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Network neighborhood for query Sequence : UBR1_HUMAN

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UBR1_HUMAN
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UBR1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

UBR1_MOUSE
θ value	0 (rank : 2)	NC score	0.997177 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

UBR2_HUMAN
θ value	0 (rank : 3)	NC score	0.979819 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

UBR2_MOUSE
θ value	0 (rank : 4)	NC score	0.980492 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q6WKZ8, Q6DIB9, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130	Gene names	Ubr2, Kiaa0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

JAK2_HUMAN
θ value	0.0193708 (rank : 5)	NC score	0.016270 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	847	Shared Neighborhood Hits	5
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	0.0563607 (rank : 6)	NC score	0.015067 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	839	Shared Neighborhood Hits	5
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

ZN583_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.006287 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	Q3V080, Q3V3L4	Gene names	Znf583, Zfp583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583.

EDD1_HUMAN
θ value	1.38821 (rank : 8)	NC score	0.036830 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	170	Shared Neighborhood Hits	6
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.036844 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

CCD46_MOUSE
θ value	2.36792 (rank : 10)	NC score	0.004067 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	1405	Shared Neighborhood Hits	6
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

ZN578_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.006223 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	755	Shared Neighborhood Hits	11
SwissProt Accessions	Q96N58	Gene names	ZNF578
Domain Architecture	No domain graphic available
Description	Zinc finger protein 578.

ZN583_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.005266 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	Q96ND8, O14850, Q2NKK3	Gene names	ZNF583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583 (Zinc finger protein L3-5).

CE110_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.025752 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CE110_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.026186 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	170	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSH4, Q6A072	Gene names	Cep110, Cp110, Kiaa0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CNN1_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.016608 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

PP1R8_HUMAN
θ value	3.0926 (rank : 16)	NC score	0.039761 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q12972, Q5TIF2, Q6PKF6, Q9UBH1, Q9UBZ0	Gene names	PPP1R8, ARD1, NIPP1
Domain Architecture
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)].

PP1R8_MOUSE
θ value	3.0926 (rank : 17)	NC score	0.039737 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3G1, Q8C087	Gene names	Ppp1r8, Nipp1
Domain Architecture	No domain graphic available
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8).

PUR6_HUMAN
θ value	3.0926 (rank : 18)	NC score	0.028972 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P22234	Gene names	PAICS, ADE2, AIRC, PAIS
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

PUR6_MOUSE
θ value	3.0926 (rank : 19)	NC score	0.028902 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DCL9	Gene names	Paics
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

ZAN_MOUSE
θ value	3.0926 (rank : 20)	NC score	0.006315 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	808	Shared Neighborhood Hits	3
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ZN283_HUMAN
θ value	3.0926 (rank : 21)	NC score	0.005954 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	760	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N7M2	Gene names	ZNF283
Domain Architecture	No domain graphic available
Description	Zinc finger protein 283.

ANR28_HUMAN
θ value	4.03905 (rank : 22)	NC score	0.005560 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	314	Shared Neighborhood Hits	3
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_MOUSE
θ value	4.03905 (rank : 23)	NC score	0.005482 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	314	Shared Neighborhood Hits	3
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

EDG4_MOUSE
θ value	4.03905 (rank : 24)	NC score	0.010794 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	461	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JL06	Gene names	Edg4, Lpa2
Domain Architecture
Description	Lysophosphatidic acid receptor Edg-4 (LPA receptor 2) (LPA-2).

SYNE1_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.006859 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	1484	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ZN236_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.006294 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	844	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UL36, Q9UL37	Gene names	ZNF236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 236.

CNN3_MOUSE
θ value	5.27518 (rank : 27)	NC score	0.014337 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

COPA_HUMAN
θ value	5.27518 (rank : 28)	NC score	0.011391 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	297	Shared Neighborhood Hits	3
SwissProt Accessions	P53621	Gene names	COPA
Domain Architecture
Description	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEPCOP) (HEP- COP) [Contains: Xenin (Xenopsin-related peptide); Proxenin].

DYDC2_HUMAN
θ value	5.27518 (rank : 29)	NC score	0.035468 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q96IM9, Q5QP07, Q5QP11	Gene names	DYDC2
Domain Architecture	No domain graphic available
Description	DPY30 domain-containing protein 2.

RYR3_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.014845 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

TR10C_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.012218 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	O14798, O14755, Q6UXM5	Gene names	TNFRSF10C, DCR1, LIT, TRAILR3, TRID
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10C precursor (Decoy receptor 1) (DcR1) (Decoy TRAIL receptor without death domain) (TNF- related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (Trail receptor without an intracellular domain) (Lymphocyte inhibitor of TRAIL) (Antagonist decoy receptor for TRAIL/Apo-2L) (CD263 antigen).

