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Network neighborhood for query Sequence : PCAF_HUMAN

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PCAF_HUMAN
SwissProt Accessions	Q92831, Q6NSK1	Gene names	PCAF
Domain Architecture
Description	Histone acetyltransferase PCAF (EC 2.3.1.48) (P300/CBP-associated factor) (P/CAF) (Histone acetylase PCAF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GCNL2_HUMAN
θ value	0 (rank : 1)	NC score	0.971080 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	159	Shared Neighborhood Hits	49
SwissProt Accessions	Q92830, Q9UCW1	Gene names	GCN5L2, GCN5, HGCN5
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (hsGCN5) (STAF97).

GCNL2_MOUSE
θ value	0 (rank : 2)	NC score	0.971223 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	146	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

PCAF_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	Q92831, Q6NSK1	Gene names	PCAF
Domain Architecture
Description	Histone acetyltransferase PCAF (EC 2.3.1.48) (P300/CBP-associated factor) (P/CAF) (Histone acetylase PCAF).

BPTF_HUMAN
θ value	2.12685e-25 (rank : 4)	NC score	0.566315 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	786	Shared Neighborhood Hits	51
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CECR2_HUMAN
θ value	3.88503e-19 (rank : 5)	NC score	0.647313 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	543	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

BRD4_HUMAN
θ value	1.24977e-17 (rank : 6)	NC score	0.600018 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BRD4_MOUSE
θ value	1.24977e-17 (rank : 7)	NC score	0.594221 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	845	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

BAZ2A_HUMAN
θ value	1.058e-16 (rank : 8)	NC score	0.547118 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	780	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BAZ2A_MOUSE
θ value	1.80466e-16 (rank : 9)	NC score	0.538836 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	744	Shared Neighborhood Hits	49
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BRD2_HUMAN
θ value	3.07829e-16 (rank : 10)	NC score	0.670021 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	242	Shared Neighborhood Hits	46
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

BRD3_HUMAN
θ value	8.95645e-16 (rank : 11)	NC score	0.647559 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	369	Shared Neighborhood Hits	48
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

BRD3_MOUSE
θ value	8.95645e-16 (rank : 12)	NC score	0.643469 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	402	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

BRDT_HUMAN
θ value	9.90251e-15 (rank : 13)	NC score	0.645974 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	280	Shared Neighborhood Hits	46
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

BAZ2B_HUMAN
θ value	8.38298e-14 (rank : 14)	NC score	0.512506 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	803	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BRDT_MOUSE
θ value	3.18553e-13 (rank : 15)	NC score	0.646685 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	243	Shared Neighborhood Hits	46
SwissProt Accessions	Q91Y44, Q59HJ4	Gene names	Brdt, Fsrg3
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein) (Bromodomain- containing female sterile homeotic-like protein).

BAZ1A_HUMAN
θ value	2.28291e-11 (rank : 16)	NC score	0.525399 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	693	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

BAZ1B_HUMAN
θ value	5.08577e-11 (rank : 17)	NC score	0.473569 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	701	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

TAF1_HUMAN
θ value	6.64225e-11 (rank : 18)	NC score	0.597178 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	P21675, Q6IUZ1	Gene names	TAF1, BA2R, CCG1, TAF2A
Domain Architecture
Description	Transcription initiation factor TFIID subunit 1 (EC 2.7.11.1) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) (TBP-associated factor 250 kDa) (p250) (Cell cycle gene 1 protein).

BAZ1B_MOUSE
θ value	1.9326e-10 (rank : 19)	NC score	0.510139 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	394	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z277, Q9CU68	Gene names	Baz1b, Wbscr9
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein homolog) (WBRS9).

TAF1L_HUMAN
θ value	1.9326e-10 (rank : 20)	NC score	0.585209 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	144	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IZX4	Gene names	TAF1L
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID 210 kDa subunit (TBP-associated factor 210 kDa) (TAF(II)210) (TBP-associated factor 1-like).

TIF1A_MOUSE
θ value	1.9326e-10 (rank : 21)	NC score	0.463332 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	Q64127, Q64126	Gene names	Trim24, Tif1, Tif1a
Domain Architecture
Description	Transcription intermediary factor 1-alpha (TIF1-alpha) (Tripartite motif-containing protein 24).

TIF1A_HUMAN
θ value	3.29651e-10 (rank : 22)	NC score	0.454834 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	327	Shared Neighborhood Hits	48
SwissProt Accessions	O15164, O95854	Gene names	TRIM24, RNF82, TIF1, TIF1A
Domain Architecture
Description	Transcription intermediary factor 1-alpha (TIF1-alpha) (Tripartite motif-containing protein 24) (RING finger protein 82).

PB1_HUMAN
θ value	6.21693e-09 (rank : 23)	NC score	0.548713 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	261	Shared Neighborhood Hits	49
SwissProt Accessions	Q86U86, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314	Gene names	PB1
Domain Architecture	No domain graphic available
Description	Protein polybromo-1 (hPB1) (Polybromo-1D) (BRG1-associated factor 180) (BAF180).

BRD7_HUMAN
θ value	1.06045e-08 (rank : 24)	NC score	0.550258 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

BRD7_MOUSE
θ value	1.06045e-08 (rank : 25)	NC score	0.542487 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	O88665, Q3UQ56, Q3UU06, Q9CT78	Gene names	Brd7, Bp75
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein).

BRD1_HUMAN
θ value	1.80886e-08 (rank : 26)	NC score	0.408337 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	188	Shared Neighborhood Hits	47
SwissProt Accessions	O95696	Gene names	BRD1, BRL, BRPF2
Domain Architecture
Description	Bromodomain-containing protein 1 (BR140-like protein).

BRD8_HUMAN
θ value	4.0297e-08 (rank : 27)	NC score	0.533472 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	292	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

BRPF3_HUMAN
θ value	8.97725e-08 (rank : 28)	NC score	0.418659 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

BRD9_MOUSE
θ value	1.17247e-07 (rank : 29)	NC score	0.553151 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	84	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UQU0, Q5FWH1, Q811F7	Gene names	Brd9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9.

