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Network neighborhood for query Sequence : DDHD1_HUMAN

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DDHD1_HUMAN
SwissProt Accessions	Q8NEL9, Q8WVH3, Q96LL2, Q9C0F8	Gene names	DDHD1, KIAA1705
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DDHD1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NEL9, Q8WVH3, Q96LL2, Q9C0F8	Gene names	DDHD1, KIAA1705
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

DDHD1_MOUSE
θ value	0 (rank : 2)	NC score	0.993365 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q80YA3, Q8VEF2	Gene names	Ddhd1
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

S23IP_HUMAN
θ value	8.08199e-25 (rank : 3)	NC score	0.602223 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

S23IP_MOUSE
θ value	7.56453e-23 (rank : 4)	NC score	0.560949 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	363	Shared Neighborhood Hits	14
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

PITM1_HUMAN
θ value	4.0297e-08 (rank : 5)	NC score	0.359202 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

PITM1_MOUSE
θ value	4.0297e-08 (rank : 6)	NC score	0.361828 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

PITM2_MOUSE
θ value	1.29631e-06 (rank : 7)	NC score	0.337168 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZPQ6, Q9R1P5	Gene names	Pitpnm2, Kiaa1457, Nir3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) (Drosophila retinal degeneration B homolog 2) (RdgB2).

PITM3_MOUSE
θ value	1.29631e-06 (rank : 8)	NC score	0.379765 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q3UHE1, Q3UH22, Q5RIT9	Gene names	Pitpnm3, Nir1
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1).

PITM3_HUMAN
θ value	1.69304e-06 (rank : 9)	NC score	0.376992 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BZ71, Q59GH9, Q9NPQ4	Gene names	PITPNM3, NIR1
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1).

PITM2_HUMAN
θ value	2.88788e-06 (rank : 10)	NC score	0.333843 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	52	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BZ72, Q9P271	Gene names	PITPNM2, KIAA1457, NIR3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3).

MBD5_HUMAN
θ value	0.125558 (rank : 11)	NC score	0.083934 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	176	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

T240L_HUMAN
θ value	0.47712 (rank : 12)	NC score	0.051095 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	132	Shared Neighborhood Hits	5
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

T240L_MOUSE
θ value	1.06291 (rank : 13)	NC score	0.048434 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	143	Shared Neighborhood Hits	6
SwissProt Accessions	Q6JPI3, Q3TRF4, Q3UQI8, Q80TM3, Q80WQ0	Gene names	Thrap2, Kiaa1025, Trap240l
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

PHOS_MOUSE
θ value	1.38821 (rank : 14)	NC score	0.050458 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QW08	Gene names	Pdc, Rpr1
Domain Architecture
Description	Phosducin (PHD) (33 kDa phototransducing protein) (Rod photoreceptor 1) (RPR-1).

ABL1_HUMAN
θ value	1.81305 (rank : 15)	NC score	0.002265 (rank : 42)
Query Neighborhood Hits	40	Target Neighborhood Hits	1220	Shared Neighborhood Hits	7
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

MYST3_HUMAN
θ value	1.81305 (rank : 16)	NC score	0.016488 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	772	Shared Neighborhood Hits	5
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

HIF1A_HUMAN
θ value	2.36792 (rank : 17)	NC score	0.019565 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

K1C12_HUMAN
θ value	2.36792 (rank : 18)	NC score	0.008404 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	372	Shared Neighborhood Hits	3
SwissProt Accessions	Q99456	Gene names	KRT12
Domain Architecture
Description	Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12).

MAP4_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.023008 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	409	Shared Neighborhood Hits	8
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

AFF4_MOUSE
θ value	3.0926 (rank : 20)	NC score	0.016737 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	581	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

IQEC1_HUMAN
θ value	3.0926 (rank : 21)	NC score	0.013167 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

SET1A_HUMAN
θ value	3.0926 (rank : 22)	NC score	0.016198 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	690	Shared Neighborhood Hits	6
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SP1_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.002236 (rank : 43)
Query Neighborhood Hits	40	Target Neighborhood Hits	722	Shared Neighborhood Hits	2
SwissProt Accessions	P08047, Q86TN8, Q9H3Q5, Q9NR51, Q9NY21, Q9NYE7	Gene names	SP1, TSFP1
Domain Architecture
Description	Transcription factor Sp1.

