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Network neighborhood for query Sequence : AREG_HUMAN

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AREG_HUMAN
SwissProt Accessions	P15514	Gene names	AREG
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AREG_HUMAN
θ value	2.64101e-84 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P15514	Gene names	AREG
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF).

AREG_MOUSE
θ value	1.90589e-58 (rank : 2)	NC score	0.976684 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	32
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

HBEGF_HUMAN
θ value	1.17247e-07 (rank : 3)	NC score	0.604656 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	Q99075	Gene names	HBEGF, DTR, HEGFL
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R).

TEFF2_MOUSE
θ value	9.92553e-07 (rank : 4)	NC score	0.423870 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

TEFF2_HUMAN
θ value	2.21117e-06 (rank : 5)	NC score	0.422359 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	211	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

HBEGF_MOUSE
θ value	2.88788e-06 (rank : 6)	NC score	0.587023 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	Q06186	Gene names	Hbegf, Dtr, Hegfl
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF).

BTC_MOUSE
θ value	0.00035302 (rank : 7)	NC score	0.529455 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q05928	Gene names	Btc, Bcn
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

EPGN_MOUSE
θ value	0.000461057 (rank : 8)	NC score	0.514061 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q924X1, Q8CEX5	Gene names	Epgn
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

NRG2_HUMAN
θ value	0.000461057 (rank : 9)	NC score	0.258037 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	419	Shared Neighborhood Hits	35
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

EGF_HUMAN
θ value	0.00134147 (rank : 10)	NC score	0.152267 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	343	Shared Neighborhood Hits	37
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EPGN_HUMAN
θ value	0.00390308 (rank : 11)	NC score	0.505705 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UW88	Gene names	EPGN
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

EREG_HUMAN
θ value	0.00390308 (rank : 12)	NC score	0.486154 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	73	Shared Neighborhood Hits	32
SwissProt Accessions	O14944	Gene names	EREG
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

EREG_MOUSE
θ value	0.00390308 (rank : 13)	NC score	0.493980 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	Q61521, Q7M0A8	Gene names	Ereg
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

NRG2_MOUSE
θ value	0.00390308 (rank : 14)	NC score	0.260212 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	392	Shared Neighborhood Hits	36
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

BTC_HUMAN
θ value	0.00665767 (rank : 15)	NC score	0.493445 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	P35070, Q96F48	Gene names	BTC
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

EGF_MOUSE
θ value	0.0148317 (rank : 16)	NC score	0.143484 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	358	Shared Neighborhood Hits	38
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

NRG4_HUMAN
θ value	0.0148317 (rank : 17)	NC score	0.422265 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	85	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WWG1	Gene names	NRG4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

TGFA_HUMAN
θ value	0.0431538 (rank : 18)	NC score	0.444499 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	28
SwissProt Accessions	P01135, Q15577	Gene names	TGFA
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

TGFA_MOUSE
θ value	0.0563607 (rank : 19)	NC score	0.451954 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	62	Shared Neighborhood Hits	29
SwissProt Accessions	P48030	Gene names	Tgfa
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

LYAM2_MOUSE
θ value	0.125558 (rank : 20)	NC score	0.078869 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	420	Shared Neighborhood Hits	25
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

NRG4_MOUSE
θ value	0.21417 (rank : 21)	NC score	0.381345 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	79	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WTX4	Gene names	Nrg4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

NRG1_HUMAN
θ value	0.279714 (rank : 22)	NC score	0.257954 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	285	Shared Neighborhood Hits	32
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

TSP2_HUMAN
θ value	0.279714 (rank : 23)	NC score	0.045776 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	359	Shared Neighborhood Hits	15
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

TP53B_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.047194 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	413	Shared Neighborhood Hits	3
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

FATH_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.040175 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	570	Shared Neighborhood Hits	31
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

NRG3_HUMAN
θ value	0.813845 (rank : 26)	NC score	0.204169 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	119	Shared Neighborhood Hits	26
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

NRG3_MOUSE
θ value	0.813845 (rank : 27)	NC score	0.208640 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	132	Shared Neighborhood Hits	26
SwissProt Accessions	O35181	Gene names	Nrg3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

LYAM1_HUMAN
θ value	1.06291 (rank : 28)	NC score	0.088369 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	315	Shared Neighborhood Hits	22
SwissProt Accessions	P14151, P15023	Gene names	SELL, LNHR, LYAM1
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (TQ1) (gp90-MEL) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

SMDF_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.207222 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q15491	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture	No domain graphic available
Description	Neuregulin-1, sensory and motor neuron-derived factor isoform.

