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Network neighborhood for query Sequence : CAN7_MOUSE

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CAN7_MOUSE
SwissProt Accessions	Q9R1S8, Q9Z0P9	Gene names	Capn7, Palbh
Domain Architecture
Description	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CAN7_HUMAN
θ value	0 (rank : 1)	NC score	0.994397 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6W3	Gene names	CAPN7, PALBH
Domain Architecture
Description	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH).

CAN7_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R1S8, Q9Z0P9	Gene names	Capn7, Palbh
Domain Architecture
Description	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH).

CAN5_MOUSE
θ value	2.05525e-28 (rank : 3)	NC score	0.765149 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	25	Shared Neighborhood Hits	19
SwissProt Accessions	O08688, Q91YU0	Gene names	Capn5
Domain Architecture
Description	Calpain-5 (EC 3.4.22.-) (nCL-3).

CAN5_HUMAN
θ value	2.51237e-26 (rank : 4)	NC score	0.761462 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	O15484, O00263	Gene names	CAPN5
Domain Architecture
Description	Calpain-5 (EC 3.4.22.-) (nCL-3) (htra-3).

CAN6_HUMAN
θ value	1.86321e-21 (rank : 5)	NC score	0.751236 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y6Q1, Q9UEQ1, Q9UJA8	Gene names	CAPN6, CALPM, CANPX
Domain Architecture
Description	Calpain-6 (Calpamodulin) (CalpM) (Calpain-like protease X-linked).

CAN6_MOUSE
θ value	2.43343e-21 (rank : 6)	NC score	0.751242 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	O35646	Gene names	Capn6, Capa6
Domain Architecture
Description	Calpain-6.

CAN1_HUMAN
θ value	2.69047e-20 (rank : 7)	NC score	0.669532 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	P07384	Gene names	CAPN1, CANPL1
Domain Architecture
Description	Calpain-1 catalytic subunit (EC 3.4.22.52) (Calpain-1 large subunit) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (muCANP) (Micromolar-calpain).

CAN2_MOUSE
θ value	5.99374e-20 (rank : 8)	NC score	0.674154 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	O08529, O35518, O54843	Gene names	Capn2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (80 kDa M-calpain subunit) (CALP80).

CAN2_HUMAN
θ value	7.82807e-20 (rank : 9)	NC score	0.675869 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	P17655, Q16738, Q6PJT3, Q8WU26, Q9HBB1	Gene names	CAPN2, CANPL2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (Calpain large polypeptide L2).

CAN11_HUMAN
θ value	1.33526e-19 (rank : 10)	NC score	0.679574 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UMQ6, Q8N4R5	Gene names	CAPN11
Domain Architecture
Description	Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11).

CAN10_HUMAN
θ value	2.27762e-19 (rank : 11)	NC score	0.741118 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HC96, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95	Gene names	CAPN10, KIAA1845
Domain Architecture
Description	Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10).

CAN9_HUMAN
θ value	8.65492e-19 (rank : 12)	NC score	0.673699 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	68	Shared Neighborhood Hits	19
SwissProt Accessions	O14815, Q9NS74	Gene names	CAPN9, NCL4
Domain Architecture
Description	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (nCL-4) (CG36 protein).

CAN1_MOUSE
θ value	1.92812e-18 (rank : 13)	NC score	0.665310 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	O35350, O88666	Gene names	Capn1, Canp1, Capa1
Domain Architecture
Description	Calpain-1 catalytic subunit (EC 3.4.22.52) (Calpain-1 large subunit) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (muCANP) (Micromolar-calpain).

CAN12_HUMAN
θ value	2.5182e-18 (rank : 14)	NC score	0.698394 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZSI9	Gene names	CAPN12
Domain Architecture	No domain graphic available
Description	Calpain-12 (EC 3.4.22.-).

CAN9_MOUSE
θ value	4.29542e-18 (rank : 15)	NC score	0.671614 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D805, O35919	Gene names	Capn9, Ncl4
Domain Architecture
Description	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (nCL-4).

CAN10_MOUSE
θ value	2.7842e-17 (rank : 16)	NC score	0.735274 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	25	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ESK3, Q99J13, Q9WVF0	Gene names	Capn10, Capn8
Domain Architecture
Description	Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10).

