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Network neighborhood for query Sequence : TREX1_HUMAN

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TREX1_HUMAN
SwissProt Accessions	Q9NSU2, Q8TEU2, Q9BPW1, Q9Y4X2	Gene names	TREX1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TREX1_HUMAN
θ value	1.08415e-162 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NSU2, Q8TEU2, Q9BPW1, Q9Y4X2	Gene names	TREX1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III).

TREX1_MOUSE
θ value	8.75112e-96 (rank : 2)	NC score	0.985919 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q91XB0, Q3TAD7, Q9D6W2, Q9R1B0	Gene names	Trex1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1).

TREX2_HUMAN
θ value	4.122e-45 (rank : 3)	NC score	0.909736 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQ50, Q45F08, Q9UN77	Gene names	TREX2
Domain Architecture
Description	Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2).

TREX2_MOUSE
θ value	6.58091e-43 (rank : 4)	NC score	0.914215 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1A9	Gene names	Trex2
Domain Architecture
Description	Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2).

MUC1_HUMAN
θ value	0.125558 (rank : 5)	NC score	0.017913 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	975	Shared Neighborhood Hits	3
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PGBM_MOUSE
θ value	0.813845 (rank : 6)	NC score	0.010510 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

DPOE1_HUMAN
θ value	1.06291 (rank : 7)	NC score	0.057686 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q07864, Q13533, Q86VH9	Gene names	POLE, POLE1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

DPOE1_MOUSE
θ value	1.38821 (rank : 8)	NC score	0.056621 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVF7, Q9QX50	Gene names	Pole, Pole1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

LIRB3_HUMAN
θ value	1.38821 (rank : 9)	NC score	0.016111 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	O75022, O15471, Q86U49	Gene names	LILRB3, ILT5, LIR3
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor (Leukocyte immunoglobulin-like receptor 3) (LIR-3) (Immunoglobulin- like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD85a antigen).

SON_HUMAN
θ value	1.81305 (rank : 10)	NC score	0.012645 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	1568	Shared Neighborhood Hits	4
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

PCDGJ_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.005260 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5F8, Q9UN63	Gene names	PCDHGB7
Domain Architecture
Description	Protocadherin gamma B7 precursor (PCDH-gamma-B7).

SSBP4_HUMAN
θ value	5.27518 (rank : 12)	NC score	0.009420 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	753	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

CAC1G_HUMAN
θ value	6.88961 (rank : 13)	NC score	0.007017 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	587	Shared Neighborhood Hits	2
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

APEX1_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.015293 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

MECR_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.012232 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

Hits sorted by NC score

TREX1_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.08415e-162 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NSU2, Q8TEU2, Q9BPW1, Q9Y4X2	Gene names	TREX1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III).

TREX1_MOUSE
NC score	0.985919 (rank : 2)	θ value	8.75112e-96 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q91XB0, Q3TAD7, Q9D6W2, Q9R1B0	Gene names	Trex1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1).

TREX2_MOUSE
NC score	0.914215 (rank : 3)	θ value	6.58091e-43 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1A9	Gene names	Trex2
Domain Architecture
Description	Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2).

TREX2_HUMAN
NC score	0.909736 (rank : 4)	θ value	4.122e-45 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BQ50, Q45F08, Q9UN77	Gene names	TREX2
Domain Architecture
Description	Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2).

DPOE1_HUMAN
NC score	0.057686 (rank : 5)	θ value	1.06291 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q07864, Q13533, Q86VH9	Gene names	POLE, POLE1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

DPOE1_MOUSE
NC score	0.056621 (rank : 6)	θ value	1.38821 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVF7, Q9QX50	Gene names	Pole, Pole1
Domain Architecture
Description	DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).

MUC1_HUMAN
NC score	0.017913 (rank : 7)	θ value	0.125558 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	975	Shared Neighborhood Hits	3
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

LIRB3_HUMAN
NC score	0.016111 (rank : 8)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	O75022, O15471, Q86U49	Gene names	LILRB3, ILT5, LIR3
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor (Leukocyte immunoglobulin-like receptor 3) (LIR-3) (Immunoglobulin- like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD85a antigen).

APEX1_MOUSE
NC score	0.015293 (rank : 9)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

SON_HUMAN
NC score	0.012645 (rank : 10)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	1568	Shared Neighborhood Hits	4
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MECR_HUMAN
NC score	0.012232 (rank : 11)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

PGBM_MOUSE
NC score	0.010510 (rank : 12)	θ value	0.813845 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

SSBP4_HUMAN
NC score	0.009420 (rank : 13)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	753	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

CAC1G_HUMAN
NC score	0.007017 (rank : 14)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	587	Shared Neighborhood Hits	2
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

PCDGJ_HUMAN
NC score	0.005260 (rank : 15)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5F8, Q9UN63	Gene names	PCDHGB7
Domain Architecture
Description	Protocadherin gamma B7 precursor (PCDH-gamma-B7).