CUBN_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.050998 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	477	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

APLP2_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.028123 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	186	Shared Neighborhood Hits	2
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

SLIT1_MOUSE
θ value	1.81305 (rank : 32)	NC score	0.049071 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

CELR2_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.026751 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	657	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

DNER_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.070920 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	460	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

LYAM1_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.069383 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	332	Shared Neighborhood Hits	18
SwissProt Accessions	P18337	Gene names	Sell, Lnhr, Ly-22
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

LYAM2_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.062718 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	394	Shared Neighborhood Hits	26
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

SLIT1_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.048474 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	700	Shared Neighborhood Hits	32
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

CRUM1_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.059922 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	457	Shared Neighborhood Hits	33
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

DNER_MOUSE
θ value	5.27518 (rank : 39)	NC score	0.067807 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	413	Shared Neighborhood Hits	34
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

HABP2_MOUSE
θ value	5.27518 (rank : 40)	NC score	0.025709 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	445	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

TGON2_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.007920 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	1037	Shared Neighborhood Hits	4
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

AGRIN_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.056454 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	582	Shared Neighborhood Hits	21
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

CRUM1_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.055096 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	444	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

DLL4_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.052028 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	440	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

SLIT3_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.051299 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	700	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

Hits sorted by NC score

AREG_HUMAN
NC score	0.999962 (rank : 1)	θ value	2.64101e-84 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P15514	Gene names	AREG
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Colorectum cell-derived growth factor) (CRDGF).

AREG_MOUSE
NC score	0.976684 (rank : 2)	θ value	1.90589e-58 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	40	Shared Neighborhood Hits	32
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

HBEGF_HUMAN
NC score	0.604656 (rank : 3)	θ value	1.17247e-07 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	Q99075	Gene names	HBEGF, DTR, HEGFL
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R).

HBEGF_MOUSE
NC score	0.587023 (rank : 4)	θ value	2.88788e-06 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	48	Shared Neighborhood Hits	27
SwissProt Accessions	Q06186	Gene names	Hbegf, Dtr, Hegfl
Domain Architecture	No domain graphic available
Description	Heparin-binding EGF-like growth factor precursor (HB-EGF) (HBEGF).

BTC_MOUSE
NC score	0.529455 (rank : 5)	θ value	0.00035302 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q05928	Gene names	Btc, Bcn
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

EPGN_MOUSE
NC score	0.514061 (rank : 6)	θ value	0.000461057 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q924X1, Q8CEX5	Gene names	Epgn
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

EPGN_HUMAN
NC score	0.505705 (rank : 7)	θ value	0.00390308 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UW88	Gene names	EPGN
Domain Architecture	No domain graphic available
Description	Epigen precursor (Epithelial mitogen) (EPG).

EREG_MOUSE
NC score	0.493980 (rank : 8)	θ value	0.00390308 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	Q61521, Q7M0A8	Gene names	Ereg
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

BTC_HUMAN
NC score	0.493445 (rank : 9)	θ value	0.00665767 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	P35070, Q96F48	Gene names	BTC
Domain Architecture	No domain graphic available
Description	Betacellulin precursor (BTC).

EREG_HUMAN
NC score	0.486154 (rank : 10)	θ value	0.00390308 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	73	Shared Neighborhood Hits	32
SwissProt Accessions	O14944	Gene names	EREG
Domain Architecture	No domain graphic available
Description	Epiregulin precursor.

TGFA_MOUSE
NC score	0.451954 (rank : 11)	θ value	0.0563607 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	62	Shared Neighborhood Hits	29
SwissProt Accessions	P48030	Gene names	Tgfa
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

TGFA_HUMAN
NC score	0.444499 (rank : 12)	θ value	0.0431538 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	61	Shared Neighborhood Hits	28
SwissProt Accessions	P01135, Q15577	Gene names	TGFA
Domain Architecture	No domain graphic available
Description	Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).

TEFF2_MOUSE
NC score	0.423870 (rank : 13)	θ value	9.92553e-07 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

TEFF2_HUMAN
NC score	0.422359 (rank : 14)	θ value	2.21117e-06 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	211	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

NRG4_HUMAN
NC score	0.422265 (rank : 15)	θ value	0.0148317 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	85	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WWG1	Gene names	NRG4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

NRG4_MOUSE
NC score	0.381345 (rank : 16)	θ value	0.21417 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	79	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WTX4	Gene names	Nrg4
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)].

