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Network neighborhood for query Sequence : S3TC1_HUMAN

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S3TC1_HUMAN
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

S3TC1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	78	Target Neighborhood Hits	78	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

S3TC2_MOUSE
θ value	2.56852e-180 (rank : 2)	NC score	0.924433 (rank : 3)
Query Neighborhood Hits	78	Target Neighborhood Hits	83	Shared Neighborhood Hits	14
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

S3TC2_HUMAN
θ value	2.17438e-179 (rank : 3)	NC score	0.928880 (rank : 2)
Query Neighborhood Hits	78	Target Neighborhood Hits	70	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

GPSM1_HUMAN
θ value	2.88788e-06 (rank : 4)	NC score	0.299154 (rank : 5)
Query Neighborhood Hits	78	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q86YR5, Q86SR5, Q969T1, Q9UFS8	Gene names	GPSM1, AGS3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

GPSM1_MOUSE
θ value	1.43324e-05 (rank : 5)	NC score	0.303308 (rank : 4)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	Q6IR34, Q61366, Q8BUK4, Q8BX78, Q8R0R9	Gene names	Gpsm1, Ags3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

GPSM2_HUMAN
θ value	5.44631e-05 (rank : 6)	NC score	0.290639 (rank : 6)
Query Neighborhood Hits	78	Target Neighborhood Hits	55	Shared Neighborhood Hits	10
SwissProt Accessions	P81274, Q8N0Z5	Gene names	GPSM2, LGN
Domain Architecture
Description	G-protein signaling modulator 2 (Mosaic protein LGN).

GPSM2_MOUSE
θ value	0.00020696 (rank : 7)	NC score	0.287130 (rank : 7)
Query Neighborhood Hits	78	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDU0, Q8BLX3	Gene names	Gpsm2, Lgn, Pins
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 2 (Pins homolog).

TTC28_MOUSE
θ value	0.000270298 (rank : 8)	NC score	0.279635 (rank : 8)
Query Neighborhood Hits	78	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_HUMAN
θ value	0.000602161 (rank : 9)	NC score	0.271081 (rank : 9)
Query Neighborhood Hits	78	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

DNMBP_MOUSE
θ value	0.0148317 (rank : 10)	NC score	0.110115 (rank : 10)
Query Neighborhood Hits	78	Target Neighborhood Hits	435	Shared Neighborhood Hits	33
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRAP_HUMAN
θ value	0.0252991 (rank : 11)	NC score	0.066767 (rank : 18)
Query Neighborhood Hits	78	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

DNMBP_HUMAN
θ value	0.0330416 (rank : 12)	NC score	0.102761 (rank : 11)
Query Neighborhood Hits	78	Target Neighborhood Hits	413	Shared Neighborhood Hits	32
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HRX_HUMAN
θ value	0.0330416 (rank : 13)	NC score	0.041212 (rank : 45)
Query Neighborhood Hits	78	Target Neighborhood Hits	825	Shared Neighborhood Hits	7
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

RP3A_MOUSE
θ value	0.0736092 (rank : 14)	NC score	0.025368 (rank : 61)
Query Neighborhood Hits	78	Target Neighborhood Hits	510	Shared Neighborhood Hits	7
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

M3K11_HUMAN
θ value	0.163984 (rank : 15)	NC score	0.021469 (rank : 65)
Query Neighborhood Hits	78	Target Neighborhood Hits	1136	Shared Neighborhood Hits	34
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

GRAP_MOUSE
θ value	0.21417 (rank : 16)	NC score	0.061985 (rank : 19)
Query Neighborhood Hits	78	Target Neighborhood Hits	309	Shared Neighborhood Hits	29
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SRP68_HUMAN
θ value	0.21417 (rank : 17)	NC score	0.052413 (rank : 28)
Query Neighborhood Hits	78	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHB9, Q8NCJ4, Q8WUK2	Gene names	SRP68
Domain Architecture	No domain graphic available
Description	Signal recognition particle 68 kDa protein (SRP68).

VAV3_HUMAN
θ value	0.279714 (rank : 18)	NC score	0.053730 (rank : 26)
Query Neighborhood Hits	78	Target Neighborhood Hits	398	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

M3K10_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.016417 (rank : 72)
Query Neighborhood Hits	78	Target Neighborhood Hits	1071	Shared Neighborhood Hits	29
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

GRAP2_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.067106 (rank : 17)
Query Neighborhood Hits	78	Target Neighborhood Hits	297	Shared Neighborhood Hits	32
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NAR3_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.037143 (rank : 50)
Query Neighborhood Hits	78	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q13508, Q8WVJ7, Q93069, Q96HL1	Gene names	ART3, TMART
Domain Architecture
Description	Ecto-ADP-ribosyltransferase 3 precursor (EC 2.4.2.31) (NAD(P)(+)-- arginine ADP-ribosyltransferase 3) (Mono(ADP-ribosyl)transferase 3).

