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Network neighborhood for query Sequence : SPHM_HUMAN

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SPHM_HUMAN
SwissProt Accessions	P51688	Gene names	SGSH, HSS
Domain Architecture
Description	N-sulphoglucosamine sulphohydrolase precursor (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPHM_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P51688	Gene names	SGSH, HSS
Domain Architecture
Description	N-sulphoglucosamine sulphohydrolase precursor (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase).

GA6S_HUMAN
θ value	1.058e-16 (rank : 2)	NC score	0.781634 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	P34059, Q86VK3	Gene names	GALNS
Domain Architecture
Description	N-acetylgalactosamine-6-sulfatase precursor (EC 3.1.6.4) (N- acetylgalactosamine-6-sulfate sulfatase) (Galactose-6-sulfate sulfatase) (GalNAc6S sulfatase) (Chondroitinsulfatase) (Chondroitinase).

ARSA_HUMAN
θ value	4.44505e-15 (rank : 3)	NC score	0.758824 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

ARSA_MOUSE
θ value	1.68911e-14 (rank : 4)	NC score	0.764792 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

IDS_MOUSE
θ value	2.88119e-14 (rank : 5)	NC score	0.726653 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	Q08890, Q3TM30	Gene names	Ids
Domain Architecture
Description	Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase).

IDS_HUMAN
θ value	3.76295e-14 (rank : 6)	NC score	0.728318 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P22304, Q14604	Gene names	IDS
Domain Architecture
Description	Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Contains: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain].

ARSI_HUMAN
θ value	3.18553e-13 (rank : 7)	NC score	0.707980 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	Q5FYB1	Gene names	ARSI
Domain Architecture	No domain graphic available
Description	Arylsulfatase I precursor (EC 3.1.6.-) (ASI).

ARSB_HUMAN
θ value	1.74796e-11 (rank : 8)	NC score	0.711285 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	P15848	Gene names	ARSB
Domain Architecture
Description	Arylsulfatase B precursor (EC 3.1.6.12) (ASB) (N-acetylgalactosamine- 4-sulfatase) (G4S).

ARSK_HUMAN
θ value	1.74796e-11 (rank : 9)	NC score	0.690484 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q6UWY0, Q8N3Q8	Gene names	ARSK, TSULF
Domain Architecture	No domain graphic available
Description	Arylsulfatase K precursor (EC 3.1.6.-) (ASK) (Telethon sulfatase).

ARSG_HUMAN
θ value	1.25267e-09 (rank : 10)	NC score	0.705207 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q96EG1, Q6UXF2, Q9Y2K4	Gene names	ARSG, KIAA1001
Domain Architecture	No domain graphic available
Description	Arylsulfatase G precursor (EC 3.1.6.-) (ASG).

ARSJ_MOUSE
θ value	1.63604e-09 (rank : 11)	NC score	0.689663 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BM89, Q8BKG5, Q8BL46	Gene names	Arsj
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

ARSJ_HUMAN
θ value	3.64472e-09 (rank : 12)	NC score	0.689930 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	27	Shared Neighborhood Hits	23
SwissProt Accessions	Q5FYB0, Q5FWE4, Q6UWT9	Gene names	ARSJ
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

ARSF_HUMAN
θ value	4.76016e-09 (rank : 13)	NC score	0.672543 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	23
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

ARSG_MOUSE
θ value	4.76016e-09 (rank : 14)	NC score	0.718791 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4	Gene names	Arsg, Kiaa1001
Domain Architecture	No domain graphic available
Description	Arylsulfatase G precursor (EC 3.1.6.-) (ASG).

STS_MOUSE
θ value	6.21693e-09 (rank : 15)	NC score	0.685663 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

SULF1_MOUSE
θ value	6.21693e-09 (rank : 16)	NC score	0.570549 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	52	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K007, Q8BLJ0, Q8C1D3	Gene names	Sulf1
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (MSulf-1).

GL6S_HUMAN
θ value	8.11959e-09 (rank : 17)	NC score	0.626586 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	P15586	Gene names	GNS
Domain Architecture
Description	N-acetylglucosamine-6-sulfatase precursor (EC 3.1.6.14) (G6S) (Glucosamine-6-sulfatase).

ARSD_HUMAN
θ value	3.08544e-08 (rank : 18)	NC score	0.671906 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	P51689, Q9UHJ8	Gene names	ARSD
Domain Architecture
Description	Arylsulfatase D precursor (EC 3.1.6.-) (ASD).

ARSE_HUMAN
θ value	5.26297e-08 (rank : 19)	NC score	0.669355 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	P51690, Q53FT2, Q53FU8	Gene names	ARSE
Domain Architecture
Description	Arylsulfatase E precursor (EC 3.1.6.-) (ASE).

SULF1_HUMAN
θ value	6.87365e-08 (rank : 20)	NC score	0.562628 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IWU6, Q86YV8, Q8NCA2, Q9UPS5	Gene names	SULF1, KIAA1077
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (HSulf-1).

SULF2_MOUSE
θ value	4.45536e-07 (rank : 21)	NC score	0.556720 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CFG0, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q9D8E2	Gene names	Sulf2
Domain Architecture
Description	Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (MSulf-2).

STS_HUMAN
θ value	9.92553e-07 (rank : 22)	NC score	0.672812 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	P08842	Gene names	STS
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

SULF2_HUMAN
θ value	1.69304e-06 (rank : 23)	NC score	0.550045 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IWU5, Q6UX86, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3	Gene names	SULF2, KIAA1247
Domain Architecture
Description	Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (HSulf-2).

