Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : HBEGF_MOUSE

For an explanation of this page, click here

HBEGF_MOUSE
SwissProt Accessions	Q06186	Gene names	Hbegf, Dtr, Hegfl
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HBEGF_MOUSE
θ value	1.76329e-96 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q06186	Gene names	Hbegf, Dtr, Hegfl
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF).

HBEGF_HUMAN
θ value	4.22625e-74 (rank : 2)	NC score	0.979980 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	61	Shared Neighborhood Hits	40
SwissProt Accessions	Q99075	Gene names	HBEGF, DTR, HEGFL
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R).

BTC_MOUSE
θ value	3.41135e-07 (rank : 3)	NC score	0.623933 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	Q05928	Gene names	Btc, Bcn
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

AREG_MOUSE
θ value	9.92553e-07 (rank : 4)	NC score	0.598697 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	40	Shared Neighborhood Hits	27
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

BTC_HUMAN
θ value	1.69304e-06 (rank : 5)	NC score	0.591256 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	70	Shared Neighborhood Hits	37
SwissProt Accessions	P35070, Q96F48	Gene names	BTC
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

AREG_HUMAN
θ value	2.88788e-06 (rank : 6)	NC score	0.587023 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	P15514	Gene names	AREG
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF).

EPGN_MOUSE
θ value	4.92598e-06 (rank : 7)	NC score	0.576889 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	63	Shared Neighborhood Hits	38
SwissProt Accessions	Q924X1, Q8CEX5	Gene names	Epgn
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

EPGN_HUMAN
θ value	1.43324e-05 (rank : 8)	NC score	0.578693 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	35
SwissProt Accessions	Q6UW88	Gene names	EPGN
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

TEFF2_HUMAN
θ value	1.43324e-05 (rank : 9)	NC score	0.424654 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	211	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TEFF2_MOUSE
θ value	1.43324e-05 (rank : 10)	NC score	0.423460 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

EREG_MOUSE
θ value	4.1701e-05 (rank : 11)	NC score	0.541311 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	Q61521, Q7M0A8	Gene names	Ereg
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

EREG_HUMAN
θ value	0.00020696 (rank : 12)	NC score	0.522081 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	73	Shared Neighborhood Hits	41
SwissProt Accessions	O14944	Gene names	EREG
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

TGFA_MOUSE
θ value	0.00035302 (rank : 13)	NC score	0.543546 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	62	Shared Neighborhood Hits	36
SwissProt Accessions	P48030	Gene names	Tgfa
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

TGFA_HUMAN
θ value	0.00134147 (rank : 14)	NC score	0.536818 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	P01135, Q15577	Gene names	TGFA
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

NRG1_HUMAN
θ value	0.00665767 (rank : 15)	NC score	0.284902 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

NRG4_HUMAN
θ value	0.0148317 (rank : 16)	NC score	0.437150 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WWG1	Gene names	NRG4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

NRG4_MOUSE
θ value	0.0431538 (rank : 17)	NC score	0.408003 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	79	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTX4	Gene names	Nrg4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

NRG2_MOUSE
θ value	0.0563607 (rank : 18)	NC score	0.224719 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	392	Shared Neighborhood Hits	44
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

EGF_HUMAN
θ value	0.0961366 (rank : 19)	NC score	0.148160 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	343	Shared Neighborhood Hits	47
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

NRG2_HUMAN
θ value	0.0961366 (rank : 20)	NC score	0.213088 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	419	Shared Neighborhood Hits	43
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

EGF_MOUSE
θ value	0.21417 (rank : 21)	NC score	0.138349 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	358	Shared Neighborhood Hits	48
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

SLIT2_HUMAN
θ value	0.279714 (rank : 22)	NC score	0.082846 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	708	Shared Neighborhood Hits	43
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	0.279714 (rank : 23)	NC score	0.080424 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	684	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT3_MOUSE
θ value	0.47712 (rank : 24)	NC score	0.085679 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	700	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

