Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PP2CD_HUMAN

For an explanation of this page, click here

PP2CD_HUMAN
SwissProt Accessions	O15297	Gene names	PPM1D, WIP1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PP2CD_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	O15297	Gene names	PPM1D, WIP1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

PP2CD_MOUSE
θ value	0 (rank : 2)	NC score	0.995479 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZ67	Gene names	Ppm1d, Wip1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

PP2CA_HUMAN
θ value	4.74913e-17 (rank : 3)	NC score	0.674324 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	P35813, O75551	Gene names	PPM1A, PPPM1A
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PP2CB_MOUSE
θ value	6.20254e-17 (rank : 4)	NC score	0.673512 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	P36993	Gene names	Ppm1b, Pp2c2, Pppm1b
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta) (IA) (Protein phosphatase 1B).

PP2CB_HUMAN
θ value	8.10077e-17 (rank : 5)	NC score	0.673068 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	O75688, Q9HAY8	Gene names	PPM1B, PP2CB
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta).

PP2CA_MOUSE
θ value	1.058e-16 (rank : 6)	NC score	0.671543 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P49443	Gene names	Ppm1a, Pppm1a
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PPM1F_HUMAN
θ value	2.20605e-14 (rank : 7)	NC score	0.661968 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	P49593, Q96PM2	Gene names	PPM1F, KIAA0015, POPX2
Domain Architecture
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein phosphatase 1F).

PPM1F_MOUSE
θ value	1.42992e-13 (rank : 8)	NC score	0.650519 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CGA0	Gene names	Ppm1f
Domain Architecture	No domain graphic available
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Protein phosphatase 1F).

PP2CL_HUMAN
θ value	4.16044e-13 (rank : 9)	NC score	0.636447 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SGD2, Q96NM7	Gene names	PPM1L, PP2CE
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CL_MOUSE
θ value	5.43371e-13 (rank : 10)	NC score	0.634807 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BHN0, Q3UGL2, Q810H0, Q8C021, Q8C1D5, Q9Z0T1	Gene names	Ppm1l, Kiaa4175
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CG_HUMAN
θ value	7.84624e-12 (rank : 11)	NC score	0.612866 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	140	Shared Neighborhood Hits	16
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

PP2CG_MOUSE
θ value	7.84624e-12 (rank : 12)	NC score	0.596210 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q61074	Gene names	Ppm1g, Fin13, Ppm1c
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C) (Fibroblast growth factor-inducible protein 13) (FIN13).

PDP1_HUMAN
θ value	6.21693e-09 (rank : 13)	NC score	0.468569 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	35	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P0J1, Q5U5K1	Gene names	PDP1, PDP, PPM2C
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PDP1_MOUSE
θ value	6.21693e-09 (rank : 14)	NC score	0.472287 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	37	Shared Neighborhood Hits	16
SwissProt Accessions	Q3UV70	Gene names	Pdp1, Ppm2c
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PDP2_HUMAN
θ value	3.41135e-07 (rank : 15)	NC score	0.490956 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2J9	Gene names	PDP2, KIAA1348
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 2, mitochondrial precursor (EC 3.1.3.43) (PDP 2) (Pyruvate dehydrogenase phosphatase, catalytic subunit 2) (PDPC 2).

PP2CE_MOUSE
θ value	0.00175202 (rank : 16)	NC score	0.386317 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BU27, Q9CSD6, Q9CU88	Gene names	Ppm1m, Ppm1e
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

LR37B_HUMAN
θ value	0.62314 (rank : 17)	NC score	0.022464 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	392	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

AFF1_MOUSE
θ value	1.81305 (rank : 18)	NC score	0.021009 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	351	Shared Neighborhood Hits	6
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

ANR25_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.011634 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	398	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

COX10_MOUSE
θ value	2.36792 (rank : 20)	NC score	0.027837 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFY5	Gene names	Cox10
Domain Architecture	No domain graphic available
Description	Protoheme IX farnesyltransferase, mitochondrial precursor (EC 2.5.1.-) (Heme O synthase).

LAD1_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.022097 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	441	Shared Neighborhood Hits	8
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

POPD2_MOUSE
θ value	2.36792 (rank : 22)	NC score	0.021799 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ES82	Gene names	Popdc2, Pop2
Domain Architecture
Description	Popeye domain-containing protein 2 (Popeye protein 2).

