory receptor OR1-42).

CELR1_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.043710 (rank : 92)
Query Neighborhood Hits	42	Target Neighborhood Hits	613	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).

DHB7_HUMAN
θ value	1.81305 (rank : 26)	NC score	0.038038 (rank : 98)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	P56937, Q7Z4V9, Q8WWS2, Q9UF00	Gene names	HSD17B7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

NOTC1_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.012136 (rank : 101)
Query Neighborhood Hits	42	Target Neighborhood Hits	906	Shared Neighborhood Hits	8
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

RPGF5_MOUSE
θ value	1.81305 (rank : 28)	NC score	0.141958 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

CELR1_MOUSE
θ value	2.36792 (rank : 29)	NC score	0.043841 (rank : 91)
Query Neighborhood Hits	42	Target Neighborhood Hits	617	Shared Neighborhood Hits	21
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.

CELR2_MOUSE
θ value	2.36792 (rank : 30)	NC score	0.044951 (rank : 90)
Query Neighborhood Hits	42	Target Neighborhood Hits	584	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

FZD7_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.129300 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	O75084, O94816, Q96B74	Gene names	FZD7
Domain Architecture
Description	Frizzled-7 precursor (Fz-7) (hFz7) (FzE3).

FZD7_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.129112 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q61090	Gene names	Fzd7
Domain Architecture	No domain graphic available
Description	Frizzled-7 precursor (Fz-7) (mFz7).

CELR2_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.042538 (rank : 93)
Query Neighborhood Hits	42	Target Neighborhood Hits	657	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

EDAD_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.038272 (rank : 97)
Query Neighborhood Hits	42	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WWZ3, Q5VYJ7	Gene names	EDARADD
Domain Architecture	No domain graphic available
Description	Ectodysplasin A receptor-associated adapter protein (EDAR-associated death domain protein) (Crinkled homolog).

GP126_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.098251 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

IBRD3_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.039713 (rank : 94)
Query Neighborhood Hits	42	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

RNF19_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.039317 (rank : 96)
Query Neighborhood Hits	42	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

RNF19_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.039400 (rank : 95)
Query Neighborhood Hits	42	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

SYEP_MOUSE
θ value	4.03905 (rank : 39)	NC score	0.054705 (rank : 80)
Query Neighborhood Hits	42	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

SF3B2_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.033223 (rank : 99)
Query Neighborhood Hits	42	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

XKR3_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.021294 (rank : 100)
Query Neighborhood Hits	42	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q5GH77, Q52PG8, Q8N7E1	Gene names	XKR3, XRG3
Domain Architecture	No domain graphic available
Description	XK-related protein 3 (XTES).

GPR97_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.099755 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q86Y34, Q6ZMF4, Q86SL9, Q8IZF1	Gene names	GPR97, PGR26
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor (G-protein coupled receptor PGR26).

BAI1_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.051948 (rank : 85)
Query Neighborhood Hits	42	Target Neighborhood Hits	375	Shared Neighborhood Hits	19
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.051855 (rank : 86)
Query Neighborhood Hits	42	Target Neighborhood Hits	340	Shared Neighborhood Hits	16
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI2_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.055785 (rank : 77)
Query Neighborhood Hits	42	Target Neighborhood Hits	332	Shared Neighborhood Hits	23
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.055775 (rank : 78)
Query Neighborhood Hits	42	Target Neighborhood Hits	323	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.050710 (rank : 88)
Query Neighborhood Hits	42	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.050668 (rank : 89)
Query Neighborhood Hits	42	Target Neighborhood Hits	250	Shared Neighborhood Hits	20
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

CD97_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.052424 (rank : 84)
Query Neighborhood Hits	42	Target Neighborhood Hits	295	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z0M6, Q923A1, Q9CVI5, Q9JLQ8	Gene names	Cd97
Domain Architecture
Description	CD97 antigen precursor.

ELTD1_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.060301 (rank : 69)
Query Neighborhood Hits	42	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HBW9	Gene names	ELTD1, ETL
Domain Architecture
Description	EGF, latrophilin and seven transmembrane domain-containing protein 1 precursor (EGF-TM7-latrophilin-related protein) (ETL protein).

