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Network neighborhood for query Sequence : LPH_HUMAN

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LPH_HUMAN
SwissProt Accessions	P09848	Gene names	LCT, LPH
Domain Architecture
Description	Lactase-phlorizin hydrolase precursor (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

KLOTB_MOUSE
θ value	0 (rank : 1)	NC score	0.964339 (rank : 5)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q99N32, Q920J2, Q99N31	Gene names	Klb, Betakl
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

KLOT_HUMAN
θ value	0 (rank : 2)	NC score	0.965022 (rank : 4)
Query Neighborhood Hits	27	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UEF7, Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0	Gene names	KL
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

KLOT_MOUSE
θ value	0 (rank : 3)	NC score	0.965089 (rank : 3)
Query Neighborhood Hits	27	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

LPH_HUMAN
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	27
SwissProt Accessions	P09848	Gene names	LCT, LPH
Domain Architecture
Description	Lactase-phlorizin hydrolase precursor (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)].

KLOTB_HUMAN
θ value	3.24166e-183 (rank : 5)	NC score	0.963502 (rank : 6)
Query Neighborhood Hits	27	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q86Z14	Gene names	KLB
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

LCTL_HUMAN
θ value	1.74296e-136 (rank : 6)	NC score	0.961316 (rank : 7)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UWM7	Gene names	LCTL, KLPH
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

LCTL_MOUSE
θ value	1.52691e-132 (rank : 7)	NC score	0.960013 (rank : 8)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K1F9, Q8BPR1, Q8K2M9	Gene names	Lctl, Klph
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

GBA3_HUMAN
θ value	8.67031e-128 (rank : 8)	NC score	0.969467 (rank : 2)
Query Neighborhood Hits	27	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H227, Q3MIH4, Q53GG8, Q6NSF4, Q8NHT8, Q9H3T4, Q9H4C6	Gene names	GBA3, CBG, CBGL1
Domain Architecture	No domain graphic available
Description	Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase- like protein 1).

ANKH_HUMAN
θ value	0.47712 (rank : 9)	NC score	0.046690 (rank : 9)
Query Neighborhood Hits	27	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCJ1, Q9NQW2	Gene names	ANKH, KIAA1581
Domain Architecture
Description	Progressive ankylosis protein homolog (ANK).

DYHC_HUMAN
θ value	0.47712 (rank : 10)	NC score	0.022464 (rank : 11)
Query Neighborhood Hits	27	Target Neighborhood Hits	733	Shared Neighborhood Hits	4
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

ANKH_MOUSE
θ value	0.813845 (rank : 11)	NC score	0.044284 (rank : 10)
Query Neighborhood Hits	27	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHZ2, O35138, O35139	Gene names	Ankh, Ank
Domain Architecture
Description	Progressive ankylosis protein (Fn54 protein).

DYHC_MOUSE
θ value	0.813845 (rank : 12)	NC score	0.021575 (rank : 12)
Query Neighborhood Hits	27	Target Neighborhood Hits	729	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

NKRF_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.014556 (rank : 14)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	O15226, Q9UJ91	Gene names	NKRF, ITBA4, NRF
Domain Architecture
Description	NF-kappa-B-repressing factor (NFKB-repressing factor) (Transcription factor NRF) (ITBA4 protein).

STON1_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.012387 (rank : 16)
Query Neighborhood Hits	27	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CDJ8, Q8CDL8, Q9D5T3	Gene names	Ston1, Salf, Sblf, Stn1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

TFAM_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.014311 (rank : 15)
Query Neighborhood Hits	27	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q00059	Gene names	TFAM, TCF6L2
Domain Architecture
Description	Transcription factor A, mitochondrial precursor (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6-like 2).

ADNP_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.011697 (rank : 19)
Query Neighborhood Hits	27	Target Neighborhood Hits	265	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2P0, O94881, Q9UG34	Gene names	ADNP, KIAA0784
Domain Architecture
Description	Activity-dependent neuroprotector (Activity-dependent neuroprotective protein).

CPNE5_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.011831 (rank : 17)
Query Neighborhood Hits	27	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
θ value	5.27518 (rank : 18)	NC score	0.011816 (rank : 18)
Query Neighborhood Hits	27	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

HPLN4_MOUSE
θ value	5.27518 (rank : 19)	NC score	0.006773 (rank : 26)
Query Neighborhood Hits	27	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q80WM4, Q80XX2	Gene names	Hapln4, Bral2, Lpr4
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2) (Link protein 4).