PEX5_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.057799 (rank : 22)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	P50542, Q15115, Q15266	Gene names	PEX5, PXR1
Domain Architecture
Description	Peroxisomal targeting signal 1 receptor (Peroxisome receptor 1) (Peroxisomal C-terminal targeting signal import receptor) (PTS1-BP) (Peroxin-5) (PTS1 receptor).

PEX5_MOUSE
θ value	1.06291 (rank : 23)	NC score	0.057459 (rank : 23)
Query Neighborhood Hits	78	Target Neighborhood Hits	89	Shared Neighborhood Hits	12
SwissProt Accessions	O09012	Gene names	Pex5, Pxr1
Domain Architecture
Description	Peroxisomal targeting signal 1 receptor (Peroxisome receptor 1) (Peroxisomal C-terminal targeting signal import receptor) (PTS1-BP) (Peroxin-5) (PTS1 receptor) (PXR1P) (PTS1R).

LIMD1_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.015959 (rank : 74)
Query Neighborhood Hits	78	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

RAPSN_MOUSE
θ value	1.38821 (rank : 25)	NC score	0.093255 (rank : 12)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	P12672	Gene names	Rapsn
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

RUSC1_MOUSE
θ value	1.38821 (rank : 26)	NC score	0.045081 (rank : 43)
Query Neighborhood Hits	78	Target Neighborhood Hits	206	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

GRAP2_HUMAN
θ value	2.36792 (rank : 27)	NC score	0.058484 (rank : 21)
Query Neighborhood Hits	78	Target Neighborhood Hits	304	Shared Neighborhood Hits	30
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

M3KL4_HUMAN
θ value	2.36792 (rank : 28)	NC score	0.019636 (rank : 67)
Query Neighborhood Hits	78	Target Neighborhood Hits	1087	Shared Neighborhood Hits	32
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PEX5R_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.048971 (rank : 37)
Query Neighborhood Hits	78	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

BCAR1_HUMAN
θ value	3.0926 (rank : 30)	NC score	0.049159 (rank : 36)
Query Neighborhood Hits	78	Target Neighborhood Hits	554	Shared Neighborhood Hits	33
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.051239 (rank : 30)
Query Neighborhood Hits	78	Target Neighborhood Hits	438	Shared Neighborhood Hits	32
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DCTN4_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.037912 (rank : 49)
Query Neighborhood Hits	78	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJW0, Q8TAN8	Gene names	DCTN4
Domain Architecture	No domain graphic available
Description	Dynactin subunit 4 (Dynactin subunit p62).

DCTN4_MOUSE
θ value	3.0926 (rank : 33)	NC score	0.037915 (rank : 48)
Query Neighborhood Hits	78	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CBY8, Q923A0, Q9D4X0	Gene names	Dctn4
Domain Architecture	No domain graphic available
Description	Dynactin subunit 4 (Dynactin subunit p62).

EFS_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.055632 (rank : 25)
Query Neighborhood Hits	78	Target Neighborhood Hits	348	Shared Neighborhood Hits	29
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.055752 (rank : 24)
Query Neighborhood Hits	78	Target Neighborhood Hits	389	Shared Neighborhood Hits	29
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

KLC2_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.026009 (rank : 60)
Query Neighborhood Hits	78	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0B6, Q9H9C8, Q9HA20	Gene names	KLC2
Domain Architecture
Description	Kinesin light chain 2 (KLC 2).

LRIG1_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.003683 (rank : 88)
Query Neighborhood Hits	78	Target Neighborhood Hits	654	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

UTX_HUMAN
θ value	3.0926 (rank : 38)	NC score	0.029548 (rank : 56)
Query Neighborhood Hits	78	Target Neighborhood Hits	161	Shared Neighborhood Hits	10
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

X3CL1_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.025245 (rank : 62)
Query Neighborhood Hits	78	Target Neighborhood Hits	152	Shared Neighborhood Hits	7
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

OGFR_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.011894 (rank : 77)
Query Neighborhood Hits	78	Target Neighborhood Hits	1582	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OSTF1_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.039824 (rank : 47)
Query Neighborhood Hits	78	Target Neighborhood Hits	466	Shared Neighborhood Hits	29
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.034653 (rank : 52)
Query Neighborhood Hits	78	Target Neighborhood Hits	467	Shared Neighborhood Hits	28
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

TAU_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.016070 (rank : 73)
Query Neighborhood Hits	78	Target Neighborhood Hits	448	Shared Neighborhood Hits	6
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TTC7B_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.020559 (rank : 66)
Query Neighborhood Hits	78	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q86TV6, Q86U24, Q86VT3	Gene names	TTC7B, TTC7L1
Domain Architecture
Description	Tetratricopeptide repeat protein 7B (Tetratricopeptide repeat protein 7-like-1).