SRRM2_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.022996 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	1296	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

DLGP3_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.022255 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	O95886, Q5TDD5, Q9H3X7	Gene names	DLGAP3, DAP3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

DYH5_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.024751 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

HIF1A_MOUSE
θ value	4.03905 (rank : 27)	NC score	0.018310 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

CACB2_HUMAN
θ value	5.27518 (rank : 28)	NC score	0.012053 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

DLGP3_MOUSE
θ value	5.27518 (rank : 29)	NC score	0.021277 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PFD5, Q6PDX0, Q6XBF2	Gene names	Dlgap3, Dap3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

AL7A1_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.008361 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P49419, O14619, Q6IPU8, Q9BUL4	Gene names	ALDH7A1, ATQ1
Domain Architecture
Description	Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Antiquitin-1).

DYH5_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.024472 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

E2AK4_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.002020 (rank : 44)
Query Neighborhood Hits	40	Target Neighborhood Hits	1012	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

MCR_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.008564 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

MCR_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.008830 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

PRP8_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.022451 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P2Q9, O14547, O75965	Gene names	PRPF8, PRPC8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) (PRP8 homolog) (220 kDa U5 snRNP-specific protein) (p220).

PRP8_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.022452 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PV0, Q5ND30, Q5ND31, Q7TQK2, Q8BRZ5, Q8K001	Gene names	Prpf8, Prp8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8).

SRRM2_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.016667 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	1470	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

WBS14_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.015740 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

ANR11_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.005881 (rank : 41)
Query Neighborhood Hits	40	Target Neighborhood Hits	1289	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

LCP2_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.014528 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	531	Shared Neighborhood Hits	9
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PIPNA_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.130726 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q00169	Gene names	PITPNA, PITPN
Domain Architecture
Description	Phosphatidylinositol transfer protein alpha isoform (PtdIns transfer protein alpha) (PtdInsTP) (PI-TP-alpha).

PIPNA_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.131267 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P53810	Gene names	Pitpna, Pitpn
Domain Architecture
Description	Phosphatidylinositol transfer protein alpha isoform (PtdIns transfer protein alpha) (PtdInsTP) (PI-TP-alpha).

PIPNB_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.129146 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	P48739, Q8N5W1	Gene names	PITPNB
Domain Architecture
Description	Phosphatidylinositol transfer protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta).

PIPNB_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.129537 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P53811	Gene names	Pitpnb
Domain Architecture
Description	Phosphatidylinositol transfer protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta).

Hits sorted by NC score

DDHD1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	40	Target Neighborhood Hits	40	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NEL9, Q8WVH3, Q96LL2, Q9C0F8	Gene names	DDHD1, KIAA1705
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

DDHD1_MOUSE
NC score	0.993365 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	40	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q80YA3, Q8VEF2	Gene names	Ddhd1
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

S23IP_HUMAN
NC score	0.602223 (rank : 3)	θ value	8.08199e-25 (rank : 3)
Query Neighborhood Hits	40	Target Neighborhood Hits	134	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y6Y8, Q8IXH5, Q9BUK5	Gene names	SEC23IP
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein (p125).

S23IP_MOUSE
NC score	0.560949 (rank : 4)	θ value	7.56453e-23 (rank : 4)
Query Neighborhood Hits	40	Target Neighborhood Hits	363	Shared Neighborhood Hits	14
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

PITM3_MOUSE
NC score	0.379765 (rank : 5)	θ value	1.29631e-06 (rank : 8)
Query Neighborhood Hits	40	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q3UHE1, Q3UH22, Q5RIT9	Gene names	Pitpnm3, Nir1
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1).

PITM3_HUMAN
NC score	0.376992 (rank : 6)	θ value	1.69304e-06 (rank : 9)
Query Neighborhood Hits	40	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BZ71, Q59GH9, Q9NPQ4	Gene names	PITPNM3, NIR1
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1).

