Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : TOP3B_HUMAN

For an explanation of this page, click here

TOP3B_HUMAN
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TOP3B_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_MOUSE
θ value	0 (rank : 2)	NC score	0.998789 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3A_MOUSE
θ value	4.32305e-111 (rank : 3)	NC score	0.889161 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_HUMAN
θ value	1.64275e-110 (rank : 4)	NC score	0.890130 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TRIP6_HUMAN
θ value	0.813845 (rank : 5)	NC score	0.016923 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	228	Shared Neighborhood Hits	2
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

APC7_HUMAN
θ value	3.0926 (rank : 6)	NC score	0.030899 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJX3, Q96AC4, Q96GF4, Q9BU24, Q9NT16	Gene names	ANAPC7, APC7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7).

APC7_MOUSE
θ value	4.03905 (rank : 7)	NC score	0.029485 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVM3, Q3UBM7, Q8BSR2, Q91W13	Gene names	Anapc7, Apc7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) (Prediabetic NOD sera-reactive autoantigen).

MLL2_HUMAN
θ value	4.03905 (rank : 8)	NC score	0.010406 (rank : 13)
Query Neighborhood Hits	12	Target Neighborhood Hits	1788	Shared Neighborhood Hits	3
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ZIM3_HUMAN
θ value	6.88961 (rank : 9)	NC score	0.000061 (rank : 16)
Query Neighborhood Hits	12	Target Neighborhood Hits	765	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PE6	Gene names	ZIM3
Domain Architecture
Description	Zinc finger imprinted 3.

ZN578_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.000750 (rank : 15)
Query Neighborhood Hits	12	Target Neighborhood Hits	755	Shared Neighborhood Hits	5
SwissProt Accessions	Q96N58	Gene names	ZNF578
Domain Architecture	No domain graphic available
Description	Zinc finger protein 578.

LRP1B_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.002361 (rank : 14)
Query Neighborhood Hits	12	Target Neighborhood Hits	602	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

SQSTM_MOUSE
θ value	8.99809 (rank : 12)	NC score	0.011653 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

APEX2_HUMAN
θ value	θ > 10 (rank : 13)	NC score	0.074157 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

APEX2_MOUSE
θ value	θ > 10 (rank : 14)	NC score	0.078219 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

NEIL3_HUMAN
θ value	θ > 10 (rank : 15)	NC score	0.104820 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_MOUSE
θ value	θ > 10 (rank : 16)	NC score	0.112883 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

Hits sorted by NC score

TOP3B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	12	Target Neighborhood Hits	12	Shared Neighborhood Hits	12
SwissProt Accessions	O95985, Q9BUP5	Gene names	TOP3B, TOP3B1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3B_MOUSE
NC score	0.998789 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	12	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z321	Gene names	Top3b, Top3b1
Domain Architecture
Description	DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta- 1).

TOP3A_HUMAN
NC score	0.890130 (rank : 3)	θ value	1.64275e-110 (rank : 4)
Query Neighborhood Hits	12	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q13472, Q13473	Gene names	TOP3A, TOP3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

TOP3A_MOUSE
NC score	0.889161 (rank : 4)	θ value	4.32305e-111 (rank : 3)
Query Neighborhood Hits	12	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	O70157	Gene names	Top3a, Top3
Domain Architecture
Description	DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha).

NEIL3_MOUSE
NC score	0.112883 (rank : 5)	θ value	θ > 10 (rank : 16)
Query Neighborhood Hits	12	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

NEIL3_HUMAN
NC score	0.104820 (rank : 6)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	12	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TAT5, Q2PPJ3, Q8NG51, Q9NV95	Gene names	NEIL3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

APEX2_MOUSE
NC score	0.078219 (rank : 7)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	12	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
NC score	0.074157 (rank : 8)	θ value	θ > 10 (rank : 13)
Query Neighborhood Hits	12	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

APC7_HUMAN
NC score	0.030899 (rank : 9)	θ value	3.0926 (rank : 6)
Query Neighborhood Hits	12	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJX3, Q96AC4, Q96GF4, Q9BU24, Q9NT16	Gene names	ANAPC7, APC7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7).

APC7_MOUSE
NC score	0.029485 (rank : 10)	θ value	4.03905 (rank : 7)
Query Neighborhood Hits	12	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WVM3, Q3UBM7, Q8BSR2, Q91W13	Gene names	Anapc7, Apc7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) (Prediabetic NOD sera-reactive autoantigen).

TRIP6_HUMAN
NC score	0.016923 (rank : 11)	θ value	0.813845 (rank : 5)
Query Neighborhood Hits	12	Target Neighborhood Hits	228	Shared Neighborhood Hits	2
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

SQSTM_MOUSE
NC score	0.011653 (rank : 12)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	12	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

MLL2_HUMAN
NC score	0.010406 (rank : 13)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	12	Target Neighborhood Hits	1788	Shared Neighborhood Hits	3
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

LRP1B_HUMAN
NC score	0.002361 (rank : 14)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	12	Target Neighborhood Hits	602	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

ZN578_HUMAN
NC score	0.000750 (rank : 15)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	12	Target Neighborhood Hits	755	Shared Neighborhood Hits	5
SwissProt Accessions	Q96N58	Gene names	ZNF578
Domain Architecture	No domain graphic available
Description	Zinc finger protein 578.

ZIM3_HUMAN
NC score	0.000061 (rank : 16)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	12	Target Neighborhood Hits	765	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PE6	Gene names	ZIM3
Domain Architecture
Description	Zinc finger imprinted 3.