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Network neighborhood for query Sequence : PUR6_HUMAN

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PUR6_HUMAN
SwissProt Accessions	P22234	Gene names	PAICS, ADE2, AIRC, PAIS
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PUR6_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	6	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P22234	Gene names	PAICS, ADE2, AIRC, PAIS
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

PUR6_MOUSE
θ value	0 (rank : 2)	NC score	0.998170 (rank : 2)
Query Neighborhood Hits	6	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DCL9	Gene names	Paics
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

ACSL5_MOUSE
θ value	3.0926 (rank : 3)	NC score	0.028947 (rank : 4)
Query Neighborhood Hits	6	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8JZR0	Gene names	Acsl5, Facl5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

UBR1_HUMAN
θ value	3.0926 (rank : 4)	NC score	0.028972 (rank : 3)
Query Neighborhood Hits	6	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

STAB2_HUMAN
θ value	5.27518 (rank : 5)	NC score	0.010535 (rank : 6)
Query Neighborhood Hits	6	Target Neighborhood Hits	534	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

ACSL5_HUMAN
θ value	6.88961 (rank : 6)	NC score	0.023314 (rank : 5)
Query Neighborhood Hits	6	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULC5, Q6UX44, Q9UIU4	Gene names	ACSL5, ACS5, FACL5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

Hits sorted by NC score

PUR6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	6	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P22234	Gene names	PAICS, ADE2, AIRC, PAIS
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

PUR6_MOUSE
NC score	0.998170 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	6	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DCL9	Gene names	Paics
Domain Architecture
Description	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)].

UBR1_HUMAN
NC score	0.028972 (rank : 3)	θ value	3.0926 (rank : 4)
Query Neighborhood Hits	6	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWV7, O60708, O75492, Q68DN9, Q8IWY6, Q96JY4	Gene names	UBR1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

ACSL5_MOUSE
NC score	0.028947 (rank : 4)	θ value	3.0926 (rank : 3)
Query Neighborhood Hits	6	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8JZR0	Gene names	Acsl5, Facl5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

ACSL5_HUMAN
NC score	0.023314 (rank : 5)	θ value	6.88961 (rank : 6)
Query Neighborhood Hits	6	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULC5, Q6UX44, Q9UIU4	Gene names	ACSL5, ACS5, FACL5
Domain Architecture
Description	Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5).

STAB2_HUMAN
NC score	0.010535 (rank : 6)	θ value	5.27518 (rank : 5)
Query Neighborhood Hits	6	Target Neighborhood Hits	534	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].