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Network neighborhood for query Sequence : GUC2A_HUMAN

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GUC2A_HUMAN
SwissProt Accessions	Q02747	Gene names	GUCA2A, GUCA2
Domain Architecture
Description	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

GUC2A_HUMAN
θ value	8.57503e-51 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	7	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q02747	Gene names	GUCA2A, GUCA2
Domain Architecture
Description	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin].

GUC2A_MOUSE
θ value	2.42779e-29 (rank : 2)	NC score	0.969640 (rank : 2)
Query Neighborhood Hits	7	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	P33680	Gene names	Guca2a, Guca2
Domain Architecture
Description	Guanylin precursor (Guanylate cyclase activator 2A).

GUC2B_HUMAN
θ value	7.34386e-10 (rank : 3)	NC score	0.738566 (rank : 3)
Query Neighborhood Hits	7	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q16661, Q52LV0	Gene names	GUCA2B
Domain Architecture
Description	Guanylate cyclase activator 2B precursor [Contains: Guanylate cyclase C-activating peptide 2 (Guanylate cyclase C-activating peptide II) (GCAP-II); Uroguanylin (UGN)].

GUC2B_MOUSE
θ value	1.06045e-08 (rank : 4)	NC score	0.698716 (rank : 4)
Query Neighborhood Hits	7	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	O09051	Gene names	Guca2b
Domain Architecture
Description	Guanylate cyclase activator 2B precursor [Contains: Uroguanylin (UGN)].

FREM2_MOUSE
θ value	1.81305 (rank : 5)	NC score	0.027735 (rank : 5)
Query Neighborhood Hits	7	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

S3TC1_HUMAN
θ value	6.88961 (rank : 6)	NC score	0.024952 (rank : 6)
Query Neighborhood Hits	7	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

TENA_HUMAN
θ value	8.99809 (rank : 7)	NC score	0.004915 (rank : 7)
Query Neighborhood Hits	7	Target Neighborhood Hits	631	Shared Neighborhood Hits	2
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

Hits sorted by NC score

GUC2A_HUMAN
NC score	0.999962 (rank : 1)	θ value	8.57503e-51 (rank : 1)
Query Neighborhood Hits	7	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q02747	Gene names	GUCA2A, GUCA2
Domain Architecture
Description	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin].

GUC2A_MOUSE
NC score	0.969640 (rank : 2)	θ value	2.42779e-29 (rank : 2)
Query Neighborhood Hits	7	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	P33680	Gene names	Guca2a, Guca2
Domain Architecture
Description	Guanylin precursor (Guanylate cyclase activator 2A).

GUC2B_HUMAN
NC score	0.738566 (rank : 3)	θ value	7.34386e-10 (rank : 3)
Query Neighborhood Hits	7	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q16661, Q52LV0	Gene names	GUCA2B
Domain Architecture
Description	Guanylate cyclase activator 2B precursor [Contains: Guanylate cyclase C-activating peptide 2 (Guanylate cyclase C-activating peptide II) (GCAP-II); Uroguanylin (UGN)].

GUC2B_MOUSE
NC score	0.698716 (rank : 4)	θ value	1.06045e-08 (rank : 4)
Query Neighborhood Hits	7	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	O09051	Gene names	Guca2b
Domain Architecture
Description	Guanylate cyclase activator 2B precursor [Contains: Uroguanylin (UGN)].

FREM2_MOUSE
NC score	0.027735 (rank : 5)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	7	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

S3TC1_HUMAN
NC score	0.024952 (rank : 6)	θ value	6.88961 (rank : 6)
Query Neighborhood Hits	7	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

TENA_HUMAN
NC score	0.004915 (rank : 7)	θ value	8.99809 (rank : 7)
Query Neighborhood Hits	7	Target Neighborhood Hits	631	Shared Neighborhood Hits	2
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).