ELTD1_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.053879 (rank : 82)
Query Neighborhood Hits	42	Target Neighborhood Hits	288	Shared Neighborhood Hits	13
SwissProt Accessions	Q923X1, Q91W44	Gene names	Eltd1
Domain Architecture
Description	EGF, latrophilin seven transmembrane domain-containing protein 1 precursor.

EMR3_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.062810 (rank : 62)
Query Neighborhood Hits	42	Target Neighborhood Hits	245	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BY15	Gene names	EMR3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 3 precursor (EGF-like module-containing mucin-like receptor EMR3).

EMR4_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.063823 (rank : 60)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	12
SwissProt Accessions	Q91ZE5, Q3U1I7, Q8BYX0, Q8VIM3	Gene names	Emr4
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 4 precursor (EGF-like module-containing mucin-like receptor EMR4) (F4/80-like-receptor) (Seven-span membrane protein FIRE).

FZD10_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.112946 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULW2	Gene names	FZD10
Domain Architecture
Description	Frizzled-10 precursor (Fz-10) (hFz10) (FzE7).

FZD10_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.112699 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BKG4	Gene names	Fzd10, Fz10
Domain Architecture	No domain graphic available
Description	Frizzled-10 precursor (Fz-10).

FZD5_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.116741 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	Q13467, Q53R22	Gene names	FZD5, HFZ5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (hFz5) (FzE5).

FZD5_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.116972 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	Q9EQD0, O08975, Q8BMR2, Q8CHK9	Gene names	Fzd5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (mFz5).

FZD8_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.110219 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H461	Gene names	FZD8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (hFz8).

FZD8_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.111101 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

FZD9_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.115117 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	O00144	Gene names	FZD9, FZD3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (hFz9) (FzE6).

FZD9_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.115115 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	66	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R216, O35494, Q9CX16, Q9R2B3	Gene names	Fzd9, Fzd3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (mFz9) (mFz3).

GP110_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.062380 (rank : 64)
Query Neighborhood Hits	42	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	Q5T601, Q5KU15, Q5T5Z9, Q86SM1, Q8IXE3, Q8IZF8, Q96DQ1	Gene names	GPR110, PGR19
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 110 precursor (G-protein coupled receptor PGR19) (G-protein coupled receptor KPG_012).

GP110_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.064112 (rank : 59)
Query Neighborhood Hits	42	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VEC3, Q8BMV8	Gene names	Gpr110
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 110 precursor.

GP111_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.056548 (rank : 75)
Query Neighborhood Hits	42	Target Neighborhood Hits	77	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF7, Q86SL6, Q8NGU5, Q8TDT5	Gene names	GPR111, PGR20
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 111 (G-protein coupled receptor PGR20).

GP113_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.062491 (rank : 63)
Query Neighborhood Hits	42	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF5, Q6UXT7, Q6UXX3, Q86SL7, Q8IXD8, Q8TDT3	Gene names	GPR113, PGR23
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 113 precursor (G-protein coupled receptor PGR23).

GP114_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.092415 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	75	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF4, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14	Gene names	GPR114, PGR27
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 114 precursor (G-protein coupled receptor PGR27).

GP115_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.059395 (rank : 71)
Query Neighborhood Hits	42	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF3, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6	Gene names	GPR115, PGR18
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 (G-protein coupled receptor PGR18).

GP115_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.060626 (rank : 67)
Query Neighborhood Hits	42	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D2L6	Gene names	Gpr115
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 precursor.

GP116_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.067863 (rank : 56)
Query Neighborhood Hits	42	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

GP133_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.074779 (rank : 54)
Query Neighborhood Hits	42	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q6QNK2, Q6ZMQ1, Q7Z7M2, Q86SM4	Gene names	GPR133, PGR25
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 133 precursor (G-protein coupled receptor PGR25).