VAV2_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.048742 (rank : 38)
Query Neighborhood Hits	78	Target Neighborhood Hits	456	Shared Neighborhood Hits	29
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CBPA3_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.009332 (rank : 81)
Query Neighborhood Hits	78	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	P15088, Q96E94	Gene names	CPA3
Domain Architecture
Description	Mast cell carboxypeptidase A precursor (EC 3.4.17.1) (MC-CPA) (Carboxypeptidase A3).

CRKL_MOUSE
θ value	5.27518 (rank : 47)	NC score	0.045936 (rank : 41)
Query Neighborhood Hits	78	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.049613 (rank : 35)
Query Neighborhood Hits	78	Target Neighborhood Hits	308	Shared Neighborhood Hits	29
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.050333 (rank : 34)
Query Neighborhood Hits	78	Target Neighborhood Hits	314	Shared Neighborhood Hits	29
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

KLC2_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.023937 (rank : 64)
Query Neighborhood Hits	78	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	O88448	Gene names	Klc2
Domain Architecture
Description	Kinesin light chain 2 (KLC 2).

KLC3_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.036872 (rank : 51)
Query Neighborhood Hits	78	Target Neighborhood Hits	135	Shared Neighborhood Hits	12
SwissProt Accessions	Q91W40, Q3TZ56	Gene names	Klc3
Domain Architecture	No domain graphic available
Description	Kinesin light chain 3.

PEX5R_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.045718 (rank : 42)
Query Neighborhood Hits	78	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C437, Q8CA31, Q9DAA1, Q9JMB9	Gene names	Pex5l, Pex2, Pex5r, Pxr2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

SNAB_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.030102 (rank : 54)
Query Neighborhood Hits	78	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H115, Q4G187, Q5JXF9, Q8N3C4	Gene names	NAPB, SNAPB
Domain Architecture	No domain graphic available
Description	Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide- sensitive factor attachment protein, beta).

SNAB_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.030102 (rank : 55)
Query Neighborhood Hits	78	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P28663	Gene names	Napb, Snapb
Domain Architecture	No domain graphic available
Description	Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide- sensitive factor attachment protein, beta) (Brain protein I47).

SPTA2_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.018350 (rank : 69)
Query Neighborhood Hits	78	Target Neighborhood Hits	888	Shared Neighborhood Hits	30
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SYTL2_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.013113 (rank : 76)
Query Neighborhood Hits	78	Target Neighborhood Hits	253	Shared Neighborhood Hits	4
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TXNL2_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.016706 (rank : 70)
Query Neighborhood Hits	78	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	O76003, Q96CE0, Q9P1B0, Q9P1B1	Gene names	TXNL2, PICOT
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

VAV3_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.046799 (rank : 40)
Query Neighborhood Hits	78	Target Neighborhood Hits	404	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

AKA12_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.010437 (rank : 78)
Query Neighborhood Hits	78	Target Neighborhood Hits	825	Shared Neighborhood Hits	4
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

CXB6_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.005894 (rank : 86)
Query Neighborhood Hits	78	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P70689	Gene names	Gjb6, Cxn-30
Domain Architecture
Description	Gap junction beta-6 protein (Connexin-30) (Cx30).

FRMD6_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.009996 (rank : 79)
Query Neighborhood Hits	78	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

GUC2A_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.024952 (rank : 63)
Query Neighborhood Hits	78	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q02747	Gene names	GUCA2A, GUCA2
Domain Architecture
Description	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin].

JHD3B_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.009145 (rank : 83)
Query Neighborhood Hits	78	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

MCF2L_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.026133 (rank : 59)
Query Neighborhood Hits	78	Target Neighborhood Hits	255	Shared Neighborhood Hits	14
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MTA3_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.009112 (rank : 84)
Query Neighborhood Hits	78	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q924K8, Q8VC18	Gene names	Mta3
Domain Architecture
Description	Metastasis-associated protein MTA3.

