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Network neighborhood for query Sequence : APEX2_HUMAN

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APEX2_HUMAN
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APEX2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

APEX2_MOUSE
θ value	0 (rank : 2)	NC score	0.994768 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	11
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX1_HUMAN
θ value	6.85773e-16 (rank : 3)	NC score	0.590288 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
θ value	1.99529e-15 (rank : 4)	NC score	0.587422 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

NEIL3_MOUSE
θ value	7.59969e-07 (rank : 5)	NC score	0.329214 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

LIN1_HUMAN
θ value	1.09739e-05 (rank : 6)	NC score	0.218120 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

NEIL3_HUMAN
θ value	2.44474e-05 (rank : 7)	NC score	0.307134 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

TOP3A_MOUSE
θ value	2.44474e-05 (rank : 8)	NC score	0.239307 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_HUMAN
θ value	0.000121331 (rank : 9)	NC score	0.230853 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

NCOA6_HUMAN
θ value	0.62314 (rank : 10)	NC score	0.027864 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	1202	Shared Neighborhood Hits	6
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SHAN1_HUMAN
θ value	0.62314 (rank : 11)	NC score	0.018076 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1041	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EP400_MOUSE
θ value	1.06291 (rank : 12)	NC score	0.025334 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	592	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

TTF2_MOUSE
θ value	1.38821 (rank : 13)	NC score	0.047759 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

MLL3_HUMAN
θ value	3.0926 (rank : 14)	NC score	0.013241 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	1644	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

BC11B_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.001685 (rank : 21)
Query Neighborhood Hits	18	Target Neighborhood Hits	767	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PV8, Q8C2I1, Q99PV6, Q99PV7, Q9JLF8	Gene names	Bcl11b, Ctip2, Rit1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (mRit1) (COUP-TF-interacting protein 2).

IDH3A_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.014433 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P50213, Q9H3X0	Gene names	IDH3A
Domain Architecture
Description	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH).

TTF2_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.035409 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	98	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

MINT_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.008538 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	1291	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

POL2_MOUSE
θ value	θ > 10 (rank : 19)	NC score	0.116962 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

TOP3B_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.074157 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_MOUSE
θ value	θ > 10 (rank : 21)	NC score	0.074399 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

Hits sorted by NC score

APEX2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

APEX2_MOUSE
NC score	0.994768 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	11
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX1_HUMAN
NC score	0.590288 (rank : 3)	θ value	6.85773e-16 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
NC score	0.587422 (rank : 4)	θ value	1.99529e-15 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

NEIL3_MOUSE
NC score	0.329214 (rank : 5)	θ value	7.59969e-07 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	39	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
NC score	0.307134 (rank : 6)	θ value	2.44474e-05 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

TOP3A_MOUSE
NC score	0.239307 (rank : 7)	θ value	2.44474e-05 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	8
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_HUMAN
NC score	0.230853 (rank : 8)	θ value	0.000121331 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

LIN1_HUMAN
NC score	0.218120 (rank : 9)	θ value	1.09739e-05 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

POL2_MOUSE
NC score	0.116962 (rank : 10)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

TOP3B_MOUSE
NC score	0.074399 (rank : 11)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	18	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_HUMAN
NC score	0.074157 (rank : 12)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TTF2_MOUSE
NC score	0.047759 (rank : 13)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TTF2_HUMAN
NC score	0.035409 (rank : 14)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	98	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UNY4, O75921, Q5T2K7, Q5VVU8, Q8N6I8	Gene names	TTF2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2) (Factor 2) (F2) (HuF2) (Lodestar homolog).

NCOA6_HUMAN
NC score	0.027864 (rank : 15)	θ value	0.62314 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	1202	Shared Neighborhood Hits	6
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

EP400_MOUSE
NC score	0.025334 (rank : 16)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	592	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

SHAN1_HUMAN
NC score	0.018076 (rank : 17)	θ value	0.62314 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	1041	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

IDH3A_HUMAN
NC score	0.014433 (rank : 18)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P50213, Q9H3X0	Gene names	IDH3A
Domain Architecture
Description	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH).

MLL3_HUMAN
NC score	0.013241 (rank : 19)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	1644	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MINT_HUMAN
NC score	0.008538 (rank : 20)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	1291	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

BC11B_MOUSE
NC score	0.001685 (rank : 21)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	767	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PV8, Q8C2I1, Q99PV6, Q99PV7, Q9JLF8	Gene names	Bcl11b, Ctip2, Rit1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (mRit1) (COUP-TF-interacting protein 2).