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Network neighborhood for query Sequence : APEX1_HUMAN

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APEX1_HUMAN
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APEX1_HUMAN
θ value	4.38123e-180 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	9	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
θ value	1.08164e-170 (rank : 2)	NC score	0.997663 (rank : 2)
Query Neighborhood Hits	9	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

APEX2_MOUSE
θ value	2.7842e-17 (rank : 3)	NC score	0.606003 (rank : 3)
Query Neighborhood Hits	9	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
θ value	6.85773e-16 (rank : 4)	NC score	0.590288 (rank : 4)
Query Neighborhood Hits	9	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

LIN1_HUMAN
θ value	4.92598e-06 (rank : 5)	NC score	0.288087 (rank : 5)
Query Neighborhood Hits	9	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

POL2_MOUSE
θ value	0.0330416 (rank : 6)	NC score	0.210660 (rank : 6)
Query Neighborhood Hits	9	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

VPS41_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.066375 (rank : 8)
Query Neighborhood Hits	9	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P49754, Q99851, Q99852	Gene names	VPS41
Domain Architecture
Description	Vacuolar protein sorting-associated protein 41 homolog (S53).

VPS41_MOUSE
θ value	1.81305 (rank : 8)	NC score	0.066466 (rank : 7)
Query Neighborhood Hits	9	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q5KU39, Q3TPS1, Q80V99, Q8BKK6, Q8CG01, Q8CJC3	Gene names	Vps41
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 41 homolog (VAM2 homolog) (mVAM2).

ZCPW1_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.030899 (rank : 10)
Query Neighborhood Hits	9	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

NEIL3_MOUSE
θ value	θ > 10 (rank : 10)	NC score	0.056055 (rank : 9)
Query Neighborhood Hits	9	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

Hits sorted by NC score

APEX1_HUMAN
NC score	0.999962 (rank : 1)	θ value	4.38123e-180 (rank : 1)
Query Neighborhood Hits	9	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	P27695, Q969L5, Q99775	Gene names	APEX1, APE, APEX, APX, HAP1, REF1
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN) (REF-1 protein).

APEX1_MOUSE
NC score	0.997663 (rank : 2)	θ value	1.08164e-170 (rank : 2)
Query Neighborhood Hits	9	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	P28352	Gene names	Apex1, Ape, Apex
Domain Architecture
Description	DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP endonuclease 1) (APEX nuclease) (APEN).

APEX2_MOUSE
NC score	0.606003 (rank : 3)	θ value	2.7842e-17 (rank : 3)
Query Neighborhood Hits	9	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	Q68G58, Q8BJP7, Q8BTR7, Q8BUZ2, Q8BYE9, Q8R018, Q8R328, Q9CS12	Gene names	Apex2, Ape2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2).

APEX2_HUMAN
NC score	0.590288 (rank : 4)	θ value	6.85773e-16 (rank : 4)
Query Neighborhood Hits	9	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UBZ4, Q9Y5X7	Gene names	APEX2, APE2, APEXL2, XTH2
Domain Architecture	No domain graphic available
Description	DNA-(apurinic or apyrimidinic site) lyase 2 (EC 4.2.99.18) (Apurinic- apyrimidinic endonuclease 2) (AP endonuclease 2) (APEX nuclease 2) (APEX nuclease-like 2) (AP endonuclease XTH2).

LIN1_HUMAN
NC score	0.288087 (rank : 5)	θ value	4.92598e-06 (rank : 5)
Query Neighborhood Hits	9	Target Neighborhood Hits	187	Shared Neighborhood Hits	6
SwissProt Accessions	P08547	Gene names
Domain Architecture	No domain graphic available
Description	LINE-1 reverse transcriptase homolog.

POL2_MOUSE
NC score	0.210660 (rank : 6)	θ value	0.0330416 (rank : 6)
Query Neighborhood Hits	9	Target Neighborhood Hits	39	Shared Neighborhood Hits	5
SwissProt Accessions	P11369, Q60713, Q61787	Gene names	Pol
Domain Architecture
Description	Retrovirus-related Pol polyprotein LINE-1 (Long interspersed element- 1) (L1) [Includes: Reverse transcriptase (EC 2.7.7.49); Endonuclease].

VPS41_MOUSE
NC score	0.066466 (rank : 7)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	9	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q5KU39, Q3TPS1, Q80V99, Q8BKK6, Q8CG01, Q8CJC3	Gene names	Vps41
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 41 homolog (VAM2 homolog) (mVAM2).

VPS41_HUMAN
NC score	0.066375 (rank : 8)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	9	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	P49754, Q99851, Q99852	Gene names	VPS41
Domain Architecture
Description	Vacuolar protein sorting-associated protein 41 homolog (S53).

NEIL3_MOUSE
NC score	0.056055 (rank : 9)	θ value	θ > 10 (rank : 10)
Query Neighborhood Hits	9	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K203, Q8CD85, Q8R3P4	Gene names	Neil3
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 3 (Nei-like 3) (DNA glycosylase FPG2).

ZCPW1_MOUSE
NC score	0.030899 (rank : 10)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	9	Target Neighborhood Hits	307	Shared Neighborhood Hits	3
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.