PPIP1_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.040792 (rank : 46)
Query Neighborhood Hits	78	Target Neighborhood Hits	389	Shared Neighborhood Hits	30
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

RTEL1_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.014046 (rank : 75)
Query Neighborhood Hits	78	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

VAV2_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.047495 (rank : 39)
Query Neighborhood Hits	78	Target Neighborhood Hits	453	Shared Neighborhood Hits	29
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

WNK3_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.004353 (rank : 87)
Query Neighborhood Hits	78	Target Neighborhood Hits	948	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

BLK_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.009268 (rank : 82)
Query Neighborhood Hits	78	Target Neighborhood Hits	992	Shared Neighborhood Hits	22
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CASL_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.043935 (rank : 44)
Query Neighborhood Hits	78	Target Neighborhood Hits	259	Shared Neighborhood Hits	29
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

FA8A1_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.019404 (rank : 68)
Query Neighborhood Hits	78	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBU6	Gene names	FAM8A1, AHCP
Domain Architecture	No domain graphic available
Description	Protein FAM8A1 (Autosomal highly conserved protein).

NFIP2_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.016579 (rank : 71)
Query Neighborhood Hits	78	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NV92, Q7Z2H3, Q7Z428, Q8TAR3, Q9ULQ5	Gene names	NDFIP2, KIAA1165, N4WBP5A
Domain Architecture	No domain graphic available
Description	NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413).

PA24B_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.008187 (rank : 85)
Query Neighborhood Hits	78	Target Neighborhood Hits	102	Shared Neighborhood Hits	3
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

RGMA_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.009459 (rank : 80)
Query Neighborhood Hits	78	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B86, Q9H0E6	Gene names	RGMA, RGM
Domain Architecture	No domain graphic available
Description	Repulsive guidance molecule A precursor (RGM domain family member A).

SNAA_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.027883 (rank : 57)
Query Neighborhood Hits	78	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P54920, Q96IK3, Q9BVJ3	Gene names	NAPA, SNAPA
Domain Architecture	No domain graphic available
Description	Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide- sensitive factor attachment protein, alpha).

SNAA_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.027165 (rank : 58)
Query Neighborhood Hits	78	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DB05, Q543I3	Gene names	Napa, Snapa
Domain Architecture	No domain graphic available
Description	Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide- sensitive factor attachment protein, alpha).

STAM1_MOUSE
θ value	8.99809 (rank : 78)	NC score	0.034024 (rank : 53)
Query Neighborhood Hits	78	Target Neighborhood Hits	273	Shared Neighborhood Hits	28
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CD2AP_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.053137 (rank : 27)
Query Neighborhood Hits	78	Target Neighborhood Hits	336	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CDC27_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.050660 (rank : 32)
Query Neighborhood Hits	78	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

GPSM3_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.069654 (rank : 16)
Query Neighborhood Hits	78	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4H4	Gene names	GPSM3, AGS4, C6orf9, G18
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3 (Activator of G-protein signaling 4) (Protein G18) (G18.1b).

GPSM3_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.058716 (rank : 20)
Query Neighborhood Hits	78	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U1Z5, Q3U1M8, Q3UJZ5, Q8VDF9	Gene names	Gpsm3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3.

OGT1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.051696 (rank : 29)
Query Neighborhood Hits	78	Target Neighborhood Hits	143	Shared Neighborhood Hits	15
SwissProt Accessions	O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57	Gene names	OGT
Domain Architecture
Description	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.-) (O-GlcNAc transferase p110 subunit).

PCP2_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.080525 (rank : 13)
Query Neighborhood Hits	78	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVA1, Q3KRG7	Gene names	PCP2
Domain Architecture
Description	Purkinje cell protein 2 homolog.

PCP2_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.076697 (rank : 14)
Query Neighborhood Hits	78	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	P12660, P22941, Q3TV53	Gene names	Pcp2, Pcp-2
Domain Architecture
Description	Purkinje cell protein 2 (Protein PCD-5) (Purkinje cell-specific protein L7).

