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Network neighborhood for query Sequence : GFRAL_HUMAN

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GFRAL_HUMAN
SwissProt Accessions	Q6UXV0, Q5VTF6	Gene names	GFRAL
Domain Architecture	No domain graphic available
Description	GDNF family receptor alpha-like precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GFRAL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UXV0, Q5VTF6	Gene names	GFRAL
Domain Architecture	No domain graphic available
Description	GDNF family receptor alpha-like precursor.

GFRAL_MOUSE
θ value	3.60074e-166 (rank : 2)	NC score	0.989000 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q6SJE0, Q6SJD9	Gene names	Gfral, Gral
Domain Architecture	No domain graphic available
Description	GDNF family receptor alpha-like precursor.

GFRA1_HUMAN
θ value	1.86753e-13 (rank : 3)	NC score	0.626376 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P56159, O15507, O43912	Gene names	GFRA1, GDNFRA, RETL1, TRNR1
Domain Architecture
Description	GDNF family receptor alpha-1 precursor (GFR-alpha-1) (GDNF receptor alpha) (GDNFR-alpha) (TGF-beta-related neurotrophic factor receptor 1) (RET ligand 1).

GFRA1_MOUSE
θ value	1.2105e-12 (rank : 4)	NC score	0.620514 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	P97785	Gene names	Gfra1, Gdnfra, Trnr1
Domain Architecture
Description	GDNF family receptor alpha-1 precursor (GFR-alpha-1) (GDNF receptor alpha) (GDNFR-alpha) (TGF-beta-related neurotrophic factor receptor 1).

GFRA3_MOUSE
θ value	4.59992e-12 (rank : 5)	NC score	0.636095 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	O35118, O35325, O55243, Q6NZC2, Q8C8L9	Gene names	Gfra3
Domain Architecture	No domain graphic available
Description	GDNF family receptor alpha-3 precursor (GFR-alpha-3).

GFRA2_HUMAN
θ value	6.00763e-12 (rank : 6)	NC score	0.609864 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	O00451, O15316, O15328, Q7Z5C2	Gene names	GFRA2, GDNFRB, RETL2, TRNR2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta) (RET ligand 2).

GFRA2_MOUSE
θ value	1.74796e-11 (rank : 7)	NC score	0.606670 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	O08842	Gene names	Gfra2, Gdnfrb, Trnr2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta).

GFRA4_MOUSE
θ value	3.89403e-11 (rank : 8)	NC score	0.638976 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJT2, Q9JJT3, Q9JJT4, Q9JJT6, Q9JJT7, Q9JJT8	Gene names	Gfra4
Domain Architecture
Description	GDNF family receptor alpha-4 precursor (GFR-alpha-4) (Persephin receptor).

GFRA3_HUMAN
θ value	5.08577e-11 (rank : 9)	NC score	0.625437 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	10
SwissProt Accessions	O60609, Q6UW20, Q8IUZ2	Gene names	GFRA3
Domain Architecture
Description	GDNF family receptor alpha-3 precursor (GFR-alpha-3).

GFRA4_HUMAN
θ value	5.26297e-08 (rank : 10)	NC score	0.610361 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	12
SwissProt Accessions	Q9GZZ7, Q9H191, Q9H192	Gene names	GFRA4
Domain Architecture
Description	GDNF family receptor alpha-4 precursor (GFR-alpha-4) (Persephin receptor).

GAS1_MOUSE
θ value	0.125558 (rank : 11)	NC score	0.145343 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q01721	Gene names	Gas1, Gas-1
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 1 precursor (GAS-1).

UTP20_MOUSE
θ value	0.279714 (rank : 12)	NC score	0.047528 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XG71, Q80V22, Q8BXH9, Q8CHL6, Q99K11	Gene names	Utp20, Drim
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein).

BMPER_MOUSE
θ value	1.38821 (rank : 13)	NC score	0.053801 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

BMPER_HUMAN
θ value	2.36792 (rank : 14)	NC score	0.042110 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	175	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

KR107_HUMAN
θ value	2.36792 (rank : 15)	NC score	0.019165 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	330	Shared Neighborhood Hits	8
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

STAB1_MOUSE
θ value	2.36792 (rank : 16)	NC score	0.013929 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	566	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

FA7_MOUSE
θ value	4.03905 (rank : 17)	NC score	0.006816 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	374	Shared Neighborhood Hits	6
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

GAS1_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.082920 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P54826	Gene names	GAS1
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 1 precursor (GAS-1).

TMPS6_HUMAN
θ value	4.03905 (rank : 19)	NC score	0.006017 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	338	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

NOTC2_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.009949 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	1069	Shared Neighborhood Hits	11
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

ZAN_MOUSE
θ value	5.27518 (rank : 21)	NC score	0.021102 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	808	Shared Neighborhood Hits	12
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

KR104_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.016261 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	313	Shared Neighborhood Hits	8
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

Hits sorted by NC score

GFRAL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q6UXV0, Q5VTF6	Gene names	GFRAL
Domain Architecture	No domain graphic available
Description	GDNF family receptor alpha-like precursor.

