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Network neighborhood for query Sequence : SFRP4_HUMAN

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SFRP4_HUMAN
SwissProt Accessions	Q6FHJ7, O14877, Q4G124, Q6FHM0, Q6PD64	Gene names	SFRP4, FRPHE
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 4 precursor (sFRP-4) (Frizzled protein, human endometrium) (FrpHE).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SFRP4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q6FHJ7, O14877, Q4G124, Q6FHM0, Q6PD64	Gene names	SFRP4, FRPHE
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 4 precursor (sFRP-4) (Frizzled protein, human endometrium) (FrpHE).

SFRP4_MOUSE
θ value	2.7506e-174 (rank : 2)	NC score	0.999186 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1N6, Q91ZX9	Gene names	Sfrp4
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related sequence protein 4 precursor (sFRP-4) (Frizzled-related protein 4) (FRP-4).

SFRP3_HUMAN
θ value	2.38869e-85 (rank : 3)	NC score	0.977143 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q92765, O00181, Q99686	Gene names	FRZB, FIZ, FRE, FRP, FRZB1, SFRP3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

SFRP3_MOUSE
θ value	6.95003e-85 (rank : 4)	NC score	0.978362 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	44	Shared Neighborhood Hits	39
SwissProt Accessions	P97401, O09075, O09093, Q91W58	Gene names	Frzb, Fiz, Fre, Frzb1, Sfrp3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

FZD5_HUMAN
θ value	9.8567e-31 (rank : 5)	NC score	0.880278 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	71	Shared Neighborhood Hits	39
SwissProt Accessions	Q13467, Q53R22	Gene names	FZD5, HFZ5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (hFz5) (FzE5).

FZD5_MOUSE
θ value	1.6813e-30 (rank : 6)	NC score	0.880905 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EQD0, O08975, Q8BMR2, Q8CHK9	Gene names	Fzd5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (mFz5).

FZD1_MOUSE
θ value	1.33217e-27 (rank : 7)	NC score	0.868314 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	39
SwissProt Accessions	O70421, O08974	Gene names	Fzd1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (mFz1).

FZD1_HUMAN
θ value	3.87602e-27 (rank : 8)	NC score	0.867171 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	62	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UP38, O94815, Q549T8	Gene names	FZD1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (hFz1) (FzE1).

FZD8_HUMAN
θ value	5.06226e-27 (rank : 9)	NC score	0.881083 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H461	Gene names	FZD8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (hFz8).

FZD8_MOUSE
θ value	5.06226e-27 (rank : 10)	NC score	0.879750 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

FZD9_HUMAN
θ value	5.06226e-27 (rank : 11)	NC score	0.871271 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	39
SwissProt Accessions	O00144	Gene names	FZD9, FZD3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (hFz9) (FzE6).

FZD7_HUMAN
θ value	6.61148e-27 (rank : 12)	NC score	0.869640 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	O75084, O94816, Q96B74	Gene names	FZD7
Domain Architecture
Description	Frizzled-7 precursor (Fz-7) (hFz7) (FzE3).

FZD7_MOUSE
θ value	6.61148e-27 (rank : 13)	NC score	0.869024 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	59	Shared Neighborhood Hits	39
SwissProt Accessions	Q61090	Gene names	Fzd7
Domain Architecture	No domain graphic available
Description	Frizzled-7 precursor (Fz-7) (mFz7).

FZD9_MOUSE
θ value	1.12775e-26 (rank : 14)	NC score	0.869484 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R216, O35494, Q9CX16, Q9R2B3	Gene names	Fzd9, Fzd3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (mFz9) (mFz3).

FZD2_HUMAN
θ value	4.28545e-26 (rank : 15)	NC score	0.867563 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	57	Shared Neighborhood Hits	39
SwissProt Accessions	Q14332	Gene names	FZD2
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (hFz2) (FzE2).

FZD2_MOUSE
θ value	4.28545e-26 (rank : 16)	NC score	0.867290 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JIP6, Q810M0, Q9JIP5, Q9WUJ2	Gene names	Fzd2, Fzd10
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (mFz2) (mFz10).