RAPSN_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.076661 (rank : 15)
Query Neighborhood Hits	78	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q13702, Q9BTD9	Gene names	RAPSN
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

SH3K1_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.050428 (rank : 33)
Query Neighborhood Hits	78	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.050894 (rank : 31)
Query Neighborhood Hits	78	Target Neighborhood Hits	332	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

Hits sorted by NC score

S3TC1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	78	Target Neighborhood Hits	78	Shared Neighborhood Hits	78
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

S3TC2_HUMAN
NC score	0.928880 (rank : 2)	θ value	2.17438e-179 (rank : 3)
Query Neighborhood Hits	78	Target Neighborhood Hits	70	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TF17, Q9H8I5	Gene names	SH3TC2, KIAA1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

S3TC2_MOUSE
NC score	0.924433 (rank : 3)	θ value	2.56852e-180 (rank : 2)
Query Neighborhood Hits	78	Target Neighborhood Hits	83	Shared Neighborhood Hits	14
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

GPSM1_MOUSE
NC score	0.303308 (rank : 4)	θ value	1.43324e-05 (rank : 5)
Query Neighborhood Hits	78	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	Q6IR34, Q61366, Q8BUK4, Q8BX78, Q8R0R9	Gene names	Gpsm1, Ags3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

GPSM1_HUMAN
NC score	0.299154 (rank : 5)	θ value	2.88788e-06 (rank : 4)
Query Neighborhood Hits	78	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q86YR5, Q86SR5, Q969T1, Q9UFS8	Gene names	GPSM1, AGS3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 1 (Activator of G-protein signaling 3).

GPSM2_HUMAN
NC score	0.290639 (rank : 6)	θ value	5.44631e-05 (rank : 6)
Query Neighborhood Hits	78	Target Neighborhood Hits	55	Shared Neighborhood Hits	10
SwissProt Accessions	P81274, Q8N0Z5	Gene names	GPSM2, LGN
Domain Architecture
Description	G-protein signaling modulator 2 (Mosaic protein LGN).

GPSM2_MOUSE
NC score	0.287130 (rank : 7)	θ value	0.00020696 (rank : 7)
Query Neighborhood Hits	78	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDU0, Q8BLX3	Gene names	Gpsm2, Lgn, Pins
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 2 (Pins homolog).

TTC28_MOUSE
NC score	0.279635 (rank : 8)	θ value	0.000270298 (rank : 8)
Query Neighborhood Hits	78	Target Neighborhood Hits	194	Shared Neighborhood Hits	15
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_HUMAN
NC score	0.271081 (rank : 9)	θ value	0.000602161 (rank : 9)
Query Neighborhood Hits	78	Target Neighborhood Hits	271	Shared Neighborhood Hits	18
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

DNMBP_MOUSE
NC score	0.110115 (rank : 10)	θ value	0.0148317 (rank : 10)
Query Neighborhood Hits	78	Target Neighborhood Hits	435	Shared Neighborhood Hits	33
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.102761 (rank : 11)	θ value	0.0330416 (rank : 12)
Query Neighborhood Hits	78	Target Neighborhood Hits	413	Shared Neighborhood Hits	32
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RAPSN_MOUSE
NC score	0.093255 (rank : 12)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	P12672	Gene names	Rapsn
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

PCP2_HUMAN
NC score	0.080525 (rank : 13)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	78	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVA1, Q3KRG7	Gene names	PCP2
Domain Architecture
Description	Purkinje cell protein 2 homolog.

PCP2_MOUSE
NC score	0.076697 (rank : 14)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	78	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	P12660, P22941, Q3TV53	Gene names	Pcp2, Pcp-2
Domain Architecture
Description	Purkinje cell protein 2 (Protein PCD-5) (Purkinje cell-specific protein L7).

RAPSN_HUMAN
NC score	0.076661 (rank : 15)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	78	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q13702, Q9BTD9	Gene names	RAPSN
Domain Architecture
Description	43 kDa receptor-associated protein of the synapse (RAPsyn) (Acetylcholine receptor-associated 43 kDa protein) (43 kDa postsynaptic protein).

GPSM3_HUMAN
NC score	0.069654 (rank : 16)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	78	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4H4	Gene names	GPSM3, AGS4, C6orf9, G18
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3 (Activator of G-protein signaling 4) (Protein G18) (G18.1b).

GRAP2_MOUSE
NC score	0.067106 (rank : 17)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	78	Target Neighborhood Hits	297	Shared Neighborhood Hits	32
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
NC score	0.066767 (rank : 18)	θ value	0.0252991 (rank : 11)
Query Neighborhood Hits	78	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.061985 (rank : 19)	θ value	0.21417 (rank : 16)
Query Neighborhood Hits	78	Target Neighborhood Hits	309	Shared Neighborhood Hits	29
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GPSM3_MOUSE
NC score	0.058716 (rank : 20)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	78	Target Neighborhood Hits	11	Shared Neighborhood Hits	4
SwissProt Accessions	Q3U1Z5, Q3U1M8, Q3UJZ5, Q8VDF9	Gene names	Gpsm3
Domain Architecture	No domain graphic available
Description	G-protein signaling modulator 3.