TRI66_HUMAN
θ value	2.61198e-07 (rank : 30)	NC score	0.429703 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	479	Shared Neighborhood Hits	48
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TRI66_MOUSE
θ value	2.61198e-07 (rank : 31)	NC score	0.426344 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	491	Shared Neighborhood Hits	48
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

BRD9_HUMAN
θ value	5.81887e-07 (rank : 32)	NC score	0.550331 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H8M2, Q2XUS1, Q6UWU9, Q8IUS4, Q9H5Q5, Q9H7R9	Gene names	BRD9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS- 40.8).

BRPF1_HUMAN
θ value	5.81887e-07 (rank : 33)	NC score	0.375313 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	259	Shared Neighborhood Hits	48
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

BRD8_MOUSE
θ value	9.92553e-07 (rank : 34)	NC score	0.479937 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	422	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

BRWD1_MOUSE
θ value	1.29631e-06 (rank : 35)	NC score	0.287957 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	478	Shared Neighborhood Hits	46
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

EP300_HUMAN
θ value	1.69304e-06 (rank : 36)	NC score	0.424144 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

BRWD1_HUMAN
θ value	2.21117e-06 (rank : 37)	NC score	0.287369 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	448	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

TIF1G_HUMAN
θ value	1.43324e-05 (rank : 38)	NC score	0.374795 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	410	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

TIF1G_MOUSE
θ value	1.43324e-05 (rank : 39)	NC score	0.369242 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	498	Shared Neighborhood Hits	48
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

CBP_MOUSE
θ value	1.87187e-05 (rank : 40)	NC score	0.398499 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	1051	Shared Neighborhood Hits	50
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SMCA4_HUMAN
θ value	1.87187e-05 (rank : 41)	NC score	0.194604 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	597	Shared Neighborhood Hits	49
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

PKCB1_HUMAN
θ value	2.44474e-05 (rank : 42)	NC score	0.398886 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	488	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

CBP_HUMAN
θ value	4.1701e-05 (rank : 43)	NC score	0.412006 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	941	Shared Neighborhood Hits	50
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SMCA2_HUMAN
θ value	4.1701e-05 (rank : 44)	NC score	0.195324 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	503	Shared Neighborhood Hits	49
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

ATAD2_HUMAN
θ value	0.00020696 (rank : 45)	NC score	0.250945 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	322	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

ATAD2_MOUSE
θ value	0.00020696 (rank : 46)	NC score	0.253812 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	167	Shared Neighborhood Hits	46
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

SNTG1_MOUSE
θ value	0.21417 (rank : 47)	NC score	0.026998 (rank : 124)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

ZN213_HUMAN
θ value	0.813845 (rank : 48)	NC score	-0.001815 (rank : 142)
Query Neighborhood Hits	68	Target Neighborhood Hits	755	Shared Neighborhood Hits	2
SwissProt Accessions	O14771, Q96IS1	Gene names	ZNF213
Domain Architecture
Description	Zinc finger protein 213 (Putative transcription factor CR53).

CDKL4_HUMAN
θ value	1.06291 (rank : 49)	NC score	-0.000366 (rank : 140)
Query Neighborhood Hits	68	Target Neighborhood Hits	828	Shared Neighborhood Hits	3
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

SNTG1_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.023495 (rank : 127)
Query Neighborhood Hits	68	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

CDKL4_MOUSE
θ value	1.81305 (rank : 51)	NC score	-0.000884 (rank : 141)
Query Neighborhood Hits	68	Target Neighborhood Hits	833	Shared Neighborhood Hits	3
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

SPN90_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.014415 (rank : 131)
Query Neighborhood Hits	68	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

NDK7_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.024731 (rank : 125)
Query Neighborhood Hits	68	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXL8	Gene names	Nme7
Domain Architecture
Description	Nucleoside diphosphate kinase 7 (EC 2.7.4.6) (NDK 7) (NDP kinase 7) (nm23-M7).

PLCB1_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.009795 (rank : 137)
Query Neighborhood Hits	68	Target Neighborhood Hits	614	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

FGD3_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.003893 (rank : 139)
Query Neighborhood Hits	68	Target Neighborhood Hits	249	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

NCOA6_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.060671 (rank : 105)
Query Neighborhood Hits	68	Target Neighborhood Hits	1076	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

DAXX_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.013719 (rank : 132)
Query Neighborhood Hits	68	Target Neighborhood Hits	207	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

LSD1_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.012623 (rank : 133)
Query Neighborhood Hits	68	Target Neighborhood Hits	455	Shared Neighborhood Hits	9
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

NAF1_MOUSE
θ value	6.88961 (rank : 59)	NC score	0.019159 (rank : 129)
Query Neighborhood Hits	68	Target Neighborhood Hits	852	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

RP3A_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.017711 (rank : 130)
Query Neighborhood Hits	68	Target Neighborhood Hits	510	Shared Neighborhood Hits	15
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

VGF_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.021400 (rank : 128)
Query Neighborhood Hits	68	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

ADCY4_MOUSE
θ value	8.99809 (rank : 62)	NC score	0.010189 (rank : 136)
Query Neighborhood Hits	68	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

ATX2L_MOUSE
θ value	8.99809 (rank : 63)	NC score	0.035814 (rank : 122)
Query Neighborhood Hits	68	Target Neighborhood Hits	401	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

CATE_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.004342 (rank : 138)
Query Neighborhood Hits	68	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P70269, O35647	Gene names	Ctse
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

K1045_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.011877 (rank : 134)
Query Neighborhood Hits	68	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPV7, Q58FE9, Q5T662	Gene names	KIAA1045
Domain Architecture	No domain graphic available
Description	Protein KIAA1045.