GP144_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.060393 (rank : 68)
Query Neighborhood Hits	42	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z7M1, Q86SL4, Q8NH12	Gene names	GPR144, PGR24
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 144 (G-protein coupled receptor PGR24).

GP157_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.052502 (rank : 83)
Query Neighborhood Hits	42	Target Neighborhood Hits	93	Shared Neighborhood Hits	21
SwissProt Accessions	Q5UAW9, Q8WWB8, Q9HA73	Gene names	GPR157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

GP157_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.059833 (rank : 70)
Query Neighborhood Hits	42	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C206, Q8C224	Gene names	Gpr157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

GPR56_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.079219 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	84	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y653, O95966, Q8NGB3, Q96HB4	Gene names	GPR56, TM7LN4, TM7XN1
Domain Architecture
Description	G-protein coupled receptor 56 precursor (TM7XN1 protein).

GPR56_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.082506 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	89	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K209, Q3UR17, Q9QZT2	Gene names	Gpr56, Cyt28
Domain Architecture
Description	G-protein coupled receptor 56 precursor (Serpentine receptor cyt28).

GPR97_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.087762 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	89	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0T6	Gene names	Gpr97
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor.

GPR98_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.059308 (rank : 72)
Query Neighborhood Hits	42	Target Neighborhood Hits	202	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

GPR98_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.056081 (rank : 76)
Query Neighborhood Hits	42	Target Neighborhood Hits	206	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

LPHN1_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.058610 (rank : 73)
Query Neighborhood Hits	42	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	O94910, Q96IE7, Q9BU07, Q9HAR3	Gene names	LPHN1, KIAA0821, LEC2
Domain Architecture
Description	Latrophilin-1 precursor (Calcium-independent alpha-latrotoxin receptor 1) (Lectomedin-2).

LPHN2_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.062010 (rank : 65)
Query Neighborhood Hits	42	Target Neighborhood Hits	136	Shared Neighborhood Hits	15
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

LPHN3_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.065455 (rank : 58)
Query Neighborhood Hits	42	Target Neighborhood Hits	139	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HAR2, O94867, Q9NWK5	Gene names	LPHN3, KIAA0768, LEC3
Domain Architecture
Description	Latrophilin-3 precursor (Calcium-independent alpha-latrotoxin receptor 3) (Lectomedin-3).

RPGF1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.060831 (rank : 66)
Query Neighborhood Hits	42	Target Neighborhood Hits	262	Shared Neighborhood Hits	3
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF2_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.066899 (rank : 57)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF3_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.123922 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.124888 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF5_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.110523 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF6_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.063281 (rank : 61)
Query Neighborhood Hits	42	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SFRP1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.079370 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N474, O00546, O14779	Gene names	SFRP1, FRP, FRP1, SARP2
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1) (Frizzled- related protein 1) (FRP-1) (Secreted apoptosis-related protein 2) (SARP-2).

SFRP1_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.080132 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C4U3, O08861, Q8R1J4	Gene names	Sfrp1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1).

SFRP2_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.079029 (rank : 51)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q96HF1, O14778, Q9HAP5	Gene names	SFRP2, FRP2, SARP1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (Frizzled-related protein 2) (FRP-2).

SFRP2_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.079137 (rank : 50)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P97299, O08862, O35297	Gene names	Sfrp2, Sarp1, Sdf5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (SDF5 protein).

SFRP3_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.083791 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q92765, O00181, Q99686	Gene names	FRZB, FIZ, FRE, FRP, FRZB1, SFRP3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

SFRP3_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.084226 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	44	Shared Neighborhood Hits	12
SwissProt Accessions	P97401, O09075, O09093, Q91W58	Gene names	Frzb, Fiz, Fre, Frzb1, Sfrp3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

SFRP4_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.085831 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q6FHJ7, O14877, Q4G124, Q6FHM0, Q6PD64	Gene names	SFRP4, FRPHE
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 4 precursor (sFRP-4) (Frizzled protein, human endometrium) (FrpHE).

SFRP4_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.085888 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1N6, Q91ZX9	Gene names	Sfrp4
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related sequence protein 4 precursor (sFRP-4) (Frizzled-related protein 4) (FRP-4).

