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Network neighborhood for query Sequence : LYAG_HUMAN

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LYAG_HUMAN
SwissProt Accessions	P10253, Q14351, Q16302	Gene names	GAA
Domain Architecture
Description	Lysosomal alpha-glucosidase precursor (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Contains: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LYAG_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P10253, Q14351, Q16302	Gene names	GAA
Domain Architecture
Description	Lysosomal alpha-glucosidase precursor (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Contains: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase].

LYAG_MOUSE
θ value	0 (rank : 2)	NC score	0.997908 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	P70699, Q3UJB2, Q8BGI6, Q91Z45	Gene names	Gaa
Domain Architecture
Description	Lysosomal alpha-glucosidase precursor (EC 3.2.1.20) (Acid maltase).

MGA_HUMAN
θ value	0 (rank : 3)	NC score	0.958692 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	O43451	Gene names	MGAM, MGA, MGAML
Domain Architecture
Description	Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha- glucosidase)].

SUIS_HUMAN
θ value	0 (rank : 4)	NC score	0.958817 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	P14410	Gene names	SI
Domain Architecture
Description	Sucrase-isomaltase, intestinal [Contains: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)].

GANC_MOUSE
θ value	1.82472e-93 (rank : 5)	NC score	0.905669 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BVW0, Q8BH03	Gene names	Ganc
Domain Architecture
Description	Neutral alpha-glucosidase C (EC 3.2.1.-).

GANAB_MOUSE
θ value	2.91321e-91 (rank : 6)	NC score	0.899464 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BHN3, O08794, Q80U81, Q9CS53	Gene names	Ganab, G2an, Kiaa0088
Domain Architecture
Description	Neutral alpha-glucosidase AB precursor (EC 3.2.1.84) (Glucosidase II subunit alpha) (Alpha glucosidase 2).

GANC_HUMAN
θ value	3.80478e-91 (rank : 7)	NC score	0.903352 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TET4, Q52LQ4, Q8IWZ0, Q8IZM4, Q8IZM5	Gene names	GANC
Domain Architecture
Description	Neutral alpha-glucosidase C (EC 3.2.1.20).

GANAB_HUMAN
θ value	9.37149e-90 (rank : 8)	NC score	0.899420 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q14697, Q8WTS9, Q9P0X0	Gene names	GANAB, G2AN, KIAA0088
Domain Architecture
Description	Neutral alpha-glucosidase AB precursor (EC 3.2.1.84) (Glucosidase II subunit alpha).

TFF3_MOUSE
θ value	0.000121331 (rank : 9)	NC score	0.235415 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q62395, Q64352	Gene names	Tff3, Itf
Domain Architecture
Description	Trefoil factor 3 precursor (Intestinal trefoil factor).

TFF2_HUMAN
θ value	0.00665767 (rank : 10)	NC score	0.174337 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q03403, Q15854	Gene names	TFF2, SML1
Domain Architecture
Description	Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin).

TFF3_HUMAN
θ value	0.0113563 (rank : 11)	NC score	0.206345 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q07654	Gene names	TFF3, ITF, TFI
Domain Architecture
Description	Trefoil factor 3 precursor (Intestinal trefoil factor) (hP1.B).

TFF1_MOUSE
θ value	0.0148317 (rank : 12)	NC score	0.202106 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q08423, Q3TVE6	Gene names	Tff1, Bcei, Ps2
Domain Architecture
Description	Trefoil factor 1 precursor (pS2 protein).

TFF1_HUMAN
θ value	0.0193708 (rank : 13)	NC score	0.196171 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P04155	Gene names	TFF1, BCEI, PS2
Domain Architecture
Description	Trefoil factor 1 precursor (pS2 protein) (HP1.A) (Breast cancer estrogen-inducible protein) (PNR-2).

DDX11_HUMAN
θ value	0.125558 (rank : 14)	NC score	0.031582 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	Q96FC9, Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999	Gene names	DDX11, CHL1, CHLR1, KRG2
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11) (CHL1 homolog) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2).