TSP1_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.060250 (rank : 67)
Query Neighborhood Hits	48	Target Neighborhood Hits	389	Shared Neighborhood Hits	28
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.060439 (rank : 66)
Query Neighborhood Hits	48	Target Neighborhood Hits	396	Shared Neighborhood Hits	27
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

LRP1_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.075389 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	617	Shared Neighborhood Hits	45
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

LRP2_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.069211 (rank : 56)
Query Neighborhood Hits	48	Target Neighborhood Hits	573	Shared Neighborhood Hits	44
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

NOTC2_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.085697 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	1113	Shared Neighborhood Hits	46
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

DLL3_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.081746 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	419	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

DLL3_MOUSE
θ value	2.36792 (rank : 31)	NC score	0.080866 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	399	Shared Neighborhood Hits	38
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

NOTC3_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.081627 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	1062	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

TSP2_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.058202 (rank : 75)
Query Neighborhood Hits	48	Target Neighborhood Hits	359	Shared Neighborhood Hits	29
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

NOTC3_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.079606 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	975	Shared Neighborhood Hits	43
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

LAMA5_MOUSE
θ value	4.03905 (rank : 35)	NC score	0.043328 (rank : 104)
Query Neighborhood Hits	48	Target Neighborhood Hits	828	Shared Neighborhood Hits	33
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

NOTC1_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.078675 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	906	Shared Neighborhood Hits	42
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.080332 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	916	Shared Neighborhood Hits	44
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

SLIT3_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.083694 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	682	Shared Neighborhood Hits	46
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

CELR3_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.030666 (rank : 106)
Query Neighborhood Hits	48	Target Neighborhood Hits	680	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

LYAM2_MOUSE
θ value	5.27518 (rank : 40)	NC score	0.044881 (rank : 103)
Query Neighborhood Hits	48	Target Neighborhood Hits	420	Shared Neighborhood Hits	35
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

NOTC4_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.072311 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	905	Shared Neighborhood Hits	43
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC4_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.075289 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	872	Shared Neighborhood Hits	44
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

NRG3_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.154663 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

NRG3_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.158517 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	O35181	Gene names	Nrg3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

DNER_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.093088 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	460	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

NOTC2_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.083573 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	1069	Shared Neighborhood Hits	46
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

DNER_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.092061 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	413	Shared Neighborhood Hits	45
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

PGBM_MOUSE
θ value	8.99809 (rank : 48)	NC score	0.040367 (rank : 105)
Query Neighborhood Hits	48	Target Neighborhood Hits	1073	Shared Neighborhood Hits	38
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

AGRIN_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.073352 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	582	Shared Neighborhood Hits	32
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

C1QR1_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.050698 (rank : 100)
Query Neighborhood Hits	48	Target Neighborhood Hits	493	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

C1QR1_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.053159 (rank : 86)
Query Neighborhood Hits	48	Target Neighborhood Hits	342	Shared Neighborhood Hits	29
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

COMP_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.058675 (rank : 73)
Query Neighborhood Hits	48	Target Neighborhood Hits	258	Shared Neighborhood Hits	26
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

COMP_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.059879 (rank : 69)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

CRUM1_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.082057 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	457	Shared Neighborhood Hits	43
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

CRUM1_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.078801 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	444	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

CRUM2_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.070767 (rank : 52)
Query Neighborhood Hits	48	Target Neighborhood Hits	453	Shared Neighborhood Hits	39
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

CUBN_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.058663 (rank : 74)
Query Neighborhood Hits	48	Target Neighborhood Hits	482	Shared Neighborhood Hits	39
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

CUBN_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.054881 (rank : 80)
Query Neighborhood Hits	48	Target Neighborhood Hits	477	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

DLK_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.065650 (rank : 60)
Query Neighborhood Hits	48	Target Neighborhood Hits	401	Shared Neighborhood Hits	31
SwissProt Accessions	P80370, P15803, Q96DW5	Gene names	DLK1, DLK
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (pG2) [Contains: Fetal antigen 1 (FA1)].