M3K4_MOUSE
θ value	8.99809 (rank : 24)	NC score	-0.001669 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	924	Shared Neighborhood Hits	2
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

Hits sorted by NC score

SPHM_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	P51688	Gene names	SGSH, HSS
Domain Architecture
Description	N-sulphoglucosamine sulphohydrolase precursor (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase).

GA6S_HUMAN
NC score	0.781634 (rank : 2)	θ value	1.058e-16 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	P34059, Q86VK3	Gene names	GALNS
Domain Architecture
Description	N-acetylgalactosamine-6-sulfatase precursor (EC 3.1.6.4) (N- acetylgalactosamine-6-sulfate sulfatase) (Galactose-6-sulfate sulfatase) (GalNAc6S sulfatase) (Chondroitinsulfatase) (Chondroitinase).

ARSA_MOUSE
NC score	0.764792 (rank : 3)	θ value	1.68911e-14 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

ARSA_HUMAN
NC score	0.758824 (rank : 4)	θ value	4.44505e-15 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

IDS_HUMAN
NC score	0.728318 (rank : 5)	θ value	3.76295e-14 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	P22304, Q14604	Gene names	IDS
Domain Architecture
Description	Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Contains: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain].

IDS_MOUSE
NC score	0.726653 (rank : 6)	θ value	2.88119e-14 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	Q08890, Q3TM30	Gene names	Ids
Domain Architecture
Description	Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase).

ARSG_MOUSE
NC score	0.718791 (rank : 7)	θ value	4.76016e-09 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4	Gene names	Arsg, Kiaa1001
Domain Architecture	No domain graphic available
Description	Arylsulfatase G precursor (EC 3.1.6.-) (ASG).

ARSB_HUMAN
NC score	0.711285 (rank : 8)	θ value	1.74796e-11 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	P15848	Gene names	ARSB
Domain Architecture
Description	Arylsulfatase B precursor (EC 3.1.6.12) (ASB) (N-acetylgalactosamine- 4-sulfatase) (G4S).

ARSI_HUMAN
NC score	0.707980 (rank : 9)	θ value	3.18553e-13 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	Q5FYB1	Gene names	ARSI
Domain Architecture	No domain graphic available
Description	Arylsulfatase I precursor (EC 3.1.6.-) (ASI).

ARSG_HUMAN
NC score	0.705207 (rank : 10)	θ value	1.25267e-09 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q96EG1, Q6UXF2, Q9Y2K4	Gene names	ARSG, KIAA1001
Domain Architecture	No domain graphic available
Description	Arylsulfatase G precursor (EC 3.1.6.-) (ASG).

ARSK_HUMAN
NC score	0.690484 (rank : 11)	θ value	1.74796e-11 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q6UWY0, Q8N3Q8	Gene names	ARSK, TSULF
Domain Architecture	No domain graphic available
Description	Arylsulfatase K precursor (EC 3.1.6.-) (ASK) (Telethon sulfatase).

ARSJ_HUMAN
NC score	0.689930 (rank : 12)	θ value	3.64472e-09 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	27	Shared Neighborhood Hits	23
SwissProt Accessions	Q5FYB0, Q5FWE4, Q6UWT9	Gene names	ARSJ
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

ARSJ_MOUSE
NC score	0.689663 (rank : 13)	θ value	1.63604e-09 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BM89, Q8BKG5, Q8BL46	Gene names	Arsj
Domain Architecture	No domain graphic available
Description	Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).

STS_MOUSE
NC score	0.685663 (rank : 14)	θ value	6.21693e-09 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

STS_HUMAN
NC score	0.672812 (rank : 15)	θ value	9.92553e-07 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	25	Shared Neighborhood Hits	23
SwissProt Accessions	P08842	Gene names	STS
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

ARSF_HUMAN
NC score	0.672543 (rank : 16)	θ value	4.76016e-09 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	33	Shared Neighborhood Hits	23
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

ARSD_HUMAN
NC score	0.671906 (rank : 17)	θ value	3.08544e-08 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	P51689, Q9UHJ8	Gene names	ARSD
Domain Architecture
Description	Arylsulfatase D precursor (EC 3.1.6.-) (ASD).

ARSE_HUMAN
NC score	0.669355 (rank : 18)	θ value	5.26297e-08 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	P51690, Q53FT2, Q53FU8	Gene names	ARSE
Domain Architecture
Description	Arylsulfatase E precursor (EC 3.1.6.-) (ASE).

GL6S_HUMAN
NC score	0.626586 (rank : 19)	θ value	8.11959e-09 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	P15586	Gene names	GNS
Domain Architecture
Description	N-acetylglucosamine-6-sulfatase precursor (EC 3.1.6.14) (G6S) (Glucosamine-6-sulfatase).

SULF1_MOUSE
NC score	0.570549 (rank : 20)	θ value	6.21693e-09 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	52	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K007, Q8BLJ0, Q8C1D3	Gene names	Sulf1
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (MSulf-1).

SULF1_HUMAN
NC score	0.562628 (rank : 21)	θ value	6.87365e-08 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IWU6, Q86YV8, Q8NCA2, Q9UPS5	Gene names	SULF1, KIAA1077
Domain Architecture
Description	Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (HSulf-1).

SULF2_MOUSE
NC score	0.556720 (rank : 22)	θ value	4.45536e-07 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	37	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CFG0, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q9D8E2	Gene names	Sulf2
Domain Architecture
Description	Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (MSulf-2).

SULF2_HUMAN
NC score	0.550045 (rank : 23)	θ value	1.69304e-06 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	31	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IWU5, Q6UX86, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3	Gene names	SULF2, KIAA1247
Domain Architecture
Description	Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (HSulf-2).

M3K4_MOUSE
NC score	-0.001669 (rank : 24)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	924	Shared Neighborhood Hits	2
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).