CAN12_MOUSE
θ value	3.40345e-15 (rank : 17)	NC score	0.687483 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ER56, Q9ER53, Q9ER54, Q9ER55	Gene names	Capn12
Domain Architecture
Description	Calpain-12 (EC 3.4.22.-).

CAN3_MOUSE
θ value	9.90251e-15 (rank : 18)	NC score	0.646703 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	115	Shared Neighborhood Hits	20
SwissProt Accessions	Q64691, Q9WUC5	Gene names	Capn3
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3).

CAN3_HUMAN
θ value	2.88119e-14 (rank : 19)	NC score	0.647208 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	P20807, Q9BTU4, Q9Y5S6, Q9Y5S7	Gene names	CAPN3, CANP3, CANPL3, NCL1
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1).

CF103_HUMAN
θ value	1.58096e-12 (rank : 20)	NC score	0.408132 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N7X0, Q5T402	Gene names	C6orf103
Domain Architecture	No domain graphic available
Description	Protein C6orf103.

VPS4B_MOUSE
θ value	0.000270298 (rank : 21)	NC score	0.090309 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4A_MOUSE
θ value	0.00390308 (rank : 22)	NC score	0.087150 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

VPS4B_HUMAN
θ value	0.00390308 (rank : 23)	NC score	0.084359 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	87	Shared Neighborhood Hits	7
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4A_HUMAN
θ value	0.00665767 (rank : 24)	NC score	0.085683 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	95	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

RRBP1_MOUSE
θ value	0.0148317 (rank : 25)	NC score	0.030950 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	1650	Shared Neighborhood Hits	25
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

ULK3_MOUSE
θ value	0.0431538 (rank : 26)	NC score	0.009195 (rank : 77)
Query Neighborhood Hits	66	Target Neighborhood Hits	872	Shared Neighborhood Hits	10
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ANR26_HUMAN
θ value	0.21417 (rank : 27)	NC score	0.018502 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	1614	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CE152_HUMAN
θ value	0.279714 (rank : 28)	NC score	0.030226 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	976	Shared Neighborhood Hits	22
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

MYO9B_MOUSE
θ value	0.279714 (rank : 29)	NC score	0.017430 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	311	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

UBP37_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.025413 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

ARHGG_MOUSE
θ value	0.47712 (rank : 31)	NC score	0.030415 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

OFD1_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.040331 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	753	Shared Neighborhood Hits	23
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

GATA4_HUMAN
θ value	0.62314 (rank : 33)	NC score	0.058136 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	P43694	Gene names	GATA4
Domain Architecture
Description	Transcription factor GATA-4 (GATA-binding factor 4).

GATA4_MOUSE
θ value	0.62314 (rank : 34)	NC score	0.058036 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	Q08369, P97491, Q9QZK4	Gene names	Gata4, Gata-4
Domain Architecture
Description	Transcription factor GATA-4 (GATA-binding factor 4).

SWP70_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.024015 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	973	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GATA5_MOUSE
θ value	0.813845 (rank : 36)	NC score	0.057001 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	P97489	Gene names	Gata5
Domain Architecture
Description	Transcription factor GATA-5 (GATA-binding factor 5).

GOGA4_MOUSE
θ value	0.813845 (rank : 37)	NC score	0.019209 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	1939	Shared Neighborhood Hits	26
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

K0146_MOUSE
θ value	0.813845 (rank : 38)	NC score	0.040731 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGX7, Q3TCD0, Q5U457, Q6A0B6, Q6IS60, Q811E1, Q8BWD6, Q8R305	Gene names	Kiaa0146
Domain Architecture	No domain graphic available
Description	Protein KIAA0146.

ROCK2_MOUSE
θ value	0.813845 (rank : 39)	NC score	0.012104 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	2072	Shared Neighborhood Hits	28
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

GATA6_HUMAN
θ value	1.06291 (rank : 40)	NC score	0.054913 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q92908, P78327	Gene names	GATA6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

GATA6_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.055007 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q61169, P97729, Q9QZK3	Gene names	Gata6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

BPA1_MOUSE
θ value	1.38821 (rank : 42)	NC score	0.024683 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	1477	Shared Neighborhood Hits	25
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SPTN5_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.018231 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	674	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

BPAEA_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.024433 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	1369	Shared Neighborhood Hits	26
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

OM34_MOUSE
θ value	1.81305 (rank : 45)	NC score	0.021208 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYG7, Q3THD0, Q9D059	Gene names	Tomm34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit).