GRAP2_HUMAN
NC score	0.058484 (rank : 21)	θ value	2.36792 (rank : 27)
Query Neighborhood Hits	78	Target Neighborhood Hits	304	Shared Neighborhood Hits	30
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PEX5_HUMAN
NC score	0.057799 (rank : 22)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	78	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	P50542, Q15115, Q15266	Gene names	PEX5, PXR1
Domain Architecture
Description	Peroxisomal targeting signal 1 receptor (Peroxisome receptor 1) (Peroxisomal C-terminal targeting signal import receptor) (PTS1-BP) (Peroxin-5) (PTS1 receptor).

PEX5_MOUSE
NC score	0.057459 (rank : 23)	θ value	1.06291 (rank : 23)
Query Neighborhood Hits	78	Target Neighborhood Hits	89	Shared Neighborhood Hits	12
SwissProt Accessions	O09012	Gene names	Pex5, Pxr1
Domain Architecture
Description	Peroxisomal targeting signal 1 receptor (Peroxisome receptor 1) (Peroxisomal C-terminal targeting signal import receptor) (PTS1-BP) (Peroxin-5) (PTS1 receptor) (PXR1P) (PTS1R).

EFS_MOUSE
NC score	0.055752 (rank : 24)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	78	Target Neighborhood Hits	389	Shared Neighborhood Hits	29
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EFS_HUMAN
NC score	0.055632 (rank : 25)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	78	Target Neighborhood Hits	348	Shared Neighborhood Hits	29
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

VAV3_HUMAN
NC score	0.053730 (rank : 26)	θ value	0.279714 (rank : 18)
Query Neighborhood Hits	78	Target Neighborhood Hits	398	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CD2AP_MOUSE
NC score	0.053137 (rank : 27)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	78	Target Neighborhood Hits	336	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SRP68_HUMAN
NC score	0.052413 (rank : 28)	θ value	0.21417 (rank : 17)
Query Neighborhood Hits	78	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHB9, Q8NCJ4, Q8WUK2	Gene names	SRP68
Domain Architecture	No domain graphic available
Description	Signal recognition particle 68 kDa protein (SRP68).

OGT1_HUMAN
NC score	0.051696 (rank : 29)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	78	Target Neighborhood Hits	143	Shared Neighborhood Hits	15
SwissProt Accessions	O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57	Gene names	OGT
Domain Architecture
Description	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.-) (O-GlcNAc transferase p110 subunit).

BCAR1_MOUSE
NC score	0.051239 (rank : 30)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	78	Target Neighborhood Hits	438	Shared Neighborhood Hits	32
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SH3K1_MOUSE
NC score	0.050894 (rank : 31)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	78	Target Neighborhood Hits	332	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CDC27_HUMAN
NC score	0.050660 (rank : 32)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	78	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

SH3K1_HUMAN
NC score	0.050428 (rank : 33)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	78	Target Neighborhood Hits	341	Shared Neighborhood Hits	29
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CRK_MOUSE
NC score	0.050333 (rank : 34)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	78	Target Neighborhood Hits	314	Shared Neighborhood Hits	29
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.049613 (rank : 35)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	78	Target Neighborhood Hits	308	Shared Neighborhood Hits	29
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

BCAR1_HUMAN
NC score	0.049159 (rank : 36)	θ value	3.0926 (rank : 30)
Query Neighborhood Hits	78	Target Neighborhood Hits	554	Shared Neighborhood Hits	33
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PEX5R_HUMAN
NC score	0.048971 (rank : 37)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	78	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

VAV2_MOUSE
NC score	0.048742 (rank : 38)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	78	Target Neighborhood Hits	456	Shared Neighborhood Hits	29
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.047495 (rank : 39)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	78	Target Neighborhood Hits	453	Shared Neighborhood Hits	29
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.046799 (rank : 40)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	78	Target Neighborhood Hits	404	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

CRKL_MOUSE
NC score	0.045936 (rank : 41)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	78	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PEX5R_MOUSE
NC score	0.045718 (rank : 42)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	78	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C437, Q8CA31, Q9DAA1, Q9JMB9	Gene names	Pex5l, Pex2, Pex5r, Pxr2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

RUSC1_MOUSE
NC score	0.045081 (rank : 43)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	78	Target Neighborhood Hits	206	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

CASL_HUMAN
NC score	0.043935 (rank : 44)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	78	Target Neighborhood Hits	259	Shared Neighborhood Hits	29
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

HRX_HUMAN
NC score	0.041212 (rank : 45)	θ value	0.0330416 (rank : 13)
Query Neighborhood Hits	78	Target Neighborhood Hits	825	Shared Neighborhood Hits	7
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

PPIP1_HUMAN
NC score	0.040792 (rank : 46)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	78	Target Neighborhood Hits	389	Shared Neighborhood Hits	30
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

OSTF1_HUMAN
NC score	0.039824 (rank : 47)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	78	Target Neighborhood Hits	466	Shared Neighborhood Hits	29
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

DCTN4_MOUSE
NC score	0.037915 (rank : 48)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	78	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CBY8, Q923A0, Q9D4X0	Gene names	Dctn4
Domain Architecture	No domain graphic available
Description	Dynactin subunit 4 (Dynactin subunit p62).