DLK_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.063594 (rank : 62)
Query Neighborhood Hits	48	Target Neighborhood Hits	374	Shared Neighborhood Hits	31
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

DLL1_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.071310 (rank : 50)
Query Neighborhood Hits	48	Target Neighborhood Hits	455	Shared Neighborhood Hits	35
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

DLL1_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.071027 (rank : 51)
Query Neighborhood Hits	48	Target Neighborhood Hits	456	Shared Neighborhood Hits	36
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

DLL4_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.075828 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	435	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

DLL4_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.079409 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	440	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

EDIL3_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.051778 (rank : 94)
Query Neighborhood Hits	48	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	O43854, O43855	Gene names	EDIL3, DEL1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

EDIL3_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.055979 (rank : 77)
Query Neighborhood Hits	48	Target Neighborhood Hits	317	Shared Neighborhood Hits	29
SwissProt Accessions	O35474, O35475	Gene names	Edil3, Del1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

EGFL9_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.069762 (rank : 55)
Query Neighborhood Hits	48	Target Neighborhood Hits	365	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

EGFL9_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.068055 (rank : 58)
Query Neighborhood Hits	48	Target Neighborhood Hits	379	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

FBN1_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.051704 (rank : 96)
Query Neighborhood Hits	48	Target Neighborhood Hits	557	Shared Neighborhood Hits	34
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.052009 (rank : 93)
Query Neighborhood Hits	48	Target Neighborhood Hits	563	Shared Neighborhood Hits	35
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

FBN2_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.053132 (rank : 87)
Query Neighborhood Hits	48	Target Neighborhood Hits	560	Shared Neighborhood Hits	33
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.052596 (rank : 89)
Query Neighborhood Hits	48	Target Neighborhood Hits	549	Shared Neighborhood Hits	32
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.052045 (rank : 92)
Query Neighborhood Hits	48	Target Neighborhood Hits	543	Shared Neighborhood Hits	32
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

JAG1_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.070669 (rank : 53)
Query Neighborhood Hits	48	Target Neighborhood Hits	514	Shared Neighborhood Hits	37
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

JAG1_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.072148 (rank : 49)
Query Neighborhood Hits	48	Target Neighborhood Hits	518	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

JAG2_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.066520 (rank : 59)
Query Neighborhood Hits	48	Target Neighborhood Hits	491	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

JAG2_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.069098 (rank : 57)
Query Neighborhood Hits	48	Target Neighborhood Hits	504	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

LRP1B_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.070132 (rank : 54)
Query Neighborhood Hits	48	Target Neighborhood Hits	602	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.065190 (rank : 61)
Query Neighborhood Hits	48	Target Neighborhood Hits	606	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LTB1S_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.051717 (rank : 95)
Query Neighborhood Hits	48	Target Neighborhood Hits	502	Shared Neighborhood Hits	33
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

MEGF6_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.059995 (rank : 68)
Query Neighborhood Hits	48	Target Neighborhood Hits	671	Shared Neighborhood Hits	41
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

NELL1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.058799 (rank : 72)
Query Neighborhood Hits	48	Target Neighborhood Hits	451	Shared Neighborhood Hits	32
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NELL2_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.058922 (rank : 71)
Query Neighborhood Hits	48	Target Neighborhood Hits	449	Shared Neighborhood Hits	33
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

NELL2_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.054525 (rank : 83)
Query Neighborhood Hits	48	Target Neighborhood Hits	436	Shared Neighborhood Hits	31
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

NID1_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.052320 (rank : 91)
Query Neighborhood Hits	48	Target Neighborhood Hits	329	Shared Neighborhood Hits	27
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID1_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.052758 (rank : 88)
Query Neighborhood Hits	48	Target Neighborhood Hits	335	Shared Neighborhood Hits	28
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID2_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.051057 (rank : 97)
Query Neighborhood Hits	48	Target Neighborhood Hits	456	Shared Neighborhood Hits	28
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

NID2_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.052436 (rank : 90)
Query Neighborhood Hits	48	Target Neighborhood Hits	338	Shared Neighborhood Hits	28
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

SLIT1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.075742 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	700	Shared Neighborhood Hits	42
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SLIT1_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.075438 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

SMDF_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.154871 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	117	Shared Neighborhood Hits	36
SwissProt Accessions	Q15491	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture	No domain graphic available
Description	Neuregulin-1, sensory and motor neuron-derived factor isoform.