OM34_HUMAN
θ value	2.36792 (rank : 46)	NC score	0.020356 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q15785, Q9NTZ3	Gene names	TOMM34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) (hTom34).

RT09_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.033309 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P82933	Gene names	MRPS9, RPMS9
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S9, mitochondrial precursor (S9mt) (MRP-S9).

CE110_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.022332 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

GATA5_HUMAN
θ value	3.0926 (rank : 49)	NC score	0.051321 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWX5	Gene names	GATA5
Domain Architecture
Description	Transcription factor GATA-5 (GATA-binding factor 5).

PCNT_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.021077 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	1551	Shared Neighborhood Hits	24
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

ROCK2_HUMAN
θ value	3.0926 (rank : 51)	NC score	0.009778 (rank : 75)
Query Neighborhood Hits	66	Target Neighborhood Hits	2073	Shared Neighborhood Hits	28
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

TPSNR_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.019232 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	336	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

ARHGG_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.017588 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MYH6_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.015966 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	1426	Shared Neighborhood Hits	25
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

SKIL_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.018530 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	719	Shared Neighborhood Hits	22
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

CENPF_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.017564 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	1932	Shared Neighborhood Hits	25
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CTGE5_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.017184 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	928	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

MYH6_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.015947 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	1501	Shared Neighborhood Hits	26
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.015782 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	1559	Shared Neighborhood Hits	26
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

PPP5_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.009424 (rank : 76)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	6
SwissProt Accessions	P53041, Q16722	Gene names	PPP5C, PPP5
Domain Architecture
Description	Serine/threonine-protein phosphatase 5 (EC 3.1.3.16) (PP5) (Protein phosphatase T) (PP-T) (PPT).

CP250_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.016388 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	1805	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

STX2_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.008665 (rank : 78)
Query Neighborhood Hits	66	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	P32856, Q86VW8	Gene names	STX2, EPIM
Domain Architecture
Description	Syntaxin-2 (Epimorphin).

AR13B_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.005551 (rank : 79)
Query Neighborhood Hits	66	Target Neighborhood Hits	528	Shared Neighborhood Hits	14
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

CHM4A_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.010650 (rank : 74)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BY43, Q32Q79, Q86SZ8, Q96QJ9, Q9P026	Gene names	CHMP4A, C14orf123, SHAX2
Domain Architecture
Description	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (Vacuolar protein sorting 7-1) (SNF7-1) (hSnf-1) (SNF7 homolog associated with Alix-2).

MYH11_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.015000 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	1777	Shared Neighborhood Hits	25
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PLEC1_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.019064 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	1326	Shared Neighborhood Hits	25
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

CALL5_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.055446 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	231	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZT1, Q8IXU8	Gene names	CALML5, CLSP
Domain Architecture
Description	Calmodulin-like protein 5 (Calmodulin-like skin protein).

CPNS1_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.334927 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	P04632, Q8WTX3, Q96EW0	Gene names	CAPNS1, CAPN4, CAPNS
Domain Architecture
Description	Calpain small subunit 1 (CSS1) (Calcium-dependent protease small subunit 1) (Calcium-dependent protease small subunit) (CDPS) (Calpain regulatory subunit) (Calcium-activated neutral proteinase small subunit) (CANP small subunit).

CPNS1_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.337402 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	11
SwissProt Accessions	O88456, Q3V0X5, Q5BKQ2, Q8CEI2, Q8VEK4, Q9R1C5	Gene names	Capns1, Capn4
Domain Architecture
Description	Calpain small subunit 1 (CSS1) (Calcium-dependent protease small subunit 1) (Calcium-dependent protease small subunit) (CDPS) (Calpain regulatory subunit) (Calcium-activated neutral proteinase small subunit) (CANP small subunit).

CPNS2_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.332514 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q96L46, Q9BPV4	Gene names	CAPNS2
Domain Architecture
Description	Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2).