FZD10_HUMAN
θ value	4.73814e-25 (rank : 17)	NC score	0.867503 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULW2	Gene names	FZD10
Domain Architecture
Description	Frizzled-10 precursor (Fz-10) (hFz10) (FzE7).

FZD10_MOUSE
θ value	4.01107e-24 (rank : 18)	NC score	0.865705 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BKG4	Gene names	Fzd10, Fz10
Domain Architecture	No domain graphic available
Description	Frizzled-10 precursor (Fz-10).

FZD4_HUMAN
θ value	2.87452e-22 (rank : 19)	NC score	0.863328 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULV1, Q6S9E4	Gene names	FZD4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (hFz4) (FzE4).

FZD3_HUMAN
θ value	6.40375e-22 (rank : 20)	NC score	0.845121 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPG1	Gene names	FZD3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (hFz3).

FZD3_MOUSE
θ value	6.40375e-22 (rank : 21)	NC score	0.845916 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	75	Shared Neighborhood Hits	39
SwissProt Accessions	Q61086	Gene names	Fzd3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (mFz3).

FZD4_MOUSE
θ value	3.17815e-21 (rank : 22)	NC score	0.861130 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q61088	Gene names	Fzd4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (mFz4).

FZD6_HUMAN
θ value	1.24977e-17 (rank : 23)	NC score	0.836557 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	84	Shared Neighborhood Hits	39
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

SFRP1_HUMAN
θ value	2.7842e-17 (rank : 24)	NC score	0.848805 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N474, O00546, O14779	Gene names	SFRP1, FRP, FRP1, SARP2
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1) (Frizzled- related protein 1) (FRP-1) (Secreted apoptosis-related protein 2) (SARP-2).

FZD6_MOUSE
θ value	8.10077e-17 (rank : 25)	NC score	0.833154 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

SFRP1_MOUSE
θ value	3.07829e-16 (rank : 26)	NC score	0.847343 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C4U3, O08861, Q8R1J4	Gene names	Sfrp1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1).

CORIN_HUMAN
θ value	5.25075e-16 (rank : 27)	NC score	0.295712 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	453	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

SFRP2_MOUSE
θ value	1.99529e-15 (rank : 28)	NC score	0.848906 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	P97299, O08862, O35297	Gene names	Sfrp2, Sarp1, Sdf5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (SDF5 protein).

SFRP5_MOUSE
θ value	2.60593e-15 (rank : 29)	NC score	0.846295 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WU66, Q8K269	Gene names	Sfrp5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5).

SFRP2_HUMAN
θ value	3.40345e-15 (rank : 30)	NC score	0.847581 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	37
SwissProt Accessions	Q96HF1, O14778, Q9HAP5	Gene names	SFRP2, FRP2, SARP1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (Frizzled-related protein 2) (FRP-2).

SFRP5_HUMAN
θ value	7.58209e-15 (rank : 31)	NC score	0.844863 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	39
SwissProt Accessions	Q5T4F7, O14780, Q86TH7	Gene names	SFRP5, FRP1B, SARP3
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5) (Secreted apoptosis-related protein 3) (SARP-3) (Frizzled-related protein 1b) (FRP-1b).

CORIN_MOUSE
θ value	2.20605e-14 (rank : 32)	NC score	0.294552 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	451	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

MFRP_HUMAN
θ value	1.133e-10 (rank : 33)	NC score	0.443730 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

MFRP_MOUSE
θ value	2.52405e-10 (rank : 34)	NC score	0.448589 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

CBPZ_HUMAN
θ value	8.97725e-08 (rank : 35)	NC score	0.433720 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q66K79, O00520, Q96MX2	Gene names	CPZ
Domain Architecture	No domain graphic available
Description	Carboxypeptidase Z precursor (EC 3.4.17.-) (CPZ).

