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Network neighborhood for query Sequence : F264_HUMAN

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F264_HUMAN
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

F261_HUMAN
θ value	0 (rank : 1)	NC score	0.991853 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	9
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_HUMAN
θ value	0 (rank : 2)	NC score	0.990773 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F263_HUMAN
θ value	0 (rank : 3)	NC score	0.988875 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q16875, O43622, O75902	Gene names	PFKFB3
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (NY-REN-56 antigen) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6- bisphosphatase (EC 3.1.3.46)].

F264_HUMAN
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_MOUSE
θ value	1.11414e-183 (rank : 5)	NC score	0.990585 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

PGAM1_HUMAN
θ value	0.000602161 (rank : 6)	NC score	0.151987 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
θ value	0.000602161 (rank : 7)	NC score	0.151938 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM4_HUMAN
θ value	0.0148317 (rank : 8)	NC score	0.120333 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

PGAM2_MOUSE
θ value	0.0252991 (rank : 9)	NC score	0.148119 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM2_HUMAN
θ value	0.0330416 (rank : 10)	NC score	0.145595 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

CN37_HUMAN
θ value	1.06291 (rank : 11)	NC score	0.089180 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P09543	Gene names	CNP
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

DHE4_HUMAN
θ value	1.38821 (rank : 12)	NC score	0.026608 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P49448, Q9UDQ4	Gene names	GLUD2, GLUDP1
Domain Architecture
Description	Glutamate dehydrogenase 2, mitochondrial precursor (EC 1.4.1.3) (GDH).

CN37_MOUSE
θ value	1.81305 (rank : 13)	NC score	0.073227 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P16330, Q61424, Q8C7C9, Q91V42, Q923F3	Gene names	Cnp, Cnp1
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

GABPA_HUMAN
θ value	1.81305 (rank : 14)	NC score	0.015994 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q06546, Q12939	Gene names	GABPA, E4TF1A
Domain Architecture
Description	GA-binding protein alpha chain (GABP-subunit alpha) (Transcription factor E4TF1-60) (Nuclear respiratory factor 2 subunit alpha).

IL3RB_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.014457 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

GABPA_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.013506 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q00422	Gene names	Gabpa, E4tf1a
Domain Architecture
Description	GA-binding protein alpha chain (GABP-subunit alpha).

DHE3_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.019862 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P26443, Q8C273	Gene names	Glud1, Glud
Domain Architecture
Description	Glutamate dehydrogenase 1, mitochondrial precursor (EC 1.4.1.3) (GDH).

SYYC_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.009385 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WQ3, Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183	Gene names	Yars
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

PMGE_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.087189 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P07738	Gene names	BPGM
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

PMGE_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.086500 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	P15327, Q543Z6	Gene names	Bpgm
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

Hits sorted by NC score

F264_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F261_HUMAN
NC score	0.991853 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	9
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_HUMAN
NC score	0.990773 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	11
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_MOUSE
NC score	0.990585 (rank : 4)	θ value	1.11414e-183 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	23	Shared Neighborhood Hits	11
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F263_HUMAN
NC score	0.988875 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q16875, O43622, O75902	Gene names	PFKFB3
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (NY-REN-56 antigen) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6- bisphosphatase (EC 3.1.3.46)].

PGAM1_HUMAN
NC score	0.151987 (rank : 6)	θ value	0.000602161 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
NC score	0.151938 (rank : 7)	θ value	0.000602161 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM2_MOUSE
NC score	0.148119 (rank : 8)	θ value	0.0252991 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM2_HUMAN
NC score	0.145595 (rank : 9)	θ value	0.0330416 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM4_HUMAN
NC score	0.120333 (rank : 10)	θ value	0.0148317 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

CN37_HUMAN
NC score	0.089180 (rank : 11)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P09543	Gene names	CNP
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

PMGE_HUMAN
NC score	0.087189 (rank : 12)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	P07738	Gene names	BPGM
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

PMGE_MOUSE
NC score	0.086500 (rank : 13)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	P15327, Q543Z6	Gene names	Bpgm
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

CN37_MOUSE
NC score	0.073227 (rank : 14)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	P16330, Q61424, Q8C7C9, Q91V42, Q923F3	Gene names	Cnp, Cnp1
Domain Architecture
Description	2',3'-cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37) (CNP) (CNPase).

DHE4_HUMAN
NC score	0.026608 (rank : 15)	θ value	1.38821 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P49448, Q9UDQ4	Gene names	GLUD2, GLUDP1
Domain Architecture
Description	Glutamate dehydrogenase 2, mitochondrial precursor (EC 1.4.1.3) (GDH).

DHE3_MOUSE
NC score	0.019862 (rank : 16)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P26443, Q8C273	Gene names	Glud1, Glud
Domain Architecture
Description	Glutamate dehydrogenase 1, mitochondrial precursor (EC 1.4.1.3) (GDH).

GABPA_HUMAN
NC score	0.015994 (rank : 17)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q06546, Q12939	Gene names	GABPA, E4TF1A
Domain Architecture
Description	GA-binding protein alpha chain (GABP-subunit alpha) (Transcription factor E4TF1-60) (Nuclear respiratory factor 2 subunit alpha).

IL3RB_HUMAN
NC score	0.014457 (rank : 18)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	P32927	Gene names	CSF2RB, IL3RB, IL5RB
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131).

GABPA_MOUSE
NC score	0.013506 (rank : 19)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q00422	Gene names	Gabpa, E4tf1a
Domain Architecture
Description	GA-binding protein alpha chain (GABP-subunit alpha).

SYYC_MOUSE
NC score	0.009385 (rank : 20)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WQ3, Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183	Gene names	Yars
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).