PITM1_MOUSE
NC score	0.361828 (rank : 7)	θ value	4.0297e-08 (rank : 6)
Query Neighborhood Hits	40	Target Neighborhood Hits	69	Shared Neighborhood Hits	11
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

PITM1_HUMAN
NC score	0.359202 (rank : 8)	θ value	4.0297e-08 (rank : 5)
Query Neighborhood Hits	40	Target Neighborhood Hits	129	Shared Neighborhood Hits	14
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

PITM2_MOUSE
NC score	0.337168 (rank : 9)	θ value	1.29631e-06 (rank : 7)
Query Neighborhood Hits	40	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZPQ6, Q9R1P5	Gene names	Pitpnm2, Kiaa1457, Nir3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) (Drosophila retinal degeneration B homolog 2) (RdgB2).

PITM2_HUMAN
NC score	0.333843 (rank : 10)	θ value	2.88788e-06 (rank : 10)
Query Neighborhood Hits	40	Target Neighborhood Hits	52	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BZ72, Q9P271	Gene names	PITPNM2, KIAA1457, NIR3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3).

PIPNA_MOUSE
NC score	0.131267 (rank : 11)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	40	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	P53810	Gene names	Pitpna, Pitpn
Domain Architecture
Description	Phosphatidylinositol transfer protein alpha isoform (PtdIns transfer protein alpha) (PtdInsTP) (PI-TP-alpha).

PIPNA_HUMAN
NC score	0.130726 (rank : 12)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	40	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q00169	Gene names	PITPNA, PITPN
Domain Architecture
Description	Phosphatidylinositol transfer protein alpha isoform (PtdIns transfer protein alpha) (PtdInsTP) (PI-TP-alpha).

PIPNB_MOUSE
NC score	0.129537 (rank : 13)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	40	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P53811	Gene names	Pitpnb
Domain Architecture
Description	Phosphatidylinositol transfer protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta).

PIPNB_HUMAN
NC score	0.129146 (rank : 14)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	40	Target Neighborhood Hits	15	Shared Neighborhood Hits	4
SwissProt Accessions	P48739, Q8N5W1	Gene names	PITPNB
Domain Architecture
Description	Phosphatidylinositol transfer protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta).

MBD5_HUMAN
NC score	0.083934 (rank : 15)	θ value	0.125558 (rank : 11)
Query Neighborhood Hits	40	Target Neighborhood Hits	176	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

T240L_HUMAN
NC score	0.051095 (rank : 16)	θ value	0.47712 (rank : 12)
Query Neighborhood Hits	40	Target Neighborhood Hits	132	Shared Neighborhood Hits	5
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

PHOS_MOUSE
NC score	0.050458 (rank : 17)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	40	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QW08	Gene names	Pdc, Rpr1
Domain Architecture
Description	Phosducin (PHD) (33 kDa phototransducing protein) (Rod photoreceptor 1) (RPR-1).

T240L_MOUSE
NC score	0.048434 (rank : 18)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	40	Target Neighborhood Hits	143	Shared Neighborhood Hits	6
SwissProt Accessions	Q6JPI3, Q3TRF4, Q3UQI8, Q80TM3, Q80WQ0	Gene names	Thrap2, Kiaa1025, Trap240l
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

DYH5_HUMAN
NC score	0.024751 (rank : 19)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	40	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

DYH5_MOUSE
NC score	0.024472 (rank : 20)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	40	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

MAP4_MOUSE
NC score	0.023008 (rank : 21)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	40	Target Neighborhood Hits	409	Shared Neighborhood Hits	8
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

SRRM2_HUMAN
NC score	0.022996 (rank : 22)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	40	Target Neighborhood Hits	1296	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PRP8_MOUSE
NC score	0.022452 (rank : 23)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	40	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PV0, Q5ND30, Q5ND31, Q7TQK2, Q8BRZ5, Q8K001	Gene names	Prpf8, Prp8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8).

PRP8_HUMAN
NC score	0.022451 (rank : 24)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	40	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P2Q9, O14547, O75965	Gene names	PRPF8, PRPC8
Domain Architecture	No domain graphic available
Description	Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) (PRP8 homolog) (220 kDa U5 snRNP-specific protein) (p220).

