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Network neighborhood for query Sequence : PGAM2_HUMAN

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PGAM2_HUMAN
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PGAM2_HUMAN
θ value	2.19465e-147 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM2_MOUSE
θ value	1.4755e-135 (rank : 2)	NC score	0.999547 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM1_HUMAN
θ value	2.70151e-121 (rank : 3)	NC score	0.997846 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
θ value	7.86017e-121 (rank : 4)	NC score	0.997826 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM4_HUMAN
θ value	3.77839e-115 (rank : 5)	NC score	0.996738 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

PMGE_HUMAN
θ value	3.34088e-79 (rank : 6)	NC score	0.981670 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	P07738	Gene names	BPGM
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

PMGE_MOUSE
θ value	6.96618e-77 (rank : 7)	NC score	0.979478 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P15327, Q543Z6	Gene names	Bpgm
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

CL005_HUMAN
θ value	0.00665767 (rank : 8)	NC score	0.260111 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQ88	Gene names	C12orf5
Domain Architecture	No domain graphic available
Description	Protein C12orf5.

F264_HUMAN
θ value	0.0330416 (rank : 9)	NC score	0.145595 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

CL005_MOUSE
θ value	0.0431538 (rank : 10)	NC score	0.244277 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BZA9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C12orf5 homolog.

F262_HUMAN
θ value	0.21417 (rank : 11)	NC score	0.084622 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F262_MOUSE
θ value	1.38821 (rank : 12)	NC score	0.075238 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

STS1_HUMAN
θ value	2.36792 (rank : 13)	NC score	0.089835 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

F261_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.077733 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

INOC1_MOUSE
θ value	8.99809 (rank : 15)	NC score	0.006125 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPV2, Q6P7V0, Q6PCP1, Q8C9T7	Gene names	Inoc1, Kiaa1259
Domain Architecture	No domain graphic available
Description	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-).

MRC2_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.003541 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	162	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBG0, Q7LGE7, Q9Y5P9	Gene names	MRC2, ENDO180, KIAA0709, UPARAP
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Urokinase receptor-associated protein) (Endocytic receptor 180) (CD280 antigen).

STS1_MOUSE
θ value	θ > 10 (rank : 17)	NC score	0.076484 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

Hits sorted by NC score

PGAM2_HUMAN
NC score	0.999962 (rank : 1)	θ value	2.19465e-147 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P15259	Gene names	PGAM2, PGAMM
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM2_MOUSE
NC score	0.999547 (rank : 2)	θ value	1.4755e-135 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	15
SwissProt Accessions	O70250	Gene names	Pgam2
Domain Architecture
Description	Phosphoglycerate mutase 2 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme M) (PGAM-M) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase).

PGAM1_HUMAN
NC score	0.997846 (rank : 3)	θ value	2.70151e-121 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	P18669, Q9BWC0	Gene names	PGAM1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM1_MOUSE
NC score	0.997826 (rank : 4)	θ value	7.86017e-121 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBJ1, Q9D6W0, Q9ERT3	Gene names	Pgam1
Domain Architecture
Description	Phosphoglycerate mutase 1 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13) (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1).

PGAM4_HUMAN
NC score	0.996738 (rank : 5)	θ value	3.77839e-115 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N0Y7, Q8NI24, Q8NI25, Q8NI26	Gene names	PGAM4, PGAM3
Domain Architecture
Description	Probable phosphoglycerate mutase 4 (EC 5.4.2.1) (EC 5.4.2.4) (EC 3.1.3.13).

PMGE_HUMAN
NC score	0.981670 (rank : 6)	θ value	3.34088e-79 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	P07738	Gene names	BPGM
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

PMGE_MOUSE
NC score	0.979478 (rank : 7)	θ value	6.96618e-77 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	P15327, Q543Z6	Gene names	Bpgm
Domain Architecture
Description	Bisphosphoglycerate mutase (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (BPGM) (EC 5.4.2.1) (EC 3.1.3.13) (BPG-dependent PGAM).

CL005_HUMAN
NC score	0.260111 (rank : 8)	θ value	0.00665767 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQ88	Gene names	C12orf5
Domain Architecture	No domain graphic available
Description	Protein C12orf5.

CL005_MOUSE
NC score	0.244277 (rank : 9)	θ value	0.0431538 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	13	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BZA9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C12orf5 homolog.

F264_HUMAN
NC score	0.145595 (rank : 10)	θ value	0.0330416 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q16877	Gene names	PFKFB4
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

STS1_HUMAN
NC score	0.089835 (rank : 11)	θ value	2.36792 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

F262_HUMAN
NC score	0.084622 (rank : 12)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	O60825, O60824, Q9H3P1	Gene names	PFKFB2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

F261_HUMAN
NC score	0.077733 (rank : 13)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

STS1_MOUSE
NC score	0.076484 (rank : 14)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

F262_MOUSE
NC score	0.075238 (rank : 15)	θ value	1.38821 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	8
SwissProt Accessions	P70265, Q8VEI9	Gene names	Pfkfb2
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru- 2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

INOC1_MOUSE
NC score	0.006125 (rank : 16)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPV2, Q6P7V0, Q6PCP1, Q8C9T7	Gene names	Inoc1, Kiaa1259
Domain Architecture	No domain graphic available
Description	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-).

MRC2_HUMAN
NC score	0.003541 (rank : 17)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	162	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBG0, Q7LGE7, Q9Y5P9	Gene names	MRC2, ENDO180, KIAA0709, UPARAP
Domain Architecture	No domain graphic available
Description	Macrophage mannose receptor 2 precursor (Urokinase receptor-associated protein) (Endocytic receptor 180) (CD280 antigen).