GFRAL_MOUSE
NC score	0.989000 (rank : 2)	θ value	3.60074e-166 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q6SJE0, Q6SJD9	Gene names	Gfral, Gral
Domain Architecture	No domain graphic available
Description	GDNF family receptor alpha-like precursor.

GFRA4_MOUSE
NC score	0.638976 (rank : 3)	θ value	3.89403e-11 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJT2, Q9JJT3, Q9JJT4, Q9JJT6, Q9JJT7, Q9JJT8	Gene names	Gfra4
Domain Architecture
Description	GDNF family receptor alpha-4 precursor (GFR-alpha-4) (Persephin receptor).

GFRA3_MOUSE
NC score	0.636095 (rank : 4)	θ value	4.59992e-12 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	10
SwissProt Accessions	O35118, O35325, O55243, Q6NZC2, Q8C8L9	Gene names	Gfra3
Domain Architecture	No domain graphic available
Description	GDNF family receptor alpha-3 precursor (GFR-alpha-3).

GFRA1_HUMAN
NC score	0.626376 (rank : 5)	θ value	1.86753e-13 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P56159, O15507, O43912	Gene names	GFRA1, GDNFRA, RETL1, TRNR1
Domain Architecture
Description	GDNF family receptor alpha-1 precursor (GFR-alpha-1) (GDNF receptor alpha) (GDNFR-alpha) (TGF-beta-related neurotrophic factor receptor 1) (RET ligand 1).

GFRA3_HUMAN
NC score	0.625437 (rank : 6)	θ value	5.08577e-11 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	10
SwissProt Accessions	O60609, Q6UW20, Q8IUZ2	Gene names	GFRA3
Domain Architecture
Description	GDNF family receptor alpha-3 precursor (GFR-alpha-3).

GFRA1_MOUSE
NC score	0.620514 (rank : 7)	θ value	1.2105e-12 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	15	Shared Neighborhood Hits	10
SwissProt Accessions	P97785	Gene names	Gfra1, Gdnfra, Trnr1
Domain Architecture
Description	GDNF family receptor alpha-1 precursor (GFR-alpha-1) (GDNF receptor alpha) (GDNFR-alpha) (TGF-beta-related neurotrophic factor receptor 1).

GFRA4_HUMAN
NC score	0.610361 (rank : 8)	θ value	5.26297e-08 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	21	Shared Neighborhood Hits	12
SwissProt Accessions	Q9GZZ7, Q9H191, Q9H192	Gene names	GFRA4
Domain Architecture
Description	GDNF family receptor alpha-4 precursor (GFR-alpha-4) (Persephin receptor).

GFRA2_HUMAN
NC score	0.609864 (rank : 9)	θ value	6.00763e-12 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	O00451, O15316, O15328, Q7Z5C2	Gene names	GFRA2, GDNFRB, RETL2, TRNR2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta) (RET ligand 2).

GFRA2_MOUSE
NC score	0.606670 (rank : 10)	θ value	1.74796e-11 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	O08842	Gene names	Gfra2, Gdnfrb, Trnr2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta).

GAS1_MOUSE
NC score	0.145343 (rank : 11)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q01721	Gene names	Gas1, Gas-1
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 1 precursor (GAS-1).

GAS1_HUMAN
NC score	0.082920 (rank : 12)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	P54826	Gene names	GAS1
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 1 precursor (GAS-1).

BMPER_MOUSE
NC score	0.053801 (rank : 13)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

UTP20_MOUSE
NC score	0.047528 (rank : 14)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XG71, Q80V22, Q8BXH9, Q8CHL6, Q99K11	Gene names	Utp20, Drim
Domain Architecture	No domain graphic available
Description	Small subunit processome component 20 homolog (Down-regulated in metastasis protein).

BMPER_HUMAN
NC score	0.042110 (rank : 15)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	175	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

ZAN_MOUSE
NC score	0.021102 (rank : 16)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	808	Shared Neighborhood Hits	12
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

KR107_HUMAN
NC score	0.019165 (rank : 17)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	330	Shared Neighborhood Hits	8
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR104_HUMAN
NC score	0.016261 (rank : 18)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	313	Shared Neighborhood Hits	8
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

STAB1_MOUSE
NC score	0.013929 (rank : 19)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	566	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R4Y4, Q8K0K6, Q8VC09	Gene names	Stab1, Feel1
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein).

NOTC2_MOUSE
NC score	0.009949 (rank : 20)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	1069	Shared Neighborhood Hits	11
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

FA7_MOUSE
NC score	0.006816 (rank : 21)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	374	Shared Neighborhood Hits	6
SwissProt Accessions	P70375, Q61109	Gene names	F7, Cf7
Domain Architecture
Description	Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Contains: Factor VII light chain; Factor VII heavy chain].

TMPS6_HUMAN
NC score	0.006017 (rank : 22)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	338	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).