Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : DPOE1_HUMAN

For an explanation of this page, click here

DPOE1_HUMAN
SwissProt Accessions	Q07864, Q13533, Q86VH9	Gene names	POLE, POLE1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DPOE1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q07864, Q13533, Q86VH9	Gene names	POLE, POLE1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

DPOE1_MOUSE
θ value	0 (rank : 2)	NC score	0.994081 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVF7, Q9QX50	Gene names	Pole, Pole1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

DPOLA_HUMAN
θ value	1.43324e-05 (rank : 3)	NC score	0.216164 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	P09884, Q86UQ7	Gene names	POLA1, POLA
Domain Architecture
Description	DNA polymerase alpha catalytic subunit (EC 2.7.7.7).

DPOLA_MOUSE
θ value	3.19293e-05 (rank : 4)	NC score	0.209954 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	P33609	Gene names	Pola1, Pola
Domain Architecture
Description	DNA polymerase alpha catalytic subunit (EC 2.7.7.7).

DPOD1_HUMAN
θ value	0.0148317 (rank : 5)	NC score	0.151195 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	P28340, Q8NER3, Q96H98	Gene names	POLD1, POLD
Domain Architecture
Description	DNA polymerase delta catalytic subunit (EC 2.7.7.7) (DNA polymerase subunit delta p125).

CBP_HUMAN
θ value	0.279714 (rank : 6)	NC score	0.047546 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	941	Shared Neighborhood Hits	6
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_MOUSE
θ value	0.279714 (rank : 7)	NC score	0.059207 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	1051	Shared Neighborhood Hits	7
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DPOLZ_MOUSE
θ value	0.365318 (rank : 8)	NC score	0.098013 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	169	Shared Neighborhood Hits	7
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

IPO11_HUMAN
θ value	0.365318 (rank : 9)	NC score	0.070463 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

EP300_HUMAN
θ value	0.62314 (rank : 10)	NC score	0.044436 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	821	Shared Neighborhood Hits	6
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

IPO11_MOUSE
θ value	0.62314 (rank : 11)	NC score	0.065562 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

DPOD1_MOUSE
θ value	0.813845 (rank : 12)	NC score	0.120896 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	P52431, O54883	Gene names	Pold1
Domain Architecture
Description	DNA polymerase delta catalytic subunit (EC 2.7.7.7).

CDR2_HUMAN
θ value	1.06291 (rank : 13)	NC score	0.025583 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	404	Shared Neighborhood Hits	3
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

TREX1_HUMAN
θ value	1.06291 (rank : 14)	NC score	0.057686 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NSU2, Q8TEU2, Q9BPW1, Q9Y4X2	Gene names	TREX1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III).

LEO1_HUMAN
θ value	2.36792 (rank : 15)	NC score	0.014676 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	958	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

PUM2_HUMAN
θ value	3.0926 (rank : 16)	NC score	0.033471 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TB72, O00234, Q53TV7, Q8WY43, Q9HAN2	Gene names	PUM2, KIAA0235, PUMH2
Domain Architecture
Description	Pumilio homolog 2 (Pumilio-2).

PUM2_MOUSE
θ value	3.0926 (rank : 17)	NC score	0.033510 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7	Gene names	Pum2, Kiaa0235
Domain Architecture
Description	Pumilio homolog 2.

APLP1_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.023846 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

JUND_HUMAN
θ value	4.03905 (rank : 19)	NC score	0.024611 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	P17535	Gene names	JUND
Domain Architecture
Description	Transcription factor jun-D.

OTUD3_HUMAN
θ value	4.03905 (rank : 20)	NC score	0.031295 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T2D3, O75047	Gene names	OTUD3, KIAA0459
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 3.

RNF8_MOUSE
θ value	4.03905 (rank : 21)	NC score	0.011833 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	618	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

I5P2_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.011659 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

RMP_HUMAN
θ value	5.27518 (rank : 23)	NC score	0.027855 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	O94763	Gene names	RMP, C19orf2
Domain Architecture
Description	RNA polymerase II subunit 5-mediating protein (RPB5-mediating protein).

TNR16_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.023401 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

CENPQ_MOUSE
θ value	6.88961 (rank : 25)	NC score	0.017317 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	160	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CPQ5, Q8C2G4, Q8VEF8, Q9CX70	Gene names	Cenpq
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

FBX32_MOUSE
θ value	6.88961 (rank : 26)	NC score	0.013104 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CPU7	Gene names	Fbxo32
Domain Architecture	No domain graphic available
Description	F-box only protein 32 (Muscle atrophy F-box protein) (MAFbx) (Atrogin- 1).

FUT1_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.012376 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P19526, O14505, O14506, O14507	Gene names	FUT1
Domain Architecture
Description	Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (Blood group H alpha 2- fucosyltransferase).

