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Network neighborhood for query Sequence : PAP21_HUMAN

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PAP21_HUMAN
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PAP21_HUMAN
θ value	3.65967e-110 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

PAP21_MOUSE
θ value	2.89973e-107 (rank : 2)	NC score	0.999925 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

EDEM3_HUMAN
θ value	2.88788e-06 (rank : 3)	NC score	0.200445 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

RN133_HUMAN
θ value	0.0961366 (rank : 4)	NC score	0.119117 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	108	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WVZ7, Q8N7G7	Gene names	RNF133
Domain Architecture	No domain graphic available
Description	RING finger protein 133.

PSL2_MOUSE
θ value	0.163984 (rank : 5)	NC score	0.137026 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JJF9, Q8R354	Gene names	Sppl2a, Psl2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (SPP-like 2A protein) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

PSL1_HUMAN
θ value	1.06291 (rank : 6)	NC score	0.101786 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	650	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PSL1_MOUSE
θ value	1.06291 (rank : 7)	NC score	0.124794 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q3TD49, Q3TLQ8, Q3UG60, Q80VZ6	Gene names	Sppl2b
Domain Architecture	No domain graphic available
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b).

PSL2_HUMAN
θ value	1.06291 (rank : 8)	NC score	0.123963 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TCT8, Q8TAW1, Q96SZ8	Gene names	SPPL2A, PSL2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

RN167_MOUSE
θ value	1.81305 (rank : 9)	NC score	0.058433 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q91XF4, Q3U4S5	Gene names	Rnf167
Domain Architecture	No domain graphic available
Description	RING finger protein 167 precursor.

GOLI_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.051718 (rank : 14)
Query Neighborhood Hits	11	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).

GOLI_MOUSE
θ value	8.99809 (rank : 11)	NC score	0.051740 (rank : 13)
Query Neighborhood Hits	11	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

EDEM1_HUMAN
θ value	θ > 10 (rank : 12)	NC score	0.052678 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	24	Shared Neighborhood Hits	1
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_MOUSE
θ value	θ > 10 (rank : 13)	NC score	0.052740 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	23	Shared Neighborhood Hits	1
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM2_HUMAN
θ value	θ > 10 (rank : 14)	NC score	0.051889 (rank : 12)
Query Neighborhood Hits	11	Target Neighborhood Hits	16	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

Hits sorted by NC score

PAP21_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.65967e-110 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

PAP21_MOUSE
NC score	0.999925 (rank : 2)	θ value	2.89973e-107 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

EDEM3_HUMAN
NC score	0.200445 (rank : 3)	θ value	2.88788e-06 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

PSL2_MOUSE
NC score	0.137026 (rank : 4)	θ value	0.163984 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JJF9, Q8R354	Gene names	Sppl2a, Psl2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (SPP-like 2A protein) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

PSL1_MOUSE
NC score	0.124794 (rank : 5)	θ value	1.06291 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q3TD49, Q3TLQ8, Q3UG60, Q80VZ6	Gene names	Sppl2b
Domain Architecture	No domain graphic available
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b).

PSL2_HUMAN
NC score	0.123963 (rank : 6)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TCT8, Q8TAW1, Q96SZ8	Gene names	SPPL2A, PSL2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

RN133_HUMAN
NC score	0.119117 (rank : 7)	θ value	0.0961366 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	108	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WVZ7, Q8N7G7	Gene names	RNF133
Domain Architecture	No domain graphic available
Description	RING finger protein 133.

PSL1_HUMAN
NC score	0.101786 (rank : 8)	θ value	1.06291 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	650	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RN167_MOUSE
NC score	0.058433 (rank : 9)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q91XF4, Q3U4S5	Gene names	Rnf167
Domain Architecture	No domain graphic available
Description	RING finger protein 167 precursor.

EDEM1_MOUSE
NC score	0.052740 (rank : 10)	θ value	θ > 10 (rank : 13)
Query Neighborhood Hits	11	Target Neighborhood Hits	23	Shared Neighborhood Hits	1
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM1_HUMAN
NC score	0.052678 (rank : 11)	θ value	θ > 10 (rank : 12)
Query Neighborhood Hits	11	Target Neighborhood Hits	24	Shared Neighborhood Hits	1
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EDEM2_HUMAN
NC score	0.051889 (rank : 12)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	11	Target Neighborhood Hits	16	Shared Neighborhood Hits	1
SwissProt Accessions	Q9BV94, Q6IA89, Q6UWZ4, Q9H4U0, Q9H886, Q9NTL9, Q9NVE6	Gene names	EDEM2, C20orf31, C20orf49
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 2 precursor.

GOLI_MOUSE
NC score	0.051740 (rank : 13)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

GOLI_HUMAN
NC score	0.051718 (rank : 14)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).