TFF2_MOUSE
θ value	0.125558 (rank : 15)	NC score	0.158367 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q03404, O08913	Gene names	Tff2, Sml1, Sp
Domain Architecture
Description	Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP).

LOXL1_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.020376 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

CRIM1_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.011627 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	362	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

ANXA7_HUMAN
θ value	1.81305 (rank : 18)	NC score	0.008278 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P20073	Gene names	ANXA7, ANX7, SNX
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

HXB2_MOUSE
θ value	1.81305 (rank : 19)	NC score	0.005310 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	350	Shared Neighborhood Hits	3
SwissProt Accessions	P0C1T1	Gene names	Hoxb2, Hox-2.8
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-B2 (Hox-2.8).

ZP4_HUMAN
θ value	2.36792 (rank : 20)	NC score	0.032564 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q12836	Gene names	ZP4, ZPB
Domain Architecture
Description	Zona pellucida sperm-binding protein 4 precursor (Zona pellucida sperm-binding protein B).

MDC1_MOUSE
θ value	3.0926 (rank : 21)	NC score	0.008002 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	998	Shared Neighborhood Hits	4
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

CHGUT_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.010345 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2E5, Q6P2I4, Q6UXD2	Gene names	CSGLCAT, KIAA1402
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (N- acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) (Chondroitin glucuronyltransferase II) (CSGlcA-T).

SRRM2_MOUSE
θ value	6.88961 (rank : 23)	NC score	0.003524 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	1470	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

FMOD_MOUSE
θ value	8.99809 (rank : 24)	NC score	0.001524 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	286	Shared Neighborhood Hits	2
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).

Hits sorted by NC score

LYAG_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P10253, Q14351, Q16302	Gene names	GAA
Domain Architecture
Description	Lysosomal alpha-glucosidase precursor (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Contains: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase].

LYAG_MOUSE
NC score	0.997908 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	P70699, Q3UJB2, Q8BGI6, Q91Z45	Gene names	Gaa
Domain Architecture
Description	Lysosomal alpha-glucosidase precursor (EC 3.2.1.20) (Acid maltase).

SUIS_HUMAN
NC score	0.958817 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	P14410	Gene names	SI
Domain Architecture
Description	Sucrase-isomaltase, intestinal [Contains: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)].

MGA_HUMAN
NC score	0.958692 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	O43451	Gene names	MGAM, MGA, MGAML
Domain Architecture
Description	Maltase-glucoamylase, intestinal [Includes: Maltase (EC 3.2.1.20) (Alpha-glucosidase); Glucoamylase (EC 3.2.1.3) (Glucan 1,4-alpha- glucosidase)].

GANC_MOUSE
NC score	0.905669 (rank : 5)	θ value	1.82472e-93 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BVW0, Q8BH03	Gene names	Ganc
Domain Architecture
Description	Neutral alpha-glucosidase C (EC 3.2.1.-).

GANC_HUMAN
NC score	0.903352 (rank : 6)	θ value	3.80478e-91 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TET4, Q52LQ4, Q8IWZ0, Q8IZM4, Q8IZM5	Gene names	GANC
Domain Architecture
Description	Neutral alpha-glucosidase C (EC 3.2.1.20).

GANAB_MOUSE
NC score	0.899464 (rank : 7)	θ value	2.91321e-91 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BHN3, O08794, Q80U81, Q9CS53	Gene names	Ganab, G2an, Kiaa0088
Domain Architecture
Description	Neutral alpha-glucosidase AB precursor (EC 3.2.1.84) (Glucosidase II subunit alpha) (Alpha glucosidase 2).

GANAB_HUMAN
NC score	0.899420 (rank : 8)	θ value	9.37149e-90 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q14697, Q8WTS9, Q9P0X0	Gene names	GANAB, G2AN, KIAA0088
Domain Architecture
Description	Neutral alpha-glucosidase AB precursor (EC 3.2.1.84) (Glucosidase II subunit alpha).