SI1L3_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.010267 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	305	Shared Neighborhood Hits	4
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SP6_MOUSE
θ value	6.88961 (rank : 29)	NC score	0.001099 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	704	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ESX2, Q6VM22	Gene names	Sp6, Epfn, Klf14
Domain Architecture	No domain graphic available
Description	Transcription factor Sp6 (Krueppel-like factor 14) (Epiprofin).

SPAG5_MOUSE
θ value	6.88961 (rank : 30)	NC score	0.009757 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	612	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SQSTM_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.018221 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

CDA7L_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.012239 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q922M5	Gene names	Cdca7l
Domain Architecture	No domain graphic available
Description	Cell division cycle-associated 7-like protein (Transcription factor RAM2).

CHKB_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.010006 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y259, Q13388	Gene names	CHKB, CHETK, CHKL
Domain Architecture
Description	Choline/ethanolamine kinase [Includes: Choline kinase beta (EC 2.7.1.32) (CK); Ethanolamine kinase (EC 2.7.1.82) (EK)].

COBA1_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.004147 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	491	Shared Neighborhood Hits	4
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COCA1_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.003894 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	458	Shared Neighborhood Hits	3
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

KIF17_HUMAN
θ value	8.99809 (rank : 36)	NC score	0.003349 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	365	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).

KLOT_MOUSE
θ value	8.99809 (rank : 37)	NC score	0.007562 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

LEO1_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.010454 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	946	Shared Neighborhood Hits	6
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

SEC63_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.007873 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	586	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

SPAG5_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.009733 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	625	Shared Neighborhood Hits	5
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

STX8_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.020767 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNK0, O60712	Gene names	STX8
Domain Architecture
Description	Syntaxin-8.

STX8_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.021001 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O88983	Gene names	Stx8
Domain Architecture
Description	Syntaxin-8 (Syntaxin-like protein 3I35).

DPOLZ_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.064322 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	200	Shared Neighborhood Hits	7
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

Hits sorted by NC score

DPOE1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q07864, Q13533, Q86VH9	Gene names	POLE, POLE1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

DPOE1_MOUSE
NC score	0.994081 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WVF7, Q9QX50	Gene names	Pole, Pole1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

DPOLA_HUMAN
NC score	0.216164 (rank : 3)	θ value	1.43324e-05 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	7
SwissProt Accessions	P09884, Q86UQ7	Gene names	POLA1, POLA
Domain Architecture
Description	DNA polymerase alpha catalytic subunit (EC 2.7.7.7).

DPOLA_MOUSE
NC score	0.209954 (rank : 4)	θ value	3.19293e-05 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	P33609	Gene names	Pola1, Pola
Domain Architecture
Description	DNA polymerase alpha catalytic subunit (EC 2.7.7.7).

DPOD1_HUMAN
NC score	0.151195 (rank : 5)	θ value	0.0148317 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	P28340, Q8NER3, Q96H98	Gene names	POLD1, POLD
Domain Architecture
Description	DNA polymerase delta catalytic subunit (EC 2.7.7.7) (DNA polymerase subunit delta p125).

DPOD1_MOUSE
NC score	0.120896 (rank : 6)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	P52431, O54883	Gene names	Pold1
Domain Architecture
Description	DNA polymerase delta catalytic subunit (EC 2.7.7.7).

DPOLZ_MOUSE
NC score	0.098013 (rank : 7)	θ value	0.365318 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	169	Shared Neighborhood Hits	7
SwissProt Accessions	Q61493, Q9JMD6, Q9QWX6	Gene names	Rev3l, Polz, Sez4
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Seizure-related protein 4).

IPO11_HUMAN
NC score	0.070463 (rank : 8)	θ value	0.365318 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UI26, Q8N5R2, Q9NSJ6, Q9NVB1	Gene names	IPO11, RANBP11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

IPO11_MOUSE
NC score	0.065562 (rank : 9)	θ value	0.62314 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2V6, Q8BU45, Q8K0B4	Gene names	Ipo11, Ranbp11
Domain Architecture	No domain graphic available
Description	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11).

DPOLZ_HUMAN
NC score	0.064322 (rank : 10)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	200	Shared Neighborhood Hits	7
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

CBP_MOUSE
NC score	0.059207 (rank : 11)	θ value	0.279714 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	1051	Shared Neighborhood Hits	7
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

TREX1_HUMAN
NC score	0.057686 (rank : 12)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NSU2, Q8TEU2, Q9BPW1, Q9Y4X2	Gene names	TREX1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III).

CBP_HUMAN
NC score	0.047546 (rank : 13)	θ value	0.279714 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	941	Shared Neighborhood Hits	6
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

EP300_HUMAN
NC score	0.044436 (rank : 14)	θ value	0.62314 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	821	Shared Neighborhood Hits	6
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

PUM2_MOUSE
NC score	0.033510 (rank : 15)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U58, Q80UZ9, Q91YW4, Q925A0, Q9ERC7	Gene names	Pum2, Kiaa0235
Domain Architecture
Description	Pumilio homolog 2.