CPNS2_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.329729 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D7J7	Gene names	Capns2
Domain Architecture	No domain graphic available
Description	Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2).

GRAN_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.253983 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	P28676	Gene names	GCA, GCL
Domain Architecture
Description	Grancalcin.

GRAN_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.259676 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VC88, Q8BL53, Q8K3Z6	Gene names	Gca
Domain Architecture	No domain graphic available
Description	Grancalcin.

PDCD6_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.195163 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	13
SwissProt Accessions	O75340	Gene names	PDCD6, ALG2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2).

PDCD6_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.194257 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	P12815, Q545I0, Q61145	Gene names	Pdcd6, Alg2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2) (PMP41) (ALG-257).

PEF1_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.232863 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBV8	Gene names	PEF1, ABP32
Domain Architecture	No domain graphic available
Description	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta- EF hand domain-containing protein 1).

PEF1_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.239550 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BFY6, Q8VCT5, Q9CYW8, Q9D934	Gene names	Pef1
Domain Architecture	No domain graphic available
Description	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta- EF hand domain-containing protein 1).

SORCN_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.255350 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	11
SwissProt Accessions	P30626	Gene names	SRI
Domain Architecture
Description	Sorcin (22 kDa protein) (CP-22) (V19).

SORCN_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.257521 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P069, Q3UKC5, Q9CR38, Q9D7V8	Gene names	Sri
Domain Architecture	No domain graphic available
Description	Sorcin.

Hits sorted by NC score

CAN7_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R1S8, Q9Z0P9	Gene names	Capn7, Palbh
Domain Architecture
Description	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH).

CAN7_HUMAN
NC score	0.994397 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6W3	Gene names	CAPN7, PALBH
Domain Architecture
Description	Calpain-7 (EC 3.4.22.-) (PalB homolog) (PalBH).

CAN5_MOUSE
NC score	0.765149 (rank : 3)	θ value	2.05525e-28 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	25	Shared Neighborhood Hits	19
SwissProt Accessions	O08688, Q91YU0	Gene names	Capn5
Domain Architecture
Description	Calpain-5 (EC 3.4.22.-) (nCL-3).

CAN5_HUMAN
NC score	0.761462 (rank : 4)	θ value	2.51237e-26 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	O15484, O00263	Gene names	CAPN5
Domain Architecture
Description	Calpain-5 (EC 3.4.22.-) (nCL-3) (htra-3).

CAN6_MOUSE
NC score	0.751242 (rank : 5)	θ value	2.43343e-21 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	20
SwissProt Accessions	O35646	Gene names	Capn6, Capa6
Domain Architecture
Description	Calpain-6.

CAN6_HUMAN
NC score	0.751236 (rank : 6)	θ value	1.86321e-21 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y6Q1, Q9UEQ1, Q9UJA8	Gene names	CAPN6, CALPM, CANPX
Domain Architecture
Description	Calpain-6 (Calpamodulin) (CalpM) (Calpain-like protease X-linked).

CAN10_HUMAN
NC score	0.741118 (rank : 7)	θ value	2.27762e-19 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HC96, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90, Q9HC91, Q9HC92, Q9HC93, Q9HC94, Q9HC95	Gene names	CAPN10, KIAA1845
Domain Architecture
Description	Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10).

CAN10_MOUSE
NC score	0.735274 (rank : 8)	θ value	2.7842e-17 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	25	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ESK3, Q99J13, Q9WVF0	Gene names	Capn10, Capn8
Domain Architecture
Description	Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10).

CAN12_HUMAN
NC score	0.698394 (rank : 9)	θ value	2.5182e-18 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZSI9	Gene names	CAPN12
Domain Architecture	No domain graphic available
Description	Calpain-12 (EC 3.4.22.-).

CAN12_MOUSE
NC score	0.687483 (rank : 10)	θ value	3.40345e-15 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ER56, Q9ER53, Q9ER54, Q9ER55	Gene names	Capn12
Domain Architecture
Description	Calpain-12 (EC 3.4.22.-).

CAN11_HUMAN
NC score	0.679574 (rank : 11)	θ value	1.33526e-19 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UMQ6, Q8N4R5	Gene names	CAPN11
Domain Architecture
Description	Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11).