SREC2_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.054792 (rank : 81)
Query Neighborhood Hits	48	Target Neighborhood Hits	605	Shared Neighborhood Hits	34
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.050074 (rank : 102)
Query Neighborhood Hits	48	Target Neighborhood Hits	645	Shared Neighborhood Hits	32
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

STAB1_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.055957 (rank : 78)
Query Neighborhood Hits	48	Target Neighborhood Hits	546	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

STAB1_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.059405 (rank : 70)
Query Neighborhood Hits	48	Target Neighborhood Hits	566	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

STAB2_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.054000 (rank : 84)
Query Neighborhood Hits	48	Target Neighborhood Hits	534	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

STAB2_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.062734 (rank : 63)
Query Neighborhood Hits	48	Target Neighborhood Hits	528	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

TSP2_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.050968 (rank : 99)
Query Neighborhood Hits	48	Target Neighborhood Hits	352	Shared Neighborhood Hits	26
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

TSP3_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.054738 (rank : 82)
Query Neighborhood Hits	48	Target Neighborhood Hits	250	Shared Neighborhood Hits	26
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP3_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.056361 (rank : 76)
Query Neighborhood Hits	48	Target Neighborhood Hits	247	Shared Neighborhood Hits	26
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP4_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.061790 (rank : 64)
Query Neighborhood Hits	48	Target Neighborhood Hits	277	Shared Neighborhood Hits	27
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

TSP4_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.060786 (rank : 65)
Query Neighborhood Hits	48	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

UROM_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.050264 (rank : 101)
Query Neighborhood Hits	48	Target Neighborhood Hits	284	Shared Neighborhood Hits	27
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

UROM_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.051043 (rank : 98)
Query Neighborhood Hits	48	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

WIF1_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.053593 (rank : 85)
Query Neighborhood Hits	48	Target Neighborhood Hits	392	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

WIF1_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.055068 (rank : 79)
Query Neighborhood Hits	48	Target Neighborhood Hits	393	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

Hits sorted by NC score

HBEGF_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.76329e-96 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q06186	Gene names	Hbegf, Dtr, Hegfl
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF).

HBEGF_HUMAN
NC score	0.979980 (rank : 2)	θ value	4.22625e-74 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	61	Shared Neighborhood Hits	40
SwissProt Accessions	Q99075	Gene names	HBEGF, DTR, HEGFL
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R).

BTC_MOUSE
NC score	0.623933 (rank : 3)	θ value	3.41135e-07 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	Q05928	Gene names	Btc, Bcn
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

AREG_MOUSE
NC score	0.598697 (rank : 4)	θ value	9.92553e-07 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	40	Shared Neighborhood Hits	27
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

BTC_HUMAN
NC score	0.591256 (rank : 5)	θ value	1.69304e-06 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	70	Shared Neighborhood Hits	37
SwissProt Accessions	P35070, Q96F48	Gene names	BTC
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

AREG_HUMAN
NC score	0.587023 (rank : 6)	θ value	2.88788e-06 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	P15514	Gene names	AREG
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF).

EPGN_HUMAN
NC score	0.578693 (rank : 7)	θ value	1.43324e-05 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	35
SwissProt Accessions	Q6UW88	Gene names	EPGN
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

EPGN_MOUSE
NC score	0.576889 (rank : 8)	θ value	4.92598e-06 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	63	Shared Neighborhood Hits	38
SwissProt Accessions	Q924X1, Q8CEX5	Gene names	Epgn
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

TGFA_MOUSE
NC score	0.543546 (rank : 9)	θ value	0.00035302 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	62	Shared Neighborhood Hits	36
SwissProt Accessions	P48030	Gene names	Tgfa
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