COIA1_MOUSE
θ value	8.97725e-08 (rank : 36)	NC score	0.287960 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	481	Shared Neighborhood Hits	37
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CBPZ_MOUSE
θ value	1.29631e-06 (rank : 37)	NC score	0.391471 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R4V4	Gene names	Cpz
Domain Architecture	No domain graphic available
Description	Carboxypeptidase Z precursor (EC 3.4.17.-) (CPZ).

SMO_HUMAN
θ value	0.00102713 (rank : 38)	NC score	0.683042 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	61	Shared Neighborhood Hits	36
SwissProt Accessions	Q99835	Gene names	SMO, SMOH
Domain Architecture
Description	Smoothened homolog precursor (SMO) (Gx protein).

SMO_MOUSE
θ value	0.00869519 (rank : 39)	NC score	0.674821 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	61	Shared Neighborhood Hits	36
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

ADIP_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.004504 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	470	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

GP158_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.007660 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	221	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

SHPS1_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.001616 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	455	Shared Neighborhood Hits	2
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

TXND2_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.004665 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	793	Shared Neighborhood Hits	3
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

GP155_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.085831 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

GP157_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.115655 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	93	Shared Neighborhood Hits	21
SwissProt Accessions	Q5UAW9, Q8WWB8, Q9HA73	Gene names	GPR157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

GP157_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.107137 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	78	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C206, Q8C224	Gene names	Gpr157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

Hits sorted by NC score

SFRP4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q6FHJ7, O14877, Q4G124, Q6FHM0, Q6PD64	Gene names	SFRP4, FRPHE
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 4 precursor (sFRP-4) (Frizzled protein, human endometrium) (FrpHE).

SFRP4_MOUSE
NC score	0.999186 (rank : 2)	θ value	2.7506e-174 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z1N6, Q91ZX9	Gene names	Sfrp4
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related sequence protein 4 precursor (sFRP-4) (Frizzled-related protein 4) (FRP-4).

SFRP3_MOUSE
NC score	0.978362 (rank : 3)	θ value	6.95003e-85 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	44	Shared Neighborhood Hits	39
SwissProt Accessions	P97401, O09075, O09093, Q91W58	Gene names	Frzb, Fiz, Fre, Frzb1, Sfrp3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

SFRP3_HUMAN
NC score	0.977143 (rank : 4)	θ value	2.38869e-85 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q92765, O00181, Q99686	Gene names	FRZB, FIZ, FRE, FRP, FRZB1, SFRP3
Domain Architecture
Description	Secreted frizzled-related protein 3 precursor (sFRP-3) (Frizzled- related protein 1) (FrzB-1) (Frezzled) (Fritz).

FZD8_HUMAN
NC score	0.881083 (rank : 5)	θ value	5.06226e-27 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H461	Gene names	FZD8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (hFz8).

FZD5_MOUSE
NC score	0.880905 (rank : 6)	θ value	1.6813e-30 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EQD0, O08975, Q8BMR2, Q8CHK9	Gene names	Fzd5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (mFz5).

FZD5_HUMAN
NC score	0.880278 (rank : 7)	θ value	9.8567e-31 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	71	Shared Neighborhood Hits	39
SwissProt Accessions	Q13467, Q53R22	Gene names	FZD5, HFZ5
Domain Architecture
Description	Frizzled-5 precursor (Fz-5) (hFz5) (FzE5).

FZD8_MOUSE
NC score	0.879750 (rank : 8)	θ value	5.06226e-27 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

FZD9_HUMAN
NC score	0.871271 (rank : 9)	θ value	5.06226e-27 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	39
SwissProt Accessions	O00144	Gene names	FZD9, FZD3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (hFz9) (FzE6).

FZD7_HUMAN
NC score	0.869640 (rank : 10)	θ value	6.61148e-27 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	O75084, O94816, Q96B74	Gene names	FZD7
Domain Architecture
Description	Frizzled-7 precursor (Fz-7) (hFz7) (FzE3).

FZD9_MOUSE
NC score	0.869484 (rank : 11)	θ value	1.12775e-26 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R216, O35494, Q9CX16, Q9R2B3	Gene names	Fzd9, Fzd3
Domain Architecture
Description	Frizzled-9 precursor (Fz-9) (mFz9) (mFz3).