CAN2_HUMAN
NC score	0.675869 (rank : 12)	θ value	7.82807e-20 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	P17655, Q16738, Q6PJT3, Q8WU26, Q9HBB1	Gene names	CAPN2, CANPL2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (Calpain large polypeptide L2).

CAN2_MOUSE
NC score	0.674154 (rank : 13)	θ value	5.99374e-20 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	O08529, O35518, O54843	Gene names	Capn2
Domain Architecture
Description	Calpain-2 catalytic subunit precursor (EC 3.4.22.53) (Calpain-2 large subunit) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M- type) (M-calpain) (Millimolar-calpain) (80 kDa M-calpain subunit) (CALP80).

CAN9_HUMAN
NC score	0.673699 (rank : 14)	θ value	8.65492e-19 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	68	Shared Neighborhood Hits	19
SwissProt Accessions	O14815, Q9NS74	Gene names	CAPN9, NCL4
Domain Architecture
Description	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (nCL-4) (CG36 protein).

CAN9_MOUSE
NC score	0.671614 (rank : 15)	θ value	4.29542e-18 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	19
SwissProt Accessions	Q9D805, O35919	Gene names	Capn9, Ncl4
Domain Architecture
Description	Calpain-9 (EC 3.4.22.-) (Digestive tract-specific calpain) (nCL-4).

CAN1_HUMAN
NC score	0.669532 (rank : 16)	θ value	2.69047e-20 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	P07384	Gene names	CAPN1, CANPL1
Domain Architecture
Description	Calpain-1 catalytic subunit (EC 3.4.22.52) (Calpain-1 large subunit) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (muCANP) (Micromolar-calpain).

CAN1_MOUSE
NC score	0.665310 (rank : 17)	θ value	1.92812e-18 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	O35350, O88666	Gene names	Capn1, Canp1, Capa1
Domain Architecture
Description	Calpain-1 catalytic subunit (EC 3.4.22.52) (Calpain-1 large subunit) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (muCANP) (Micromolar-calpain).

CAN3_HUMAN
NC score	0.647208 (rank : 18)	θ value	2.88119e-14 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	P20807, Q9BTU4, Q9Y5S6, Q9Y5S7	Gene names	CAPN3, CANP3, CANPL3, NCL1
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1).

CAN3_MOUSE
NC score	0.646703 (rank : 19)	θ value	9.90251e-15 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	115	Shared Neighborhood Hits	20
SwissProt Accessions	Q64691, Q9WUC5	Gene names	Capn3
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3).

CF103_HUMAN
NC score	0.408132 (rank : 20)	θ value	1.58096e-12 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N7X0, Q5T402	Gene names	C6orf103
Domain Architecture	No domain graphic available
Description	Protein C6orf103.

CPNS1_MOUSE
NC score	0.337402 (rank : 21)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	11
SwissProt Accessions	O88456, Q3V0X5, Q5BKQ2, Q8CEI2, Q8VEK4, Q9R1C5	Gene names	Capns1, Capn4
Domain Architecture
Description	Calpain small subunit 1 (CSS1) (Calcium-dependent protease small subunit 1) (Calcium-dependent protease small subunit) (CDPS) (Calpain regulatory subunit) (Calcium-activated neutral proteinase small subunit) (CANP small subunit).

CPNS1_HUMAN
NC score	0.334927 (rank : 22)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	P04632, Q8WTX3, Q96EW0	Gene names	CAPNS1, CAPN4, CAPNS
Domain Architecture
Description	Calpain small subunit 1 (CSS1) (Calcium-dependent protease small subunit 1) (Calcium-dependent protease small subunit) (CDPS) (Calpain regulatory subunit) (Calcium-activated neutral proteinase small subunit) (CANP small subunit).

CPNS2_HUMAN
NC score	0.332514 (rank : 23)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q96L46, Q9BPV4	Gene names	CAPNS2
Domain Architecture
Description	Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2).

CPNS2_MOUSE
NC score	0.329729 (rank : 24)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D7J7	Gene names	Capns2
Domain Architecture	No domain graphic available
Description	Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2).

GRAN_MOUSE
NC score	0.259676 (rank : 25)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VC88, Q8BL53, Q8K3Z6	Gene names	Gca
Domain Architecture	No domain graphic available
Description	Grancalcin.

