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Network neighborhood for query Sequence : ARSK_HUMAN

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ARSK_HUMAN
 
SwissProt Accessions Q6UWY0, Q8N3Q8 Gene names ARSK, TSULF
Domain
Architecture

No domain graphic available

Description Arylsulfatase K precursor (EC 3.1.6.-) (ASK) (Telethon sulfatase).
Rank Plots



Hits sorted by θ


ARSK_HUMAN
 
θ value 0 (rank : 1) NC score 0.999962 (rank : 1)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 26
SwissProt Accessions Q6UWY0, Q8N3Q8 Gene names ARSK, TSULF
Domain
Architecture

No domain graphic available

Description Arylsulfatase K precursor (EC 3.1.6.-) (ASK) (Telethon sulfatase).
IDS_MOUSE
 
θ value 4.15078e-21 (rank : 2) NC score 0.752116 (rank : 2)
Query Neighborhood Hits 26 Target Neighborhood Hits 36 Shared Neighborhood Hits 23
SwissProt Accessions Q08890, Q3TM30 Gene names Ids
Domain
Architecture
Description Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase).
SULF2_HUMAN
 
θ value 5.99374e-20 (rank : 3) NC score 0.709042 (rank : 5)
Query Neighborhood Hits 26 Target Neighborhood Hits 31 Shared Neighborhood Hits 23
SwissProt Accessions Q8IWU5, Q6UX86, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3 Gene names SULF2, KIAA1247
Domain
Architecture
Description Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (HSulf-2).
SULF2_MOUSE
 
θ value 1.33526e-19 (rank : 4) NC score 0.710701 (rank : 4)
Query Neighborhood Hits 26 Target Neighborhood Hits 37 Shared Neighborhood Hits 23
SwissProt Accessions Q8CFG0, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q9D8E2 Gene names Sulf2
Domain
Architecture
Description Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (MSulf-2).
IDS_HUMAN
 
θ value 6.62687e-19 (rank : 5) NC score 0.744425 (rank : 3)
Query Neighborhood Hits 26 Target Neighborhood Hits 30 Shared Neighborhood Hits 23
SwissProt Accessions P22304, Q14604 Gene names IDS
Domain
Architecture
Description Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Contains: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain].
SULF1_HUMAN
 
θ value 3.28887e-18 (rank : 6) NC score 0.708465 (rank : 6)
Query Neighborhood Hits 26 Target Neighborhood Hits 55 Shared Neighborhood Hits 23
SwissProt Accessions Q8IWU6, Q86YV8, Q8NCA2, Q9UPS5 Gene names SULF1, KIAA1077
Domain
Architecture
Description Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (HSulf-1).
SULF1_MOUSE
 
θ value 1.63225e-17 (rank : 7) NC score 0.708321 (rank : 7)
Query Neighborhood Hits 26 Target Neighborhood Hits 52 Shared Neighborhood Hits 23
SwissProt Accessions Q8K007, Q8BLJ0, Q8C1D3 Gene names Sulf1
Domain
Architecture
Description Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (MSulf-1).
SPHM_HUMAN
 
θ value 1.74796e-11 (rank : 8) NC score 0.690484 (rank : 9)
Query Neighborhood Hits 26 Target Neighborhood Hits 24 Shared Neighborhood Hits 23
SwissProt Accessions P51688 Gene names SGSH, HSS
Domain
Architecture
Description N-sulphoglucosamine sulphohydrolase precursor (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase).
ARSA_HUMAN
 
θ value 1.133e-10 (rank : 9) NC score 0.610923 (rank : 12)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 23
SwissProt Accessions P15289, Q6ICI5, Q96CJ0 Gene names ARSA
Domain
Architecture
Description Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].
GL6S_HUMAN
 
θ value 2.52405e-10 (rank : 10) NC score 0.703612 (rank : 8)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 23
SwissProt Accessions P15586 Gene names GNS
Domain
Architecture
Description N-acetylglucosamine-6-sulfatase precursor (EC 3.1.6.14) (G6S) (Glucosamine-6-sulfatase).
ARSA_MOUSE
 
θ value 1.06045e-08 (rank : 11) NC score 0.624356 (rank : 10)
Query Neighborhood Hits 26 Target Neighborhood Hits 30 Shared Neighborhood Hits 23
SwissProt Accessions P50428 Gene names Arsa, As2
Domain
Architecture
Description Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).
ARSF_HUMAN
 