FZD7_MOUSE
NC score	0.869024 (rank : 12)	θ value	6.61148e-27 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	59	Shared Neighborhood Hits	39
SwissProt Accessions	Q61090	Gene names	Fzd7
Domain Architecture	No domain graphic available
Description	Frizzled-7 precursor (Fz-7) (mFz7).

FZD1_MOUSE
NC score	0.868314 (rank : 13)	θ value	1.33217e-27 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	39
SwissProt Accessions	O70421, O08974	Gene names	Fzd1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (mFz1).

FZD2_HUMAN
NC score	0.867563 (rank : 14)	θ value	4.28545e-26 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	57	Shared Neighborhood Hits	39
SwissProt Accessions	Q14332	Gene names	FZD2
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (hFz2) (FzE2).

FZD10_HUMAN
NC score	0.867503 (rank : 15)	θ value	4.73814e-25 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULW2	Gene names	FZD10
Domain Architecture
Description	Frizzled-10 precursor (Fz-10) (hFz10) (FzE7).

FZD2_MOUSE
NC score	0.867290 (rank : 16)	θ value	4.28545e-26 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	60	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JIP6, Q810M0, Q9JIP5, Q9WUJ2	Gene names	Fzd2, Fzd10
Domain Architecture
Description	Frizzled-2 precursor (Fz-2) (mFz2) (mFz10).

FZD1_HUMAN
NC score	0.867171 (rank : 17)	θ value	3.87602e-27 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	62	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UP38, O94815, Q549T8	Gene names	FZD1
Domain Architecture
Description	Frizzled-1 precursor (Fz-1) (hFz1) (FzE1).

FZD10_MOUSE
NC score	0.865705 (rank : 18)	θ value	4.01107e-24 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BKG4	Gene names	Fzd10, Fz10
Domain Architecture	No domain graphic available
Description	Frizzled-10 precursor (Fz-10).

FZD4_HUMAN
NC score	0.863328 (rank : 19)	θ value	2.87452e-22 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ULV1, Q6S9E4	Gene names	FZD4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (hFz4) (FzE4).

FZD4_MOUSE
NC score	0.861130 (rank : 20)	θ value	3.17815e-21 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q61088	Gene names	Fzd4
Domain Architecture
Description	Frizzled-4 precursor (Fz-4) (mFz4).

SFRP2_MOUSE
NC score	0.848906 (rank : 21)	θ value	1.99529e-15 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	P97299, O08862, O35297	Gene names	Sfrp2, Sarp1, Sdf5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (SDF5 protein).

SFRP1_HUMAN
NC score	0.848805 (rank : 22)	θ value	2.7842e-17 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N474, O00546, O14779	Gene names	SFRP1, FRP, FRP1, SARP2
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1) (Frizzled- related protein 1) (FRP-1) (Secreted apoptosis-related protein 2) (SARP-2).

SFRP2_HUMAN
NC score	0.847581 (rank : 23)	θ value	3.40345e-15 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	46	Shared Neighborhood Hits	37
SwissProt Accessions	Q96HF1, O14778, Q9HAP5	Gene names	SFRP2, FRP2, SARP1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 2 precursor (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) (Frizzled-related protein 2) (FRP-2).

SFRP1_MOUSE
NC score	0.847343 (rank : 24)	θ value	3.07829e-16 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q8C4U3, O08861, Q8R1J4	Gene names	Sfrp1
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 1 precursor (sFRP-1).

SFRP5_MOUSE
NC score	0.846295 (rank : 25)	θ value	2.60593e-15 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WU66, Q8K269	Gene names	Sfrp5
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5).

FZD3_MOUSE
NC score	0.845916 (rank : 26)	θ value	6.40375e-22 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	75	Shared Neighborhood Hits	39
SwissProt Accessions	Q61086	Gene names	Fzd3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (mFz3).

FZD3_HUMAN
NC score	0.845121 (rank : 27)	θ value	6.40375e-22 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPG1	Gene names	FZD3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (hFz3).