SFRP5_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.077198 (rank : 52)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T4F7, O14780, Q86TH7	Gene names	SFRP5, FRP1B, SARP3
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5) (Secreted apoptosis-related protein 3) (SARP-3) (Frizzled-related protein 1b) (FRP-1b).

SFRP5_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.077023 (rank : 53)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WU66, Q8K269	Gene names	Sfrp5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5).

SMO_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.106909 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	Q99835	Gene names	SMO, SMOH
Domain Architecture
Description	Smoothened homolog precursor (SMO) (Gx protein).

SMO_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.107008 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

SOS1_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.054974 (rank : 79)
Query Neighborhood Hits	42	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.054047 (rank : 81)
Query Neighborhood Hits	42	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.051408 (rank : 87)
Query Neighborhood Hits	42	Target Neighborhood Hits	193	Shared Neighborhood Hits	4
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

Hits sorted by NC score

GP155_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

RPGF4_MOUSE
NC score	0.218179 (rank : 2)	θ value	3.41135e-07 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.216562 (rank : 3)	θ value	4.45536e-07 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

FYV1_MOUSE
NC score	0.194293 (rank : 4)	θ value	0.000121331 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.194045 (rank : 5)	θ value	0.000121331 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FZD3_HUMAN
NC score	0.164916 (rank : 6)	θ value	0.00298849 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPG1	Gene names	FZD3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (hFz3).

FZD3_MOUSE
NC score	0.164226 (rank : 7)	θ value	0.00390308 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	75	Shared Neighborhood Hits	15
SwissProt Accessions	Q61086	Gene names	Fzd3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (mFz3).

PREX1_HUMAN
NC score	0.159394 (rank : 8)	θ value	8.11959e-09 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	177	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

GP128_MOUSE
NC score	0.154498 (rank : 9)	θ value	0.00175202 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	141	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BM96, Q80T42	Gene names	Gpr128
Domain Architecture
Description	Probable G-protein coupled receptor 128 precursor.

FZD6_HUMAN
NC score	0.150029 (rank : 10)	θ value	0.21417 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	84	Shared Neighborhood Hits	18
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

FZD6_MOUSE
NC score	0.147519 (rank : 11)	θ value	0.279714 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	135	Shared Neighborhood Hits	18
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

RPGF5_MOUSE
NC score	0.141958 (rank : 12)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

GP112_HUMAN
NC score	0.140958 (rank : 13)	θ value	0.000158464 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	441	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

FZD1_MOUSE
NC score	0.138566 (rank : 14)	θ value	0.21417 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	17
SwissProt Accessions	O70421, O08974	Gene names	Fzd1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (mFz1).

FZD1_HUMAN
NC score	0.136616 (rank : 15)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	62	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UP38, O94815, Q549T8	Gene names	FZD1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (hFz1) (FzE1).

FZD2_MOUSE
NC score	0.135558 (rank : 16)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JIP6, Q810M0, Q9JIP5, Q9WUJ2	Gene names	Fzd2, Fzd10
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (mFz2) (mFz10).

FZD2_HUMAN
NC score	0.135511 (rank : 17)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	57	Shared Neighborhood Hits	16
SwissProt Accessions	Q14332	Gene names	FZD2
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (hFz2) (FzE2).

GP128_HUMAN
NC score	0.131141 (rank : 18)	θ value	0.0330416 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	135	Shared Neighborhood Hits	13
SwissProt Accessions	Q96K78, Q86SQ2	Gene names	GPR128
Domain Architecture
Description	Probable G-protein coupled receptor 128 precursor.

FZD7_HUMAN
NC score	0.129300 (rank : 19)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	O75084, O94816, Q96B74	Gene names	FZD7
Domain Architecture
Description	Frizzled-7 precursor (Fz-7) (hFz7) (FzE3).

FZD4_MOUSE
NC score	0.129235 (rank : 20)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	Q61088	Gene names	Fzd4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (mFz4).

FZD4_HUMAN
NC score	0.129116 (rank : 21)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULV1, Q6S9E4	Gene names	FZD4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (hFz4) (FzE4).