EREG_MOUSE
NC score	0.541311 (rank : 10)	θ value	4.1701e-05 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	Q61521, Q7M0A8	Gene names	Ereg
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

TGFA_HUMAN
NC score	0.536818 (rank : 11)	θ value	0.00134147 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	P01135, Q15577	Gene names	TGFA
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

EREG_HUMAN
NC score	0.522081 (rank : 12)	θ value	0.00020696 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	73	Shared Neighborhood Hits	41
SwissProt Accessions	O14944	Gene names	EREG
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

NRG4_HUMAN
NC score	0.437150 (rank : 13)	θ value	0.0148317 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	85	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WWG1	Gene names	NRG4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

TEFF2_HUMAN
NC score	0.424654 (rank : 14)	θ value	1.43324e-05 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	211	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TEFF2_MOUSE
NC score	0.423460 (rank : 15)	θ value	1.43324e-05 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

NRG4_MOUSE
NC score	0.408003 (rank : 16)	θ value	0.0431538 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	79	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTX4	Gene names	Nrg4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

NRG1_HUMAN
NC score	0.284902 (rank : 17)	θ value	0.00665767 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

NRG2_MOUSE
NC score	0.224719 (rank : 18)	θ value	0.0563607 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	392	Shared Neighborhood Hits	44
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

NRG2_HUMAN
NC score	0.213088 (rank : 19)	θ value	0.0961366 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	419	Shared Neighborhood Hits	43
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

NRG3_MOUSE
NC score	0.158517 (rank : 20)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	O35181	Gene names	Nrg3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

SMDF_HUMAN
NC score	0.154871 (rank : 21)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	48	Target Neighborhood Hits	117	Shared Neighborhood Hits	36
SwissProt Accessions	Q15491	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture	No domain graphic available
Description	Neuregulin-1, sensory and motor neuron-derived factor isoform.

NRG3_HUMAN
NC score	0.154663 (rank : 22)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

EGF_HUMAN
NC score	0.148160 (rank : 23)	θ value	0.0961366 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	343	Shared Neighborhood Hits	47
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
NC score	0.138349 (rank : 24)	θ value	0.21417 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	358	Shared Neighborhood Hits	48
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

DNER_HUMAN
NC score	0.093088 (rank : 25)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	460	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

DNER_MOUSE
NC score	0.092061 (rank : 26)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	413	Shared Neighborhood Hits	45
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

NOTC2_HUMAN
NC score	0.085697 (rank : 27)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	1113	Shared Neighborhood Hits	46
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

SLIT3_MOUSE
NC score	0.085679 (rank : 28)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	700	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SLIT3_HUMAN
NC score	0.083694 (rank : 29)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	682	Shared Neighborhood Hits	46
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

NOTC2_MOUSE
NC score	0.083573 (rank : 30)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	1069	Shared Neighborhood Hits	46
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

SLIT2_HUMAN
NC score	0.082846 (rank : 31)	θ value	0.279714 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	708	Shared Neighborhood Hits	43
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

CRUM1_HUMAN
NC score	0.082057 (rank : 32)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	48	Target Neighborhood Hits	457	Shared Neighborhood Hits	43
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

DLL3_HUMAN
NC score	0.081746 (rank : 33)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	419	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NYJ7	Gene names	DLL3
Domain Architecture
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3).

NOTC3_HUMAN
NC score	0.081627 (rank : 34)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	1062	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

DLL3_MOUSE
NC score	0.080866 (rank : 35)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	399	Shared Neighborhood Hits	38
SwissProt Accessions	O88516, O35675, Q80W06, Q9QWL9, Q9QWZ7	Gene names	Dll3
Domain Architecture	No domain graphic available
Description	Delta-like protein 3 precursor (Drosophila Delta homolog 3) (M-Delta- 3).