ATX2_MOUSE
θ value	6.88961 (rank : 20)	NC score	0.007469 (rank : 25)
Query Neighborhood Hits	27	Target Neighborhood Hits	445	Shared Neighborhood Hits	2
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

CPNE8_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.011230 (rank : 20)
Query Neighborhood Hits	27	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

DCNL4_MOUSE
θ value	6.88961 (rank : 22)	NC score	0.010689 (rank : 21)
Query Neighborhood Hits	27	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCA0	Gene names	Dcun1d4
Domain Architecture	No domain graphic available
Description	DCN1-like protein 4 (Defective in cullin neddylation protein 1-like protein 4) (DCUN1 domain-containing protein 4).

FXL13_HUMAN
θ value	6.88961 (rank : 23)	NC score	0.008319 (rank : 24)
Query Neighborhood Hits	27	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

RIFK_HUMAN
θ value	6.88961 (rank : 24)	NC score	0.015703 (rank : 13)
Query Neighborhood Hits	27	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q969G6, Q9NUT7	Gene names	RFK
Domain Architecture
Description	Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase).

SGCD_MOUSE
θ value	6.88961 (rank : 25)	NC score	0.008875 (rank : 23)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P82347	Gene names	Sgcd
Domain Architecture
Description	Delta-sarcoglycan (SG-delta) (35 kDa dystrophin-associated glycoprotein) (35DAG).

CPNE8_HUMAN
θ value	8.99809 (rank : 26)	NC score	0.010643 (rank : 22)
Query Neighborhood Hits	27	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

MEOX2_MOUSE
θ value	8.99809 (rank : 27)	NC score	0.001396 (rank : 27)
Query Neighborhood Hits	27	Target Neighborhood Hits	341	Shared Neighborhood Hits	2
SwissProt Accessions	P32443, Q544T6	Gene names	Meox2, Gax, Mox-2, Mox2
Domain Architecture
Description	Homeobox protein MOX-2 (Mesenchyme homeobox 2).

Hits sorted by NC score

LPH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	27	Target Neighborhood Hits	27	Shared Neighborhood Hits	27
SwissProt Accessions	P09848	Gene names	LCT, LPH
Domain Architecture
Description	Lactase-phlorizin hydrolase precursor (Lactase-glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Phlorizin hydrolase (EC 3.2.1.62)].

GBA3_HUMAN
NC score	0.969467 (rank : 2)	θ value	8.67031e-128 (rank : 8)
Query Neighborhood Hits	27	Target Neighborhood Hits	12	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H227, Q3MIH4, Q53GG8, Q6NSF4, Q8NHT8, Q9H3T4, Q9H4C6	Gene names	GBA3, CBG, CBGL1
Domain Architecture	No domain graphic available
Description	Cytosolic beta-glucosidase (EC 3.2.1.21) (Cytosolic beta-glucosidase- like protein 1).

KLOT_MOUSE
NC score	0.965089 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	27	Target Neighborhood Hits	17	Shared Neighborhood Hits	8
SwissProt Accessions	O35082, O70175, O70621	Gene names	Kl
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

KLOT_HUMAN
NC score	0.965022 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	27	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UEF7, Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0	Gene names	KL
Domain Architecture	No domain graphic available
Description	Klotho precursor (EC 3.2.1.31) [Contains: Klotho peptide].

KLOTB_MOUSE
NC score	0.964339 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q99N32, Q920J2, Q99N31	Gene names	Klb, Betakl
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

KLOTB_HUMAN
NC score	0.963502 (rank : 6)	θ value	3.24166e-183 (rank : 5)
Query Neighborhood Hits	27	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q86Z14	Gene names	KLB
Domain Architecture	No domain graphic available
Description	Beta klotho (BetaKlotho) (Klotho beta-like protein).

LCTL_HUMAN
NC score	0.961316 (rank : 7)	θ value	1.74296e-136 (rank : 6)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UWM7	Gene names	LCTL, KLPH
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

LCTL_MOUSE
NC score	0.960013 (rank : 8)	θ value	1.52691e-132 (rank : 7)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K1F9, Q8BPR1, Q8K2M9	Gene names	Lctl, Klph
Domain Architecture	No domain graphic available
Description	Lactase-like protein precursor (Klotho/lactase-phlorizin hydrolase- related protein).