FZD7_MOUSE
NC score	0.129112 (rank : 22)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q61090	Gene names	Fzd7
Domain Architecture	No domain graphic available
Description	Frizzled-7 precursor (Fz-7) (mFz7).

GPR64_MOUSE
NC score	0.126865 (rank : 23)	θ value	0.0252991 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	156	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CJ12, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10	Gene names	Gpr64, Me6
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (Me6 receptor).

RPGF3_MOUSE
NC score	0.124888 (rank : 24)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	42	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

GPR64_HUMAN
NC score	0.124606 (rank : 25)	θ value	0.0330416 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	207	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZP9, O00406, Q8IWT2, Q8IZE4, Q8IZE5, Q8IZE6, Q8IZE7, Q8IZP3, Q8IZP4	Gene names	GPR64, HE6, TM7LN2
Domain Architecture
Description	G-protein coupled receptor 64 precursor (Epididymis-specific protein 6) (He6 receptor).

RPGF3_HUMAN
NC score	0.123922 (rank : 26)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

FZD5_MOUSE
NC score	0.116972 (rank : 27)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	42	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	Q9EQD0, O08975, Q8BMR2, Q8CHK9	Gene names	Fzd5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (mFz5).

FZD5_HUMAN
NC score	0.116741 (rank : 28)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	42	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	Q13467, Q53R22	Gene names	FZD5, HFZ5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (hFz5) (FzE5).

FZD9_HUMAN
NC score	0.115117 (rank : 29)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	O00144	Gene names	FZD9, FZD3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (hFz9) (FzE6).

FZD9_MOUSE
NC score	0.115115 (rank : 30)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	42	Target Neighborhood Hits	66	Shared Neighborhood Hits	18
SwissProt Accessions	Q9R216, O35494, Q9CX16, Q9R2B3	Gene names	Fzd9, Fzd3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (mFz9) (mFz3).

FZD10_HUMAN
NC score	0.112946 (rank : 31)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ULW2	Gene names	FZD10
Domain Architecture
Description	Frizzled-10 precursor (Fz-10) (hFz10) (FzE7).

FZD10_MOUSE
NC score	0.112699 (rank : 32)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BKG4	Gene names	Fzd10, Fz10
Domain Architecture	No domain graphic available
Description	Frizzled-10 precursor (Fz-10).

FZD8_MOUSE
NC score	0.111101 (rank : 33)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	42	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

RPGF5_HUMAN
NC score	0.110523 (rank : 34)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

FZD8_HUMAN
NC score	0.110219 (rank : 35)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	42	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H461	Gene names	FZD8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (hFz8).

SMO_MOUSE
NC score	0.107008 (rank : 36)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	42	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

SMO_HUMAN
NC score	0.106909 (rank : 37)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	42	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	Q99835	Gene names	SMO, SMOH
Domain Architecture
Description	Smoothened homolog precursor (SMO) (Gx protein).

GPR97_HUMAN
NC score	0.099755 (rank : 38)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	86	Shared Neighborhood Hits	12
SwissProt Accessions	Q86Y34, Q6ZMF4, Q86SL9, Q8IZF1	Gene names	GPR97, PGR26
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor (G-protein coupled receptor PGR26).

GP126_HUMAN
NC score	0.098251 (rank : 39)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	187	Shared Neighborhood Hits	20
SwissProt Accessions	Q86SQ4, Q6MZU7, Q8NC14, Q96JW0	Gene names	GPR126
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 126 precursor.

GP114_HUMAN
NC score	0.092415 (rank : 40)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	42	Target Neighborhood Hits	75	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF4, Q6ZMH7, Q6ZML4, Q86SL8, Q8IZ14	Gene names	GPR114, PGR27
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 114 precursor (G-protein coupled receptor PGR27).

GPR97_MOUSE
NC score	0.087762 (rank : 41)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	42	Target Neighborhood Hits	89	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0T6	Gene names	Gpr97
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor.

