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Network neighborhood for query Sequence : GPNMB_HUMAN

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GPNMB_HUMAN
SwissProt Accessions	Q14956, Q6UVX1, Q8N1A1	Gene names	GPNMB, HGFIN, NMB
Domain Architecture
Description	Transmembrane glycoprotein NMB precursor (Transmembrane glycoprotein HGFIN).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GPNMB_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q14956, Q6UVX1, Q8N1A1	Gene names	GPNMB, HGFIN, NMB
Domain Architecture
Description	Transmembrane glycoprotein NMB precursor (Transmembrane glycoprotein HGFIN).

GPNMB_MOUSE
θ value	0 (rank : 2)	NC score	0.985487 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q99P91, Q8BVV9, Q8BXL4, Q9QXA0	Gene names	Gpnmb, Dchil, Nmb
Domain Architecture	No domain graphic available
Description	Transmembrane glycoprotein NMB precursor (Dendritic cell-associated transmembrane protein) (DC-HIL).

PME17_MOUSE
θ value	2.11701e-41 (rank : 3)	NC score	0.790487 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q60696	Gene names	Silv, D10H12S53E, Pmel17, Si
Domain Architecture
Description	Melanocyte protein Pmel 17 precursor (Silver locus protein).

PME17_HUMAN
θ value	4.71619e-41 (rank : 4)	NC score	0.760006 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P40967, Q12763, Q14448, Q14817, Q16565	Gene names	SILV, D12S53E, PMEL17
Domain Architecture
Description	Melanocyte protein Pmel 17 precursor (Melanocyte lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (ME20M/ME20S) (ME20- M/ME20-S) (95 kDa melanocyte-specific secreted glycoprotein).

PKD1_HUMAN
θ value	0.0736092 (rank : 5)	NC score	0.092130 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

BAZ2A_MOUSE
θ value	0.125558 (rank : 6)	NC score	0.032482 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	744	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

GIDRP_HUMAN
θ value	0.47712 (rank : 7)	NC score	0.061499 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z5L2, O60598, Q5W0B4, Q5W0B5, Q86VT9, Q8N9H0	Gene names	GIDRP88, C10orf28
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 (Putative mitochondrial space protein 32.1).

TNAP3_HUMAN
θ value	2.36792 (rank : 8)	NC score	0.029857 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	P21580, Q5VXQ7, Q9NSR6	Gene names	TNFAIP3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

IRF3_HUMAN
θ value	3.0926 (rank : 9)	NC score	0.021824 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

MINK1_HUMAN
θ value	4.03905 (rank : 10)	NC score	0.001763 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	1477	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

NGLY1_MOUSE
θ value	4.03905 (rank : 11)	NC score	0.023644 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI78, Q8K113, Q9CTK3	Gene names	Ngly1
Domain Architecture	No domain graphic available
Description	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC 3.5.1.52) (PNGase) (mPNGase) (Peptide:N-glycanase) (N-glycanase 1).

C2TA_MOUSE
θ value	6.88961 (rank : 12)	NC score	0.013480 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

SORC3_HUMAN
θ value	6.88961 (rank : 13)	NC score	0.016715 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_MOUSE
θ value	6.88961 (rank : 14)	NC score	0.016770 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

CP007_MOUSE
θ value	8.99809 (rank : 15)	NC score	0.013431 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	231	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

MAGAC_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.005197 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P43365, Q9NSD3	Gene names	MAGEA12, MAGE12
Domain Architecture
Description	Melanoma-associated antigen 12 (MAGE-12 antigen) (MAGE12F).

TNAP3_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.023825 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q60769	Gene names	Tnfaip3, Tnfip3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

Hits sorted by NC score

GPNMB_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q14956, Q6UVX1, Q8N1A1	Gene names	GPNMB, HGFIN, NMB
Domain Architecture
Description	Transmembrane glycoprotein NMB precursor (Transmembrane glycoprotein HGFIN).

GPNMB_MOUSE
NC score	0.985487 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	40	Shared Neighborhood Hits	7
SwissProt Accessions	Q99P91, Q8BVV9, Q8BXL4, Q9QXA0	Gene names	Gpnmb, Dchil, Nmb
Domain Architecture	No domain graphic available
Description	Transmembrane glycoprotein NMB precursor (Dendritic cell-associated transmembrane protein) (DC-HIL).

PME17_MOUSE
NC score	0.790487 (rank : 3)	θ value	2.11701e-41 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q60696	Gene names	Silv, D10H12S53E, Pmel17, Si
Domain Architecture
Description	Melanocyte protein Pmel 17 precursor (Silver locus protein).

PME17_HUMAN
NC score	0.760006 (rank : 4)	θ value	4.71619e-41 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	P40967, Q12763, Q14448, Q14817, Q16565	Gene names	SILV, D12S53E, PMEL17
Domain Architecture
Description	Melanocyte protein Pmel 17 precursor (Melanocyte lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (ME20M/ME20S) (ME20- M/ME20-S) (95 kDa melanocyte-specific secreted glycoprotein).

PKD1_HUMAN
NC score	0.092130 (rank : 5)	θ value	0.0736092 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	387	Shared Neighborhood Hits	7
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

GIDRP_HUMAN
NC score	0.061499 (rank : 6)	θ value	0.47712 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z5L2, O60598, Q5W0B4, Q5W0B5, Q86VT9, Q8N9H0	Gene names	GIDRP88, C10orf28
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 (Putative mitochondrial space protein 32.1).

BAZ2A_MOUSE
NC score	0.032482 (rank : 7)	θ value	0.125558 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	744	Shared Neighborhood Hits	4
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

TNAP3_HUMAN
NC score	0.029857 (rank : 8)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	58	Shared Neighborhood Hits	3
SwissProt Accessions	P21580, Q5VXQ7, Q9NSR6	Gene names	TNFAIP3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

TNAP3_MOUSE
NC score	0.023825 (rank : 9)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q60769	Gene names	Tnfaip3, Tnfip3
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 3 (EC 3.-.-.-) (Putative DNA-binding protein A20) (Zinc finger protein A20).

NGLY1_MOUSE
NC score	0.023644 (rank : 10)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JI78, Q8K113, Q9CTK3	Gene names	Ngly1
Domain Architecture	No domain graphic available
Description	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC 3.5.1.52) (PNGase) (mPNGase) (Peptide:N-glycanase) (N-glycanase 1).

IRF3_HUMAN
NC score	0.021824 (rank : 11)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

SORC3_MOUSE
NC score	0.016770 (rank : 12)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VI51, Q9CTR4	Gene names	Sorcs3
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

SORC3_HUMAN
NC score	0.016715 (rank : 13)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UPU3, Q5VXF9, Q9NQJ2	Gene names	SORCS3, KIAA1059
Domain Architecture
Description	VPS10 domain-containing receptor SorCS3 precursor.

C2TA_MOUSE
NC score	0.013480 (rank : 14)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

CP007_MOUSE
NC score	0.013431 (rank : 15)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	231	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

MAGAC_HUMAN
NC score	0.005197 (rank : 16)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P43365, Q9NSD3	Gene names	MAGEA12, MAGE12
Domain Architecture
Description	Melanoma-associated antigen 12 (MAGE-12 antigen) (MAGE12F).

MINK1_HUMAN
NC score	0.001763 (rank : 17)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	1477	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).