OSBL8_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.010888 (rank : 135)
Query Neighborhood Hits	68	Target Neighborhood Hits	289	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PYGO2_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.029623 (rank : 123)
Query Neighborhood Hits	68	Target Neighborhood Hits	189	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

RAI1_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.024667 (rank : 126)
Query Neighborhood Hits	68	Target Neighborhood Hits	344	Shared Neighborhood Hits	8
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

AF10_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.059274 (rank : 106)
Query Neighborhood Hits	68	Target Neighborhood Hits	198	Shared Neighborhood Hits	9
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

AF10_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.060798 (rank : 104)
Query Neighborhood Hits	68	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	O54826	Gene names	Mllt10, Af10
Domain Architecture
Description	Protein AF-10.

AF17_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.068175 (rank : 97)
Query Neighborhood Hits	68	Target Neighborhood Hits	230	Shared Neighborhood Hits	13
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

AIRE_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.156472 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	O43918, O43922, O43932, O75745	Gene names	AIRE, APECED
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein).

AIRE_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.153118 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	196	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

CHD3_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.085791 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	397	Shared Neighborhood Hits	19
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CHD4_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.085489 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	365	Shared Neighborhood Hits	21
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.085581 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	408	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CHD5_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.086266 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	349	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

CK024_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.076314 (rank : 90)
Query Neighborhood Hits	68	Target Neighborhood Hits	408	Shared Neighborhood Hits	13
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CP003_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.053094 (rank : 116)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	O95177, O95176	Gene names	C16orf3
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf3.

CXCC1_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.052472 (rank : 117)
Query Neighborhood Hits	68	Target Neighborhood Hits	143	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P0U4, Q8N2W4, Q96BC8, Q9P2V7	Gene names	CXXC1, CGBP, PCCX1, PHF18
Domain Architecture
Description	CpG-binding protein (PHD finger and CXXC domain-containing protein 1) (CXXC-type zinc finger protein 1).

DIDO1_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.055290 (rank : 115)
Query Neighborhood Hits	68	Target Neighborhood Hits	960	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DPF1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.081445 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	136	Shared Neighborhood Hits	17
SwissProt Accessions	Q92782	Gene names	DPF1, NEUD4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

DPF1_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.086550 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	491	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QX66, Q9QX65, Q9QYA4	Gene names	Dpf1, Neud4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

JAD1A_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.076458 (rank : 89)
Query Neighborhood Hits	68	Target Neighborhood Hits	328	Shared Neighborhood Hits	18
SwissProt Accessions	P29375	Gene names	JARID1A, RBBP2, RBP2
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1A (Retinoblastoma-binding protein 2) (RBBP-2).

JAD1C_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.065614 (rank : 102)
Query Neighborhood Hits	68	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	P41229	Gene names	SMCX, DXS1272E, JARID1C, XE169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (Protein SmcX) (Protein Xe169).

JAD1C_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.065744 (rank : 101)
Query Neighborhood Hits	68	Target Neighborhood Hits	164	Shared Neighborhood Hits	16
SwissProt Accessions	P41230, O54995, Q9CVI4, Q9D0C3, Q9QVR8, Q9R039	Gene names	Smcx, Jarid1c, Xe169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (SmcX protein) (Xe169 protein).

JAD1D_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.074181 (rank : 93)
Query Neighborhood Hits	68	Target Neighborhood Hits	147	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

JAD1D_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.068300 (rank : 96)
Query Neighborhood Hits	68	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q62240, Q9QVR9, Q9R040	Gene names	Smcy, Hya, Jarid1d
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

JADE1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.080608 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

JADE1_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.080608 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	160	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

JADE2_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.078550 (rank : 85)
Query Neighborhood Hits	68	Target Neighborhood Hits	199	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

JADE2_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.078542 (rank : 86)
Query Neighborhood Hits	68	Target Neighborhood Hits	560	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

JADE3_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.083885 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	148	Shared Neighborhood Hits	18
SwissProt Accessions	Q92613, Q6IE79	Gene names	PHF16, JADE3, KIAA0215
Domain Architecture
Description	Protein Jade-3 (PHD finger protein 16).

JADE3_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.086593 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q6IE82, Q6ZQG2	Gene names	Phf16, Jade3, Kiaa0215
Domain Architecture	No domain graphic available
Description	Protein Jade-3 (PHD finger protein 16).

LY10_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.180338 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	151	Shared Neighborhood Hits	33
SwissProt Accessions	Q13342, Q13341, Q92881, Q96TG3	Gene names	SP140, LYSP100
Domain Architecture
Description	Nuclear body protein SP140 (Nuclear autoantigen Sp-140) (Speckled 140 kDa) (LYSp100 protein) (Lymphoid-restricted homolog of Sp100).

MDC1_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.052030 (rank : 118)
Query Neighborhood Hits	68	Target Neighborhood Hits	1446	Shared Neighborhood Hits	24
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MLL2_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.071604 (rank : 94)
Query Neighborhood Hits	68	Target Neighborhood Hits	1788	Shared Neighborhood Hits	32
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MLL3_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.080526 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	1644	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.079404 (rank : 83)
Query Neighborhood Hits	68	Target Neighborhood Hits	1399	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MTF2_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.056110 (rank : 113)
Query Neighborhood Hits	68	Target Neighborhood Hits	119	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y483, Q9UES9, Q9UP40	Gene names	MTF2
Domain Architecture
Description	Metal-response element-binding transcription factor 2 (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

MTF2_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.055669 (rank : 114)
Query Neighborhood Hits	68	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q02395, Q569Z8, Q6PG89, Q8BGP9, Q8BSJ7	Gene names	Mtf2
Domain Architecture	No domain graphic available
Description	Metal-response element-binding transcription factor 2 (Zinc-regulated factor 1) (ZiRF1) (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

MYST3_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.078520 (rank : 87)
Query Neighborhood Hits	68	Target Neighborhood Hits	772	Shared Neighborhood Hits	25
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

MYST3_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.076146 (rank : 91)
Query Neighborhood Hits	68	Target Neighborhood Hits	688	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

MYST4_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.079952 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	671	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

MYST4_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.078923 (rank : 84)
Query Neighborhood Hits	68	Target Neighborhood Hits	416	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