SLIT2_MOUSE
NC score	0.080424 (rank : 36)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	684	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

NOTC1_MOUSE
NC score	0.080332 (rank : 37)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	916	Shared Neighborhood Hits	44
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC3_MOUSE
NC score	0.079606 (rank : 38)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	975	Shared Neighborhood Hits	43
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

DLL4_MOUSE
NC score	0.079409 (rank : 39)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	48	Target Neighborhood Hits	440	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

CRUM1_MOUSE
NC score	0.078801 (rank : 40)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	48	Target Neighborhood Hits	444	Shared Neighborhood Hits	44
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

NOTC1_HUMAN
NC score	0.078675 (rank : 41)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	906	Shared Neighborhood Hits	42
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

DLL4_HUMAN
NC score	0.075828 (rank : 42)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	48	Target Neighborhood Hits	435	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NR61, Q9NQT9	Gene names	DLL4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

SLIT1_HUMAN
NC score	0.075742 (rank : 43)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	48	Target Neighborhood Hits	700	Shared Neighborhood Hits	42
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SLIT1_MOUSE
NC score	0.075438 (rank : 44)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	48	Target Neighborhood Hits	715	Shared Neighborhood Hits	42
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

LRP1_HUMAN
NC score	0.075389 (rank : 45)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	617	Shared Neighborhood Hits	45
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

NOTC4_MOUSE
NC score	0.075289 (rank : 46)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	872	Shared Neighborhood Hits	44
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

AGRIN_HUMAN
NC score	0.073352 (rank : 47)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	48	Target Neighborhood Hits	582	Shared Neighborhood Hits	32
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

NOTC4_HUMAN
NC score	0.072311 (rank : 48)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	905	Shared Neighborhood Hits	43
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

JAG1_MOUSE
NC score	0.072148 (rank : 49)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	48	Target Neighborhood Hits	518	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXX0	Gene names	Jag1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (CD339 antigen).

DLL1_HUMAN
NC score	0.071310 (rank : 50)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	48	Target Neighborhood Hits	455	Shared Neighborhood Hits	35
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

DLL1_MOUSE
NC score	0.071027 (rank : 51)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	48	Target Neighborhood Hits	456	Shared Neighborhood Hits	36
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

CRUM2_HUMAN
NC score	0.070767 (rank : 52)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	48	Target Neighborhood Hits	453	Shared Neighborhood Hits	39
SwissProt Accessions	Q5IJ48, Q5JS41, Q5JS43, Q6ZTA9, Q6ZWI6	Gene names	CRB2
Domain Architecture	No domain graphic available
Description	Crumbs homolog 2 precursor (Crumbs-like protein 2).

JAG1_HUMAN
NC score	0.070669 (rank : 53)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	48	Target Neighborhood Hits	514	Shared Neighborhood Hits	37
SwissProt Accessions	P78504, O14902, O15122, Q15816	Gene names	JAG1, JAGL1
Domain Architecture
Description	Jagged-1 precursor (Jagged1) (hJ1) (CD339 antigen).

LRP1B_HUMAN
NC score	0.070132 (rank : 54)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	48	Target Neighborhood Hits	602	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

EGFL9_HUMAN
NC score	0.069762 (rank : 55)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	48	Target Neighborhood Hits	365	Shared Neighborhood Hits	36
SwissProt Accessions	Q6UY11, Q9BQ54	Gene names	EGFL9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9).

LRP2_HUMAN
NC score	0.069211 (rank : 56)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	573	Shared Neighborhood Hits	44
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

JAG2_MOUSE
NC score	0.069098 (rank : 57)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	48	Target Neighborhood Hits	504	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

EGFL9_MOUSE
NC score	0.068055 (rank : 58)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	48	Target Neighborhood Hits	379	Shared Neighborhood Hits	34
SwissProt Accessions	Q8K1E3, Q9QYP3	Gene names	Egfl9
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 9 precursor (Multiple EGF-like domain protein 9) (Endothelial cell-specific protein S-1).

JAG2_HUMAN
NC score	0.066520 (rank : 59)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	48	Target Neighborhood Hits	491	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

DLK_HUMAN
NC score	0.065650 (rank : 60)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	48	Target Neighborhood Hits	401	Shared Neighborhood Hits	31
SwissProt Accessions	P80370, P15803, Q96DW5	Gene names	DLK1, DLK
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (pG2) [Contains: Fetal antigen 1 (FA1)].