SFRP5_HUMAN
NC score	0.844863 (rank : 28)	θ value	7.58209e-15 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	39
SwissProt Accessions	Q5T4F7, O14780, Q86TH7	Gene names	SFRP5, FRP1B, SARP3
Domain Architecture	No domain graphic available
Description	Secreted frizzled-related protein 5 precursor (sFRP-5) (Secreted apoptosis-related protein 3) (SARP-3) (Frizzled-related protein 1b) (FRP-1b).

FZD6_HUMAN
NC score	0.836557 (rank : 29)	θ value	1.24977e-17 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	84	Shared Neighborhood Hits	39
SwissProt Accessions	O60353, Q6P9C3	Gene names	FZD6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (hFz6).

FZD6_MOUSE
NC score	0.833154 (rank : 30)	θ value	8.10077e-17 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q61089	Gene names	Fzd6
Domain Architecture
Description	Frizzled-6 precursor (Fz-6) (mFz6).

SMO_HUMAN
NC score	0.683042 (rank : 31)	θ value	0.00102713 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	61	Shared Neighborhood Hits	36
SwissProt Accessions	Q99835	Gene names	SMO, SMOH
Domain Architecture
Description	Smoothened homolog precursor (SMO) (Gx protein).

SMO_MOUSE
NC score	0.674821 (rank : 32)	θ value	0.00869519 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	61	Shared Neighborhood Hits	36
SwissProt Accessions	P56726	Gene names	Smo, Smoh
Domain Architecture	No domain graphic available
Description	Smoothened homolog precursor (SMO).

MFRP_MOUSE
NC score	0.448589 (rank : 33)	θ value	2.52405e-10 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	166	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K480, Q8BPP4	Gene names	Mfrp
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

MFRP_HUMAN
NC score	0.443730 (rank : 34)	θ value	1.133e-10 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BY79, Q335M3, Q96DQ9	Gene names	MFRP
Domain Architecture	No domain graphic available
Description	Membrane frizzled-related protein (Membrane-type frizzled-related protein).

CBPZ_HUMAN
NC score	0.433720 (rank : 35)	θ value	8.97725e-08 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q66K79, O00520, Q96MX2	Gene names	CPZ
Domain Architecture	No domain graphic available
Description	Carboxypeptidase Z precursor (EC 3.4.17.-) (CPZ).

CBPZ_MOUSE
NC score	0.391471 (rank : 36)	θ value	1.29631e-06 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R4V4	Gene names	Cpz
Domain Architecture	No domain graphic available
Description	Carboxypeptidase Z precursor (EC 3.4.17.-) (CPZ).

CORIN_HUMAN
NC score	0.295712 (rank : 37)	θ value	5.25075e-16 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	453	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y5Q5, Q9UHY2	Gene names	CORIN, CRN, TMPRSS10
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).

CORIN_MOUSE
NC score	0.294552 (rank : 38)	θ value	2.20605e-14 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	451	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z319	Gene names	Corin, Crn, Lrp4
Domain Architecture
Description	Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Low density lipoprotein receptor-related protein 4).

COIA1_MOUSE
NC score	0.287960 (rank : 39)	θ value	8.97725e-08 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	481	Shared Neighborhood Hits	37
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

GP157_HUMAN
NC score	0.115655 (rank : 40)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	93	Shared Neighborhood Hits	21
SwissProt Accessions	Q5UAW9, Q8WWB8, Q9HA73	Gene names	GPR157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

GP157_MOUSE
NC score	0.107137 (rank : 41)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	78	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C206, Q8C224	Gene names	Gpr157
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 157.

GP155_HUMAN
NC score	0.085831 (rank : 42)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

GP158_HUMAN
NC score	0.007660 (rank : 43)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	221	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

TXND2_HUMAN
NC score	0.004665 (rank : 44)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	793	Shared Neighborhood Hits	3
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ADIP_HUMAN
NC score	0.004504 (rank : 45)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	470	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

SHPS1_HUMAN
NC score	0.001616 (rank : 46)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	455	Shared Neighborhood Hits	2
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).