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Network neighborhood for query Sequence : PARP6_HUMAN

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PARP6_HUMAN
SwissProt Accessions	Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4	Gene names	PARP6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PARP6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4	Gene names	PARP6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP6_MOUSE
θ value	0 (rank : 2)	NC score	0.999919 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	16
SwissProt Accessions	Q6P6P7, Q8BVW1	Gene names	Parp6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP8_HUMAN
θ value	1.62005e-158 (rank : 3)	NC score	0.966588 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARP8_MOUSE
θ value	1.05009e-157 (rank : 4)	NC score	0.965127 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PAR16_HUMAN
θ value	1.80886e-08 (rank : 5)	NC score	0.446758 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N5Y8, Q6PK64, Q9NX03	Gene names	PARP16
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 16 (EC 2.4.2.30) (PARP-16).

PAR16_MOUSE
θ value	1.17247e-07 (rank : 6)	NC score	0.448272 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	8	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TMM8, Q3V031, Q8CC71	Gene names	Parp16
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 16 (EC 2.4.2.30) (PARP-16).

PARP2_HUMAN
θ value	0.0148317 (rank : 7)	NC score	0.187971 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	33	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

PARP2_MOUSE
θ value	0.0330416 (rank : 8)	NC score	0.181736 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	53	Shared Neighborhood Hits	9
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

PARP1_HUMAN
θ value	0.0736092 (rank : 9)	NC score	0.148819 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	P09874, Q8IUZ9	Gene names	PARP1, ADPRT, PPOL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1).

PARP1_MOUSE
θ value	0.163984 (rank : 10)	NC score	0.140392 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

PARP3_HUMAN
θ value	0.21417 (rank : 11)	NC score	0.144574 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

HTRA2_MOUSE
θ value	1.81305 (rank : 12)	NC score	0.028501 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

TPP1_HUMAN
θ value	1.81305 (rank : 13)	NC score	0.051968 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	O14773, Q53HT1, Q5JAK6, Q6UX56, Q96C37	Gene names	TPP1, CLN2, GIG1
Domain Architecture
Description	Tripeptidyl-peptidase 1 precursor (EC 3.4.14.9) (Tripeptidyl-peptidase I) (TPP-I) (Tripeptidyl aminopeptidase) (Lysosomal pepstatin insensitive protease) (LPIC) (Growth-inhibiting gene 1 protein).

TPP1_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.046830 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	O89023, Q543Q8, Q9QUS7	Gene names	Tpp1, Cln2
Domain Architecture
Description	Tripeptidyl-peptidase 1 precursor (EC 3.4.14.9) (Tripeptidyl-peptidase I) (TPP-I) (Tripeptidyl aminopeptidase) (Lysosomal pepstatin insensitive protease) (LPIC).

ORCT3_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.010779 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y226, Q8IYG1	Gene names	SLC22A13, ORCTL3
Domain Architecture	No domain graphic available
Description	Organic-cation transporter-like 3 (Solute carrier family 22 member 13).

PAR12_MOUSE
θ value	6.88961 (rank : 16)	NC score	0.015268 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BZ20, Q80VL6, Q8K333, Q8R3U2	Gene names	Parp12, Zc3hdc1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 12 (EC 2.4.2.30) (PARP-12) (Zinc finger CCCH domain-containing protein 1).

Hits sorted by NC score

PARP6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q2NL67, Q9H7C5, Q9H9X6, Q9HAF3, Q9NPS6, Q9UFG4	Gene names	PARP6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP6_MOUSE
NC score	0.999919 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	16
SwissProt Accessions	Q6P6P7, Q8BVW1	Gene names	Parp6
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 6 (EC 2.4.2.30) (PARP-6).

PARP8_HUMAN
NC score	0.966588 (rank : 3)	θ value	1.62005e-158 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARP8_MOUSE
NC score	0.965127 (rank : 4)	θ value	1.05009e-157 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PAR16_MOUSE
NC score	0.448272 (rank : 5)	θ value	1.17247e-07 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	8	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TMM8, Q3V031, Q8CC71	Gene names	Parp16
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 16 (EC 2.4.2.30) (PARP-16).

PAR16_HUMAN
NC score	0.446758 (rank : 6)	θ value	1.80886e-08 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N5Y8, Q6PK64, Q9NX03	Gene names	PARP16
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 16 (EC 2.4.2.30) (PARP-16).

PARP2_HUMAN
NC score	0.187971 (rank : 7)	θ value	0.0148317 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	33	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UGN5, Q8TEU4, Q9NUV2, Q9UMR4, Q9Y6C8	Gene names	PARP2, ADPRT2, ADPRTL2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (hPARP-2).

PARP2_MOUSE
NC score	0.181736 (rank : 8)	θ value	0.0330416 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	53	Shared Neighborhood Hits	9
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

PARP1_HUMAN
NC score	0.148819 (rank : 9)	θ value	0.0736092 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	P09874, Q8IUZ9	Gene names	PARP1, ADPRT, PPOL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1).

PARP3_HUMAN
NC score	0.144574 (rank : 10)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	30	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6F1, Q8NER9, Q96CG2, Q9UG81	Gene names	PARP3, ADPRT3, ADPRTL3
Domain Architecture
Description	Poly [ADP-ribose] polymerase 3 (EC 2.4.2.30) (PARP-3) (NAD(+) ADP- ribosyltransferase 3) (Poly[ADP-ribose] synthetase 3) (pADPRT-3) (hPARP-3) (IRT1).

PARP1_MOUSE
NC score	0.140392 (rank : 11)	θ value	0.163984 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	P11103, Q9JLX4, Q9QVQ3	Gene names	Parp1, Adprp, Adprt, Adprt1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 1 (EC 2.4.2.30) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) (msPARP).

TPP1_HUMAN
NC score	0.051968 (rank : 12)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	O14773, Q53HT1, Q5JAK6, Q6UX56, Q96C37	Gene names	TPP1, CLN2, GIG1
Domain Architecture
Description	Tripeptidyl-peptidase 1 precursor (EC 3.4.14.9) (Tripeptidyl-peptidase I) (TPP-I) (Tripeptidyl aminopeptidase) (Lysosomal pepstatin insensitive protease) (LPIC) (Growth-inhibiting gene 1 protein).

TPP1_MOUSE
NC score	0.046830 (rank : 13)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	O89023, Q543Q8, Q9QUS7	Gene names	Tpp1, Cln2
Domain Architecture
Description	Tripeptidyl-peptidase 1 precursor (EC 3.4.14.9) (Tripeptidyl-peptidase I) (TPP-I) (Tripeptidyl aminopeptidase) (Lysosomal pepstatin insensitive protease) (LPIC).

HTRA2_MOUSE
NC score	0.028501 (rank : 14)	θ value	1.81305 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

PAR12_MOUSE
NC score	0.015268 (rank : 15)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BZ20, Q80VL6, Q8K333, Q8R3U2	Gene names	Parp12, Zc3hdc1
Domain Architecture
Description	Poly [ADP-ribose] polymerase 12 (EC 2.4.2.30) (PARP-12) (Zinc finger CCCH domain-containing protein 1).

ORCT3_HUMAN
NC score	0.010779 (rank : 16)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y226, Q8IYG1	Gene names	SLC22A13, ORCTL3
Domain Architecture	No domain graphic available
Description	Organic-cation transporter-like 3 (Solute carrier family 22 member 13).