NCOA6_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.057043 (rank : 111)
Query Neighborhood Hits	68	Target Neighborhood Hits	1202	Shared Neighborhood Hits	23
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NSD1_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.077138 (rank : 88)
Query Neighborhood Hits	68	Target Neighborhood Hits	427	Shared Neighborhood Hits	22
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NSD1_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.079841 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	472	Shared Neighborhood Hits	24
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

OGFR_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.061603 (rank : 103)
Query Neighborhood Hits	68	Target Neighborhood Hits	1582	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PF21A_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.133234 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	303	Shared Neighborhood Hits	20
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

PF21A_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.137665 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	285	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

PF21B_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.107900 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q96EK2, Q5TFL2, Q6ICC0	Gene names	PHF21B
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

PF21B_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.098746 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

PHF10_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.090236 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

PHF10_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.089090 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

PHF12_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.117042 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

PHF12_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.116509 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	172	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

PHF14_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.086023 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	447	Shared Neighborhood Hits	22
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

PHF14_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.085372 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	342	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

PHF1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.057056 (rank : 110)
Query Neighborhood Hits	68	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	O43189, O60929, Q96KM7	Gene names	PHF1
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1).

PHF1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.056790 (rank : 112)
Query Neighborhood Hits	68	Target Neighborhood Hits	116	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1B8, O54808	Gene names	Phf1, Tctex-3, Tctex3
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1) (T-complex testis-expressed 3) (Polycomblike 1) (mPCl1).

PHF20_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.057789 (rank : 107)
Query Neighborhood Hits	68	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

PML_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.051896 (rank : 119)
Query Neighborhood Hits	68	Target Neighborhood Hits	248	Shared Neighborhood Hits	8
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

PML_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.050148 (rank : 121)
Query Neighborhood Hits	68	Target Neighborhood Hits	246	Shared Neighborhood Hits	7
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

R3HD2_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.057467 (rank : 108)
Query Neighborhood Hits	68	Target Neighborhood Hits	397	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

REQU_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.093856 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	523	Shared Neighborhood Hits	20
SwissProt Accessions	Q92785	Gene names	DPF2, REQ, UBID4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

REQU_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.092292 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	519	Shared Neighborhood Hits	21
SwissProt Accessions	Q61103, Q3UNP5, Q60663, Q9QYA3	Gene names	Dpf2, Req, Ubid4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

RSF1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.127971 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	539	Shared Neighborhood Hits	22
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

SELPL_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.084196 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	588	Shared Neighborhood Hits	18
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SON_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.050392 (rank : 120)
Query Neighborhood Hits	68	Target Neighborhood Hits	1568	Shared Neighborhood Hits	30
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SP110_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.089970 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	141	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HB58, Q14976, Q14977, Q8WUZ6, Q9HCT8	Gene names	SP110
Domain Architecture
Description	Sp110 nuclear body protein (Speckled 110 kDa) (Transcriptional coactivator Sp110) (Interferon-induced protein 41/75).

SPR1B_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.057176 (rank : 109)
Query Neighborhood Hits	68	Target Neighborhood Hits	395	Shared Neighborhood Hits	13
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

TIF1B_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.157450 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	312	Shared Neighborhood Hits	19
SwissProt Accessions	Q13263, O00677, Q7Z632, Q93040, Q96IM1	Gene names	TRIM28, KAP1, RNF96, TIF1B
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (RING finger protein 96).

TIF1B_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.155480 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q62318, P70391, Q8C283, Q99PN4	Gene names	Trim28, Krip1, Tif1b
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (KRAB-A-interacting protein) (KRIP-1).

TRI45_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.068475 (rank : 95)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8W5, Q5T2K4, Q5T2K5, Q8IYV6	Gene names	TRIM45, RNF99
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45 (RING finger protein 99).

TRI45_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.067484 (rank : 99)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PFY8, Q8BVT5	Gene names	Trim45
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45.

UHRF1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.075355 (rank : 92)
Query Neighborhood Hits	68	Target Neighborhood Hits	272	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

UHRF1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.080426 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

UHRF2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.067112 (rank : 100)
Query Neighborhood Hits	68	Target Neighborhood Hits	269	Shared Neighborhood Hits	17
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

UHRF2_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.067628 (rank : 98)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

ZMY11_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.175851 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	201	Shared Neighborhood Hits	37
SwissProt Accessions	Q15326	Gene names	ZMYND11, BS69
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A- binding protein) (BS69 protein).

ZMY11_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.176536 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5C8, Q8C155	Gene names	Zmynd11
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11.

Hits sorted by NC score

PCAF_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	Q92831, Q6NSK1	Gene names	PCAF
Domain Architecture
Description	Histone acetyltransferase PCAF (EC 2.3.1.48) (P300/CBP-associated factor) (P/CAF) (Histone acetylase PCAF).

GCNL2_MOUSE
NC score	0.971223 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	146	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JHD2	Gene names	Gcn5l2
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (mmGCN5).

GCNL2_HUMAN
NC score	0.971080 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	159	Shared Neighborhood Hits	49
SwissProt Accessions	Q92830, Q9UCW1	Gene names	GCN5L2, GCN5, HGCN5
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (hsGCN5) (STAF97).

BRD2_HUMAN
NC score	0.670021 (rank : 4)	θ value	3.07829e-16 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	242	Shared Neighborhood Hits	46
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

BRD3_HUMAN
NC score	0.647559 (rank : 5)	θ value	8.95645e-16 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	369	Shared Neighborhood Hits	48
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

CECR2_HUMAN
NC score	0.647313 (rank : 6)	θ value	3.88503e-19 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	543	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

BRDT_MOUSE
NC score	0.646685 (rank : 7)	θ value	3.18553e-13 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	243	Shared Neighborhood Hits	46
SwissProt Accessions	Q91Y44, Q59HJ4	Gene names	Brdt, Fsrg3
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein) (Bromodomain- containing female sterile homeotic-like protein).