SORCN_MOUSE
NC score	0.257521 (rank : 26)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	66	Target Neighborhood Hits	72	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P069, Q3UKC5, Q9CR38, Q9D7V8	Gene names	Sri
Domain Architecture	No domain graphic available
Description	Sorcin.

SORCN_HUMAN
NC score	0.255350 (rank : 27)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	11
SwissProt Accessions	P30626	Gene names	SRI
Domain Architecture
Description	Sorcin (22 kDa protein) (CP-22) (V19).

GRAN_HUMAN
NC score	0.253983 (rank : 28)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	11
SwissProt Accessions	P28676	Gene names	GCA, GCL
Domain Architecture
Description	Grancalcin.

PEF1_MOUSE
NC score	0.239550 (rank : 29)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	66	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BFY6, Q8VCT5, Q9CYW8, Q9D934	Gene names	Pef1
Domain Architecture	No domain graphic available
Description	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta- EF hand domain-containing protein 1).

PEF1_HUMAN
NC score	0.232863 (rank : 30)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UBV8	Gene names	PEF1, ABP32
Domain Architecture	No domain graphic available
Description	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta- EF hand domain-containing protein 1).

PDCD6_HUMAN
NC score	0.195163 (rank : 31)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	13
SwissProt Accessions	O75340	Gene names	PDCD6, ALG2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2).

PDCD6_MOUSE
NC score	0.194257 (rank : 32)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	66	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	P12815, Q545I0, Q61145	Gene names	Pdcd6, Alg2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2) (PMP41) (ALG-257).

VPS4B_MOUSE
NC score	0.090309 (rank : 33)	θ value	0.000270298 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	86	Shared Neighborhood Hits	8
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4A_MOUSE
NC score	0.087150 (rank : 34)	θ value	0.00390308 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

VPS4A_HUMAN
NC score	0.085683 (rank : 35)	θ value	0.00665767 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	95	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4B_HUMAN
NC score	0.084359 (rank : 36)	θ value	0.00390308 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	87	Shared Neighborhood Hits	7
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

GATA4_HUMAN
NC score	0.058136 (rank : 37)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	8
SwissProt Accessions	P43694	Gene names	GATA4
Domain Architecture
Description	Transcription factor GATA-4 (GATA-binding factor 4).

GATA4_MOUSE
NC score	0.058036 (rank : 38)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	Q08369, P97491, Q9QZK4	Gene names	Gata4, Gata-4
Domain Architecture
Description	Transcription factor GATA-4 (GATA-binding factor 4).

GATA5_MOUSE
NC score	0.057001 (rank : 39)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	P97489	Gene names	Gata5
Domain Architecture
Description	Transcription factor GATA-5 (GATA-binding factor 5).

CALL5_HUMAN
NC score	0.055446 (rank : 40)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	231	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZT1, Q8IXU8	Gene names	CALML5, CLSP
Domain Architecture
Description	Calmodulin-like protein 5 (Calmodulin-like skin protein).

GATA6_MOUSE
NC score	0.055007 (rank : 41)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q61169, P97729, Q9QZK3	Gene names	Gata6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

GATA6_HUMAN
NC score	0.054913 (rank : 42)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q92908, P78327	Gene names	GATA6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

GATA5_HUMAN
NC score	0.051321 (rank : 43)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BWX5	Gene names	GATA5
Domain Architecture
Description	Transcription factor GATA-5 (GATA-binding factor 5).

K0146_MOUSE
NC score	0.040731 (rank : 44)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGX7, Q3TCD0, Q5U457, Q6A0B6, Q6IS60, Q811E1, Q8BWD6, Q8R305	Gene names	Kiaa0146
Domain Architecture	No domain graphic available
Description	Protein KIAA0146.

OFD1_HUMAN
NC score	0.040331 (rank : 45)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	753	Shared Neighborhood Hits	23
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

RT09_HUMAN
NC score	0.033309 (rank : 46)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P82933	Gene names	MRPS9, RPMS9
Domain Architecture	No domain graphic available
Description	28S ribosomal protein S9, mitochondrial precursor (S9mt) (MRP-S9).