PUM2_HUMAN
NC score	0.033471 (rank : 16)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	67	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TB72, O00234, Q53TV7, Q8WY43, Q9HAN2	Gene names	PUM2, KIAA0235, PUMH2
Domain Architecture
Description	Pumilio homolog 2 (Pumilio-2).

OTUD3_HUMAN
NC score	0.031295 (rank : 17)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T2D3, O75047	Gene names	OTUD3, KIAA0459
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 3.

RMP_HUMAN
NC score	0.027855 (rank : 18)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	O94763	Gene names	RMP, C19orf2
Domain Architecture
Description	RNA polymerase II subunit 5-mediating protein (RPB5-mediating protein).

CDR2_HUMAN
NC score	0.025583 (rank : 19)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	404	Shared Neighborhood Hits	3
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

JUND_HUMAN
NC score	0.024611 (rank : 20)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	P17535	Gene names	JUND
Domain Architecture
Description	Transcription factor jun-D.

APLP1_MOUSE
NC score	0.023846 (rank : 21)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

TNR16_MOUSE
NC score	0.023401 (rank : 22)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

STX8_MOUSE
NC score	0.021001 (rank : 23)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O88983	Gene names	Stx8
Domain Architecture
Description	Syntaxin-8 (Syntaxin-like protein 3I35).

STX8_HUMAN
NC score	0.020767 (rank : 24)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UNK0, O60712	Gene names	STX8
Domain Architecture
Description	Syntaxin-8.

SQSTM_MOUSE
NC score	0.018221 (rank : 25)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	82	Shared Neighborhood Hits	5
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

CENPQ_MOUSE
NC score	0.017317 (rank : 26)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	160	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CPQ5, Q8C2G4, Q8VEF8, Q9CX70	Gene names	Cenpq
Domain Architecture	No domain graphic available
Description	Centromere protein Q (CENP-Q).

LEO1_HUMAN
NC score	0.014676 (rank : 27)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	958	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

FBX32_MOUSE
NC score	0.013104 (rank : 28)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CPU7	Gene names	Fbxo32
Domain Architecture	No domain graphic available
Description	F-box only protein 32 (Muscle atrophy F-box protein) (MAFbx) (Atrogin- 1).

FUT1_HUMAN
NC score	0.012376 (rank : 29)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P19526, O14505, O14506, O14507	Gene names	FUT1
Domain Architecture
Description	Galactoside 2-alpha-L-fucosyltransferase 1 (EC 2.4.1.69) (GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1) (Alpha(1,2)FT 1) (Fucosyltransferase 1) (Blood group H alpha 2- fucosyltransferase).

CDA7L_MOUSE
NC score	0.012239 (rank : 30)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q922M5	Gene names	Cdca7l
Domain Architecture	No domain graphic available
Description	Cell division cycle-associated 7-like protein (Transcription factor RAM2).

RNF8_MOUSE
NC score	0.011833 (rank : 31)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	618	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

I5P2_HUMAN
NC score	0.011659 (rank : 32)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

LEO1_MOUSE
NC score	0.010454 (rank : 33)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	946	Shared Neighborhood Hits	6
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

SI1L3_HUMAN
NC score	0.010267 (rank : 34)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	305	Shared Neighborhood Hits	4
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

CHKB_HUMAN
NC score	0.010006 (rank : 35)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y259, Q13388	Gene names	CHKB, CHETK, CHKL
Domain Architecture
Description	Choline/ethanolamine kinase [Includes: Choline kinase beta (EC 2.7.1.32) (CK); Ethanolamine kinase (EC 2.7.1.82) (EK)].

SPAG5_MOUSE
NC score	0.009757 (rank : 36)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	612	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SPAG5_HUMAN
NC score	0.009733 (rank : 37)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	625	Shared Neighborhood Hits	5
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

SEC63_HUMAN
NC score	0.007873 (rank : 38)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	586	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

KLOT_MOUSE
NC score	0.007562 (rank : 39)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

COBA1_HUMAN
NC score	0.004147 (rank : 40)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	491	Shared Neighborhood Hits	4
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COCA1_HUMAN
NC score	0.003894 (rank : 41)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	458	Shared Neighborhood Hits	3
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

KIF17_HUMAN
NC score	0.003349 (rank : 42)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	365	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).

SP6_MOUSE
NC score	0.001099 (rank : 43)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	704	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ESX2, Q6VM22	Gene names	Sp6, Epfn, Klf14
Domain Architecture	No domain graphic available
Description	Transcription factor Sp6 (Krueppel-like factor 14) (Epiprofin).