θ value 4.0297e-08 (rank : 12) NC score 0.569080 (rank : 15)
Query Neighborhood Hits 26 Target Neighborhood Hits 33 Shared Neighborhood Hits 23
SwissProt Accessions P54793, Q8TCC5 Gene names ARSF
Domain
Architecture
Description Arylsulfatase F precursor (EC 3.1.6.-) (ASF).
GA6S_HUMAN
 
θ value 4.0297e-08 (rank : 13) NC score 0.621365 (rank : 11)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 23
SwissProt Accessions P34059, Q86VK3 Gene names GALNS
Domain
Architecture
Description N-acetylgalactosamine-6-sulfatase precursor (EC 3.1.6.4) (N- acetylgalactosamine-6-sulfate sulfatase) (Galactose-6-sulfate sulfatase) (GalNAc6S sulfatase) (Chondroitinsulfatase) (Chondroitinase).
STS_HUMAN
 
θ value 5.26297e-08 (rank : 14) NC score 0.590637 (rank : 13)
Query Neighborhood Hits 26 Target Neighborhood Hits 25 Shared Neighborhood Hits 23
SwissProt Accessions P08842 Gene names STS
Domain
Architecture
Description Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).
ARSE_HUMAN
 
θ value 3.41135e-07 (rank : 15) NC score 0.566475 (rank : 16)
Query Neighborhood Hits 26 Target Neighborhood Hits 29 Shared Neighborhood Hits 23
SwissProt Accessions P51690, Q53FT2, Q53FU8 Gene names ARSE
Domain
Architecture
Description Arylsulfatase E precursor (EC 3.1.6.-) (ASE).
ARSD_HUMAN
 
θ value 9.92553e-07 (rank : 16) NC score 0.558404 (rank : 18)
Query Neighborhood Hits 26 Target Neighborhood Hits 28 Shared Neighborhood Hits 23
SwissProt Accessions P51689, Q9UHJ8 Gene names ARSD
Domain
Architecture
Description Arylsulfatase D precursor (EC 3.1.6.-) (ASD).
STS_MOUSE
 
θ value 9.92553e-07 (rank : 17) NC score 0.576320 (rank : 14)
Query Neighborhood Hits 26 Target Neighborhood Hits 38 Shared Neighborhood Hits 23
SwissProt Accessions P50427 Gene names Sts
Domain
Architecture
Description Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).
ARSJ_MOUSE
 
θ value 0.000158464 (rank : 18) NC score 0.503291 (rank : 21)
Query Neighborhood Hits 26 Target Neighborhood Hits 32 Shared Neighborhood Hits 23
SwissProt Accessions Q8BM89, Q8BKG5, Q8BL46 Gene names Arsj
Domain
Architecture

No domain graphic available

Description Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).
ARSJ_HUMAN
 
θ value 0.00020696 (rank : 19) NC score 0.504428 (rank : 20)
Query Neighborhood Hits 26 Target Neighborhood Hits 27 Shared Neighborhood Hits 23
SwissProt Accessions Q5FYB0, Q5FWE4, Q6UWT9 Gene names ARSJ
Domain
Architecture

No domain graphic available

Description Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).
ARSG_MOUSE
 
θ value 0.00035302 (rank : 20) NC score 0.563967 (rank : 17)
Query Neighborhood Hits 26 Target Neighborhood Hits 34 Shared Neighborhood Hits 23
SwissProt Accessions Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4 Gene names Arsg, Kiaa1001
Domain
Architecture

No domain graphic available

Description Arylsulfatase G precursor (EC 3.1.6.-) (ASG).
ARSG_HUMAN
 
θ value 0.0148317 (rank : 21) NC score 0.522287 (rank : 19)
Query Neighborhood Hits 26 Target Neighborhood Hits 32 Shared Neighborhood Hits 23
SwissProt Accessions Q96EG1, Q6UXF2, Q9Y2K4 Gene names ARSG, KIAA1001
Domain
Architecture

