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Network neighborhood for query Sequence : TPH1_HUMAN

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TPH1_HUMAN
SwissProt Accessions	P17752, O95188, O95189, Q16736	Gene names	TPH1, TPH, TRPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TPH1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P17752, O95188, O95189, Q16736	Gene names	TPH1, TPH, TRPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

TPH1_MOUSE
θ value	0 (rank : 2)	NC score	0.999098 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	P17532	Gene names	Tph1, Tph
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

TPH2_HUMAN
θ value	0 (rank : 3)	NC score	0.996531 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWU9	Gene names	TPH2, NTPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

TPH2_MOUSE
θ value	0 (rank : 4)	NC score	0.996424 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGV2	Gene names	Tph2, Ntph
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

PH4H_MOUSE
θ value	5.78879e-140 (rank : 5)	NC score	0.989015 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P16331	Gene names	Pah
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

PH4H_HUMAN
θ value	4.90052e-139 (rank : 6)	NC score	0.988778 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P00439, Q16717, Q8TC14	Gene names	PAH
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

TY3H_MOUSE
θ value	4.92331e-123 (rank : 7)	NC score	0.983765 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	P24529	Gene names	Th
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

TY3H_HUMAN
θ value	1.02657e-120 (rank : 8)	NC score	0.982214 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P07101, Q15585, Q15588, Q15589	Gene names	TH, TYH
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

EMR1_HUMAN
θ value	0.62314 (rank : 9)	NC score	0.019423 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	382	Shared Neighborhood Hits	5
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

ERCC5_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.016914 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	P28715, Q7Z2V3, Q8IZL6, Q8N1B7, Q9HD59	Gene names	ERCC5, XPG, XPGC
Domain Architecture
Description	DNA-repair protein complementing XP-G cells (Xeroderma pigmentosum group G-complementing protein) (DNA excision repair protein ERCC-5).

MYST3_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.012548 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	772	Shared Neighborhood Hits	8
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

MYST3_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.013055 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	688	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

MYST4_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.012946 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	671	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

MYST4_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.014399 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	416	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

RENR_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.018677 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	O75787, Q5QTQ7, Q6T7F5, Q8NBP3, Q8NG15, Q96FV6, Q96LB5, Q9H2P8, Q9UG89	Gene names	ATP6AP2, ATP6IP2, CAPER, ELDF10
Domain Architecture	No domain graphic available
Description	Renin receptor precursor (Renin/prorenin receptor) (ATPase H(+)- transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (V-ATPase M8.9 subunit) (ATP6M8-9) (N14F) (ER-localized type I transmembrane adaptor) (Embryonic liver differentiation factor 10).

Z297B_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.001863 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	792	Shared Neighborhood Hits	5
SwissProt Accessions	O43298	Gene names	ZNF297B, KIAA0414, ZBTB22B
Domain Architecture
Description	Zinc finger protein 297B (ZnF-x) (Zinc finger and BTB domain- containing protein 22B).

STAG2_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.009308 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O35638, Q6NZN7	Gene names	Stag2, Sa2, Sap2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

CBPB2_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.006320 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q96IY4, Q15114, Q5T9K1, Q5T9K2, Q9P2Y6	Gene names	CPB2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase B2 precursor (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Thrombin-activable fibrinolysis inhibitor) (TAFI) (Plasma carboxypeptidase B) (pCPB).

MYT1L_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.004228 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	461	Shared Neighborhood Hits	5
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

P55G_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.003094 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	401	Shared Neighborhood Hits	2
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

RENR_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.016304 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYN9, Q8BVU6, Q91YU5	Gene names	Atp6ap2, Atp6ip2
Domain Architecture	No domain graphic available
Description	Renin receptor precursor (Renin/prorenin receptor) (ATPase H(+)- transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2).

Hits sorted by NC score

TPH1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P17752, O95188, O95189, Q16736	Gene names	TPH1, TPH, TRPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

TPH1_MOUSE
NC score	0.999098 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	11
SwissProt Accessions	P17532	Gene names	Tph1, Tph
Domain Architecture
Description	Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1).