RRBP1_MOUSE
NC score	0.030950 (rank : 47)	θ value	0.0148317 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	1650	Shared Neighborhood Hits	25
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

ARHGG_MOUSE
NC score	0.030415 (rank : 48)	θ value	0.47712 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

CE152_HUMAN
NC score	0.030226 (rank : 49)	θ value	0.279714 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	976	Shared Neighborhood Hits	22
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

UBP37_HUMAN
NC score	0.025413 (rank : 50)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

BPA1_MOUSE
NC score	0.024683 (rank : 51)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	1477	Shared Neighborhood Hits	25
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BPAEA_HUMAN
NC score	0.024433 (rank : 52)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	1369	Shared Neighborhood Hits	26
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

SWP70_HUMAN
NC score	0.024015 (rank : 53)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	973	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CE110_HUMAN
NC score	0.022332 (rank : 54)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

OM34_MOUSE
NC score	0.021208 (rank : 55)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYG7, Q3THD0, Q9D059	Gene names	Tomm34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit).

PCNT_HUMAN
NC score	0.021077 (rank : 56)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	1551	Shared Neighborhood Hits	24
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

OM34_HUMAN
NC score	0.020356 (rank : 57)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q15785, Q9NTZ3	Gene names	TOMM34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) (hTom34).

TPSNR_MOUSE
NC score	0.019232 (rank : 58)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	336	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

GOGA4_MOUSE
NC score	0.019209 (rank : 59)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	1939	Shared Neighborhood Hits	26
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

PLEC1_HUMAN
NC score	0.019064 (rank : 60)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	1326	Shared Neighborhood Hits	25
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

SKIL_MOUSE
NC score	0.018530 (rank : 61)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	719	Shared Neighborhood Hits	22
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

ANR26_HUMAN
NC score	0.018502 (rank : 62)	θ value	0.21417 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	1614	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

SPTN5_HUMAN
NC score	0.018231 (rank : 63)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	674	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

ARHGG_HUMAN
NC score	0.017588 (rank : 64)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

CENPF_HUMAN
NC score	0.017564 (rank : 65)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	1932	Shared Neighborhood Hits	25
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MYO9B_MOUSE
NC score	0.017430 (rank : 66)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	311	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CTGE5_MOUSE
NC score	0.017184 (rank : 67)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	928	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

CP250_HUMAN
NC score	0.016388 (rank : 68)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	1805	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

MYH6_HUMAN
NC score	0.015966 (rank : 69)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	1426	Shared Neighborhood Hits	25
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_MOUSE
NC score	0.015947 (rank : 70)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	1501	Shared Neighborhood Hits	26
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
NC score	0.015782 (rank : 71)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	1559	Shared Neighborhood Hits	26
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH11_MOUSE
NC score	0.015000 (rank : 72)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	1777	Shared Neighborhood Hits	25
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

ROCK2_MOUSE
NC score	0.012104 (rank : 73)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	2072	Shared Neighborhood Hits	28
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

CHM4A_HUMAN
NC score	0.010650 (rank : 74)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BY43, Q32Q79, Q86SZ8, Q96QJ9, Q9P026	Gene names	CHMP4A, C14orf123, SHAX2
Domain Architecture
Description	Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (Vacuolar protein sorting 7-1) (SNF7-1) (hSnf-1) (SNF7 homolog associated with Alix-2).

ROCK2_HUMAN
NC score	0.009778 (rank : 75)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	2073	Shared Neighborhood Hits	28
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

PPP5_HUMAN
NC score	0.009424 (rank : 76)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	6
SwissProt Accessions	P53041, Q16722	Gene names	PPP5C, PPP5
Domain Architecture
Description	Serine/threonine-protein phosphatase 5 (EC 3.1.3.16) (PP5) (Protein phosphatase T) (PP-T) (PPT).

ULK3_MOUSE
NC score	0.009195 (rank : 77)	θ value	0.0431538 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	872	Shared Neighborhood Hits	10
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STX2_HUMAN
NC score	0.008665 (rank : 78)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	P32856, Q86VW8	Gene names	STX2, EPIM
Domain Architecture
Description	Syntaxin-2 (Epimorphin).

AR13B_HUMAN
NC score	0.005551 (rank : 79)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	528	Shared Neighborhood Hits	14
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).