No domain graphic available

Description Arylsulfatase G precursor (EC 3.1.6.-) (ASG).
ARSB_HUMAN
 
θ value 0.0563607 (rank : 22) NC score 0.499413 (rank : 22)
Query Neighborhood Hits 26 Target Neighborhood Hits 25 Shared Neighborhood Hits 23
SwissProt Accessions P15848 Gene names ARSB
Domain
Architecture
Description Arylsulfatase B precursor (EC 3.1.6.12) (ASB) (N-acetylgalactosamine- 4-sulfatase) (G4S).
ARSI_HUMAN
 
θ value 0.125558 (rank : 23) NC score 0.488343 (rank : 23)
Query Neighborhood Hits 26 Target Neighborhood Hits 29 Shared Neighborhood Hits 23
SwissProt Accessions Q5FYB1 Gene names ARSI
Domain
Architecture

No domain graphic available

Description Arylsulfatase I precursor (EC 3.1.6.-) (ASI).
GDPD1_MOUSE
 
θ value 6.88961 (rank : 24) NC score 0.016218 (rank : 25)
Query Neighborhood Hits 26 Target Neighborhood Hits 16 Shared Neighborhood Hits 2
SwissProt Accessions Q9CRY7, Q9CT14, Q9D4X7 Gene names Gdpd1, Gde4
Domain
Architecture

No domain graphic available

Description Glycerophosphodiester phosphodiesterase domain-containing protein 1 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 4).
HERC5_HUMAN
 
θ value 6.88961 (rank : 25) NC score 0.007729 (rank : 26)
Query Neighborhood Hits 26 Target Neighborhood Hits 66 Shared Neighborhood Hits 2
SwissProt Accessions Q9UII4 Gene names HERC5, CEB1, CEBP1
Domain
Architecture
Description HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).
PIGN_HUMAN
 
θ value 6.88961 (rank : 26) NC score 0.016906 (rank : 24)
Query Neighborhood Hits 26 Target Neighborhood Hits 19 Shared Neighborhood Hits 2
SwissProt Accessions O95427, Q7L8F8, Q8TC01, Q9NT05 Gene names PIGN, MCD4
Domain
Architecture

No domain graphic available

Description GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).

Hits sorted by NC score


ARSK_HUMAN
 
NC score 0.999962 (rank : 1) θ value 0 (rank : 1)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 26
SwissProt Accessions Q6UWY0, Q8N3Q8 Gene names ARSK, TSULF
Domain
Architecture

No domain graphic available

Description Arylsulfatase K precursor (EC 3.1.6.-) (ASK) (Telethon sulfatase).
IDS_MOUSE
 
NC score 0.752116 (rank : 2) θ value 4.15078e-21 (rank : 2)
Query Neighborhood Hits 26 Target Neighborhood Hits 36 Shared Neighborhood Hits 23
SwissProt Accessions Q08890, Q3TM30 Gene names Ids
Domain
Architecture
Description Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase).
IDS_HUMAN
 
NC score 0.744425 (rank : 3) θ value 6.62687e-19 (rank : 5)
Query Neighborhood Hits 26 Target Neighborhood Hits 30 Shared Neighborhood Hits 23
SwissProt Accessions P22304, Q14604 Gene names IDS
Domain
Architecture
Description Iduronate 2-sulfatase precursor (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Contains: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain].
SULF2_MOUSE
 
NC score 0.710701 (rank : 4) θ value 1.33526e-19 (rank : 4)
Query Neighborhood Hits 26 Target Neighborhood Hits 37 Shared Neighborhood Hits 23
SwissProt Accessions Q8CFG0, Q8BM68, Q8BUZ4, Q8BX28, Q8BZ51, Q8C169, Q9D8E2 Gene names Sulf2
Domain
Architecture
Description Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (MSulf-2).
SULF2_HUMAN
 
NC score 0.709042 (rank : 5) θ value 5.99374e-20 (rank : 3)
Query Neighborhood Hits 26 Target Neighborhood Hits 31 Shared Neighborhood Hits 23
SwissProt Accessions Q8IWU5, Q6UX86, Q96SG2, Q9H1H0, Q9UJR3, Q9ULH3 Gene names SULF2, KIAA1247
Domain
Architecture
Description Extracellular sulfatase Sulf-2 precursor (EC 3.1.6.-) (HSulf-2).
SULF1_HUMAN
 