TPH2_HUMAN
NC score	0.996531 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWU9	Gene names	TPH2, NTPH
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

TPH2_MOUSE
NC score	0.996424 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGV2	Gene names	Tph2, Ntph
Domain Architecture
Description	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 2) (Neuronal tryptophan hydroxylase).

PH4H_MOUSE
NC score	0.989015 (rank : 5)	θ value	5.78879e-140 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P16331	Gene names	Pah
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

PH4H_HUMAN
NC score	0.988778 (rank : 6)	θ value	4.90052e-139 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	P00439, Q16717, Q8TC14	Gene names	PAH
Domain Architecture
Description	Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase).

TY3H_MOUSE
NC score	0.983765 (rank : 7)	θ value	4.92331e-123 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	P24529	Gene names	Th
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

TY3H_HUMAN
NC score	0.982214 (rank : 8)	θ value	1.02657e-120 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P07101, Q15585, Q15588, Q15589	Gene names	TH, TYH
Domain Architecture
Description	Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH).

EMR1_HUMAN
NC score	0.019423 (rank : 9)	θ value	0.62314 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	382	Shared Neighborhood Hits	5
SwissProt Accessions	Q14246, Q8NGA7	Gene names	EMR1, TM7LN3
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor).

RENR_HUMAN
NC score	0.018677 (rank : 10)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	O75787, Q5QTQ7, Q6T7F5, Q8NBP3, Q8NG15, Q96FV6, Q96LB5, Q9H2P8, Q9UG89	Gene names	ATP6AP2, ATP6IP2, CAPER, ELDF10
Domain Architecture	No domain graphic available
Description	Renin receptor precursor (Renin/prorenin receptor) (ATPase H(+)- transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (V-ATPase M8.9 subunit) (ATP6M8-9) (N14F) (ER-localized type I transmembrane adaptor) (Embryonic liver differentiation factor 10).

ERCC5_HUMAN
NC score	0.016914 (rank : 11)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	P28715, Q7Z2V3, Q8IZL6, Q8N1B7, Q9HD59	Gene names	ERCC5, XPG, XPGC
Domain Architecture
Description	DNA-repair protein complementing XP-G cells (Xeroderma pigmentosum group G-complementing protein) (DNA excision repair protein ERCC-5).

RENR_MOUSE
NC score	0.016304 (rank : 12)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYN9, Q8BVU6, Q91YU5	Gene names	Atp6ap2, Atp6ip2
Domain Architecture	No domain graphic available
Description	Renin receptor precursor (Renin/prorenin receptor) (ATPase H(+)- transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2).

MYST4_MOUSE
NC score	0.014399 (rank : 13)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	416	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BRB7, Q7TNW5, Q8BG35, Q8C441, Q9JKX5	Gene names	Myst4
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Querkopf protein).

MYST3_MOUSE
NC score	0.013055 (rank : 14)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	688	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

MYST4_HUMAN
NC score	0.012946 (rank : 15)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	671	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

MYST3_HUMAN
NC score	0.012548 (rank : 16)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	772	Shared Neighborhood Hits	8
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

STAG2_MOUSE
NC score	0.009308 (rank : 17)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O35638, Q6NZN7	Gene names	Stag2, Sa2, Sap2
Domain Architecture
Description	Cohesin subunit SA-2 (Stromal antigen 2) (SCC3 homolog 2).

CBPB2_HUMAN
NC score	0.006320 (rank : 18)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q96IY4, Q15114, Q5T9K1, Q5T9K2, Q9P2Y6	Gene names	CPB2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase B2 precursor (EC 3.4.17.20) (Carboxypeptidase U) (CPU) (Thrombin-activable fibrinolysis inhibitor) (TAFI) (Plasma carboxypeptidase B) (pCPB).

MYT1L_MOUSE
NC score	0.004228 (rank : 19)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	461	Shared Neighborhood Hits	5
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

P55G_MOUSE
NC score	0.003094 (rank : 20)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	401	Shared Neighborhood Hits	2
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

Z297B_HUMAN
NC score	0.001863 (rank : 21)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	792	Shared Neighborhood Hits	5
SwissProt Accessions	O43298	Gene names	ZNF297B, KIAA0414, ZBTB22B
Domain Architecture
Description	Zinc finger protein 297B (ZnF-x) (Zinc finger and BTB domain- containing protein 22B).