NRG2_MOUSE
NC score	0.260212 (rank : 17)	θ value	0.00390308 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	392	Shared Neighborhood Hits	36
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

NRG2_HUMAN
NC score	0.258037 (rank : 18)	θ value	0.000461057 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	419	Shared Neighborhood Hits	35
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

NRG1_HUMAN
NC score	0.257954 (rank : 19)	θ value	0.279714 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	285	Shared Neighborhood Hits	32
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

NRG3_MOUSE
NC score	0.208640 (rank : 20)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	132	Shared Neighborhood Hits	26
SwissProt Accessions	O35181	Gene names	Nrg3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

SMDF_HUMAN
NC score	0.207222 (rank : 21)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q15491	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture	No domain graphic available
Description	Neuregulin-1, sensory and motor neuron-derived factor isoform.

NRG3_HUMAN
NC score	0.204169 (rank : 22)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	119	Shared Neighborhood Hits	26
SwissProt Accessions	P56975	Gene names	NRG3
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-3, membrane-bound isoform precursor (Pro-NRG3) [Contains: Neuregulin-3 (NRG-3)].

EGF_HUMAN
NC score	0.152267 (rank : 23)	θ value	0.00134147 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	343	Shared Neighborhood Hits	37
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
NC score	0.143484 (rank : 24)	θ value	0.0148317 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	358	Shared Neighborhood Hits	38
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

LYAM1_HUMAN
NC score	0.088369 (rank : 25)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	315	Shared Neighborhood Hits	22
SwissProt Accessions	P14151, P15023	Gene names	SELL, LNHR, LYAM1
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (TQ1) (gp90-MEL) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

LYAM2_MOUSE
NC score	0.078869 (rank : 26)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	420	Shared Neighborhood Hits	25
SwissProt Accessions	Q00690	Gene names	Sele, Elam-1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

DNER_HUMAN
NC score	0.070920 (rank : 27)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	460	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

LYAM1_MOUSE
NC score	0.069383 (rank : 28)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	332	Shared Neighborhood Hits	18
SwissProt Accessions	P18337	Gene names	Sell, Lnhr, Ly-22
Domain Architecture
Description	L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule 1) (LAM-1) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L antigen).

DNER_MOUSE
NC score	0.067807 (rank : 29)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	413	Shared Neighborhood Hits	34
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

LYAM2_HUMAN
NC score	0.062718 (rank : 30)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	394	Shared Neighborhood Hits	26
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

CRUM1_HUMAN
NC score	0.059922 (rank : 31)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	457	Shared Neighborhood Hits	33
SwissProt Accessions	P82279, Q5K3A6, Q5TC28, Q5VUT1, Q6N027, Q8WWY0	Gene names	CRB1
Domain Architecture
Description	Crumbs homolog 1 precursor.

AGRIN_HUMAN
NC score	0.056454 (rank : 32)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	582	Shared Neighborhood Hits	21
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

CRUM1_MOUSE
NC score	0.055096 (rank : 33)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	444	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VHS2, Q6ST50, Q71JF2, Q8BGR4	Gene names	Crb1
Domain Architecture	No domain graphic available
Description	Crumbs homolog 1 precursor.

DLL4_MOUSE
NC score	0.052028 (rank : 34)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	440	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JI71, Q9JHZ7	Gene names	Dll4
Domain Architecture
Description	Delta-like protein 4 precursor (Drosophila Delta homolog 4).

SLIT3_MOUSE
NC score	0.051299 (rank : 35)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	700	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

CUBN_MOUSE
NC score	0.050998 (rank : 36)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	477	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

SLIT1_MOUSE
NC score	0.049071 (rank : 37)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	715	Shared Neighborhood Hits	32
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

SLIT1_HUMAN
NC score	0.048474 (rank : 38)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	700	Shared Neighborhood Hits	32
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

TP53B_HUMAN
NC score	0.047194 (rank : 39)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	413	Shared Neighborhood Hits	3
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TSP2_HUMAN
NC score	0.045776 (rank : 40)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	359	Shared Neighborhood Hits	15
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

FATH_HUMAN
NC score	0.040175 (rank : 41)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	570	Shared Neighborhood Hits	31
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

APLP2_MOUSE
NC score	0.028123 (rank : 42)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	186	Shared Neighborhood Hits	2
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

CELR2_HUMAN
NC score	0.026751 (rank : 43)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	657	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

HABP2_MOUSE
NC score	0.025709 (rank : 44)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	445	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K0D2	Gene names	Habp2, Phbp
Domain Architecture	No domain graphic available
Description	Hyaluronan-binding protein 2 precursor (EC 3.4.21.-) (Plasma hyaluronan-binding protein) [Contains: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form].

TGON2_HUMAN
NC score	0.007920 (rank : 45)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	1037	Shared Neighborhood Hits	4
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).