Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : MA2B1_HUMAN

For an explanation of this page, click here

MA2B1_HUMAN
SwissProt Accessions	O00754, O15330, Q16680, Q93094, Q9BW13	Gene names	MAN2B1, LAMAN, MANB
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1) [Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MA2B1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	O00754, O15330, Q16680, Q93094, Q9BW13	Gene names	MAN2B1, LAMAN, MANB
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1) [Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide].

MA2B1_MOUSE
θ value	0 (rank : 2)	NC score	0.996726 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	O09159, O55037, Q64443, Q9DBQ1	Gene names	Man2b1, Laman, Man2b, Manb
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1).

MA2B2_HUMAN
θ value	4.66183e-81 (rank : 3)	NC score	0.892872 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2E5, Q66MP2, Q86T67	Gene names	MAN2B2, KIAA0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B2_MOUSE
θ value	4.82422e-78 (rank : 4)	NC score	0.890427 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2A1_HUMAN
θ value	1.71583e-75 (rank : 5)	NC score	0.870359 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q16706, Q16767	Gene names	MAN2A1, MANA2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1).

MA2A1_MOUSE
θ value	1.7756e-72 (rank : 6)	NC score	0.866819 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	8
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

MA2A2_HUMAN
θ value	8.83269e-64 (rank : 7)	NC score	0.863192 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P49641, Q13754	Gene names	MAN2A2, MANA2X
Domain Architecture
Description	Alpha-mannosidase IIx (EC 3.2.1.114) (Mannosyl-oligosaccharide 1,3- 1,6-alpha-mannosidase) (MAN IIx) (Mannosidase alpha class 2A member 2).

MA2C1_MOUSE
θ value	0.0113563 (rank : 8)	NC score	0.222301 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

TLK1_HUMAN
θ value	0.279714 (rank : 9)	NC score	0.009393 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	967	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	0.47712 (rank : 10)	NC score	0.008937 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	947	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

KCD10_MOUSE
θ value	3.0926 (rank : 11)	NC score	0.034559 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q922M3	Gene names	Kctd10
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD10.

CENB1_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.006531 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	383	Shared Neighborhood Hits	2
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

KCD13_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.033414 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WZ19, Q96P93, Q96SA1	Gene names	KCTD13, PDIP1, POLDIP1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD13 (Polymerase delta-interacting protein 1) (TNFAIP1-like protein).

KCD13_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.035187 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGV7, Q6AXE9	Gene names	Kctd13, Poldip1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD13 (Polymerase delta-interacting protein 1).

ANC4_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.010426 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UJX5, Q9NSH6	Gene names	ANAPC4, APC4
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4).

CASP1_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.006628 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

GHC1_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.005102 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D6M3, Q3TRY1	Gene names	Slc25a22, Gc1
Domain Architecture
Description	Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22).

KCD10_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.029167 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H3F6, Q53HN2, Q59FV1, Q6PL47, Q96SU0	Gene names	KCTD10, ULR061
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD10.

SPON2_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.009828 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

MA2C1_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.167600 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

Hits sorted by NC score

MA2B1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	O00754, O15330, Q16680, Q93094, Q9BW13	Gene names	MAN2B1, LAMAN, MANB
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1) [Contains: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha- mannosidase E peptide].

MA2B1_MOUSE
NC score	0.996726 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	O09159, O55037, Q64443, Q9DBQ1	Gene names	Man2b1, Laman, Man2b, Manb
Domain Architecture
Description	Lysosomal alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase, alpha B) (Lysosomal acid alpha-mannosidase) (Laman) (Mannosidase alpha class 2B member 1).

MA2B2_HUMAN
NC score	0.892872 (rank : 3)	θ value	4.66183e-81 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2E5, Q66MP2, Q86T67	Gene names	MAN2B2, KIAA0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2B2_MOUSE
NC score	0.890427 (rank : 4)	θ value	4.82422e-78 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	O54782, Q69ZV1, Q8BH85, Q9DBK2	Gene names	Man2b2, Kiaa0935
Domain Architecture
Description	Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24) (Mannosidase alpha class 2B member 2).

MA2A1_HUMAN
NC score	0.870359 (rank : 5)	θ value	1.71583e-75 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q16706, Q16767	Gene names	MAN2A1, MANA2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1).

MA2A1_MOUSE
NC score	0.866819 (rank : 6)	θ value	1.7756e-72 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	25	Shared Neighborhood Hits	8
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

MA2A2_HUMAN
NC score	0.863192 (rank : 7)	θ value	8.83269e-64 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P49641, Q13754	Gene names	MAN2A2, MANA2X
Domain Architecture
Description	Alpha-mannosidase IIx (EC 3.2.1.114) (Mannosyl-oligosaccharide 1,3- 1,6-alpha-mannosidase) (MAN IIx) (Mannosidase alpha class 2A member 2).

MA2C1_MOUSE
NC score	0.222301 (rank : 8)	θ value	0.0113563 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q91W89	Gene names	Man2c1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1).

MA2C1_HUMAN
NC score	0.167600 (rank : 9)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NTJ4, Q13358, Q9UL64	Gene names	MAN2C1
Domain Architecture
Description	Alpha-mannosidase 2C1 (EC 3.2.1.24) (Alpha-D-mannoside mannohydrolase) (Mannosidase alpha class 2C member 1) (Alpha mannosidase 6A8B).

KCD13_MOUSE
NC score	0.035187 (rank : 10)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGV7, Q6AXE9	Gene names	Kctd13, Poldip1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD13 (Polymerase delta-interacting protein 1).

KCD10_MOUSE
NC score	0.034559 (rank : 11)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q922M3	Gene names	Kctd10
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD10.

KCD13_HUMAN
NC score	0.033414 (rank : 12)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	45	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WZ19, Q96P93, Q96SA1	Gene names	KCTD13, PDIP1, POLDIP1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD13 (Polymerase delta-interacting protein 1) (TNFAIP1-like protein).

KCD10_HUMAN
NC score	0.029167 (rank : 13)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H3F6, Q53HN2, Q59FV1, Q6PL47, Q96SU0	Gene names	KCTD10, ULR061
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD10.

ANC4_HUMAN
NC score	0.010426 (rank : 14)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UJX5, Q9NSH6	Gene names	ANAPC4, APC4
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4).

SPON2_HUMAN
NC score	0.009828 (rank : 15)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

TLK1_HUMAN
NC score	0.009393 (rank : 16)	θ value	0.279714 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	967	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
NC score	0.008937 (rank : 17)	θ value	0.47712 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	947	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

CASP1_HUMAN
NC score	0.006628 (rank : 18)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CENB1_HUMAN
NC score	0.006531 (rank : 19)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	383	Shared Neighborhood Hits	2
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

GHC1_MOUSE
NC score	0.005102 (rank : 20)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D6M3, Q3TRY1	Gene names	Slc25a22, Gc1
Domain Architecture
Description	Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22).