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Network neighborhood for query Sequence : PP2CE_HUMAN

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PP2CE_HUMAN
SwissProt Accessions	Q96MI6, Q8N8J9, Q96DB8	Gene names	PPM1M, PPM1E
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PP2CE_HUMAN
θ value	3.16907e-146 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q96MI6, Q8N8J9, Q96DB8	Gene names	PPM1M, PPM1E
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

PP2CE_MOUSE
θ value	1.02419e-128 (rank : 2)	NC score	0.980804 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BU27, Q9CSD6, Q9CU88	Gene names	Ppm1m, Ppm1e
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

PP2CL_HUMAN
θ value	6.87365e-08 (rank : 3)	NC score	0.524374 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SGD2, Q96NM7	Gene names	PPM1L, PP2CE
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CL_MOUSE
θ value	6.87365e-08 (rank : 4)	NC score	0.523140 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BHN0, Q3UGL2, Q810H0, Q8C021, Q8C1D5, Q9Z0T1	Gene names	Ppm1l, Kiaa4175
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CB_HUMAN
θ value	2.61198e-07 (rank : 5)	NC score	0.495918 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	O75688, Q9HAY8	Gene names	PPM1B, PP2CB
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta).

PP2CB_MOUSE
θ value	2.61198e-07 (rank : 6)	NC score	0.500404 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P36993	Gene names	Ppm1b, Pp2c2, Pppm1b
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta) (IA) (Protein phosphatase 1B).

PP2CA_HUMAN
θ value	1.09739e-05 (rank : 7)	NC score	0.482045 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	P35813, O75551	Gene names	PPM1A, PPPM1A
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PP2CA_MOUSE
θ value	1.09739e-05 (rank : 8)	NC score	0.483547 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	17
SwissProt Accessions	P49443	Gene names	Ppm1a, Pppm1a
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PPM1F_HUMAN
θ value	1.43324e-05 (rank : 9)	NC score	0.496042 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	P49593, Q96PM2	Gene names	PPM1F, KIAA0015, POPX2
Domain Architecture
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein phosphatase 1F).

PP2CG_HUMAN
θ value	7.1131e-05 (rank : 10)	NC score	0.462941 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	140	Shared Neighborhood Hits	17
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

PP2CG_MOUSE
θ value	7.1131e-05 (rank : 11)	NC score	0.451048 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q61074	Gene names	Ppm1g, Fin13, Ppm1c
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C) (Fibroblast growth factor-inducible protein 13) (FIN13).

PDP1_HUMAN
θ value	0.00035302 (rank : 12)	NC score	0.377947 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P0J1, Q5U5K1	Gene names	PDP1, PDP, PPM2C
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PDP1_MOUSE
θ value	0.000461057 (rank : 13)	NC score	0.379963 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	37	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UV70	Gene names	Pdp1, Ppm2c
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PPM1F_MOUSE
θ value	0.00390308 (rank : 14)	NC score	0.440292 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CGA0	Gene names	Ppm1f
Domain Architecture	No domain graphic available
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Protein phosphatase 1F).

TAB1_MOUSE
θ value	0.0193708 (rank : 15)	NC score	0.277802 (rank : 18)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CF89, Q7TQJ5, Q80V65, Q8R0D1	Gene names	Map3k7ip1, Tab1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

PDP2_HUMAN
θ value	0.0252991 (rank : 16)	NC score	0.385328 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2J9	Gene names	PDP2, KIAA1348
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 2, mitochondrial precursor (EC 3.1.3.43) (PDP 2) (Pyruvate dehydrogenase phosphatase, catalytic subunit 2) (PDPC 2).

TAB1_HUMAN
θ value	0.0252991 (rank : 17)	NC score	0.267632 (rank : 19)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q15750, Q2PP09	Gene names	MAP3K7IP1, TAB1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

PHLPP_HUMAN
θ value	θ > 10 (rank : 18)	NC score	0.055583 (rank : 21)
Query Neighborhood Hits	17	Target Neighborhood Hits	604	Shared Neighborhood Hits	12
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PHLPP_MOUSE
θ value	θ > 10 (rank : 19)	NC score	0.056818 (rank : 20)
Query Neighborhood Hits	17	Target Neighborhood Hits	394	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PP2CD_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.282452 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	O15297	Gene names	PPM1D, WIP1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

