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Network neighborhood for query Sequence : MA2B2_MOUSE

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MA2B2_MOUSE
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MA2B2_HUMAN
θ value	0 (rank : 1)	NC score	0.996689 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2E5, Q66MP2, Q86T67	Gene names	MAN2B2, KIAA0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B1_MOUSE
θ value	1.65806e-78 (rank : 3)	NC score	0.891510 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	O09159, O55037, Q64443, Q9DBQ1	Gene names	Man2b1, Laman, Man2b, Manb
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1).

MA2B1_HUMAN
θ value	4.82422e-78 (rank : 4)	NC score	0.890427 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O00754, O15330, Q16680, Q93094, Q9BW13	Gene names	MAN2B1, LAMAN, MANB
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1) [Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide].

MA2A1_HUMAN
θ value	6.96618e-77 (rank : 5)	NC score	0.869904 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	Q16706, Q16767	Gene names	MAN2A1, MANA2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1).

MA2A1_MOUSE
θ value	2.56397e-71 (rank : 6)	NC score	0.864820 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

MA2A2_HUMAN
θ value	3.974e-56 (rank : 7)	NC score	0.857121 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	P49641, Q13754	Gene names	MAN2A2, MANA2X
Domain Architecture
Description	Alpha-mannosidase IIx (EC 3.2.1.114) (Mannosyl-oligosaccharide 1,3- 1,6-alpha-mannosidase) (MAN IIx) (Mannosidase alpha class 2A member 2).

MA2C1_HUMAN
θ value	0.000602161 (rank : 8)	NC score	0.239104 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

MA2C1_MOUSE
θ value	0.00102713 (rank : 9)	NC score	0.271798 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

HDAC6_HUMAN
θ value	0.47712 (rank : 10)	NC score	0.020101 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	145	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

GLCE_HUMAN
θ value	1.81305 (rank : 11)	NC score	0.025403 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	O94923, Q6GUQ2	Gene names	GLCE, KIAA0836
Domain Architecture	No domain graphic available
Description	D-glucuronyl C5-epimerase (EC 5.1.3.-) (Heparin/heparan sulfate:glucuronic acid C5 epimerase).

FOXD4_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.005827 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q12950, Q5VVK1, Q8WXT6	Gene names	FOXD4, FKHL9, FOXD4A, FREAC5
Domain Architecture
Description	Forkhead box protein D4 (Forkhead-related protein FKHL9) (Forkhead- related transcription factor 5) (FREAC-5) (Myeloid factor-alpha).

GBRT_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.005326 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLF1	Gene names	Gabrq
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit theta precursor (GABA(A) receptor subunit theta).

FGD5_HUMAN
θ value	8.99809 (rank : 14)	NC score	0.004822 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

VILL_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.004908 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	O15195, Q9BT80, Q9BWH7	Gene names	VILL
Domain Architecture
Description	Villin-like protein.

Hits sorted by NC score

MA2B2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	15	Target Neighborhood Hits	15	Shared Neighborhood Hits	15
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B2_HUMAN
NC score	0.996689 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	15	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y2E5, Q66MP2, Q86T67	Gene names	MAN2B2, KIAA0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B1_MOUSE
NC score	0.891510 (rank : 3)	θ value	1.65806e-78 (rank : 3)
Query Neighborhood Hits	15	Target Neighborhood Hits	17	Shared Neighborhood Hits	9
SwissProt Accessions	O09159, O55037, Q64443, Q9DBQ1	Gene names	Man2b1, Laman, Man2b, Manb
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1).

MA2B1_HUMAN
NC score	0.890427 (rank : 4)	θ value	4.82422e-78 (rank : 4)
Query Neighborhood Hits	15	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O00754, O15330, Q16680, Q93094, Q9BW13	Gene names	MAN2B1, LAMAN, MANB
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1) [Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide].

MA2A1_HUMAN
NC score	0.869904 (rank : 5)	θ value	6.96618e-77 (rank : 5)
Query Neighborhood Hits	15	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	Q16706, Q16767	Gene names	MAN2A1, MANA2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1).

MA2A1_MOUSE
NC score	0.864820 (rank : 6)	θ value	2.56397e-71 (rank : 6)
Query Neighborhood Hits	15	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

MA2A2_HUMAN
NC score	0.857121 (rank : 7)	θ value	3.974e-56 (rank : 7)
Query Neighborhood Hits	15	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	P49641, Q13754	Gene names	MAN2A2, MANA2X
Domain Architecture
Description	Alpha-mannosidase IIx (EC 3.2.1.114) (Mannosyl-oligosaccharide 1,3- 1,6-alpha-mannosidase) (MAN IIx) (Mannosidase alpha class 2A member 2).

MA2C1_MOUSE
NC score	0.271798 (rank : 8)	θ value	0.00102713 (rank : 9)
Query Neighborhood Hits	15	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

MA2C1_HUMAN
NC score	0.239104 (rank : 9)	θ value	0.000602161 (rank : 8)
Query Neighborhood Hits	15	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

GLCE_HUMAN
NC score	0.025403 (rank : 10)	θ value	1.81305 (rank : 11)
Query Neighborhood Hits	15	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	O94923, Q6GUQ2	Gene names	GLCE, KIAA0836
Domain Architecture	No domain graphic available
Description	D-glucuronyl C5-epimerase (EC 5.1.3.-) (Heparin/heparan sulfate:glucuronic acid C5 epimerase).

HDAC6_HUMAN
NC score	0.020101 (rank : 11)	θ value	0.47712 (rank : 10)
Query Neighborhood Hits	15	Target Neighborhood Hits	145	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBN7	Gene names	HDAC6
Domain Architecture
Description	Histone deacetylase 6 (HD6).

FOXD4_HUMAN
NC score	0.005827 (rank : 12)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	15	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q12950, Q5VVK1, Q8WXT6	Gene names	FOXD4, FKHL9, FOXD4A, FREAC5
Domain Architecture
Description	Forkhead box protein D4 (Forkhead-related protein FKHL9) (Forkhead- related transcription factor 5) (FREAC-5) (Myeloid factor-alpha).

GBRT_MOUSE
NC score	0.005326 (rank : 13)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	15	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLF1	Gene names	Gabrq
Domain Architecture
Description	Gamma-aminobutyric-acid receptor subunit theta precursor (GABA(A) receptor subunit theta).

VILL_HUMAN
NC score	0.004908 (rank : 14)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	15	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	O15195, Q9BT80, Q9BWH7	Gene names	VILL
Domain Architecture
Description	Villin-like protein.

FGD5_HUMAN
NC score	0.004822 (rank : 15)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	15	Target Neighborhood Hits	235	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).