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Network neighborhood for query Sequence : APEX1_MOUSE

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APEX1_MOUSE
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APEX1_HUMAN
θ value	1.08164e-170 (rank : 1)	NC score	0.997663 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
θ value	1.01238e-168 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

APEX2_MOUSE
θ value	8.10077e-17 (rank : 3)	NC score	0.603800 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
θ value	1.99529e-15 (rank : 4)	NC score	0.587422 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

LIN1_HUMAN
θ value	1.17247e-07 (rank : 5)	NC score	0.312475 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

POL2_MOUSE
θ value	0.00390308 (rank : 6)	NC score	0.237481 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

FMN1A_MOUSE
θ value	0.125558 (rank : 7)	NC score	0.042217 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	423	Shared Neighborhood Hits	2
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

ZCPW1_MOUSE
θ value	1.81305 (rank : 8)	NC score	0.039284 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

VPS41_HUMAN
θ value	2.36792 (rank : 9)	NC score	0.062788 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P49754, Q99851, Q99852	Gene names	VPS41
Domain Architecture
Description	Vacuolar protein sorting-associated protein 41 homolog (S53).

VPS41_MOUSE
θ value	2.36792 (rank : 10)	NC score	0.062874 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q5KU39, Q3TPS1, Q80V99, Q8BKK6, Q8CG01, Q8CJC3	Gene names	Vps41
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 41 homolog (VAM2 homolog) (mVAM2).

TTRAP_MOUSE
θ value	4.03905 (rank : 11)	NC score	0.029288 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJX7	Gene names	Ttrap
Domain Architecture	No domain graphic available
Description	TRAF and TNF receptor-associated protein.

RNT2_HUMAN
θ value	6.88961 (rank : 12)	NC score	0.022518 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O00584, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47	Gene names	RNASET2, RNASE6PL
Domain Architecture
Description	Ribonuclease T2 precursor (EC 3.1.27.-) (Ribonuclease 6).

TREX1_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.015293 (rank : 14)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NSU2, Q8TEU2, Q9BPW1, Q9Y4X2	Gene names	TREX1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III).

NEIL3_MOUSE
θ value	θ > 10 (rank : 14)	NC score	0.055370 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

Hits sorted by NC score

APEX1_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.01238e-168 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

APEX1_HUMAN
NC score	0.997663 (rank : 2)	θ value	1.08164e-170 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX2_MOUSE
NC score	0.603800 (rank : 3)	θ value	8.10077e-17 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
NC score	0.587422 (rank : 4)	θ value	1.99529e-15 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

LIN1_HUMAN
NC score	0.312475 (rank : 5)	θ value	1.17247e-07 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

POL2_MOUSE
NC score	0.237481 (rank : 6)	θ value	0.00390308 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

VPS41_MOUSE
NC score	0.062874 (rank : 7)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q5KU39, Q3TPS1, Q80V99, Q8BKK6, Q8CG01, Q8CJC3	Gene names	Vps41
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 41 homolog (VAM2 homolog) (mVAM2).

VPS41_HUMAN
NC score	0.062788 (rank : 8)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P49754, Q99851, Q99852	Gene names	VPS41
Domain Architecture
Description	Vacuolar protein sorting-associated protein 41 homolog (S53).

NEIL3_MOUSE
NC score	0.055370 (rank : 9)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	13	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

FMN1A_MOUSE
NC score	0.042217 (rank : 10)	θ value	0.125558 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	423	Shared Neighborhood Hits	2
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

ZCPW1_MOUSE
NC score	0.039284 (rank : 11)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

TTRAP_MOUSE
NC score	0.029288 (rank : 12)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJX7	Gene names	Ttrap
Domain Architecture	No domain graphic available
Description	TRAF and TNF receptor-associated protein.

RNT2_HUMAN
NC score	0.022518 (rank : 13)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O00584, Q5T8Q0, Q8TCU2, Q9BZ46, Q9BZ47	Gene names	RNASET2, RNASE6PL
Domain Architecture
Description	Ribonuclease T2 precursor (EC 3.1.27.-) (Ribonuclease 6).

TREX1_HUMAN
NC score	0.015293 (rank : 14)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NSU2, Q8TEU2, Q9BPW1, Q9Y4X2	Gene names	TREX1
Domain Architecture
Description	Three prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (DNase III).