LRP1B_MOUSE
NC score	0.065190 (rank : 61)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	48	Target Neighborhood Hits	606	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

DLK_MOUSE
NC score	0.063594 (rank : 62)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	48	Target Neighborhood Hits	374	Shared Neighborhood Hits	31
SwissProt Accessions	Q09163, Q07645, Q62208	Gene names	Dlk1, Dlk, Pref1, Scp-1
Domain Architecture	No domain graphic available
Description	Delta-like protein precursor (DLK) (Preadipocyte factor 1) (Pref-1) (Adipocyte differentiation inhibitor protein) [Contains: Fetal antigen 1 (FA1)].

STAB2_MOUSE
NC score	0.062734 (rank : 63)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	48	Target Neighborhood Hits	528	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R4U0, Q8BM87	Gene names	Stab2
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor [Contains: Short form stabilin-2].

TSP4_HUMAN
NC score	0.061790 (rank : 64)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	48	Target Neighborhood Hits	277	Shared Neighborhood Hits	27
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

TSP4_MOUSE
NC score	0.060786 (rank : 65)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	48	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

TSP1_MOUSE
NC score	0.060439 (rank : 66)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	396	Shared Neighborhood Hits	27
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_HUMAN
NC score	0.060250 (rank : 67)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	389	Shared Neighborhood Hits	28
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

MEGF6_HUMAN
NC score	0.059995 (rank : 68)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	48	Target Neighborhood Hits	671	Shared Neighborhood Hits	41
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

COMP_MOUSE
NC score	0.059879 (rank : 69)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	48	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

STAB1_MOUSE
NC score	0.059405 (rank : 70)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	48	Target Neighborhood Hits	566	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

NELL2_HUMAN
NC score	0.058922 (rank : 71)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	48	Target Neighborhood Hits	449	Shared Neighborhood Hits	33
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

NELL1_HUMAN
NC score	0.058799 (rank : 72)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	48	Target Neighborhood Hits	451	Shared Neighborhood Hits	32
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

COMP_HUMAN
NC score	0.058675 (rank : 73)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	48	Target Neighborhood Hits	258	Shared Neighborhood Hits	26
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

CUBN_HUMAN
NC score	0.058663 (rank : 74)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	48	Target Neighborhood Hits	482	Shared Neighborhood Hits	39
SwissProt Accessions	O60494, Q5VTA6, Q96RU9	Gene names	CUBN, IFCR
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor) (Intrinsic factor-vitamin B12 receptor) (460 kDa receptor) (Intestinal intrinsic factor receptor).

TSP2_HUMAN
NC score	0.058202 (rank : 75)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	359	Shared Neighborhood Hits	29
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

TSP3_MOUSE
NC score	0.056361 (rank : 76)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	48	Target Neighborhood Hits	247	Shared Neighborhood Hits	26
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

EDIL3_MOUSE
NC score	0.055979 (rank : 77)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	48	Target Neighborhood Hits	317	Shared Neighborhood Hits	29
SwissProt Accessions	O35474, O35475	Gene names	Edil3, Del1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

STAB1_HUMAN
NC score	0.055957 (rank : 78)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	48	Target Neighborhood Hits	546	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

WIF1_MOUSE
NC score	0.055068 (rank : 79)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	48	Target Neighborhood Hits	393	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WUA1	Gene names	Wif1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

CUBN_MOUSE
NC score	0.054881 (rank : 80)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	48	Target Neighborhood Hits	477	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

SREC2_MOUSE
NC score	0.054792 (rank : 81)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	48	Target Neighborhood Hits	605	Shared Neighborhood Hits	34
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

TSP3_HUMAN
NC score	0.054738 (rank : 82)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	48	Target Neighborhood Hits	250	Shared Neighborhood Hits	26
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

NELL2_MOUSE
NC score	0.054525 (rank : 83)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	48	Target Neighborhood Hits	436	Shared Neighborhood Hits	31
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

STAB2_HUMAN
NC score	0.054000 (rank : 84)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	48	Target Neighborhood Hits	534	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

WIF1_HUMAN
NC score	0.053593 (rank : 85)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	48	Target Neighborhood Hits	392	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y5W5, Q6UXI1, Q8WVG4	Gene names	WIF1
Domain Architecture
Description	Wnt inhibitory factor 1 precursor (WIF-1).