NC score 0.708465 (rank : 6) θ value 3.28887e-18 (rank : 6)
Query Neighborhood Hits 26 Target Neighborhood Hits 55 Shared Neighborhood Hits 23
SwissProt Accessions Q8IWU6, Q86YV8, Q8NCA2, Q9UPS5 Gene names SULF1, KIAA1077
Domain
Architecture
Description Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (HSulf-1).
SULF1_MOUSE
 
NC score 0.708321 (rank : 7) θ value 1.63225e-17 (rank : 7)
Query Neighborhood Hits 26 Target Neighborhood Hits 52 Shared Neighborhood Hits 23
SwissProt Accessions Q8K007, Q8BLJ0, Q8C1D3 Gene names Sulf1
Domain
Architecture
Description Extracellular sulfatase Sulf-1 precursor (EC 3.1.6.-) (MSulf-1).
GL6S_HUMAN
 
NC score 0.703612 (rank : 8) θ value 2.52405e-10 (rank : 10)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 23
SwissProt Accessions P15586 Gene names GNS
Domain
Architecture
Description N-acetylglucosamine-6-sulfatase precursor (EC 3.1.6.14) (G6S) (Glucosamine-6-sulfatase).
SPHM_HUMAN
 
NC score 0.690484 (rank : 9) θ value 1.74796e-11 (rank : 8)
Query Neighborhood Hits 26 Target Neighborhood Hits 24 Shared Neighborhood Hits 23
SwissProt Accessions P51688 Gene names SGSH, HSS
Domain
Architecture
Description N-sulphoglucosamine sulphohydrolase precursor (EC 3.10.1.1) (Sulfoglucosamine sulfamidase) (Sulphamidase).
ARSA_MOUSE
 
NC score 0.624356 (rank : 10) θ value 1.06045e-08 (rank : 11)
Query Neighborhood Hits 26 Target Neighborhood Hits 30 Shared Neighborhood Hits 23
SwissProt Accessions P50428 Gene names Arsa, As2
Domain
Architecture
Description Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).
GA6S_HUMAN
 
NC score 0.621365 (rank : 11) θ value 4.0297e-08 (rank : 13)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 23
SwissProt Accessions P34059, Q86VK3 Gene names GALNS
Domain
Architecture
Description N-acetylgalactosamine-6-sulfatase precursor (EC 3.1.6.4) (N- acetylgalactosamine-6-sulfate sulfatase) (Galactose-6-sulfate sulfatase) (GalNAc6S sulfatase) (Chondroitinsulfatase) (Chondroitinase).
ARSA_HUMAN
 
NC score 0.610923 (rank : 12) θ value 1.133e-10 (rank : 9)
Query Neighborhood Hits 26 Target Neighborhood Hits 26 Shared Neighborhood Hits 23
SwissProt Accessions P15289, Q6ICI5, Q96CJ0 Gene names ARSA
Domain
Architecture
Description Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].
STS_HUMAN
 
NC score 0.590637 (rank : 13) θ value 5.26297e-08 (rank : 14)
Query Neighborhood Hits 26 Target Neighborhood Hits 25 Shared Neighborhood Hits 23
SwissProt Accessions P08842 Gene names STS
Domain
Architecture
Description Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).
STS_MOUSE
 
NC score 0.576320 (rank : 14) θ value 9.92553e-07 (rank : 17)
Query Neighborhood Hits 26 Target Neighborhood Hits 38 Shared Neighborhood Hits 23
SwissProt Accessions P50427 Gene names Sts
Domain
Architecture
Description Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).
ARSF_HUMAN
 
NC score 0.569080 (rank : 15) θ value 4.0297e-08 (rank : 12)
Query Neighborhood Hits 26 Target Neighborhood Hits 33 Shared Neighborhood Hits 23
SwissProt Accessions P54793, Q8TCC5 Gene names ARSF
Domain
Architecture
Description Arylsulfatase F precursor (EC 3.1.6.-) (ASF).
ARSE_HUMAN
 
NC score 0.566475 (rank : 16) θ value 3.41135e-07 (rank : 15)
Query Neighborhood Hits 26 Target Neighborhood Hits 29 Shared Neighborhood Hits 23
SwissProt Accessions P51690, Q53FT2, Q53FU8 Gene names ARSE
Domain
Architecture
Description Arylsulfatase E precursor (EC 3.1.6.-) (ASE).
ARSG_MOUSE
 
