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Network neighborhood for query Sequence : PSPB_HUMAN

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PSPB_HUMAN
SwissProt Accessions	P07988, Q96R04	Gene names	SFTPB, SFTP3
Domain Architecture
Description	Pulmonary surfactant-associated protein B precursor (SP-B) (6 kDa protein) (Pulmonary surfactant-associated proteolipid SPL(Phe)) (18 kDa pulmonary-surfactant protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PSPB_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P07988, Q96R04	Gene names	SFTPB, SFTP3
Domain Architecture
Description	Pulmonary surfactant-associated protein B precursor (SP-B) (6 kDa protein) (Pulmonary surfactant-associated proteolipid SPL(Phe)) (18 kDa pulmonary-surfactant protein).

PSPB_MOUSE
θ value	1.62758e-142 (rank : 2)	NC score	0.990135 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	P50405	Gene names	Sftpb, Sftp3
Domain Architecture
Description	Pulmonary surfactant-associated protein B precursor (SP-B) (Pulmonary surfactant-associated proteolipid SPL(Phe)).

SAP_HUMAN
θ value	6.62687e-19 (rank : 3)	NC score	0.647315 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

SAP_MOUSE
θ value	2.35696e-16 (rank : 4)	NC score	0.632409 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q61207, Q60861, Q64006, Q64219	Gene names	Psap, Sgp1
Domain Architecture
Description	Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin).

AOAH_HUMAN
θ value	0.0736092 (rank : 5)	NC score	0.118010 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	P28039, Q53F13	Gene names	AOAH
Domain Architecture
Description	Acyloxyacyl hydrolase precursor (EC 3.1.1.77) [Contains: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit].

PAPPA_HUMAN
θ value	0.62314 (rank : 6)	NC score	0.037820 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

TRI25_HUMAN
θ value	1.38821 (rank : 7)	NC score	0.023415 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	472	Shared Neighborhood Hits	3
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

LAMB1_MOUSE
θ value	1.81305 (rank : 8)	NC score	0.009913 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	919	Shared Neighborhood Hits	2
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

ETV6_HUMAN
θ value	2.36792 (rank : 9)	NC score	0.019802 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	P41212, Q9UMF6	Gene names	ETV6, TEL, TEL1
Domain Architecture
Description	Transcription factor ETV6 (ETS-related protein Tel1) (Tel) (ETS translocation variant 6).

AMNLS_HUMAN
θ value	3.0926 (rank : 10)	NC score	0.033719 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXJ7, Q6UX83	Gene names	AMN
Domain Architecture	No domain graphic available
Description	Amnionless protein precursor.

SUSD2_MOUSE
θ value	3.0926 (rank : 11)	NC score	0.025128 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

FACE1_MOUSE
θ value	6.88961 (rank : 12)	NC score	0.020501 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q80W54, Q8BJK4, Q8K569	Gene names	Zmpste24, Face1
Domain Architecture	No domain graphic available
Description	CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Prenyl protein-specific endoprotease 1) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Zinc metalloproteinase Ste24 homolog).

VIPR1_HUMAN
θ value	6.88961 (rank : 13)	NC score	0.006961 (rank : 15)
Query Neighborhood Hits	14	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P32241, Q15871	Gene names	VIPR1
Domain Architecture
Description	Vasoactive intestinal polypeptide receptor 1 precursor (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2).

PAPPA_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.028844 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	153	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4K8, Q80VW3, Q80YY1, Q8K423, Q8R4K7, Q9ES06, Q9JK57	Gene names	Pappa
Domain Architecture	No domain graphic available
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

AOAH_MOUSE
θ value	θ > 10 (rank : 15)	NC score	0.060590 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O35298	Gene names	Aoah
Domain Architecture	No domain graphic available
Description	Acyloxyacyl hydrolase precursor (EC 3.1.1.77) [Contains: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit].