BRDT_HUMAN
NC score	0.645974 (rank : 8)	θ value	9.90251e-15 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	280	Shared Neighborhood Hits	46
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

BRD3_MOUSE
NC score	0.643469 (rank : 9)	θ value	8.95645e-16 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	402	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

BRD4_HUMAN
NC score	0.600018 (rank : 10)	θ value	1.24977e-17 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	851	Shared Neighborhood Hits	49
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

TAF1_HUMAN
NC score	0.597178 (rank : 11)	θ value	6.64225e-11 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	P21675, Q6IUZ1	Gene names	TAF1, BA2R, CCG1, TAF2A
Domain Architecture
Description	Transcription initiation factor TFIID subunit 1 (EC 2.7.11.1) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250) (TBP-associated factor 250 kDa) (p250) (Cell cycle gene 1 protein).

BRD4_MOUSE
NC score	0.594221 (rank : 12)	θ value	1.24977e-17 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	845	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

TAF1L_HUMAN
NC score	0.585209 (rank : 13)	θ value	1.9326e-10 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	144	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IZX4	Gene names	TAF1L
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID 210 kDa subunit (TBP-associated factor 210 kDa) (TAF(II)210) (TBP-associated factor 1-like).

BPTF_HUMAN
NC score	0.566315 (rank : 14)	θ value	2.12685e-25 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	786	Shared Neighborhood Hits	51
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

BRD9_MOUSE
NC score	0.553151 (rank : 15)	θ value	1.17247e-07 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	84	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UQU0, Q5FWH1, Q811F7	Gene names	Brd9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9.

BRD9_HUMAN
NC score	0.550331 (rank : 16)	θ value	5.81887e-07 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H8M2, Q2XUS1, Q6UWU9, Q8IUS4, Q9H5Q5, Q9H7R9	Gene names	BRD9
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 9 (Rhabdomyosarcoma antigen MU-RMS- 40.8).

BRD7_HUMAN
NC score	0.550258 (rank : 17)	θ value	1.06045e-08 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

PB1_HUMAN
NC score	0.548713 (rank : 18)	θ value	6.21693e-09 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	261	Shared Neighborhood Hits	49
SwissProt Accessions	Q86U86, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314	Gene names	PB1
Domain Architecture	No domain graphic available
Description	Protein polybromo-1 (hPB1) (Polybromo-1D) (BRG1-associated factor 180) (BAF180).

BAZ2A_HUMAN
NC score	0.547118 (rank : 19)	θ value	1.058e-16 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	780	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BRD7_MOUSE
NC score	0.542487 (rank : 20)	θ value	1.06045e-08 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	O88665, Q3UQ56, Q3UU06, Q9CT78	Gene names	Brd7, Bp75
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein).

BAZ2A_MOUSE
NC score	0.538836 (rank : 21)	θ value	1.80466e-16 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	744	Shared Neighborhood Hits	49
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BRD8_HUMAN
NC score	0.533472 (rank : 22)	θ value	4.0297e-08 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	292	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

BAZ1A_HUMAN
NC score	0.525399 (rank : 23)	θ value	2.28291e-11 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	693	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

BAZ2B_HUMAN
NC score	0.512506 (rank : 24)	θ value	8.38298e-14 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	803	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BAZ1B_MOUSE
NC score	0.510139 (rank : 25)	θ value	1.9326e-10 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	394	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z277, Q9CU68	Gene names	Baz1b, Wbscr9
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein homolog) (WBRS9).

BRD8_MOUSE
NC score	0.479937 (rank : 26)	θ value	9.92553e-07 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	422	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

BAZ1B_HUMAN
NC score	0.473569 (rank : 27)	θ value	5.08577e-11 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	701	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

TIF1A_MOUSE
NC score	0.463332 (rank : 28)	θ value	1.9326e-10 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	307	Shared Neighborhood Hits	48
SwissProt Accessions	Q64127, Q64126	Gene names	Trim24, Tif1, Tif1a
Domain Architecture
Description	Transcription intermediary factor 1-alpha (TIF1-alpha) (Tripartite motif-containing protein 24).

TIF1A_HUMAN
NC score	0.454834 (rank : 29)	θ value	3.29651e-10 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	327	Shared Neighborhood Hits	48
SwissProt Accessions	O15164, O95854	Gene names	TRIM24, RNF82, TIF1, TIF1A
Domain Architecture
Description	Transcription intermediary factor 1-alpha (TIF1-alpha) (Tripartite motif-containing protein 24) (RING finger protein 82).

TRI66_HUMAN
NC score	0.429703 (rank : 30)	θ value	2.61198e-07 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	479	Shared Neighborhood Hits	48
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TRI66_MOUSE
NC score	0.426344 (rank : 31)	θ value	2.61198e-07 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	491	Shared Neighborhood Hits	48
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

EP300_HUMAN
NC score	0.424144 (rank : 32)	θ value	1.69304e-06 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	821	Shared Neighborhood Hits	50
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

BRPF3_HUMAN
NC score	0.418659 (rank : 33)	θ value	8.97725e-08 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ULD4, Q5R3K8	Gene names	BRPF3, KIAA1286
Domain Architecture	No domain graphic available
Description	Bromodomain and PHD finger-containing protein 3.

CBP_HUMAN
NC score	0.412006 (rank : 34)	θ value	4.1701e-05 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	941	Shared Neighborhood Hits	50
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

BRD1_HUMAN
NC score	0.408337 (rank : 35)	θ value	1.80886e-08 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	188	Shared Neighborhood Hits	47
SwissProt Accessions	O95696	Gene names	BRD1, BRL, BRPF2
Domain Architecture
Description	Bromodomain-containing protein 1 (BR140-like protein).