NC score 0.563967 (rank : 17) θ value 0.00035302 (rank : 20)
Query Neighborhood Hits 26 Target Neighborhood Hits 34 Shared Neighborhood Hits 23
SwissProt Accessions Q3TYD4, Q5XFU5, Q69ZT6, Q8CHS3, Q8VBZ5, Q9D3B4 Gene names Arsg, Kiaa1001
Domain
Architecture

No domain graphic available

Description Arylsulfatase G precursor (EC 3.1.6.-) (ASG).
ARSD_HUMAN
 
NC score 0.558404 (rank : 18) θ value 9.92553e-07 (rank : 16)
Query Neighborhood Hits 26 Target Neighborhood Hits 28 Shared Neighborhood Hits 23
SwissProt Accessions P51689, Q9UHJ8 Gene names ARSD
Domain
Architecture
Description Arylsulfatase D precursor (EC 3.1.6.-) (ASD).
ARSG_HUMAN
 
NC score 0.522287 (rank : 19) θ value 0.0148317 (rank : 21)
Query Neighborhood Hits 26 Target Neighborhood Hits 32 Shared Neighborhood Hits 23
SwissProt Accessions Q96EG1, Q6UXF2, Q9Y2K4 Gene names ARSG, KIAA1001
Domain
Architecture

No domain graphic available

Description Arylsulfatase G precursor (EC 3.1.6.-) (ASG).
ARSJ_HUMAN
 
NC score 0.504428 (rank : 20) θ value 0.00020696 (rank : 19)
Query Neighborhood Hits 26 Target Neighborhood Hits 27 Shared Neighborhood Hits 23
SwissProt Accessions Q5FYB0, Q5FWE4, Q6UWT9 Gene names ARSJ
Domain
Architecture

No domain graphic available

Description Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).
ARSJ_MOUSE
 
NC score 0.503291 (rank : 21) θ value 0.000158464 (rank : 18)
Query Neighborhood Hits 26 Target Neighborhood Hits 32 Shared Neighborhood Hits 23
SwissProt Accessions Q8BM89, Q8BKG5, Q8BL46 Gene names Arsj
Domain
Architecture

No domain graphic available

Description Arylsulfatase J precursor (EC 3.1.6.-) (ASJ).
ARSB_HUMAN
 
NC score 0.499413 (rank : 22) θ value 0.0563607 (rank : 22)
Query Neighborhood Hits 26 Target Neighborhood Hits 25 Shared Neighborhood Hits 23
SwissProt Accessions P15848 Gene names ARSB
Domain
Architecture
Description Arylsulfatase B precursor (EC 3.1.6.12) (ASB) (N-acetylgalactosamine- 4-sulfatase) (G4S).
ARSI_HUMAN
 
NC score 0.488343 (rank : 23) θ value 0.125558 (rank : 23)
Query Neighborhood Hits 26 Target Neighborhood Hits 29 Shared Neighborhood Hits 23
SwissProt Accessions Q5FYB1 Gene names ARSI
Domain
Architecture

No domain graphic available

Description Arylsulfatase I precursor (EC 3.1.6.-) (ASI).
PIGN_HUMAN
 
NC score 0.016906 (rank : 24) θ value 6.88961 (rank : 26)
Query Neighborhood Hits 26 Target Neighborhood Hits 19 Shared Neighborhood Hits 2
SwissProt Accessions O95427, Q7L8F8, Q8TC01, Q9NT05 Gene names PIGN, MCD4
Domain
Architecture

No domain graphic available

Description GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).
GDPD1_MOUSE
 
NC score 0.016218 (rank : 25) θ value 6.88961 (rank : 24)
Query Neighborhood Hits 26 Target Neighborhood Hits 16 Shared Neighborhood Hits 2
SwissProt Accessions Q9CRY7, Q9CT14, Q9D4X7 Gene names Gdpd1, Gde4
Domain
Architecture

No domain graphic available

Description Glycerophosphodiester phosphodiesterase domain-containing protein 1 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 4).
HERC5_HUMAN
 
NC score 0.007729 (rank : 26) θ value 6.88961 (rank : 25)
Query Neighborhood Hits 26 Target Neighborhood Hits 66 Shared Neighborhood Hits 2
SwissProt Accessions Q9UII4 Gene names HERC5, CEB1, CEBP1
Domain
Architecture
Description HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).