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Network neighborhood for query Sequence : PP1R8_HUMAN

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PP1R8_HUMAN
SwissProt Accessions	Q12972, Q5TIF2, Q6PKF6, Q9UBH1, Q9UBZ0	Gene names	PPP1R8, ARD1, NIPP1
Domain Architecture
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PP1R8_HUMAN
θ value	3.04115e-173 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q12972, Q5TIF2, Q6PKF6, Q9UBH1, Q9UBZ0	Gene names	PPP1R8, ARD1, NIPP1
Domain Architecture
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)].

PP1R8_MOUSE
θ value	4.11024e-170 (rank : 2)	NC score	0.996893 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R3G1, Q8C087	Gene names	Ppp1r8, Nipp1
Domain Architecture	No domain graphic available
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8).

SNIP1_HUMAN
θ value	5.62301e-10 (rank : 3)	NC score	0.483403 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

SNIP1_MOUSE
θ value	5.62301e-10 (rank : 4)	NC score	0.476026 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BIZ6, Q3V106, Q8BIZ4	Gene names	Snip1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

NADAP_HUMAN
θ value	4.76016e-09 (rank : 5)	NC score	0.428623 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	208	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

IRS2_MOUSE
θ value	0.62314 (rank : 6)	NC score	0.037033 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	248	Shared Neighborhood Hits	2
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

TAB2_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.050189 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	245	Shared Neighborhood Hits	4
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

NADK_HUMAN
θ value	1.06291 (rank : 8)	NC score	0.091597 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	O95544, Q9H931	Gene names	NADK
Domain Architecture
Description	NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase).

NADK_MOUSE
θ value	1.06291 (rank : 9)	NC score	0.091060 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P58058	Gene names	Nadk
Domain Architecture
Description	NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase).

NCA11_MOUSE
θ value	1.81305 (rank : 10)	NC score	0.013250 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	661	Shared Neighborhood Hits	5
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CSKI1_HUMAN
θ value	3.0926 (rank : 11)	NC score	0.014218 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	997	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

UBR1_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.039761 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

PF21A_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.033070 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	303	Shared Neighborhood Hits	6
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

PF21A_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.032688 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	285	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

UBR1_MOUSE
θ value	4.03905 (rank : 15)	NC score	0.037880 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

RAPH1_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.022031 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	593	Shared Neighborhood Hits	8
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

WBS14_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.030052 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	273	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

CSKI1_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.012752 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	1031	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MILK1_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.009951 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	788	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MYH11_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.002073 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	1777	Shared Neighborhood Hits	4
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PEF1_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.009902 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	135	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBV8	Gene names	PEF1, ABP32
Domain Architecture	No domain graphic available
Description	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta- EF hand domain-containing protein 1).

SF3B2_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.019328 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

Hits sorted by NC score

PP1R8_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.04115e-173 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q12972, Q5TIF2, Q6PKF6, Q9UBH1, Q9UBZ0	Gene names	PPP1R8, ARD1, NIPP1
Domain Architecture
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)].

PP1R8_MOUSE
NC score	0.996893 (rank : 2)	θ value	4.11024e-170 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R3G1, Q8C087	Gene names	Ppp1r8, Nipp1
Domain Architecture	No domain graphic available
Description	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8).

SNIP1_HUMAN
NC score	0.483403 (rank : 3)	θ value	5.62301e-10 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

SNIP1_MOUSE
NC score	0.476026 (rank : 4)	θ value	5.62301e-10 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BIZ6, Q3V106, Q8BIZ4	Gene names	Snip1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

NADAP_HUMAN
NC score	0.428623 (rank : 5)	θ value	4.76016e-09 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	208	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

NADK_HUMAN
NC score	0.091597 (rank : 6)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	O95544, Q9H931	Gene names	NADK
Domain Architecture
Description	NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase).

NADK_MOUSE
NC score	0.091060 (rank : 7)	θ value	1.06291 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P58058	Gene names	Nadk
Domain Architecture
Description	NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase).

TAB2_MOUSE
NC score	0.050189 (rank : 8)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	245	Shared Neighborhood Hits	4
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

UBR1_HUMAN
NC score	0.039761 (rank : 9)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

UBR1_MOUSE
NC score	0.037880 (rank : 10)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

IRS2_MOUSE
NC score	0.037033 (rank : 11)	θ value	0.62314 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	248	Shared Neighborhood Hits	2
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

PF21A_HUMAN
NC score	0.033070 (rank : 12)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	303	Shared Neighborhood Hits	6
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

PF21A_MOUSE
NC score	0.032688 (rank : 13)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	285	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

WBS14_HUMAN
NC score	0.030052 (rank : 14)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	273	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

RAPH1_HUMAN
NC score	0.022031 (rank : 15)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	593	Shared Neighborhood Hits	8
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SF3B2_HUMAN
NC score	0.019328 (rank : 16)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

CSKI1_HUMAN
NC score	0.014218 (rank : 17)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	997	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NCA11_MOUSE
NC score	0.013250 (rank : 18)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	661	Shared Neighborhood Hits	5
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CSKI1_MOUSE
NC score	0.012752 (rank : 19)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	1031	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MILK1_MOUSE
NC score	0.009951 (rank : 20)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	788	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PEF1_HUMAN
NC score	0.009902 (rank : 21)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	135	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBV8	Gene names	PEF1, ABP32
Domain Architecture	No domain graphic available
Description	Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta- EF hand domain-containing protein 1).

MYH11_MOUSE
NC score	0.002073 (rank : 22)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	1777	Shared Neighborhood Hits	4
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).