SFRP4_MOUSE
NC score	0.085888 (rank : 42)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1N6, Q91ZX9	Gene names	Sfrp4
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related sequence protein 4 precursor (sFRP-4) (Frizzled-related protein 4) (FRP-4).

SFRP4_HUMAN
NC score	0.085831 (rank : 43)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q6FHJ7, O14877, Q4G124, Q6FHM0, Q6PD64	Gene names	SFRP4, FRPHE
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 4 precursor (sFRP-4) (Frizzled protein, human endometrium) (FrpHE).

SFRP3_MOUSE
NC score	0.084226 (rank : 44)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	42	Target Neighborhood Hits	44	Shared Neighborhood Hits	12
SwissProt Accessions	P97401, O09075, O09093, Q91W58	Gene names	Frzb, Fiz, Fre, Frzb1, Sfrp3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

SFRP3_HUMAN
NC score	0.083791 (rank : 45)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q92765, O00181, Q99686	Gene names	FRZB, FIZ, FRE, FRP, FRZB1, SFRP3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

GPR56_MOUSE
NC score	0.082506 (rank : 46)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	42	Target Neighborhood Hits	89	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K209, Q3UR17, Q9QZT2	Gene names	Gpr56, Cyt28
Domain Architecture
Description	G-protein coupled receptor 56 precursor (Serpentine receptor cyt28).

SFRP1_MOUSE
NC score	0.080132 (rank : 47)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C4U3, O08861, Q8R1J4	Gene names	Sfrp1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1).

SFRP1_HUMAN
NC score	0.079370 (rank : 48)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N474, O00546, O14779	Gene names	SFRP1, FRP, FRP1, SARP2
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1) (Frizzled- related protein 1) (FRP-1) (Secreted apoptosis-related protein 2) (SARP-2).

GPR56_HUMAN
NC score	0.079219 (rank : 49)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	42	Target Neighborhood Hits	84	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y653, O95966, Q8NGB3, Q96HB4	Gene names	GPR56, TM7LN4, TM7XN1
Domain Architecture
Description	G-protein coupled receptor 56 precursor (TM7XN1 protein).

SFRP2_MOUSE
NC score	0.079137 (rank : 50)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	42	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P97299, O08862, O35297	Gene names	Sfrp2, Sarp1, Sdf5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (SDF5 protein).

SFRP2_HUMAN
NC score	0.079029 (rank : 51)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	Q96HF1, O14778, Q9HAP5	Gene names	SFRP2, FRP2, SARP1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (Frizzled-related protein 2) (FRP-2).

SFRP5_HUMAN
NC score	0.077198 (rank : 52)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T4F7, O14780, Q86TH7	Gene names	SFRP5, FRP1B, SARP3
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5) (Secreted apoptosis-related protein 3) (SARP-3) (Frizzled-related protein 1b) (FRP-1b).

SFRP5_MOUSE
NC score	0.077023 (rank : 53)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WU66, Q8K269	Gene names	Sfrp5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5).

GP133_HUMAN
NC score	0.074779 (rank : 54)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	42	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q6QNK2, Q6ZMQ1, Q7Z7M2, Q86SM4	Gene names	GPR133, PGR25
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 133 precursor (G-protein coupled receptor PGR25).

SYEP_HUMAN
NC score	0.071812 (rank : 55)	θ value	0.279714 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

GP116_HUMAN
NC score	0.067863 (rank : 56)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	42	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

RPGF2_HUMAN
NC score	0.066899 (rank : 57)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	42	Target Neighborhood Hits	242	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

LPHN3_HUMAN
NC score	0.065455 (rank : 58)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	42	Target Neighborhood Hits	139	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HAR2, O94867, Q9NWK5	Gene names	LPHN3, KIAA0768, LEC3
Domain Architecture
Description	Latrophilin-3 precursor (Calcium-independent alpha-latrotoxin receptor 3) (Lectomedin-3).

GP110_MOUSE
NC score	0.064112 (rank : 59)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	42	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VEC3, Q8BMV8	Gene names	Gpr110
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 110 precursor.

