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Network neighborhood for query Sequence : CHKB_HUMAN

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CHKB_HUMAN
SwissProt Accessions	Q9Y259, Q13388	Gene names	CHKB, CHETK, CHKL
Domain Architecture
Description	Choline/ethanolamine kinase [Includes: Choline kinase beta (EC 2.7.1.32) (CK); Ethanolamine kinase (EC 2.7.1.82) (EK)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CHKB_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y259, Q13388	Gene names	CHKB, CHETK, CHKL
Domain Architecture
Description	Choline/ethanolamine kinase [Includes: Choline kinase beta (EC 2.7.1.32) (CK); Ethanolamine kinase (EC 2.7.1.82) (EK)].

CHKB_MOUSE
θ value	0 (rank : 2)	NC score	0.998955 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	O55229	Gene names	Chkb, Chetk, Chkl
Domain Architecture
Description	Choline/ethanolamine kinase [Includes: Choline kinase beta (EC 2.7.1.32) (CK); Ethanolamine kinase (EC 2.7.1.82) (EK)].

CHKA_MOUSE
θ value	2.61056e-124 (rank : 3)	NC score	0.984214 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O54804, Q8BPL3, Q8BPW6, Q9CXP3, Q9QX56	Gene names	Chka, Chk
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

CHKA_HUMAN
θ value	9.92011e-124 (rank : 4)	NC score	0.982669 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	P35790, Q8NE29	Gene names	CHKA, CHK, CKI
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

EKI1_HUMAN
θ value	1.16164e-39 (rank : 5)	NC score	0.857876 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBU6	Gene names	ETNK1, EKI1
Domain Architecture
Description	Ethanolamine kinase 1 (EC 2.7.1.82) (EKI 1).

EKI2_HUMAN
θ value	2.12685e-25 (rank : 6)	NC score	0.780494 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NVF9	Gene names	ETNK2, EKI2
Domain Architecture
Description	Ethanolamine kinase 2 (EC 2.7.1.82) (EKI 2) (Ethanolamine kinase-like protein).

DAAM2_HUMAN
θ value	4.03905 (rank : 7)	NC score	0.009835 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	350	Shared Neighborhood Hits	2
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DPP4_MOUSE
θ value	4.03905 (rank : 8)	NC score	0.014128 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	P28843, Q3U514	Gene names	Dpp4, Cd26
Domain Architecture
Description	Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (Thymocyte-activating molecule) (THAM) [Contains: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)].

KCD16_HUMAN
θ value	5.27518 (rank : 9)	NC score	0.009645 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q68DU8, Q9P2M9	Gene names	KCTD16, KIAA1317
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD16.

DPOE1_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.010006 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q07864, Q13533, Q86VH9	Gene names	POLE, POLE1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

ERBB2_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.000123 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

KS6A6_HUMAN
θ value	8.99809 (rank : 12)	NC score	-0.000648 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	853	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

Hits sorted by NC score

CHKB_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y259, Q13388	Gene names	CHKB, CHETK, CHKL
Domain Architecture
Description	Choline/ethanolamine kinase [Includes: Choline kinase beta (EC 2.7.1.32) (CK); Ethanolamine kinase (EC 2.7.1.82) (EK)].

CHKB_MOUSE
NC score	0.998955 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	O55229	Gene names	Chkb, Chetk, Chkl
Domain Architecture
Description	Choline/ethanolamine kinase [Includes: Choline kinase beta (EC 2.7.1.32) (CK); Ethanolamine kinase (EC 2.7.1.82) (EK)].

CHKA_MOUSE
NC score	0.984214 (rank : 3)	θ value	2.61056e-124 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	O54804, Q8BPL3, Q8BPW6, Q9CXP3, Q9QX56	Gene names	Chka, Chk
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

CHKA_HUMAN
NC score	0.982669 (rank : 4)	θ value	9.92011e-124 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	P35790, Q8NE29	Gene names	CHKA, CHK, CKI
Domain Architecture
Description	Choline kinase alpha (EC 2.7.1.32) (CK) (CHETK-alpha).

EKI1_HUMAN
NC score	0.857876 (rank : 5)	θ value	1.16164e-39 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBU6	Gene names	ETNK1, EKI1
Domain Architecture
Description	Ethanolamine kinase 1 (EC 2.7.1.82) (EKI 1).

EKI2_HUMAN
NC score	0.780494 (rank : 6)	θ value	2.12685e-25 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NVF9	Gene names	ETNK2, EKI2
Domain Architecture
Description	Ethanolamine kinase 2 (EC 2.7.1.82) (EKI 2) (Ethanolamine kinase-like protein).

DPP4_MOUSE
NC score	0.014128 (rank : 7)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	P28843, Q3U514	Gene names	Dpp4, Cd26
Domain Architecture
Description	Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (Thymocyte-activating molecule) (THAM) [Contains: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)].

DPOE1_HUMAN
NC score	0.010006 (rank : 8)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q07864, Q13533, Q86VH9	Gene names	POLE, POLE1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

DAAM2_HUMAN
NC score	0.009835 (rank : 9)	θ value	4.03905 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	350	Shared Neighborhood Hits	2
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

KCD16_HUMAN
NC score	0.009645 (rank : 10)	θ value	5.27518 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q68DU8, Q9P2M9	Gene names	KCTD16, KIAA1317
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD16.

ERBB2_HUMAN
NC score	0.000123 (rank : 11)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

KS6A6_HUMAN
NC score	-0.000648 (rank : 12)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	853	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).