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Network neighborhood for query Sequence : TY3H_HUMAN

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TY3H_HUMAN
SwissProt Accessions	P07101, Q15585, Q15588, Q15589	Gene names	TH, TYH
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TY3H_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P07101, Q15585, Q15588, Q15589	Gene names	TH, TYH
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

TY3H_MOUSE
θ value	0 (rank : 2)	NC score	0.999128 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	P24529	Gene names	Th
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

PH4H_MOUSE
θ value	1.13238e-127 (rank : 3)	NC score	0.985427 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P16331	Gene names	Pah
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

PH4H_HUMAN
θ value	4.75757e-126 (rank : 4)	NC score	0.985180 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P00439, Q16717, Q8TC14	Gene names	PAH
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

TPH2_HUMAN
θ value	7.10925e-122 (rank : 5)	NC score	0.981123 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWU9	Gene names	TPH2, NTPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

TPH1_HUMAN
θ value	1.02657e-120 (rank : 6)	NC score	0.982214 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	P17752, O95188, O95189, Q16736	Gene names	TPH1, TPH, TRPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

TPH2_MOUSE
θ value	4.31301e-119 (rank : 7)	NC score	0.980452 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGV2	Gene names	Tph2, Ntph
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

TPH1_MOUSE
θ value	9.60843e-119 (rank : 8)	NC score	0.981987 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	P17532	Gene names	Tph1, Tph
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

GFAP_HUMAN
θ value	1.81305 (rank : 9)	NC score	0.003065 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	723	Shared Neighborhood Hits	2
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

PHLPP_HUMAN
θ value	4.03905 (rank : 10)	NC score	0.004458 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	604	Shared Neighborhood Hits	3
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

EDN3_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.011871 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P14138, Q03229	Gene names	EDN3
Domain Architecture
Description	Endothelin-3 precursor (ET-3) (Preproendothelin-3) (PPET3).

K2027_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.008360 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

TEP1_MOUSE
θ value	8.99809 (rank : 13)	NC score	0.003248 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

Hits sorted by NC score

TY3H_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P07101, Q15585, Q15588, Q15589	Gene names	TH, TYH
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

TY3H_MOUSE
NC score	0.999128 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	P24529	Gene names	Th
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

PH4H_MOUSE
NC score	0.985427 (rank : 3)	θ value	1.13238e-127 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P16331	Gene names	Pah
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

PH4H_HUMAN
NC score	0.985180 (rank : 4)	θ value	4.75757e-126 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P00439, Q16717, Q8TC14	Gene names	PAH
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

TPH1_HUMAN
NC score	0.982214 (rank : 5)	θ value	1.02657e-120 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	P17752, O95188, O95189, Q16736	Gene names	TPH1, TPH, TRPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

TPH1_MOUSE
NC score	0.981987 (rank : 6)	θ value	9.60843e-119 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	P17532	Gene names	Tph1, Tph
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

TPH2_HUMAN
NC score	0.981123 (rank : 7)	θ value	7.10925e-122 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWU9	Gene names	TPH2, NTPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

TPH2_MOUSE
NC score	0.980452 (rank : 8)	θ value	4.31301e-119 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CGV2	Gene names	Tph2, Ntph
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

EDN3_HUMAN
NC score	0.011871 (rank : 9)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P14138, Q03229	Gene names	EDN3
Domain Architecture
Description	Endothelin-3 precursor (ET-3) (Preproendothelin-3) (PPET3).

K2027_HUMAN
NC score	0.008360 (rank : 10)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

PHLPP_HUMAN
NC score	0.004458 (rank : 11)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	604	Shared Neighborhood Hits	3
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

TEP1_MOUSE
NC score	0.003248 (rank : 12)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	344	Shared Neighborhood Hits	2
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

GFAP_HUMAN
NC score	0.003065 (rank : 13)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	723	Shared Neighborhood Hits	2
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).