SACS_MOUSE
θ value	2.36792 (rank : 23)	NC score	0.021529 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

CGRE1_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.018539 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	354	Shared Neighborhood Hits	2
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

LPHN2_HUMAN
θ value	3.0926 (rank : 25)	NC score	0.007987 (rank : 36)
Query Neighborhood Hits	34	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

SFR12_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.013747 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	486	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

SRRM1_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.013171 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	690	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SSH2_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.012130 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

MAST2_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.000118 (rank : 39)
Query Neighborhood Hits	34	Target Neighborhood Hits	1110	Shared Neighborhood Hits	4
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MNT_MOUSE
θ value	4.03905 (rank : 30)	NC score	0.014909 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	432	Shared Neighborhood Hits	2
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

P3C2A_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.008372 (rank : 35)
Query Neighborhood Hits	34	Target Neighborhood Hits	181	Shared Neighborhood Hits	2
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

RAI1_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.011992 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	344	Shared Neighborhood Hits	5
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

ZN292_HUMAN
θ value	8.99809 (rank : 33)	NC score	0.005341 (rank : 37)
Query Neighborhood Hits	34	Target Neighborhood Hits	918	Shared Neighborhood Hits	3
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

ZO1_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.005302 (rank : 38)
Query Neighborhood Hits	34	Target Neighborhood Hits	474	Shared Neighborhood Hits	6
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PHLPP_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.068026 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	604	Shared Neighborhood Hits	12
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PHLPP_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.069608 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	394	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PP2CE_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.282452 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q96MI6, Q8N8J9, Q96DB8	Gene names	PPM1M, PPM1E
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

TAB1_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.109216 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q15750, Q2PP09	Gene names	MAP3K7IP1, TAB1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

TAB1_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.122095 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CF89, Q7TQJ5, Q80V65, Q8R0D1	Gene names	Map3k7ip1, Tab1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

Hits sorted by NC score

PP2CD_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	O15297	Gene names	PPM1D, WIP1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

PP2CD_MOUSE
NC score	0.995479 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZ67	Gene names	Ppm1d, Wip1
Domain Architecture
Description	Protein phosphatase 2C isoform delta (EC 3.1.3.16) (PP2C-delta) (p53- induced protein phosphatase 1) (Protein phosphatase magnesium- dependent 1 delta).

PP2CA_HUMAN
NC score	0.674324 (rank : 3)	θ value	4.74913e-17 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	P35813, O75551	Gene names	PPM1A, PPPM1A
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PP2CB_MOUSE
NC score	0.673512 (rank : 4)	θ value	6.20254e-17 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	P36993	Gene names	Ppm1b, Pp2c2, Pppm1b
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta) (IA) (Protein phosphatase 1B).

PP2CB_HUMAN
NC score	0.673068 (rank : 5)	θ value	8.10077e-17 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	O75688, Q9HAY8	Gene names	PPM1B, PP2CB
Domain Architecture
Description	Protein phosphatase 2C isoform beta (EC 3.1.3.16) (PP2C-beta).

PP2CA_MOUSE
NC score	0.671543 (rank : 6)	θ value	1.058e-16 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P49443	Gene names	Ppm1a, Pppm1a
Domain Architecture
Description	Protein phosphatase 2C isoform alpha (EC 3.1.3.16) (PP2C-alpha) (IA) (Protein phosphatase 1A).

PPM1F_HUMAN
NC score	0.661968 (rank : 7)	θ value	2.20605e-14 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	P49593, Q96PM2	Gene names	PPM1F, KIAA0015, POPX2
Domain Architecture
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (hFEM-2) (Protein phosphatase 1F).

PPM1F_MOUSE
NC score	0.650519 (rank : 8)	θ value	1.42992e-13 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CGA0	Gene names	Ppm1f
Domain Architecture	No domain graphic available
Description	Ca(2+)/calmodulin-dependent protein kinase phosphatase (EC 3.1.3.16) (CaM-kinase phosphatase) (CaMKPase) (Protein phosphatase 1F).

PP2CL_HUMAN
NC score	0.636447 (rank : 9)	θ value	4.16044e-13 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SGD2, Q96NM7	Gene names	PPM1L, PP2CE
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CL_MOUSE
NC score	0.634807 (rank : 10)	θ value	5.43371e-13 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BHN0, Q3UGL2, Q810H0, Q8C021, Q8C1D5, Q9Z0T1	Gene names	Ppm1l, Kiaa4175
Domain Architecture	No domain graphic available
Description	Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like).

PP2CG_HUMAN
NC score	0.612866 (rank : 11)	θ value	7.84624e-12 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	140	Shared Neighborhood Hits	16
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

PP2CG_MOUSE
NC score	0.596210 (rank : 12)	θ value	7.84624e-12 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	185	Shared Neighborhood Hits	16
SwissProt Accessions	Q61074	Gene names	Ppm1g, Fin13, Ppm1c
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C) (Fibroblast growth factor-inducible protein 13) (FIN13).