Hits sorted by NC score

PSPB_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	P07988, Q96R04	Gene names	SFTPB, SFTP3
Domain Architecture
Description	Pulmonary surfactant-associated protein B precursor (SP-B) (6 kDa protein) (Pulmonary surfactant-associated proteolipid SPL(Phe)) (18 kDa pulmonary-surfactant protein).

PSPB_MOUSE
NC score	0.990135 (rank : 2)	θ value	1.62758e-142 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	P50405	Gene names	Sftpb, Sftp3
Domain Architecture
Description	Pulmonary surfactant-associated protein B precursor (SP-B) (Pulmonary surfactant-associated proteolipid SPL(Phe)).

SAP_HUMAN
NC score	0.647315 (rank : 3)	θ value	6.62687e-19 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	P07602, P07292, P15793, P78538, P78541, P78546, P78547, P78558, Q6IBQ6, Q92739, Q92740, Q92741, Q92742	Gene names	PSAP
Domain Architecture
Description	Proactivator polypeptide precursor [Contains: Saposin A (Protein A); Saposin B-Val; Saposin B (Sphingolipid activator protein 1) (SAP-1) (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sulfatide/GM1 activator); Saposin C (Co-beta-glucosidase) (A1 activator) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin D (Protein C) (Component C)].

SAP_MOUSE
NC score	0.632409 (rank : 4)	θ value	2.35696e-16 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q61207, Q60861, Q64006, Q64219	Gene names	Psap, Sgp1
Domain Architecture
Description	Sulfated glycoprotein 1 precursor (SGP-1) (Prosaposin).

AOAH_HUMAN
NC score	0.118010 (rank : 5)	θ value	0.0736092 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	5
SwissProt Accessions	P28039, Q53F13	Gene names	AOAH
Domain Architecture
Description	Acyloxyacyl hydrolase precursor (EC 3.1.1.77) [Contains: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit].

AOAH_MOUSE
NC score	0.060590 (rank : 6)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	14	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O35298	Gene names	Aoah
Domain Architecture	No domain graphic available
Description	Acyloxyacyl hydrolase precursor (EC 3.1.1.77) [Contains: Acyloxyacyl hydrolase small subunit; Acyloxyacyl hydrolase large subunit].

PAPPA_HUMAN
NC score	0.037820 (rank : 7)	θ value	0.62314 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	161	Shared Neighborhood Hits	4
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

AMNLS_HUMAN
NC score	0.033719 (rank : 8)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXJ7, Q6UX83	Gene names	AMN
Domain Architecture	No domain graphic available
Description	Amnionless protein precursor.

PAPPA_MOUSE
NC score	0.028844 (rank : 9)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	153	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4K8, Q80VW3, Q80YY1, Q8K423, Q8R4K7, Q9ES06, Q9JK57	Gene names	Pappa
Domain Architecture	No domain graphic available
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

SUSD2_MOUSE
NC score	0.025128 (rank : 10)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

TRI25_HUMAN
NC score	0.023415 (rank : 11)	θ value	1.38821 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	472	Shared Neighborhood Hits	3
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

FACE1_MOUSE
NC score	0.020501 (rank : 12)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q80W54, Q8BJK4, Q8K569	Gene names	Zmpste24, Face1
Domain Architecture	No domain graphic available
Description	CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Prenyl protein-specific endoprotease 1) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Zinc metalloproteinase Ste24 homolog).

ETV6_HUMAN
NC score	0.019802 (rank : 13)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	P41212, Q9UMF6	Gene names	ETV6, TEL, TEL1
Domain Architecture
Description	Transcription factor ETV6 (ETS-related protein Tel1) (Tel) (ETS translocation variant 6).

LAMB1_MOUSE
NC score	0.009913 (rank : 14)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	919	Shared Neighborhood Hits	2
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

VIPR1_HUMAN
NC score	0.006961 (rank : 15)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	P32241, Q15871	Gene names	VIPR1
Domain Architecture
Description	Vasoactive intestinal polypeptide receptor 1 precursor (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2).