EMR4_MOUSE
NC score	0.063823 (rank : 60)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	12
SwissProt Accessions	Q91ZE5, Q3U1I7, Q8BYX0, Q8VIM3	Gene names	Emr4
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 4 precursor (EGF-like module-containing mucin-like receptor EMR4) (F4/80-like-receptor) (Seven-span membrane protein FIRE).

RPGF6_HUMAN
NC score	0.063281 (rank : 61)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	42	Target Neighborhood Hits	266	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

EMR3_HUMAN
NC score	0.062810 (rank : 62)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	42	Target Neighborhood Hits	245	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BY15	Gene names	EMR3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 3 precursor (EGF-like module-containing mucin-like receptor EMR3).

GP113_HUMAN
NC score	0.062491 (rank : 63)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	42	Target Neighborhood Hits	102	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF5, Q6UXT7, Q6UXX3, Q86SL7, Q8IXD8, Q8TDT3	Gene names	GPR113, PGR23
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 113 precursor (G-protein coupled receptor PGR23).

GP110_HUMAN
NC score	0.062380 (rank : 64)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	42	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	Q5T601, Q5KU15, Q5T5Z9, Q86SM1, Q8IXE3, Q8IZF8, Q96DQ1	Gene names	GPR110, PGR19
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 110 precursor (G-protein coupled receptor PGR19) (G-protein coupled receptor KPG_012).

LPHN2_HUMAN
NC score	0.062010 (rank : 65)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	42	Target Neighborhood Hits	136	Shared Neighborhood Hits	15
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

RPGF1_HUMAN
NC score	0.060831 (rank : 66)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	42	Target Neighborhood Hits	262	Shared Neighborhood Hits	3
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GP115_MOUSE
NC score	0.060626 (rank : 67)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	42	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D2L6	Gene names	Gpr115
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 precursor.

GP144_HUMAN
NC score	0.060393 (rank : 68)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	42	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z7M1, Q86SL4, Q8NH12	Gene names	GPR144, PGR24
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 144 (G-protein coupled receptor PGR24).

ELTD1_HUMAN
NC score	0.060301 (rank : 69)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	42	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HBW9	Gene names	ELTD1, ETL
Domain Architecture
Description	EGF, latrophilin and seven transmembrane domain-containing protein 1 precursor (EGF-TM7-latrophilin-related protein) (ETL protein).

GP157_MOUSE
NC score	0.059833 (rank : 70)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	42	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C206, Q8C224	Gene names	Gpr157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

GP115_HUMAN
NC score	0.059395 (rank : 71)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	42	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF3, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6	Gene names	GPR115, PGR18
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 115 (G-protein coupled receptor PGR18).

GPR98_HUMAN
NC score	0.059308 (rank : 72)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	42	Target Neighborhood Hits	202	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

LPHN1_HUMAN
NC score	0.058610 (rank : 73)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	42	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	O94910, Q96IE7, Q9BU07, Q9HAR3	Gene names	LPHN1, KIAA0821, LEC2
Domain Architecture
Description	Latrophilin-1 precursor (Calcium-independent alpha-latrotoxin receptor 1) (Lectomedin-2).

DVL3_HUMAN
NC score	0.056705 (rank : 74)	θ value	0.0961366 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	194	Shared Neighborhood Hits	7
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

GP111_HUMAN
NC score	0.056548 (rank : 75)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	42	Target Neighborhood Hits	77	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZF7, Q86SL6, Q8NGU5, Q8TDT5	Gene names	GPR111, PGR20
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 111 (G-protein coupled receptor PGR20).

GPR98_MOUSE
NC score	0.056081 (rank : 76)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	42	Target Neighborhood Hits	206	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

BAI2_HUMAN
NC score	0.055785 (rank : 77)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	332	Shared Neighborhood Hits	23
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
NC score	0.055775 (rank : 78)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	323	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

SOS1_HUMAN
NC score	0.054974 (rank : 79)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	42	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SYEP_MOUSE
NC score	0.054705 (rank : 80)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

SOS1_MOUSE
NC score	0.054047 (rank : 81)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	42	Target Neighborhood Hits	281	Shared Neighborhood Hits	4
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ELTD1_MOUSE
NC score	0.053879 (rank : 82)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	42	Target Neighborhood Hits	288	Shared Neighborhood Hits	13
SwissProt Accessions	Q923X1, Q91W44	Gene names	Eltd1
Domain Architecture
Description	EGF, latrophilin seven transmembrane domain-containing protein 1 precursor.