ANKH_HUMAN
NC score	0.046690 (rank : 9)	θ value	0.47712 (rank : 9)
Query Neighborhood Hits	27	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCJ1, Q9NQW2	Gene names	ANKH, KIAA1581
Domain Architecture
Description	Progressive ankylosis protein homolog (ANK).

ANKH_MOUSE
NC score	0.044284 (rank : 10)	θ value	0.813845 (rank : 11)
Query Neighborhood Hits	27	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JHZ2, O35138, O35139	Gene names	Ankh, Ank
Domain Architecture
Description	Progressive ankylosis protein (Fn54 protein).

DYHC_HUMAN
NC score	0.022464 (rank : 11)	θ value	0.47712 (rank : 10)
Query Neighborhood Hits	27	Target Neighborhood Hits	733	Shared Neighborhood Hits	4
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
NC score	0.021575 (rank : 12)	θ value	0.813845 (rank : 12)
Query Neighborhood Hits	27	Target Neighborhood Hits	729	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

RIFK_HUMAN
NC score	0.015703 (rank : 13)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	27	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q969G6, Q9NUT7	Gene names	RFK
Domain Architecture
Description	Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase).

NKRF_HUMAN
NC score	0.014556 (rank : 14)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	27	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	O15226, Q9UJ91	Gene names	NKRF, ITBA4, NRF
Domain Architecture
Description	NF-kappa-B-repressing factor (NFKB-repressing factor) (Transcription factor NRF) (ITBA4 protein).

TFAM_HUMAN
NC score	0.014311 (rank : 15)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	27	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q00059	Gene names	TFAM, TCF6L2
Domain Architecture
Description	Transcription factor A, mitochondrial precursor (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6-like 2).

STON1_MOUSE
NC score	0.012387 (rank : 16)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	27	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CDJ8, Q8CDL8, Q9D5T3	Gene names	Ston1, Salf, Sblf, Stn1
Domain Architecture
Description	Stonin-1 (Stoned B-like factor).

CPNE5_HUMAN
NC score	0.011831 (rank : 17)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	27	Target Neighborhood Hits	88	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCH3	Gene names	CPNE5, KIAA1599
Domain Architecture
Description	Copine-5 (Copine V).

CPNE5_MOUSE
NC score	0.011816 (rank : 18)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	27	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	Q8JZW4	Gene names	Cpne5
Domain Architecture
Description	Copine-5 (Copine V).

ADNP_HUMAN
NC score	0.011697 (rank : 19)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	27	Target Neighborhood Hits	265	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2P0, O94881, Q9UG34	Gene names	ADNP, KIAA0784
Domain Architecture
Description	Activity-dependent neuroprotector (Activity-dependent neuroprotective protein).

CPNE8_MOUSE
NC score	0.011230 (rank : 20)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	27	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DC53, Q9CUZ8	Gene names	Cpne8
Domain Architecture
Description	Copine-8 (Copine VIII).

DCNL4_MOUSE
NC score	0.010689 (rank : 21)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	27	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CCA0	Gene names	Dcun1d4
Domain Architecture	No domain graphic available
Description	DCN1-like protein 4 (Defective in cullin neddylation protein 1-like protein 4) (DCUN1 domain-containing protein 4).

CPNE8_HUMAN
NC score	0.010643 (rank : 22)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	27	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	Q86YQ8, Q2TB41	Gene names	CPNE8
Domain Architecture
Description	Copine-8 (Copine VIII).

SGCD_MOUSE
NC score	0.008875 (rank : 23)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	27	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P82347	Gene names	Sgcd
Domain Architecture
Description	Delta-sarcoglycan (SG-delta) (35 kDa dystrophin-associated glycoprotein) (35DAG).

FXL13_HUMAN
NC score	0.008319 (rank : 24)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	27	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

ATX2_MOUSE
NC score	0.007469 (rank : 25)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	27	Target Neighborhood Hits	445	Shared Neighborhood Hits	2
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

HPLN4_MOUSE
NC score	0.006773 (rank : 26)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	27	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q80WM4, Q80XX2	Gene names	Hapln4, Bral2, Lpr4
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2) (Link protein 4).

MEOX2_MOUSE
NC score	0.001396 (rank : 27)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	27	Target Neighborhood Hits	341	Shared Neighborhood Hits	2
SwissProt Accessions	P32443, Q544T6	Gene names	Meox2, Gax, Mox-2, Mox2
Domain Architecture
Description	Homeobox protein MOX-2 (Mesenchyme homeobox 2).