TFF3_MOUSE
NC score	0.235415 (rank : 9)	θ value	0.000121331 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q62395, Q64352	Gene names	Tff3, Itf
Domain Architecture
Description	Trefoil factor 3 precursor (Intestinal trefoil factor).

TFF3_HUMAN
NC score	0.206345 (rank : 10)	θ value	0.0113563 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	Q07654	Gene names	TFF3, ITF, TFI
Domain Architecture
Description	Trefoil factor 3 precursor (Intestinal trefoil factor) (hP1.B).

TFF1_MOUSE
NC score	0.202106 (rank : 11)	θ value	0.0148317 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q08423, Q3TVE6	Gene names	Tff1, Bcei, Ps2
Domain Architecture
Description	Trefoil factor 1 precursor (pS2 protein).

TFF1_HUMAN
NC score	0.196171 (rank : 12)	θ value	0.0193708 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	11	Shared Neighborhood Hits	10
SwissProt Accessions	P04155	Gene names	TFF1, BCEI, PS2
Domain Architecture
Description	Trefoil factor 1 precursor (pS2 protein) (HP1.A) (Breast cancer estrogen-inducible protein) (PNR-2).

TFF2_HUMAN
NC score	0.174337 (rank : 13)	θ value	0.00665767 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q03403, Q15854	Gene names	TFF2, SML1
Domain Architecture
Description	Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin).

TFF2_MOUSE
NC score	0.158367 (rank : 14)	θ value	0.125558 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q03404, O08913	Gene names	Tff2, Sml1, Sp
Domain Architecture
Description	Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP).

ZP4_HUMAN
NC score	0.032564 (rank : 15)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q12836	Gene names	ZP4, ZPB
Domain Architecture
Description	Zona pellucida sperm-binding protein 4 precursor (Zona pellucida sperm-binding protein B).

DDX11_HUMAN
NC score	0.031582 (rank : 16)	θ value	0.125558 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	124	Shared Neighborhood Hits	2
SwissProt Accessions	Q96FC9, Q13333, Q86VQ4, Q86W62, Q92498, Q92770, Q92998, Q92999	Gene names	DDX11, CHL1, CHLR1, KRG2
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-) (DEAD/H box protein 11) (CHL1 homolog) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2).

LOXL1_HUMAN
NC score	0.020376 (rank : 17)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q08397, Q96BW7	Gene names	LOXL1, LOXL
Domain Architecture
Description	Lysyl oxidase homolog 1 precursor (EC 1.4.3.-) (Lysyl oxidase-like protein 1) (LOL).

CRIM1_HUMAN
NC score	0.011627 (rank : 18)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	362	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

CHGUT_HUMAN
NC score	0.010345 (rank : 19)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2E5, Q6P2I4, Q6UXD2	Gene names	CSGLCAT, KIAA1402
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) (N- acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase) (Chondroitin glucuronyltransferase II) (CSGlcA-T).

ANXA7_HUMAN
NC score	0.008278 (rank : 20)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	P20073	Gene names	ANXA7, ANX7, SNX
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

MDC1_MOUSE
NC score	0.008002 (rank : 21)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	998	Shared Neighborhood Hits	4
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

HXB2_MOUSE
NC score	0.005310 (rank : 22)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	350	Shared Neighborhood Hits	3
SwissProt Accessions	P0C1T1	Gene names	Hoxb2, Hox-2.8
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-B2 (Hox-2.8).

SRRM2_MOUSE
NC score	0.003524 (rank : 23)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	1470	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

FMOD_MOUSE
NC score	0.001524 (rank : 24)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	286	Shared Neighborhood Hits	2
SwissProt Accessions	P50608	Gene names	Fmod
Domain Architecture
Description	Fibromodulin precursor (FM) (Collagen-binding 59 kDa protein) (Keratan sulfate proteoglycan fibromodulin) (KSPG fibromodulin).