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Network neighborhood for query Sequence : EDEM2_HUMAN

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EDEM2_HUMAN
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EDEM2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

EDEM1_MOUSE
θ value	3.21347e-98 (rank : 2)	NC score	0.960813 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_HUMAN
θ value	7.15887e-98 (rank : 3)	NC score	0.961903 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM3_HUMAN
θ value	2.47191e-82 (rank : 4)	NC score	0.927857 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

MA1A1_MOUSE
θ value	7.25919e-50 (rank : 5)	NC score	0.880031 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A1_HUMAN
θ value	4.40402e-47 (rank : 6)	NC score	0.879240 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	P33908, Q9NU44, Q9UJI3	Gene names	MAN1A1
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1B1_HUMAN
θ value	5.03882e-43 (rank : 7)	NC score	0.884530 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

MA1C1_HUMAN
θ value	6.58091e-43 (rank : 8)	NC score	0.881438 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

MA1A2_HUMAN
θ value	2.76489e-41 (rank : 9)	NC score	0.873601 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	O60476, Q9H510	Gene names	MAN1A2, MAN1B
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1A2_MOUSE
θ value	4.71619e-41 (rank : 10)	NC score	0.871812 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P39098, Q5SUY6, Q5SUY7, Q60599, Q9CUY9	Gene names	Man1a2, Man1b
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

FGD2_MOUSE
θ value	0.0113563 (rank : 11)	NC score	0.025634 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

MSLN_HUMAN
θ value	1.38821 (rank : 12)	NC score	0.034634 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q13421, Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UK57	Gene names	MSLN, MPF
Domain Architecture
Description	Mesothelin precursor (Pre-pro-megakaryocyte potentiating factor) (CAK1 antigen) [Contains: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form].

TRPM6_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.010801 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	91	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

CCD93_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.006432 (rank : 18)
Query Neighborhood Hits	16	Target Neighborhood Hits	600	Shared Neighborhood Hits	2
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

DPOG1_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.012275 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P54098, Q8NFM2, Q92515	Gene names	POLG, MDP1, POLG1, POLGA
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

MSLN_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.023793 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q61468	Gene names	Msln, Mes, Mpf
Domain Architecture	No domain graphic available
Description	Mesothelin precursor (Pre-pro-megakaryocyte potentiating factor) [Contains: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form].

PAP21_HUMAN
θ value	θ > 10 (rank : 17)	NC score	0.051889 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

PAP21_MOUSE
θ value	θ > 10 (rank : 18)	NC score	0.051916 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

Hits sorted by NC score

EDEM2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

EDEM1_HUMAN
NC score	0.961903 (rank : 2)	θ value	7.15887e-98 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_MOUSE
NC score	0.960813 (rank : 3)	θ value	3.21347e-98 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	23	Shared Neighborhood Hits	10
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM3_HUMAN
NC score	0.927857 (rank : 4)	θ value	2.47191e-82 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

MA1B1_HUMAN
NC score	0.884530 (rank : 5)	θ value	5.03882e-43 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

MA1C1_HUMAN
NC score	0.881438 (rank : 6)	θ value	6.58091e-43 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

MA1A1_MOUSE
NC score	0.880031 (rank : 7)	θ value	7.25919e-50 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	P45700	Gene names	Man1a1, Man1a
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A1_HUMAN
NC score	0.879240 (rank : 8)	θ value	4.40402e-47 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	P33908, Q9NU44, Q9UJI3	Gene names	MAN1A1
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).

MA1A2_HUMAN
NC score	0.873601 (rank : 9)	θ value	2.76489e-41 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	O60476, Q9H510	Gene names	MAN1A2, MAN1B
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

MA1A2_MOUSE
NC score	0.871812 (rank : 10)	θ value	4.71619e-41 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P39098, Q5SUY6, Q5SUY7, Q60599, Q9CUY9	Gene names	Man1a2, Man1b
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB) (Mannosidase alpha class 1A member 2).

PAP21_MOUSE
NC score	0.051916 (rank : 11)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

PAP21_HUMAN
NC score	0.051889 (rank : 12)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

MSLN_HUMAN
NC score	0.034634 (rank : 13)	θ value	1.38821 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q13421, Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2, Q9UK57	Gene names	MSLN, MPF
Domain Architecture
Description	Mesothelin precursor (Pre-pro-megakaryocyte potentiating factor) (CAK1 antigen) [Contains: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form].

FGD2_MOUSE
NC score	0.025634 (rank : 14)	θ value	0.0113563 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

MSLN_MOUSE
NC score	0.023793 (rank : 15)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q61468	Gene names	Msln, Mes, Mpf
Domain Architecture	No domain graphic available
Description	Mesothelin precursor (Pre-pro-megakaryocyte potentiating factor) [Contains: Megakaryocyte-potentiating factor (MPF); Mesothelin, cleaved form].

DPOG1_HUMAN
NC score	0.012275 (rank : 16)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P54098, Q8NFM2, Q92515	Gene names	POLG, MDP1, POLG1, POLGA
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

TRPM6_HUMAN
NC score	0.010801 (rank : 17)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	91	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

CCD93_HUMAN
NC score	0.006432 (rank : 18)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	600	Shared Neighborhood Hits	2
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.