UBP34_MOUSE
θ value	5.27518 (rank : 32)	NC score	0.013754 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	189	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

ZN471_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.003850 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	771	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BX82, O75260, Q8N3V1, Q9P2F1	Gene names	ZNF471, ERP1, KIAA1396
Domain Architecture
Description	Zinc finger protein 471 (EZFIT-related protein 1).

ZN572_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.004755 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	754	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z3I7, Q8N1Q0	Gene names	ZNF572
Domain Architecture	No domain graphic available
Description	Zinc finger protein 572.

ZNF34_HUMAN
θ value	5.27518 (rank : 35)	NC score	0.003757 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	760	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZ26	Gene names	ZNF34, KOX32
Domain Architecture	No domain graphic available
Description	Zinc finger protein 34 (Zinc finger protein KOX32).

ENKUR_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.014590 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TC29	Gene names	C10orf63
Domain Architecture	No domain graphic available
Description	Enkurin.

CNN1_MOUSE
θ value	8.99809 (rank : 37)	NC score	0.013216 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CP3AG_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.002161 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q64481	Gene names	Cyp3a16, Cyp3a-16
Domain Architecture
Description	Cytochrome P450 3A16 (EC 1.14.14.1) (CYPIIIA16).

ERBB3_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.003811 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	898	Shared Neighborhood Hits	4
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

GNPAT_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.009355 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	O15228	Gene names	GNPAT, DAPAT, DHAPAT
Domain Architecture
Description	Dihydroxyacetone phosphate acyltransferase (EC 2.3.1.42) (DHAP-AT) (DAP-AT) (Glycerone-phosphate O-acyltransferase) (Acyl- CoA:dihydroxyacetonephosphateacyltransferase).

GOGA5_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.001793 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	1168	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

HKR1_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.004067 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	759	Shared Neighborhood Hits	11
SwissProt Accessions	P10072, Q9BSW9, Q9UM09	Gene names	HKR1
Domain Architecture
Description	Krueppel-related zinc finger protein 1 (Protein HKR1).

IFNK_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.014244 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P0W0, Q5T166	Gene names	IFNK
Domain Architecture	No domain graphic available
Description	Interferon kappa precursor (IFN-kappa).

Hits sorted by NC score

UBR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

UBR1_MOUSE
NC score	0.997177 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	52	Shared Neighborhood Hits	24
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

UBR2_MOUSE
NC score	0.980492 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q6WKZ8, Q6DIB9, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130	Gene names	Ubr2, Kiaa0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

UBR2_HUMAN
NC score	0.979819 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

PP1R8_HUMAN
NC score	0.039761 (rank : 5)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q12972, Q5TIF2, Q6PKF6, Q9UBH1, Q9UBZ0	Gene names	PPP1R8, ARD1, NIPP1
Domain Architecture
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)].

PP1R8_MOUSE
NC score	0.039737 (rank : 6)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3G1, Q8C087	Gene names	Ppp1r8, Nipp1
Domain Architecture	No domain graphic available
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8).

EDD1_MOUSE
NC score	0.036844 (rank : 7)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.036830 (rank : 8)	θ value	1.38821 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	170	Shared Neighborhood Hits	6
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

DYDC2_HUMAN
NC score	0.035468 (rank : 9)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q96IM9, Q5QP07, Q5QP11	Gene names	DYDC2
Domain Architecture	No domain graphic available
Description	DPY30 domain-containing protein 2.

PUR6_HUMAN
NC score	0.028972 (rank : 10)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P22234	Gene names	PAICS, ADE2, AIRC, PAIS
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

PUR6_MOUSE
NC score	0.028902 (rank : 11)	θ value	3.0926 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DCL9	Gene names	Paics
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

CE110_MOUSE
NC score	0.026186 (rank : 12)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	170	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSH4, Q6A072	Gene names	Cep110, Cp110, Kiaa0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CE110_HUMAN
NC score	0.025752 (rank : 13)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CNN1_HUMAN
NC score	0.016608 (rank : 14)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

JAK2_HUMAN
NC score	0.016270 (rank : 15)	θ value	0.0193708 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	847	Shared Neighborhood Hits	5
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
NC score	0.015067 (rank : 16)	θ value	0.0563607 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	839	Shared Neighborhood Hits	5
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

RYR3_HUMAN
NC score	0.014845 (rank : 17)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

ENKUR_HUMAN
NC score	0.014590 (rank : 18)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TC29	Gene names	C10orf63
Domain Architecture	No domain graphic available
Description	Enkurin.

CNN3_MOUSE
NC score	0.014337 (rank : 19)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

IFNK_HUMAN
NC score	0.014244 (rank : 20)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P0W0, Q5T166	Gene names	IFNK
Domain Architecture	No domain graphic available
Description	Interferon kappa precursor (IFN-kappa).