GP157_HUMAN
NC score	0.052502 (rank : 83)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	42	Target Neighborhood Hits	93	Shared Neighborhood Hits	21
SwissProt Accessions	Q5UAW9, Q8WWB8, Q9HA73	Gene names	GPR157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

CD97_MOUSE
NC score	0.052424 (rank : 84)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	42	Target Neighborhood Hits	295	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z0M6, Q923A1, Q9CVI5, Q9JLQ8	Gene names	Cd97
Domain Architecture
Description	CD97 antigen precursor.

BAI1_HUMAN
NC score	0.051948 (rank : 85)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	375	Shared Neighborhood Hits	19
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
NC score	0.051855 (rank : 86)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	340	Shared Neighborhood Hits	16
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

SOS2_HUMAN
NC score	0.051408 (rank : 87)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	42	Target Neighborhood Hits	193	Shared Neighborhood Hits	4
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

BAI3_HUMAN
NC score	0.050710 (rank : 88)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_MOUSE
NC score	0.050668 (rank : 89)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	250	Shared Neighborhood Hits	20
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

CELR2_MOUSE
NC score	0.044951 (rank : 90)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	584	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

CELR1_MOUSE
NC score	0.043841 (rank : 91)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	617	Shared Neighborhood Hits	21
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.

CELR1_HUMAN
NC score	0.043710 (rank : 92)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	613	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).

CELR2_HUMAN
NC score	0.042538 (rank : 93)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	657	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

IBRD3_HUMAN
NC score	0.039713 (rank : 94)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZMZ0, Q6P6A4	Gene names	IBRDC3
Domain Architecture	No domain graphic available
Description	IBR domain-containing protein 3.

RNF19_MOUSE
NC score	0.039400 (rank : 95)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	P50636, Q9QUJ5	Gene names	Rnf19, Geg-154, Xybp
Domain Architecture
Description	RING finger protein 19 (XY body protein) (XYbp) (Gametogenesis expressed protein GEG-154) (UBCM4-interacting protein 117) (UIP117).

RNF19_HUMAN
NC score	0.039317 (rank : 96)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	105	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NV58, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1	Gene names	RNF19
Domain Architecture
Description	RING finger protein 19 (Dorfin) (Double ring-finger protein) (p38 protein).

EDAD_HUMAN
NC score	0.038272 (rank : 97)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WWZ3, Q5VYJ7	Gene names	EDARADD
Domain Architecture	No domain graphic available
Description	Ectodysplasin A receptor-associated adapter protein (EDAR-associated death domain protein) (Crinkled homolog).

DHB7_HUMAN
NC score	0.038038 (rank : 98)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	2
SwissProt Accessions	P56937, Q7Z4V9, Q8WWS2, Q9UF00	Gene names	HSD17B7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

SF3B2_HUMAN
NC score	0.033223 (rank : 99)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

XKR3_HUMAN
NC score	0.021294 (rank : 100)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q5GH77, Q52PG8, Q8N7E1	Gene names	XKR3, XRG3
Domain Architecture	No domain graphic available
Description	XK-related protein 3 (XTES).

NOTC1_HUMAN
NC score	0.012136 (rank : 101)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	906	Shared Neighborhood Hits	8
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

OR1C1_HUMAN
NC score	0.003366 (rank : 102)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	842	Shared Neighborhood Hits	2
SwissProt Accessions	Q15619, Q5VVD2, Q6IF97, Q8NGZ1, Q96R83	Gene names	OR1C1
Domain Architecture
Description	Olfactory receptor 1C1 (Olfactory receptor TPCR27) (Olfactory receptor OR1-42).