DLGP3_HUMAN
NC score	0.022255 (rank : 25)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	40	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	O95886, Q5TDD5, Q9H3X7	Gene names	DLGAP3, DAP3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

DLGP3_MOUSE
NC score	0.021277 (rank : 26)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	40	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PFD5, Q6PDX0, Q6XBF2	Gene names	Dlgap3, Dap3
Domain Architecture	No domain graphic available
Description	Disks large-associated protein 3 (DAP-3) (SAP90/PSD-95-associated protein 3) (SAPAP3) (PSD-95/SAP90-binding protein 3).

HIF1A_HUMAN
NC score	0.019565 (rank : 27)	θ value	2.36792 (rank : 17)
Query Neighborhood Hits	40	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
NC score	0.018310 (rank : 28)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	40	Target Neighborhood Hits	90	Shared Neighborhood Hits	6
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

AFF4_MOUSE
NC score	0.016737 (rank : 29)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	40	Target Neighborhood Hits	581	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

SRRM2_MOUSE
NC score	0.016667 (rank : 30)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	40	Target Neighborhood Hits	1470	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

MYST3_HUMAN
NC score	0.016488 (rank : 31)	θ value	1.81305 (rank : 16)
Query Neighborhood Hits	40	Target Neighborhood Hits	772	Shared Neighborhood Hits	5
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

SET1A_HUMAN
NC score	0.016198 (rank : 32)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	40	Target Neighborhood Hits	690	Shared Neighborhood Hits	6
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

WBS14_MOUSE
NC score	0.015740 (rank : 33)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	40	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

LCP2_HUMAN
NC score	0.014528 (rank : 34)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	40	Target Neighborhood Hits	531	Shared Neighborhood Hits	9
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

IQEC1_HUMAN
NC score	0.013167 (rank : 35)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	40	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

CACB2_HUMAN
NC score	0.012053 (rank : 36)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	40	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q08289, O00304, Q8WX81, Q96NZ3, Q96NZ4, Q96NZ5, Q9BWU2, Q9HD32, Q9Y340, Q9Y341	Gene names	CACNB2, CACNLB2, MYSB
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB).

MCR_MOUSE
NC score	0.008830 (rank : 37)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	40	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VII8, Q8VII9	Gene names	Nr3c2, Mlr
Domain Architecture	No domain graphic available
Description	Mineralocorticoid receptor (MR).

MCR_HUMAN
NC score	0.008564 (rank : 38)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	40	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	P08235, Q96KQ8, Q96KQ9	Gene names	NR3C2, MCR, MLR
Domain Architecture
Description	Mineralocorticoid receptor (MR).

K1C12_HUMAN
NC score	0.008404 (rank : 39)	θ value	2.36792 (rank : 18)
Query Neighborhood Hits	40	Target Neighborhood Hits	372	Shared Neighborhood Hits	3
SwissProt Accessions	Q99456	Gene names	KRT12
Domain Architecture
Description	Keratin, type I cytoskeletal 12 (Cytokeratin-12) (CK-12) (Keratin-12) (K12).

AL7A1_HUMAN
NC score	0.008361 (rank : 40)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	40	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	P49419, O14619, Q6IPU8, Q9BUL4	Gene names	ALDH7A1, ATQ1
Domain Architecture
Description	Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Antiquitin-1).

ANR11_HUMAN
NC score	0.005881 (rank : 41)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	40	Target Neighborhood Hits	1289	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ABL1_HUMAN
NC score	0.002265 (rank : 42)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	40	Target Neighborhood Hits	1220	Shared Neighborhood Hits	7
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SP1_HUMAN
NC score	0.002236 (rank : 43)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	40	Target Neighborhood Hits	722	Shared Neighborhood Hits	2
SwissProt Accessions	P08047, Q86TN8, Q9H3Q5, Q9NR51, Q9NY21, Q9NYE7	Gene names	SP1, TSFP1
Domain Architecture
Description	Transcription factor Sp1.

E2AK4_HUMAN
NC score	0.002020 (rank : 44)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	40	Target Neighborhood Hits	1012	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).