UBP34_MOUSE
NC score	0.013754 (rank : 21)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	189	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

CNN1_MOUSE
NC score	0.013216 (rank : 22)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

TR10C_HUMAN
NC score	0.012218 (rank : 23)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	O14798, O14755, Q6UXM5	Gene names	TNFRSF10C, DCR1, LIT, TRAILR3, TRID
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10C precursor (Decoy receptor 1) (DcR1) (Decoy TRAIL receptor without death domain) (TNF- related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (Trail receptor without an intracellular domain) (Lymphocyte inhibitor of TRAIL) (Antagonist decoy receptor for TRAIL/Apo-2L) (CD263 antigen).

COPA_HUMAN
NC score	0.011391 (rank : 24)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	297	Shared Neighborhood Hits	3
SwissProt Accessions	P53621	Gene names	COPA
Domain Architecture
Description	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEPCOP) (HEP- COP) [Contains: Xenin (Xenopsin-related peptide); Proxenin].

EDG4_MOUSE
NC score	0.010794 (rank : 25)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	461	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JL06	Gene names	Edg4, Lpa2
Domain Architecture
Description	Lysophosphatidic acid receptor Edg-4 (LPA receptor 2) (LPA-2).

GNPAT_HUMAN
NC score	0.009355 (rank : 26)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	O15228	Gene names	GNPAT, DAPAT, DHAPAT
Domain Architecture
Description	Dihydroxyacetone phosphate acyltransferase (EC 2.3.1.42) (DHAP-AT) (DAP-AT) (Glycerone-phosphate O-acyltransferase) (Acyl- CoA:dihydroxyacetonephosphateacyltransferase).

SYNE1_HUMAN
NC score	0.006859 (rank : 27)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	1484	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ZAN_MOUSE
NC score	0.006315 (rank : 28)	θ value	3.0926 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	808	Shared Neighborhood Hits	3
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ZN236_HUMAN
NC score	0.006294 (rank : 29)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	844	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UL36, Q9UL37	Gene names	ZNF236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 236.

ZN583_MOUSE
NC score	0.006287 (rank : 30)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	Q3V080, Q3V3L4	Gene names	Znf583, Zfp583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583.

ZN578_HUMAN
NC score	0.006223 (rank : 31)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	755	Shared Neighborhood Hits	11
SwissProt Accessions	Q96N58	Gene names	ZNF578
Domain Architecture	No domain graphic available
Description	Zinc finger protein 578.

ZN283_HUMAN
NC score	0.005954 (rank : 32)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	760	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N7M2	Gene names	ZNF283
Domain Architecture	No domain graphic available
Description	Zinc finger protein 283.

ANR28_HUMAN
NC score	0.005560 (rank : 33)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	314	Shared Neighborhood Hits	3
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_MOUSE
NC score	0.005482 (rank : 34)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	314	Shared Neighborhood Hits	3
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ZN583_HUMAN
NC score	0.005266 (rank : 35)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	774	Shared Neighborhood Hits	11
SwissProt Accessions	Q96ND8, O14850, Q2NKK3	Gene names	ZNF583
Domain Architecture	No domain graphic available
Description	Zinc finger protein 583 (Zinc finger protein L3-5).

ZN572_HUMAN
NC score	0.004755 (rank : 36)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	754	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z3I7, Q8N1Q0	Gene names	ZNF572
Domain Architecture	No domain graphic available
Description	Zinc finger protein 572.

HKR1_HUMAN
NC score	0.004067 (rank : 37)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	759	Shared Neighborhood Hits	11
SwissProt Accessions	P10072, Q9BSW9, Q9UM09	Gene names	HKR1
Domain Architecture
Description	Krueppel-related zinc finger protein 1 (Protein HKR1).

CCD46_MOUSE
NC score	0.004067 (rank : 38)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	1405	Shared Neighborhood Hits	6
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

ZN471_HUMAN
NC score	0.003850 (rank : 39)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	771	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BX82, O75260, Q8N3V1, Q9P2F1	Gene names	ZNF471, ERP1, KIAA1396
Domain Architecture
Description	Zinc finger protein 471 (EZFIT-related protein 1).

ERBB3_MOUSE
NC score	0.003811 (rank : 40)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	898	Shared Neighborhood Hits	4
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ZNF34_HUMAN
NC score	0.003757 (rank : 41)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	760	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZ26	Gene names	ZNF34, KOX32
Domain Architecture	No domain graphic available
Description	Zinc finger protein 34 (Zinc finger protein KOX32).

CP3AG_MOUSE
NC score	0.002161 (rank : 42)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q64481	Gene names	Cyp3a16, Cyp3a-16
Domain Architecture
Description	Cytochrome P450 3A16 (EC 1.14.14.1) (CYPIIIA16).

GOGA5_HUMAN
NC score	0.001793 (rank : 43)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	1168	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).