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Network neighborhood for query Sequence : PSL2_HUMAN

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PSL2_HUMAN
SwissProt Accessions	Q8TCT8, Q8TAW1, Q96SZ8	Gene names	SPPL2A, PSL2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PSL2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCT8, Q8TAW1, Q96SZ8	Gene names	SPPL2A, PSL2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

PSL2_MOUSE
θ value	0 (rank : 2)	NC score	0.996976 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJF9, Q8R354	Gene names	Sppl2a, Psl2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (SPP-like 2A protein) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

PSL1_MOUSE
θ value	5.61992e-127 (rank : 3)	NC score	0.973681 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q3TD49, Q3TLQ8, Q3UG60, Q80VZ6	Gene names	Sppl2b
Domain Architecture	No domain graphic available
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b).

PSL1_HUMAN
θ value	1.58377e-121 (rank : 4)	NC score	0.804993 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	650	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

HM13_HUMAN
θ value	1.2077e-20 (rank : 5)	NC score	0.707681 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCT9, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5, Q7Z4F2, Q86Y35, Q95H87, Q9H110, Q9H111	Gene names	HM13, H13, IMP1, PSL3, SPP
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3) (hIMP1 protein).

HM13_MOUSE
θ value	6.62687e-19 (rank : 6)	NC score	0.702011 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D8V0, O19444, Q542R3, Q811Z6, Q9CQA4, Q9CSK9	Gene names	Hm13, H13, Psl3
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3).

PSL4_HUMAN
θ value	4.29542e-18 (rank : 7)	NC score	0.697969 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT6, Q8TAU4, Q96DD9	Gene names	SPPL3, PSL4
Domain Architecture
Description	Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3 protein) (Intramembrane protease 2) (IMP2) (Presenilin-like protein 4).

PSL4_MOUSE
θ value	1.24977e-17 (rank : 8)	NC score	0.697071 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CUS9, Q8R597	Gene names	Sppl3, Psl4, Usmg3
Domain Architecture
Description	Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3 protein) (Intramembrane protease 2) (IMP2) (Presenilin-like protein 4).

EDEM3_HUMAN
θ value	0.0961366 (rank : 9)	NC score	0.071494 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

PAP21_HUMAN
θ value	1.06291 (rank : 10)	NC score	0.123963 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

PAP21_MOUSE
θ value	1.06291 (rank : 11)	NC score	0.124012 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

PSN1_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.035345 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	P49768, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0	Gene names	PSEN1, AD3, PS1, PSNL1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN1_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.035361 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P49769, Q91WK6, Q9JLP9	Gene names	Psen1, Ad3h, Psnl1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

KCMA1_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.027731 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCMA1_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.027749 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

MYH6_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.001660 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	1426	Shared Neighborhood Hits	3
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.001423 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	1501	Shared Neighborhood Hits	3
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

PSN2_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.033750 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

TSN12_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.014352 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	O95859	Gene names	TSPAN12, NET2, TM4SF12
Domain Architecture
Description	Tetraspanin-12 (Tspan-12) (Transmembrane 4 superfamily member 12) (Tetraspan NET-2).

PS1C2_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.054018 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	66	Shared Neighborhood Hits	1
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

PS1C2_MOUSE
θ value	θ > 10 (rank : 21)	NC score	0.058302 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	59	Shared Neighborhood Hits	1
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

Hits sorted by NC score

PSL2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCT8, Q8TAW1, Q96SZ8	Gene names	SPPL2A, PSL2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (Protein SPP-like 2A) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

PSL2_MOUSE
NC score	0.996976 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JJF9, Q8R354	Gene names	Sppl2a, Psl2
Domain Architecture
Description	Signal peptide peptidase-like 2A (EC 3.4.23.-) (SPP-like 2A protein) (Protein SPPL2a) (Intramembrane protease 3) (IMP3) (Presenilin-like protein 2).

PSL1_MOUSE
NC score	0.973681 (rank : 3)	θ value	5.61992e-127 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q3TD49, Q3TLQ8, Q3UG60, Q80VZ6	Gene names	Sppl2b
Domain Architecture	No domain graphic available
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b).

PSL1_HUMAN
NC score	0.804993 (rank : 4)	θ value	1.58377e-121 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	650	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

HM13_HUMAN
NC score	0.707681 (rank : 5)	θ value	1.2077e-20 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TCT9, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5, Q7Z4F2, Q86Y35, Q95H87, Q9H110, Q9H111	Gene names	HM13, H13, IMP1, PSL3, SPP
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3) (hIMP1 protein).

HM13_MOUSE
NC score	0.702011 (rank : 6)	θ value	6.62687e-19 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D8V0, O19444, Q542R3, Q811Z6, Q9CQA4, Q9CSK9	Gene names	Hm13, H13, Psl3
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3).

PSL4_HUMAN
NC score	0.697969 (rank : 7)	θ value	4.29542e-18 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TCT6, Q8TAU4, Q96DD9	Gene names	SPPL3, PSL4
Domain Architecture
Description	Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3 protein) (Intramembrane protease 2) (IMP2) (Presenilin-like protein 4).

PSL4_MOUSE
NC score	0.697071 (rank : 8)	θ value	1.24977e-17 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CUS9, Q8R597	Gene names	Sppl3, Psl4, Usmg3
Domain Architecture
Description	Signal peptide peptidase-like 3 (EC 3.4.23.-) (SPP-like 3 protein) (Intramembrane protease 2) (IMP2) (Presenilin-like protein 4).

PAP21_MOUSE
NC score	0.124012 (rank : 9)	θ value	1.06291 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D9N8	Gene names	Pap21
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor.

PAP21_HUMAN
NC score	0.123963 (rank : 10)	θ value	1.06291 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	11	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BSG0	Gene names	PAP21, C2orf7
Domain Architecture	No domain graphic available
Description	Protease-associated domain-containing protein of 21 kDa precursor (hPAP21).

EDEM3_HUMAN
NC score	0.071494 (rank : 11)	θ value	0.0961366 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZQ6, Q5TEZ0, Q9HCW1, Q9UFV7	Gene names	EDEM3, C1orf22
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 3.

PS1C2_MOUSE
NC score	0.058302 (rank : 12)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	19	Target Neighborhood Hits	59	Shared Neighborhood Hits	1
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

PS1C2_HUMAN
NC score	0.054018 (rank : 13)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	66	Shared Neighborhood Hits	1
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

PSN1_MOUSE
NC score	0.035361 (rank : 14)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P49769, Q91WK6, Q9JLP9	Gene names	Psen1, Ad3h, Psnl1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN1_HUMAN
NC score	0.035345 (rank : 15)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	P49768, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0	Gene names	PSEN1, AD3, PS1, PSNL1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN2_HUMAN
NC score	0.033750 (rank : 16)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

KCMA1_MOUSE
NC score	0.027749 (rank : 17)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KCMA1_HUMAN
NC score	0.027731 (rank : 18)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

TSN12_HUMAN
NC score	0.014352 (rank : 19)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	O95859	Gene names	TSPAN12, NET2, TM4SF12
Domain Architecture
Description	Tetraspanin-12 (Tspan-12) (Transmembrane 4 superfamily member 12) (Tetraspan NET-2).

MYH6_HUMAN
NC score	0.001660 (rank : 20)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	1426	Shared Neighborhood Hits	3
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH6_MOUSE
NC score	0.001423 (rank : 21)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	1501	Shared Neighborhood Hits	3
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).