DCTN4_HUMAN
NC score	0.037912 (rank : 49)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	78	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJW0, Q8TAN8	Gene names	DCTN4
Domain Architecture	No domain graphic available
Description	Dynactin subunit 4 (Dynactin subunit p62).

NAR3_HUMAN
NC score	0.037143 (rank : 50)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	78	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q13508, Q8WVJ7, Q93069, Q96HL1	Gene names	ART3, TMART
Domain Architecture
Description	Ecto-ADP-ribosyltransferase 3 precursor (EC 2.4.2.31) (NAD(P)(+)-- arginine ADP-ribosyltransferase 3) (Mono(ADP-ribosyl)transferase 3).

KLC3_MOUSE
NC score	0.036872 (rank : 51)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	78	Target Neighborhood Hits	135	Shared Neighborhood Hits	12
SwissProt Accessions	Q91W40, Q3TZ56	Gene names	Klc3
Domain Architecture	No domain graphic available
Description	Kinesin light chain 3.

OSTF1_MOUSE
NC score	0.034653 (rank : 52)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	78	Target Neighborhood Hits	467	Shared Neighborhood Hits	28
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

STAM1_MOUSE
NC score	0.034024 (rank : 53)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	78	Target Neighborhood Hits	273	Shared Neighborhood Hits	28
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SNAB_HUMAN
NC score	0.030102 (rank : 54)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	78	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H115, Q4G187, Q5JXF9, Q8N3C4	Gene names	NAPB, SNAPB
Domain Architecture	No domain graphic available
Description	Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide- sensitive factor attachment protein, beta).

SNAB_MOUSE
NC score	0.030102 (rank : 55)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	78	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	P28663	Gene names	Napb, Snapb
Domain Architecture	No domain graphic available
Description	Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide- sensitive factor attachment protein, beta) (Brain protein I47).

UTX_HUMAN
NC score	0.029548 (rank : 56)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	78	Target Neighborhood Hits	161	Shared Neighborhood Hits	10
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

SNAA_HUMAN
NC score	0.027883 (rank : 57)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	78	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P54920, Q96IK3, Q9BVJ3	Gene names	NAPA, SNAPA
Domain Architecture	No domain graphic available
Description	Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide- sensitive factor attachment protein, alpha).

SNAA_MOUSE
NC score	0.027165 (rank : 58)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	78	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DB05, Q543I3	Gene names	Napa, Snapa
Domain Architecture	No domain graphic available
Description	Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide- sensitive factor attachment protein, alpha).

MCF2L_MOUSE
NC score	0.026133 (rank : 59)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	78	Target Neighborhood Hits	255	Shared Neighborhood Hits	14
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

KLC2_HUMAN
NC score	0.026009 (rank : 60)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	78	Target Neighborhood Hits	227	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0B6, Q9H9C8, Q9HA20	Gene names	KLC2
Domain Architecture
Description	Kinesin light chain 2 (KLC 2).

RP3A_MOUSE
NC score	0.025368 (rank : 61)	θ value	0.0736092 (rank : 14)
Query Neighborhood Hits	78	Target Neighborhood Hits	510	Shared Neighborhood Hits	7
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

X3CL1_HUMAN
NC score	0.025245 (rank : 62)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	78	Target Neighborhood Hits	152	Shared Neighborhood Hits	7
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

GUC2A_HUMAN
NC score	0.024952 (rank : 63)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	78	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q02747	Gene names	GUCA2A, GUCA2
Domain Architecture
Description	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin].

KLC2_MOUSE
NC score	0.023937 (rank : 64)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	78	Target Neighborhood Hits	244	Shared Neighborhood Hits	9
SwissProt Accessions	O88448	Gene names	Klc2
Domain Architecture
Description	Kinesin light chain 2 (KLC 2).