PDP2_HUMAN
NC score	0.490956 (rank : 13)	θ value	3.41135e-07 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2J9	Gene names	PDP2, KIAA1348
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 2, mitochondrial precursor (EC 3.1.3.43) (PDP 2) (Pyruvate dehydrogenase phosphatase, catalytic subunit 2) (PDPC 2).

PDP1_MOUSE
NC score	0.472287 (rank : 14)	θ value	6.21693e-09 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	37	Shared Neighborhood Hits	16
SwissProt Accessions	Q3UV70	Gene names	Pdp1, Ppm2c
Domain Architecture	No domain graphic available
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PDP1_HUMAN
NC score	0.468569 (rank : 15)	θ value	6.21693e-09 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	35	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P0J1, Q5U5K1	Gene names	PDP1, PDP, PPM2C
Domain Architecture
Description	[Pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (EC 3.1.3.43) (PDP 1) (Pyruvate dehydrogenase phosphatase, catalytic subunit 1) (PDPC 1) (Protein phosphatase 2C).

PP2CE_MOUSE
NC score	0.386317 (rank : 16)	θ value	0.00175202 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BU27, Q9CSD6, Q9CU88	Gene names	Ppm1m, Ppm1e
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

PP2CE_HUMAN
NC score	0.282452 (rank : 17)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	34	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q96MI6, Q8N8J9, Q96DB8	Gene names	PPM1M, PPM1E
Domain Architecture
Description	Protein phosphatase 2C isoform eta (EC 3.1.3.16) (PP2C-eta) (PP2CE) (Protein phosphatase 1M).

TAB1_MOUSE
NC score	0.122095 (rank : 18)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	34	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CF89, Q7TQJ5, Q80V65, Q8R0D1	Gene names	Map3k7ip1, Tab1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

TAB1_HUMAN
NC score	0.109216 (rank : 19)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	34	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q15750, Q2PP09	Gene names	MAP3K7IP1, TAB1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1).

PHLPP_MOUSE
NC score	0.069608 (rank : 20)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	34	Target Neighborhood Hits	394	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PHLPP_HUMAN
NC score	0.068026 (rank : 21)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	34	Target Neighborhood Hits	604	Shared Neighborhood Hits	12
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

COX10_MOUSE
NC score	0.027837 (rank : 22)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CFY5	Gene names	Cox10
Domain Architecture	No domain graphic available
Description	Protoheme IX farnesyltransferase, mitochondrial precursor (EC 2.5.1.-) (Heme O synthase).

LR37B_HUMAN
NC score	0.022464 (rank : 23)	θ value	0.62314 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	392	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

LAD1_HUMAN
NC score	0.022097 (rank : 24)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	441	Shared Neighborhood Hits	8
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

POPD2_MOUSE
NC score	0.021799 (rank : 25)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ES82	Gene names	Popdc2, Pop2
Domain Architecture
Description	Popeye domain-containing protein 2 (Popeye protein 2).

SACS_MOUSE
NC score	0.021529 (rank : 26)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

AFF1_MOUSE
NC score	0.021009 (rank : 27)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	351	Shared Neighborhood Hits	6
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CGRE1_HUMAN
NC score	0.018539 (rank : 28)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	354	Shared Neighborhood Hits	2
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

MNT_MOUSE
NC score	0.014909 (rank : 29)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	432	Shared Neighborhood Hits	2
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

SFR12_MOUSE
NC score	0.013747 (rank : 30)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	486	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

SRRM1_HUMAN
NC score	0.013171 (rank : 31)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	690	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SSH2_MOUSE
NC score	0.012130 (rank : 32)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

RAI1_MOUSE
NC score	0.011992 (rank : 33)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	344	Shared Neighborhood Hits	5
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

ANR25_MOUSE
NC score	0.011634 (rank : 34)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	398	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

P3C2A_MOUSE
NC score	0.008372 (rank : 35)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	181	Shared Neighborhood Hits	2
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

LPHN2_HUMAN
NC score	0.007987 (rank : 36)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	136	Shared Neighborhood Hits	2
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

ZN292_HUMAN
NC score	0.005341 (rank : 37)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	918	Shared Neighborhood Hits	3
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

ZO1_HUMAN
NC score	0.005302 (rank : 38)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	474	Shared Neighborhood Hits	6
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MAST2_MOUSE
NC score	0.000118 (rank : 39)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	1110	Shared Neighborhood Hits	4
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).