PKCB1_HUMAN
NC score	0.398886 (rank : 36)	θ value	2.44474e-05 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	488	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

CBP_MOUSE
NC score	0.398499 (rank : 37)	θ value	1.87187e-05 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	1051	Shared Neighborhood Hits	50
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

BRPF1_HUMAN
NC score	0.375313 (rank : 38)	θ value	5.81887e-07 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	259	Shared Neighborhood Hits	48
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

TIF1G_HUMAN
NC score	0.374795 (rank : 39)	θ value	1.43324e-05 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	410	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

TIF1G_MOUSE
NC score	0.369242 (rank : 40)	θ value	1.43324e-05 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	498	Shared Neighborhood Hits	48
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

BRWD1_MOUSE
NC score	0.287957 (rank : 41)	θ value	1.29631e-06 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	478	Shared Neighborhood Hits	46
SwissProt Accessions	Q921C3, Q921C2	Gene names	Brwd1, Wdr9
Domain Architecture	No domain graphic available
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

BRWD1_HUMAN
NC score	0.287369 (rank : 42)	θ value	2.21117e-06 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	448	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

ATAD2_MOUSE
NC score	0.253812 (rank : 43)	θ value	0.00020696 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	167	Shared Neighborhood Hits	46
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

ATAD2_HUMAN
NC score	0.250945 (rank : 44)	θ value	0.00020696 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	322	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

SMCA2_HUMAN
NC score	0.195324 (rank : 45)	θ value	4.1701e-05 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	503	Shared Neighborhood Hits	49
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SMCA4_HUMAN
NC score	0.194604 (rank : 46)	θ value	1.87187e-05 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	597	Shared Neighborhood Hits	49
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

LY10_HUMAN
NC score	0.180338 (rank : 47)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	68	Target Neighborhood Hits	151	Shared Neighborhood Hits	33
SwissProt Accessions	Q13342, Q13341, Q92881, Q96TG3	Gene names	SP140, LYSP100
Domain Architecture
Description	Nuclear body protein SP140 (Nuclear autoantigen Sp-140) (Speckled 140 kDa) (LYSp100 protein) (Lymphoid-restricted homolog of Sp100).

ZMY11_MOUSE
NC score	0.176536 (rank : 48)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	68	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5C8, Q8C155	Gene names	Zmynd11
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11.

ZMY11_HUMAN
NC score	0.175851 (rank : 49)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	68	Target Neighborhood Hits	201	Shared Neighborhood Hits	37
SwissProt Accessions	Q15326	Gene names	ZMYND11, BS69
Domain Architecture
Description	Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A- binding protein) (BS69 protein).

TIF1B_HUMAN
NC score	0.157450 (rank : 50)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	68	Target Neighborhood Hits	312	Shared Neighborhood Hits	19
SwissProt Accessions	Q13263, O00677, Q7Z632, Q93040, Q96IM1	Gene names	TRIM28, KAP1, RNF96, TIF1B
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (RING finger protein 96).

AIRE_HUMAN
NC score	0.156472 (rank : 51)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	144	Shared Neighborhood Hits	18
SwissProt Accessions	O43918, O43922, O43932, O75745	Gene names	AIRE, APECED
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein).

TIF1B_MOUSE
NC score	0.155480 (rank : 52)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	68	Target Neighborhood Hits	276	Shared Neighborhood Hits	15
SwissProt Accessions	Q62318, P70391, Q8C283, Q99PN4	Gene names	Trim28, Krip1, Tif1b
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (KRAB-A-interacting protein) (KRIP-1).

AIRE_MOUSE
NC score	0.153118 (rank : 53)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	196	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

PF21A_MOUSE
NC score	0.137665 (rank : 54)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	68	Target Neighborhood Hits	285	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

PF21A_HUMAN
NC score	0.133234 (rank : 55)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	68	Target Neighborhood Hits	303	Shared Neighborhood Hits	20
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

RSF1_HUMAN
NC score	0.127971 (rank : 56)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	68	Target Neighborhood Hits	539	Shared Neighborhood Hits	22
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

PHF12_HUMAN
NC score	0.117042 (rank : 57)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	68	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

PHF12_MOUSE
NC score	0.116509 (rank : 58)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	68	Target Neighborhood Hits	172	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

PF21B_HUMAN
NC score	0.107900 (rank : 59)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	68	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q96EK2, Q5TFL2, Q6ICC0	Gene names	PHF21B
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

PF21B_MOUSE
NC score	0.098746 (rank : 60)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

REQU_HUMAN
NC score	0.093856 (rank : 61)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	68	Target Neighborhood Hits	523	Shared Neighborhood Hits	20
SwissProt Accessions	Q92785	Gene names	DPF2, REQ, UBID4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

REQU_MOUSE
NC score	0.092292 (rank : 62)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	68	Target Neighborhood Hits	519	Shared Neighborhood Hits	21
SwissProt Accessions	Q61103, Q3UNP5, Q60663, Q9QYA3	Gene names	Dpf2, Req, Ubid4
Domain Architecture
Description	Zinc-finger protein ubi-d4 (Requiem) (Apoptosis response zinc finger protein) (D4, zinc and double PHD fingers family 2).

PHF10_HUMAN
NC score	0.090236 (rank : 63)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	68	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WUB8, Q2YDA3, Q9BXD2, Q9NV26	Gene names	PHF10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10 (XAP135).

SP110_HUMAN
NC score	0.089970 (rank : 64)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	68	Target Neighborhood Hits	141	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HB58, Q14976, Q14977, Q8WUZ6, Q9HCT8	Gene names	SP110
Domain Architecture
Description	Sp110 nuclear body protein (Speckled 110 kDa) (Transcriptional coactivator Sp110) (Interferon-induced protein 41/75).

PHF10_MOUSE
NC score	0.089090 (rank : 65)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	68	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D8M7, Q99LV5	Gene names	Phf10
Domain Architecture	No domain graphic available
Description	PHD finger protein 10.

JADE3_MOUSE
NC score	0.086593 (rank : 66)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	68	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q6IE82, Q6ZQG2	Gene names	Phf16, Jade3, Kiaa0215
Domain Architecture	No domain graphic available
Description	Protein Jade-3 (PHD finger protein 16).

