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Network neighborhood for query Sequence : PGAM1_HUMAN

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PGAM1_HUMAN
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PGAM1_HUMAN
θ value	8.35901e-139 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
θ value	2.4321e-138 (rank : 2)	NC score	0.999961 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM4_HUMAN
θ value	2.20485e-131 (rank : 3)	NC score	0.998353 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

PGAM2_HUMAN
θ value	2.70151e-121 (rank : 4)	NC score	0.997846 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM2_MOUSE
θ value	4.31301e-119 (rank : 5)	NC score	0.998005 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PMGE_HUMAN
θ value	5.50685e-82 (rank : 6)	NC score	0.982387 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	P07738	Gene names	BPGM
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

PMGE_MOUSE
θ value	1.65806e-78 (rank : 7)	NC score	0.980695 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	P15327, Q543Z6	Gene names	Bpgm
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

F264_HUMAN
θ value	0.000602161 (rank : 8)	NC score	0.151987 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

CL005_MOUSE
θ value	0.0431538 (rank : 9)	NC score	0.236117 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BZA9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C12orf5 homolog.

CL005_HUMAN
θ value	0.0736092 (rank : 10)	NC score	0.248830 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQ88	Gene names	C12orf5
Domain Architecture	No domain graphic available
Description	Protein C12orf5.

STS1_HUMAN
θ value	0.125558 (rank : 11)	NC score	0.119071 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	0.163984 (rank : 12)	NC score	0.106302 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	104	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

F261_HUMAN
θ value	1.06291 (rank : 13)	NC score	0.083162 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.087690 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.078551 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

FMO6_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.006682 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	O60774	Gene names	FMO6
Domain Architecture
Description	Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC 1.14.13.8) (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6).

F263_HUMAN
θ value	θ > 10 (rank : 17)	NC score	0.051169 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q16875, O43622, O75902	Gene names	PFKFB3
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (NY-REN-56 antigen) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6- bisphosphatase (EC 3.1.3.46)].

Hits sorted by NC score

PGAM1_HUMAN
NC score	0.999962 (rank : 1)	θ value	8.35901e-139 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
NC score	0.999961 (rank : 2)	θ value	2.4321e-138 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM4_HUMAN
NC score	0.998353 (rank : 3)	θ value	2.20485e-131 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

PGAM2_MOUSE
NC score	0.998005 (rank : 4)	θ value	4.31301e-119 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM2_HUMAN
NC score	0.997846 (rank : 5)	θ value	2.70151e-121 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PMGE_HUMAN
NC score	0.982387 (rank : 6)	θ value	5.50685e-82 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	P07738	Gene names	BPGM
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

PMGE_MOUSE
NC score	0.980695 (rank : 7)	θ value	1.65806e-78 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	P15327, Q543Z6	Gene names	Bpgm
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

CL005_HUMAN
NC score	0.248830 (rank : 8)	θ value	0.0736092 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQ88	Gene names	C12orf5
Domain Architecture	No domain graphic available
Description	Protein C12orf5.

CL005_MOUSE
NC score	0.236117 (rank : 9)	θ value	0.0431538 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BZA9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C12orf5 homolog.

F264_HUMAN
NC score	0.151987 (rank : 10)	θ value	0.000602161 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

STS1_HUMAN
NC score	0.119071 (rank : 11)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	106	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.106302 (rank : 12)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	104	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

F262_HUMAN
NC score	0.087690 (rank : 13)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F261_HUMAN
NC score	0.083162 (rank : 14)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_MOUSE
NC score	0.078551 (rank : 15)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F263_HUMAN
NC score	0.051169 (rank : 16)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q16875, O43622, O75902	Gene names	PFKFB3
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) (NY-REN-56 antigen) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6- bisphosphatase (EC 3.1.3.46)].

FMO6_HUMAN
NC score	0.006682 (rank : 17)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	O60774	Gene names	FMO6
Domain Architecture
Description	Putative dimethylaniline monooxygenase [N-oxide-forming] 6 (EC 1.14.13.8) (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6).