C1QR1_MOUSE
NC score	0.053159 (rank : 86)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	48	Target Neighborhood Hits	342	Shared Neighborhood Hits	29
SwissProt Accessions	O89103, Q3U2X0	Gene names	Cd93, Aa4, C1qr1, C1qrp, Ly68
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (Cell surface antigen AA4) (Lymphocyte antigen 68).

FBN2_HUMAN
NC score	0.053132 (rank : 87)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	48	Target Neighborhood Hits	560	Shared Neighborhood Hits	33
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

NID1_MOUSE
NC score	0.052758 (rank : 88)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	48	Target Neighborhood Hits	335	Shared Neighborhood Hits	28
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

FBN2_MOUSE
NC score	0.052596 (rank : 89)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	48	Target Neighborhood Hits	549	Shared Neighborhood Hits	32
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

NID2_MOUSE
NC score	0.052436 (rank : 90)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	48	Target Neighborhood Hits	338	Shared Neighborhood Hits	28
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NID1_HUMAN
NC score	0.052320 (rank : 91)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	48	Target Neighborhood Hits	329	Shared Neighborhood Hits	27
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

FBN3_HUMAN
NC score	0.052045 (rank : 92)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	48	Target Neighborhood Hits	543	Shared Neighborhood Hits	32
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

FBN1_MOUSE
NC score	0.052009 (rank : 93)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	48	Target Neighborhood Hits	563	Shared Neighborhood Hits	35
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

EDIL3_HUMAN
NC score	0.051778 (rank : 94)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	48	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	O43854, O43855	Gene names	EDIL3, DEL1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

LTB1S_HUMAN
NC score	0.051717 (rank : 95)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	48	Target Neighborhood Hits	502	Shared Neighborhood Hits	33
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

FBN1_HUMAN
NC score	0.051704 (rank : 96)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	48	Target Neighborhood Hits	557	Shared Neighborhood Hits	34
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

NID2_HUMAN
NC score	0.051057 (rank : 97)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	48	Target Neighborhood Hits	456	Shared Neighborhood Hits	28
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

UROM_MOUSE
NC score	0.051043 (rank : 98)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	48	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q91X17, Q3TN64, Q3TP60, Q62285	Gene names	Umod
Domain Architecture	No domain graphic available
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

TSP2_MOUSE
NC score	0.050968 (rank : 99)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	48	Target Neighborhood Hits	352	Shared Neighborhood Hits	26
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

C1QR1_HUMAN
NC score	0.050698 (rank : 100)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	48	Target Neighborhood Hits	493	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

UROM_HUMAN
NC score	0.050264 (rank : 101)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	48	Target Neighborhood Hits	284	Shared Neighborhood Hits	27
SwissProt Accessions	P07911, Q540J6, Q6ZS84, Q8IYG0	Gene names	UMOD
Domain Architecture
Description	Uromodulin precursor (Tamm-Horsfall urinary glycoprotein) (THP).

SREC_HUMAN
NC score	0.050074 (rank : 102)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	48	Target Neighborhood Hits	645	Shared Neighborhood Hits	32
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

LYAM2_MOUSE
NC score	0.044881 (rank : 103)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	420	Shared Neighborhood Hits	35
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

LAMA5_MOUSE
NC score	0.043328 (rank : 104)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	828	Shared Neighborhood Hits	33
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

PGBM_MOUSE
NC score	0.040367 (rank : 105)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	1073	Shared Neighborhood Hits	38
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CELR3_HUMAN
NC score	0.030666 (rank : 106)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	680	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).