DPF1_MOUSE
NC score	0.086550 (rank : 67)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	68	Target Neighborhood Hits	491	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QX66, Q9QX65, Q9QYA4	Gene names	Dpf1, Neud4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

CHD5_HUMAN
NC score	0.086266 (rank : 68)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	68	Target Neighborhood Hits	349	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

PHF14_HUMAN
NC score	0.086023 (rank : 69)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	68	Target Neighborhood Hits	447	Shared Neighborhood Hits	22
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

CHD3_HUMAN
NC score	0.085791 (rank : 70)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	397	Shared Neighborhood Hits	19
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CHD4_MOUSE
NC score	0.085581 (rank : 71)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	68	Target Neighborhood Hits	408	Shared Neighborhood Hits	22
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CHD4_HUMAN
NC score	0.085489 (rank : 72)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	68	Target Neighborhood Hits	365	Shared Neighborhood Hits	21
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

PHF14_MOUSE
NC score	0.085372 (rank : 73)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	68	Target Neighborhood Hits	342	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

SELPL_MOUSE
NC score	0.084196 (rank : 74)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	68	Target Neighborhood Hits	588	Shared Neighborhood Hits	18
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

JADE3_HUMAN
NC score	0.083885 (rank : 75)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	68	Target Neighborhood Hits	148	Shared Neighborhood Hits	18
SwissProt Accessions	Q92613, Q6IE79	Gene names	PHF16, JADE3, KIAA0215
Domain Architecture
Description	Protein Jade-3 (PHD finger protein 16).

DPF1_HUMAN
NC score	0.081445 (rank : 76)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	68	Target Neighborhood Hits	136	Shared Neighborhood Hits	17
SwissProt Accessions	Q92782	Gene names	DPF1, NEUD4
Domain Architecture
Description	Zinc-finger protein neuro-d4 (D4, zinc and double PHD fingers family 1).

JADE1_HUMAN
NC score	0.080608 (rank : 77)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	68	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

JADE1_MOUSE
NC score	0.080608 (rank : 78)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	68	Target Neighborhood Hits	160	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

MLL3_HUMAN
NC score	0.080526 (rank : 79)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	68	Target Neighborhood Hits	1644	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

UHRF1_MOUSE
NC score	0.080426 (rank : 80)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	68	Target Neighborhood Hits	278	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

MYST4_HUMAN
NC score	0.079952 (rank : 81)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	68	Target Neighborhood Hits	671	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

NSD1_MOUSE
NC score	0.079841 (rank : 82)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	68	Target Neighborhood Hits	472	Shared Neighborhood Hits	24
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

MLL3_MOUSE
NC score	0.079404 (rank : 83)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	68	Target Neighborhood Hits	1399	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MYST4_MOUSE
NC score	0.078923 (rank : 84)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	68	Target Neighborhood Hits	416	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

JADE2_HUMAN
NC score	0.078550 (rank : 85)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	68	Target Neighborhood Hits	199	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

JADE2_MOUSE
NC score	0.078542 (rank : 86)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	68	Target Neighborhood Hits	560	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

MYST3_HUMAN
NC score	0.078520 (rank : 87)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	68	Target Neighborhood Hits	772	Shared Neighborhood Hits	25
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

NSD1_HUMAN
NC score	0.077138 (rank : 88)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	68	Target Neighborhood Hits	427	Shared Neighborhood Hits	22
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

JAD1A_HUMAN
NC score	0.076458 (rank : 89)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	68	Target Neighborhood Hits	328	Shared Neighborhood Hits	18
SwissProt Accessions	P29375	Gene names	JARID1A, RBBP2, RBP2
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1A (Retinoblastoma-binding protein 2) (RBBP-2).

CK024_HUMAN
NC score	0.076314 (rank : 90)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	68	Target Neighborhood Hits	408	Shared Neighborhood Hits	13
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

MYST3_MOUSE
NC score	0.076146 (rank : 91)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	68	Target Neighborhood Hits	688	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

UHRF1_HUMAN
NC score	0.075355 (rank : 92)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	68	Target Neighborhood Hits	272	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

JAD1D_HUMAN
NC score	0.074181 (rank : 93)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	68	Target Neighborhood Hits	147	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

MLL2_HUMAN
NC score	0.071604 (rank : 94)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	68	Target Neighborhood Hits	1788	Shared Neighborhood Hits	32
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

TRI45_HUMAN
NC score	0.068475 (rank : 95)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8W5, Q5T2K4, Q5T2K5, Q8IYV6	Gene names	TRIM45, RNF99
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45 (RING finger protein 99).

JAD1D_MOUSE
NC score	0.068300 (rank : 96)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	68	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q62240, Q9QVR9, Q9R040	Gene names	Smcy, Hya, Jarid1d
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

AF17_HUMAN
NC score	0.068175 (rank : 97)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	230	Shared Neighborhood Hits	13
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

UHRF2_MOUSE
NC score	0.067628 (rank : 98)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	68	Target Neighborhood Hits	275	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

TRI45_MOUSE
NC score	0.067484 (rank : 99)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PFY8, Q8BVT5	Gene names	Trim45
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45.

UHRF2_HUMAN
NC score	0.067112 (rank : 100)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	68	Target Neighborhood Hits	269	Shared Neighborhood Hits	17
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

JAD1C_MOUSE
NC score	0.065744 (rank : 101)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	68	Target Neighborhood Hits	164	Shared Neighborhood Hits	16
SwissProt Accessions	P41230, O54995, Q9CVI4, Q9D0C3, Q9QVR8, Q9R039	Gene names	Smcx, Jarid1c, Xe169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (SmcX protein) (Xe169 protein).

JAD1C_HUMAN
NC score	0.065614 (rank : 102)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	68	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	P41229	Gene names	SMCX, DXS1272E, JARID1C, XE169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (Protein SmcX) (Protein Xe169).

OGFR_HUMAN
NC score	0.061603 (rank : 103)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	68	Target Neighborhood Hits	1582	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

AF10_MOUSE
NC score	0.060798 (rank : 104)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	182	Shared Neighborhood Hits	11
SwissProt Accessions	O54826	Gene names	Mllt10, Af10
Domain Architecture
Description	Protein AF-10.

NCOA6_MOUSE
NC score	0.060671 (rank : 105)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	1076	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

AF10_HUMAN
NC score	0.059274 (rank : 106)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	198	Shared Neighborhood Hits	9
SwissProt Accessions	P55197	Gene names	MLLT10, AF10
Domain Architecture
Description	Protein AF-10.

