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Network neighborhood for query Sequence : PEO1_HUMAN

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PEO1_HUMAN
SwissProt Accessions	Q96RR1, Q6MZX2, Q96RR0	Gene names	PEO1, C10orf2
Domain Architecture	No domain graphic available
Description	Twinkle protein, mitochondrial precursor (EC 3.6.1.-) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Progressive external ophthalmoplegia 1 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PEO1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RR1, Q6MZX2, Q96RR0	Gene names	PEO1, C10orf2
Domain Architecture	No domain graphic available
Description	Twinkle protein, mitochondrial precursor (EC 3.6.1.-) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Progressive external ophthalmoplegia 1 protein).

PEO1_MOUSE
θ value	0 (rank : 2)	NC score	0.996307 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CIW5, Q8K1Z1	Gene names	Peo1
Domain Architecture	No domain graphic available
Description	Twinkle protein, mitochondrial precursor (EC 3.6.1.-) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Progressive external ophthalmoplegia 1 protein homolog).

CFTR_HUMAN
θ value	0.62314 (rank : 3)	NC score	0.036292 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	P13569	Gene names	CFTR, ABCC7
Domain Architecture
Description	Cystic fibrosis transmembrane conductance regulator (CFTR) (cAMP- dependent chloride channel) (ATP-binding cassette transporter sub- family C member 7).

NALP7_HUMAN
θ value	0.62314 (rank : 4)	NC score	0.029406 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

SMBP2_HUMAN
θ value	2.36792 (rank : 5)	NC score	0.045950 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	107	Shared Neighborhood Hits	9
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

SMBP2_MOUSE
θ value	2.36792 (rank : 6)	NC score	0.045748 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

DHX57_MOUSE
θ value	3.0926 (rank : 7)	NC score	0.034314 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

RHG12_MOUSE
θ value	4.03905 (rank : 8)	NC score	0.016363 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	204	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ABCA9_MOUSE
θ value	5.27518 (rank : 9)	NC score	0.009988 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K449, Q8C114	Gene names	Abca9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

DHX57_HUMAN
θ value	5.27518 (rank : 10)	NC score	0.033691 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	109	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

ERN2_MOUSE
θ value	5.27518 (rank : 11)	NC score	0.009996 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	825	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ABCBB_HUMAN
θ value	6.88961 (rank : 12)	NC score	0.009961 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	O95342, Q9UNB2	Gene names	ABCB11, BSEP
Domain Architecture
Description	Bile salt export pump (ATP-binding cassette sub-family B member 11).

DHX33_MOUSE
θ value	6.88961 (rank : 13)	NC score	0.023792 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VY9, Q8BS50	Gene names	Dhx33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

CFTR_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.018664 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	P26361, Q63893, Q63894, Q9JKQ6	Gene names	Cftr, Abcc7
Domain Architecture
Description	Cystic fibrosis transmembrane conductance regulator (CFTR) (cAMP- dependent chloride channel) (ATP-binding cassette transporter sub- family C member 7).

DHX16_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.029159 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	356	Shared Neighborhood Hits	11
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

DHX34_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.024970 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q14147	Gene names	DHX34, DDX34, KIAA0134
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DHX34_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.022208 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	235	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DHX36_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.026052 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHK9, Q6ZPP7, Q9CSE8	Gene names	Dhx36, Ddx36, Kiaa1488, Mlel1
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

Hits sorted by NC score

PEO1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RR1, Q6MZX2, Q96RR0	Gene names	PEO1, C10orf2
Domain Architecture	No domain graphic available
Description	Twinkle protein, mitochondrial precursor (EC 3.6.1.-) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Progressive external ophthalmoplegia 1 protein).

PEO1_MOUSE
NC score	0.996307 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CIW5, Q8K1Z1	Gene names	Peo1
Domain Architecture	No domain graphic available
Description	Twinkle protein, mitochondrial precursor (EC 3.6.1.-) (T7 gp4-like protein with intramitochondrial nucleoid localization) (T7-like mitochondrial DNA helicase) (Progressive external ophthalmoplegia 1 protein homolog).

SMBP2_HUMAN
NC score	0.045950 (rank : 3)	θ value	2.36792 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	107	Shared Neighborhood Hits	9
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

SMBP2_MOUSE
NC score	0.045748 (rank : 4)	θ value	2.36792 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

CFTR_HUMAN
NC score	0.036292 (rank : 5)	θ value	0.62314 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	104	Shared Neighborhood Hits	6
SwissProt Accessions	P13569	Gene names	CFTR, ABCC7
Domain Architecture
Description	Cystic fibrosis transmembrane conductance regulator (CFTR) (cAMP- dependent chloride channel) (ATP-binding cassette transporter sub- family C member 7).

DHX57_MOUSE
NC score	0.034314 (rank : 6)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P5D3, Q3TS93, Q6NZK4, Q6P1B4, Q8BI63, Q8BIA2, Q8R360	Gene names	Dhx57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

DHX57_HUMAN
NC score	0.033691 (rank : 7)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	109	Shared Neighborhood Hits	12
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

NALP7_HUMAN
NC score	0.029406 (rank : 8)	θ value	0.62314 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

DHX16_HUMAN
NC score	0.029159 (rank : 9)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	356	Shared Neighborhood Hits	11
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

DHX36_MOUSE
NC score	0.026052 (rank : 10)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	114	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHK9, Q6ZPP7, Q9CSE8	Gene names	Dhx36, Ddx36, Kiaa1488, Mlel1
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

DHX34_HUMAN
NC score	0.024970 (rank : 11)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q14147	Gene names	DHX34, DDX34, KIAA0134
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

DHX33_MOUSE
NC score	0.023792 (rank : 12)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VY9, Q8BS50	Gene names	Dhx33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

DHX34_MOUSE
NC score	0.022208 (rank : 13)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	235	Shared Neighborhood Hits	8
SwissProt Accessions	Q9DBV3	Gene names	Dhx34, Ddx34, Kiaa0134
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX34 (EC 3.6.1.-) (DEAH box protein 34).

CFTR_MOUSE
NC score	0.018664 (rank : 14)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	P26361, Q63893, Q63894, Q9JKQ6	Gene names	Cftr, Abcc7
Domain Architecture
Description	Cystic fibrosis transmembrane conductance regulator (CFTR) (cAMP- dependent chloride channel) (ATP-binding cassette transporter sub- family C member 7).

RHG12_MOUSE
NC score	0.016363 (rank : 15)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	204	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ERN2_MOUSE
NC score	0.009996 (rank : 16)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	825	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ABCA9_MOUSE
NC score	0.009988 (rank : 17)	θ value	5.27518 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K449, Q8C114	Gene names	Abca9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

ABCBB_HUMAN
NC score	0.009961 (rank : 18)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	103	Shared Neighborhood Hits	5
SwissProt Accessions	O95342, Q9UNB2	Gene names	ABCB11, BSEP
Domain Architecture
Description	Bile salt export pump (ATP-binding cassette sub-family B member 11).