M3K11_HUMAN
NC score	0.021469 (rank : 65)	θ value	0.163984 (rank : 15)
Query Neighborhood Hits	78	Target Neighborhood Hits	1136	Shared Neighborhood Hits	34
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TTC7B_HUMAN
NC score	0.020559 (rank : 66)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	78	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	Q86TV6, Q86U24, Q86VT3	Gene names	TTC7B, TTC7L1
Domain Architecture
Description	Tetratricopeptide repeat protein 7B (Tetratricopeptide repeat protein 7-like-1).

M3KL4_HUMAN
NC score	0.019636 (rank : 67)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	78	Target Neighborhood Hits	1087	Shared Neighborhood Hits	32
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

FA8A1_HUMAN
NC score	0.019404 (rank : 68)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	78	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBU6	Gene names	FAM8A1, AHCP
Domain Architecture	No domain graphic available
Description	Protein FAM8A1 (Autosomal highly conserved protein).

SPTA2_HUMAN
NC score	0.018350 (rank : 69)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	78	Target Neighborhood Hits	888	Shared Neighborhood Hits	30
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

TXNL2_HUMAN
NC score	0.016706 (rank : 70)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	78	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	O76003, Q96CE0, Q9P1B0, Q9P1B1	Gene names	TXNL2, PICOT
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

NFIP2_HUMAN
NC score	0.016579 (rank : 71)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	78	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NV92, Q7Z2H3, Q7Z428, Q8TAR3, Q9ULQ5	Gene names	NDFIP2, KIAA1165, N4WBP5A
Domain Architecture	No domain graphic available
Description	NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413).

M3K10_HUMAN
NC score	0.016417 (rank : 72)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	78	Target Neighborhood Hits	1071	Shared Neighborhood Hits	29
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

TAU_HUMAN
NC score	0.016070 (rank : 73)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	78	Target Neighborhood Hits	448	Shared Neighborhood Hits	6
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

LIMD1_HUMAN
NC score	0.015959 (rank : 74)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	78	Target Neighborhood Hits	201	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

RTEL1_HUMAN
NC score	0.014046 (rank : 75)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	78	Target Neighborhood Hits	116	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

SYTL2_MOUSE
NC score	0.013113 (rank : 76)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	78	Target Neighborhood Hits	253	Shared Neighborhood Hits	4
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

OGFR_HUMAN
NC score	0.011894 (rank : 77)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	78	Target Neighborhood Hits	1582	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

AKA12_HUMAN
NC score	0.010437 (rank : 78)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	78	Target Neighborhood Hits	825	Shared Neighborhood Hits	4
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

FRMD6_MOUSE
NC score	0.009996 (rank : 79)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	78	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C0V9, Q8BW34	Gene names	Frmd6
Domain Architecture
Description	FERM domain-containing protein 6.

RGMA_HUMAN
NC score	0.009459 (rank : 80)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	78	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B86, Q9H0E6	Gene names	RGMA, RGM
Domain Architecture	No domain graphic available
Description	Repulsive guidance molecule A precursor (RGM domain family member A).

CBPA3_HUMAN
NC score	0.009332 (rank : 81)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	78	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	P15088, Q96E94	Gene names	CPA3
Domain Architecture
Description	Mast cell carboxypeptidase A precursor (EC 3.4.17.1) (MC-CPA) (Carboxypeptidase A3).

BLK_MOUSE
NC score	0.009268 (rank : 82)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	78	Target Neighborhood Hits	992	Shared Neighborhood Hits	22
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

JHD3B_MOUSE
NC score	0.009145 (rank : 83)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	78	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

MTA3_MOUSE
NC score	0.009112 (rank : 84)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	78	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q924K8, Q8VC18	Gene names	Mta3
Domain Architecture
Description	Metastasis-associated protein MTA3.

PA24B_MOUSE
NC score	0.008187 (rank : 85)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	78	Target Neighborhood Hits	102	Shared Neighborhood Hits	3
SwissProt Accessions	Q4QQM1, Q80VV8, Q91W88	Gene names	Pla2g4b
Domain Architecture	No domain graphic available
Description	Cytosolic phospholipase A2 beta (EC 3.1.1.4) (cPLA2-beta) (Phospholipase A2 group IVB).

CXB6_MOUSE
NC score	0.005894 (rank : 86)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	78	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P70689	Gene names	Gjb6, Cxn-30
Domain Architecture
Description	Gap junction beta-6 protein (Connexin-30) (Cx30).

WNK3_HUMAN
NC score	0.004353 (rank : 87)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	78	Target Neighborhood Hits	948	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

LRIG1_HUMAN
NC score	0.003683 (rank : 88)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	78	Target Neighborhood Hits	654	Shared Neighborhood Hits	2
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).