PHF20_HUMAN
NC score	0.057789 (rank : 107)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	68	Target Neighborhood Hits	394	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BVI0, Q5JWY9, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22	Gene names	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58) (Glioma-expressed antigen 2) (Transcription factor TZP) (Novel zinc finger protein).

R3HD2_MOUSE
NC score	0.057467 (rank : 108)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	68	Target Neighborhood Hits	397	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

SPR1B_MOUSE
NC score	0.057176 (rank : 109)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	68	Target Neighborhood Hits	395	Shared Neighborhood Hits	13
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

PHF1_HUMAN
NC score	0.057056 (rank : 110)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	68	Target Neighborhood Hits	117	Shared Neighborhood Hits	14
SwissProt Accessions	O43189, O60929, Q96KM7	Gene names	PHF1
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1).

NCOA6_HUMAN
NC score	0.057043 (rank : 111)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	68	Target Neighborhood Hits	1202	Shared Neighborhood Hits	23
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PHF1_MOUSE
NC score	0.056790 (rank : 112)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	68	Target Neighborhood Hits	116	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1B8, O54808	Gene names	Phf1, Tctex-3, Tctex3
Domain Architecture
Description	PHD finger protein 1 (Protein PHF1) (T-complex testis-expressed 3) (Polycomblike 1) (mPCl1).

MTF2_HUMAN
NC score	0.056110 (rank : 113)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	68	Target Neighborhood Hits	119	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y483, Q9UES9, Q9UP40	Gene names	MTF2
Domain Architecture
Description	Metal-response element-binding transcription factor 2 (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

MTF2_MOUSE
NC score	0.055669 (rank : 114)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	68	Target Neighborhood Hits	126	Shared Neighborhood Hits	17
SwissProt Accessions	Q02395, Q569Z8, Q6PG89, Q8BGP9, Q8BSJ7	Gene names	Mtf2
Domain Architecture	No domain graphic available
Description	Metal-response element-binding transcription factor 2 (Zinc-regulated factor 1) (ZiRF1) (Metal-response element DNA-binding protein M96) (Metal-regulatory transcription factor 2) (PCL2).

DIDO1_HUMAN
NC score	0.055290 (rank : 115)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	68	Target Neighborhood Hits	960	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

CP003_HUMAN
NC score	0.053094 (rank : 116)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	O95177, O95176	Gene names	C16orf3
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf3.

CXCC1_HUMAN
NC score	0.052472 (rank : 117)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	68	Target Neighborhood Hits	143	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P0U4, Q8N2W4, Q96BC8, Q9P2V7	Gene names	CXXC1, CGBP, PCCX1, PHF18
Domain Architecture
Description	CpG-binding protein (PHD finger and CXXC domain-containing protein 1) (CXXC-type zinc finger protein 1).

MDC1_HUMAN
NC score	0.052030 (rank : 118)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	68	Target Neighborhood Hits	1446	Shared Neighborhood Hits	24
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PML_HUMAN
NC score	0.051896 (rank : 119)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	68	Target Neighborhood Hits	248	Shared Neighborhood Hits	8
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

SON_HUMAN
NC score	0.050392 (rank : 120)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	68	Target Neighborhood Hits	1568	Shared Neighborhood Hits	30
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

PML_MOUSE
NC score	0.050148 (rank : 121)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	68	Target Neighborhood Hits	246	Shared Neighborhood Hits	7
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

ATX2L_MOUSE
NC score	0.035814 (rank : 122)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	401	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

PYGO2_HUMAN
NC score	0.029623 (rank : 123)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	189	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

SNTG1_MOUSE
NC score	0.026998 (rank : 124)	θ value	0.21417 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	179	Shared Neighborhood Hits	3
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

NDK7_MOUSE
NC score	0.024731 (rank : 125)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QXL8	Gene names	Nme7
Domain Architecture
Description	Nucleoside diphosphate kinase 7 (EC 2.7.4.6) (NDK 7) (NDP kinase 7) (nm23-M7).

RAI1_MOUSE
NC score	0.024667 (rank : 126)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	344	Shared Neighborhood Hits	8
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SNTG1_HUMAN
NC score	0.023495 (rank : 127)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

VGF_HUMAN
NC score	0.021400 (rank : 128)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

NAF1_MOUSE
NC score	0.019159 (rank : 129)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	852	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

RP3A_MOUSE
NC score	0.017711 (rank : 130)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	510	Shared Neighborhood Hits	15
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SPN90_HUMAN
NC score	0.014415 (rank : 131)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

DAXX_HUMAN
NC score	0.013719 (rank : 132)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	207	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

LSD1_HUMAN
NC score	0.012623 (rank : 133)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	455	Shared Neighborhood Hits	9
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

K1045_HUMAN
NC score	0.011877 (rank : 134)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPV7, Q58FE9, Q5T662	Gene names	KIAA1045
Domain Architecture	No domain graphic available
Description	Protein KIAA1045.

OSBL8_HUMAN
NC score	0.010888 (rank : 135)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	289	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

ADCY4_MOUSE
NC score	0.010189 (rank : 136)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

PLCB1_HUMAN
NC score	0.009795 (rank : 137)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	614	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

CATE_MOUSE
NC score	0.004342 (rank : 138)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	P70269, O35647	Gene names	Ctse
Domain Architecture
Description	Cathepsin E precursor (EC 3.4.23.34).

FGD3_HUMAN
NC score	0.003893 (rank : 139)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	249	Shared Neighborhood Hits	2
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

CDKL4_HUMAN
NC score	-0.000366 (rank : 140)	θ value	1.06291 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	828	Shared Neighborhood Hits	3
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
NC score	-0.000884 (rank : 141)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	833	Shared Neighborhood Hits	3
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

ZN213_HUMAN
NC score	-0.001815 (rank : 142)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	755	Shared Neighborhood Hits	2
SwissProt Accessions	O14771, Q96IS1	Gene names	ZNF213
Domain Architecture
Description	Zinc finger protein 213 (Putative transcription factor CR53).