PP2CD_MOUSE
θ value	θ > 10 (rank : 21)	NC score	0.279640 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QZ67	Gene names	Ppm1d, Wip1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

Hits sorted by NC score

PP2CE_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.16907e-146 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q96MI6, Q8N8J9, Q96DB8	Gene names	PPM1M, PPM1E
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

PP2CE_MOUSE
NC score	0.980804 (rank : 2)	θ value	1.02419e-128 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BU27, Q9CSD6, Q9CU88	Gene names	Ppm1m, Ppm1e
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

PP2CL_HUMAN
NC score	0.524374 (rank : 3)	θ value	6.87365e-08 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SGD2, Q96NM7	Gene names	PPM1L, PP2CE
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CL_MOUSE
NC score	0.523140 (rank : 4)	θ value	6.87365e-08 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	27	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BHN0, Q3UGL2, Q810H0, Q8C021, Q8C1D5, Q9Z0T1	Gene names	Ppm1l, Kiaa4175
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CB_MOUSE
NC score	0.500404 (rank : 5)	θ value	2.61198e-07 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	17
SwissProt Accessions	P36993	Gene names	Ppm1b, Pp2c2, Pppm1b
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta) (IA) (Protein phosphatase 1B).

PPM1F_HUMAN
NC score	0.496042 (rank : 6)	θ value	1.43324e-05 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	P49593, Q96PM2	Gene names	PPM1F, KIAA0015, POPX2
Domain Architecture
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein phosphatase 1F).

PP2CB_HUMAN
NC score	0.495918 (rank : 7)	θ value	2.61198e-07 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	25	Shared Neighborhood Hits	15
SwissProt Accessions	O75688, Q9HAY8	Gene names	PPM1B, PP2CB
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta).

PP2CA_MOUSE
NC score	0.483547 (rank : 8)	θ value	1.09739e-05 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	23	Shared Neighborhood Hits	17
SwissProt Accessions	P49443	Gene names	Ppm1a, Pppm1a
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PP2CA_HUMAN
NC score	0.482045 (rank : 9)	θ value	1.09739e-05 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	P35813, O75551	Gene names	PPM1A, PPPM1A
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PP2CG_HUMAN
NC score	0.462941 (rank : 10)	θ value	7.1131e-05 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	140	Shared Neighborhood Hits	17
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

PP2CG_MOUSE
NC score	0.451048 (rank : 11)	θ value	7.1131e-05 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q61074	Gene names	Ppm1g, Fin13, Ppm1c
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C) (Fibroblast growth factor-inducible protein 13) (FIN13).

PPM1F_MOUSE
NC score	0.440292 (rank : 12)	θ value	0.00390308 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CGA0	Gene names	Ppm1f
Domain Architecture	No domain graphic available
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Protein phosphatase 1F).

PDP2_HUMAN
NC score	0.385328 (rank : 13)	θ value	0.0252991 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2J9	Gene names	PDP2, KIAA1348
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 2, mitochondrial precursor (EC 3.1.3.43) (PDP 2) (Pyruvate dehydrogenase phosphatase, catalytic subunit 2) (PDPC 2).

PDP1_MOUSE
NC score	0.379963 (rank : 14)	θ value	0.000461057 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	37	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UV70	Gene names	Pdp1, Ppm2c
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PDP1_HUMAN
NC score	0.377947 (rank : 15)	θ value	0.00035302 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P0J1, Q5U5K1	Gene names	PDP1, PDP, PPM2C
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PP2CD_HUMAN
NC score	0.282452 (rank : 16)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	17	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	O15297	Gene names	PPM1D, WIP1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

PP2CD_MOUSE
NC score	0.279640 (rank : 17)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QZ67	Gene names	Ppm1d, Wip1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

TAB1_MOUSE
NC score	0.277802 (rank : 18)	θ value	0.0193708 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CF89, Q7TQJ5, Q80V65, Q8R0D1	Gene names	Map3k7ip1, Tab1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

TAB1_HUMAN
NC score	0.267632 (rank : 19)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q15750, Q2PP09	Gene names	MAP3K7IP1, TAB1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

PHLPP_MOUSE
NC score	0.056818 (rank : 20)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	17	Target Neighborhood Hits	394	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PHLPP_HUMAN
NC score	0.055583 (rank : 21)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	17	Target Neighborhood Hits	604	Shared Neighborhood Hits	12
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).